Click here to switch to the map view.

The map label for this gene is ytpA [H]

Identifier: 73543056

GI number: 73543056

Start: 3694325

End: 3695266

Strand: Reverse

Name: ytpA [H]

Synonym: Reut_A3374

Alternate gene names: 73543056

Gene position: 3695266-3694325 (Counterclockwise)

Preceding gene: 73543057

Following gene: 73543054

Centisome position: 97.08

GC content: 66.03

Gene sequence:

>942_bases
ATGGACAAGCCCATGACGGAAAACCCCGTTCATCCTGCTGAAGCAGGCCCATCCGGTCCTGCGGACGCGGCTGGCAAAGC
GCCCGGTCTTGCAGCAGTAGAAAGCCGCCAGCGTATGCGCGACGGCACCGAACTGCTGCTGCGCACCTGGGAACCGGATC
CGTGCATGTTCCCCGAAACGGTCGGCTGCGTGTTGCTCGTCCATGGGCTGGCTGAGCACTGCGGCCGCTACCAGCATGTG
GCCGAGGTGCTGTGCGGATTGGGCCTGCGTGTGCGCGCATACGACCAGCGCGGCCATGGTGCGAGCGGTGGGGCGCGCAT
GGTCGCGGAACATCCCGATGCCTACCTCAATGACCTTGTCGAAATCCATGACGCGGCAGTGCGGGTCTGGAAGGAACTGC
CGATCCTGCTCGGCCACAGCATGGGAGGGCTGGTCGCCGCGCGCTTCGCCACTGCGCGCTTGCGCCCGGTGCGTGCGCTG
GTGCTGTCGTCGCCGGCGCTGGCATTGCGGTTGTCTCCGACGATGCTGACGATCCACCGCGTACTTCTTACGCTGGCGCC
GCGCTTGCGCGTGCCCAACCCGATCGATGCGCGCATGCTGTCGCACGACGCGCATGTCGTGGCGCGCTATCGCGCTGATC
CGCTGGTACAGACCACGATTACGGCCGGCGTACTTGAGAGCTTCATCCGGGGCATGGCGCAAGCGCAGACCGATGCGCCG
CGGCTGGAGGCACCGATGCTGATGCTAGTCGGCGGCGCGGACAAGATCGTCGATCCGGGCGGAAGCCGGACCTTCTTCGA
TCATGCGCCGGCAGATCTCCGCGAAGAAGTGTGGTTCGGCGAGGGCTACCATGAGATCTTCAACGAGGCCGAGCCGTTGC
GCAGCAAGGTATTTGCGGCGCTGACGGACTGGCTGCGGCGGCATCTGGCGCAGCCAGTCTAG

Upstream 100 bases:

>100_bases
CCATGGTGAGGGCGCATGTAGCGGTACGGTGGCGGACGAACAATAATCAGAAACGCAATGCCCCCGCGCCGGTCGGGCGG
CATCGGGAGGAGACCCGCGG

Downstream 100 bases:

>100_bases
GTTCGAAAAACGGACTCAGCGACGCCGAACACTGCGCTGACGACGGGATCTTCACGTCGGCTGGCCAGCGCGACAAGCAT
CAGTTCCGTCTGCACGGACA

Product: Alpha/beta hydrolase fold

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MDKPMTENPVHPAEAGPSGPADAAGKAPGLAAVESRQRMRDGTELLLRTWEPDPCMFPETVGCVLLVHGLAEHCGRYQHV
AEVLCGLGLRVRAYDQRGHGASGGARMVAEHPDAYLNDLVEIHDAAVRVWKELPILLGHSMGGLVAARFATARLRPVRAL
VLSSPALALRLSPTMLTIHRVLLTLAPRLRVPNPIDARMLSHDAHVVARYRADPLVQTTITAGVLESFIRGMAQAQTDAP
RLEAPMLMLVGGADKIVDPGGSRTFFDHAPADLREEVWFGEGYHEIFNEAEPLRSKVFAALTDWLRRHLAQPV

Sequences:

>Translated_313_residues
MDKPMTENPVHPAEAGPSGPADAAGKAPGLAAVESRQRMRDGTELLLRTWEPDPCMFPETVGCVLLVHGLAEHCGRYQHV
AEVLCGLGLRVRAYDQRGHGASGGARMVAEHPDAYLNDLVEIHDAAVRVWKELPILLGHSMGGLVAARFATARLRPVRAL
VLSSPALALRLSPTMLTIHRVLLTLAPRLRVPNPIDARMLSHDAHVVARYRADPLVQTTITAGVLESFIRGMAQAQTDAP
RLEAPMLMLVGGADKIVDPGGSRTFFDHAPADLREEVWFGEGYHEIFNEAEPLRSKVFAALTDWLRRHLAQPV
>Mature_313_residues
MDKPMTENPVHPAEAGPSGPADAAGKAPGLAAVESRQRMRDGTELLLRTWEPDPCMFPETVGCVLLVHGLAEHCGRYQHV
AEVLCGLGLRVRAYDQRGHGASGGARMVAEHPDAYLNDLVEIHDAAVRVWKELPILLGHSMGGLVAARFATARLRPVRAL
VLSSPALALRLSPTMLTIHRVLLTLAPRLRVPNPIDARMLSHDAHVVARYRADPLVQTTITAGVLESFIRGMAQAQTDAP
RLEAPMLMLVGGADKIVDPGGSRTFFDHAPADLREEVWFGEGYHEIFNEAEPLRSKVFAALTDWLRRHLAQPV

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=279, Percent_Identity=31.1827956989247, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI6005786, Length=279, Percent_Identity=31.1827956989247, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1787678, Length=278, Percent_Identity=26.6187050359712, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 34137; Mature: 34137

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKPMTENPVHPAEAGPSGPADAAGKAPGLAAVESRQRMRDGTELLLRTWEPDPCMFPET
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHH
VGCVLLVHGLAEHCGRYQHVAEVLCGLGLRVRAYDQRGHGASGGARMVAEHPDAYLNDLV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCCCHHHHHHH
EIHDAAVRVWKELPILLGHSMGGLVAARFATARLRPVRALVLSSPALALRLSPTMLTIHR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
VLLTLAPRLRVPNPIDARMLSHDAHVVARYRADPLVQTTITAGVLESFIRGMAQAQTDAP
HHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RLEAPMLMLVGGADKIVDPGGSRTFFDHAPADLREEVWFGEGYHEIFNEAEPLRSKVFAA
CCCCCEEEEECCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
LTDWLRRHLAQPV
HHHHHHHHHCCCC
>Mature Secondary Structure
MDKPMTENPVHPAEAGPSGPADAAGKAPGLAAVESRQRMRDGTELLLRTWEPDPCMFPET
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHH
VGCVLLVHGLAEHCGRYQHVAEVLCGLGLRVRAYDQRGHGASGGARMVAEHPDAYLNDLV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCCCHHHHHHH
EIHDAAVRVWKELPILLGHSMGGLVAARFATARLRPVRALVLSSPALALRLSPTMLTIHR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
VLLTLAPRLRVPNPIDARMLSHDAHVVARYRADPLVQTTITAGVLESFIRGMAQAQTDAP
HHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RLEAPMLMLVGGADKIVDPGGSRTFFDHAPADLREEVWFGEGYHEIFNEAEPLRSKVFAA
CCCCCEEEEECCCHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
LTDWLRRHLAQPV
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]