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The map label for this gene is envZ [H]

Identifier: 73543007

GI number: 73543007

Start: 3633729

End: 3634805

Strand: Reverse

Name: envZ [H]

Synonym: Reut_A3325

Alternate gene names: 73543007

Gene position: 3634805-3633729 (Counterclockwise)

Preceding gene: 73543008

Following gene: 73543005

Centisome position: 95.49

GC content: 70.01

Gene sequence:

>1077_bases
ATGGCCCGCTTCGCGCGCTACGACTCGATGTTCCTGCGGCTGTTCGTGGTCATGGCCACGATCATGCTGTGCGTGCACCT
GCTCGGCGTGACCGTGATCGAAAGCCTGTTTCCGCGTCCCGGCGGGCACCATGTCCCGCATGAGATGCGCGGCAATCCGC
CCCCCGGAGCGCCTGGCCCGCCGCAGGGCAGTCGCCCGCCACCGCCGCCGCCAGGGCTGCGCGGAATCTGGCCGCCTCAT
CTCGGCATGCTGTTCCAGCTGGCTGCCATCGTGGCCGCGTCATGGGCCGGCGCACGCCTTCTGGCGCGCCCCGTACAGCA
ACTCGCAAGCGGAGCAGGGCGCCTTGCGCAGGATGTGCACGCGCCGCCGCTGGACGAGCACACCGGCCCGGCCGAGGCGC
GCGCGGCCGCGCAGGCGTTCAACCATATGCAGCAACGCATCCGCATGCAGCTTGCGCAGCAGTCGCGCTTCCTCGCCGCG
GTCTCGCACGATCTGCGCACACCGCTCACGCGCATGAGCCTGCGCCTCGAGGGAATTGCCGACAACCCGGTGCAGTACCG
GCTGCGCCAGGACTTGGCCGAGATGAACGGGCTCATCGATTCGACGCTGTATTACCTGCGCGACCGCGACGAGGCCGCTG
GTCCGCGCCAGCGCGTCGACGTGCTGGCGTTGCTGCAGGCGGTCGTGGACGACGCTGCGGAGCTTGGCCACGAGGTGTTG
CTGAACGGCCAGGCGGCGCCGCTGCTGGCTTACCCGGCAGAGTTGCGGCGCGCCGTGGTCAACCTTGTGGAGAACGCGCA
GCGCTATGGCGAGCGCGCACACATTGTGTTGACCGACAGCGCGCAGCGAGTGCGGATCGATATCTGCGACGAAGGCCCGG
GCATTCCGCCCGAAGAGCTGGCGCGCGTGCTGGAGCCGTTCTACCGGCTTGAATCGTCGCGCAGCCGCGCCACCGGCGGC
GTCGGCATGGGCTTGTCGATCGCGGCCGACATCGTCGCGCGCCACGGCGGTGAACTGACGATTGCCAACCGCGAGGCCGG
CGGCCTGCGCGTGCGCATCGACCTACCGCGCGCCTGA

Upstream 100 bases:

>100_bases
CTGCGCCAGAAGCTGCGCGATGATCCGCGCGACCCCGTACTGATCCGCACTGTGCGCGGCGAAGGCTACGTGTTCACCAC
GGCGCCGGAGCGCTGAAGCC

Downstream 100 bases:

>100_bases
CGCGGCGAGCTGGACGTAGCGCGAGCCGCGCTGTCCCTGCGTGAAATCGAGCGTGAAGTCGCCGACGTCCACGCGCGCCT
GCAGTGCGCGTCGCAGTTCC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MARFARYDSMFLRLFVVMATIMLCVHLLGVTVIESLFPRPGGHHVPHEMRGNPPPGAPGPPQGSRPPPPPPGLRGIWPPH
LGMLFQLAAIVAASWAGARLLARPVQQLASGAGRLAQDVHAPPLDEHTGPAEARAAAQAFNHMQQRIRMQLAQQSRFLAA
VSHDLRTPLTRMSLRLEGIADNPVQYRLRQDLAEMNGLIDSTLYYLRDRDEAAGPRQRVDVLALLQAVVDDAAELGHEVL
LNGQAAPLLAYPAELRRAVVNLVENAQRYGERAHIVLTDSAQRVRIDICDEGPGIPPEELARVLEPFYRLESSRSRATGG
VGMGLSIAADIVARHGGELTIANREAGGLRVRIDLPRA

Sequences:

>Translated_358_residues
MARFARYDSMFLRLFVVMATIMLCVHLLGVTVIESLFPRPGGHHVPHEMRGNPPPGAPGPPQGSRPPPPPPGLRGIWPPH
LGMLFQLAAIVAASWAGARLLARPVQQLASGAGRLAQDVHAPPLDEHTGPAEARAAAQAFNHMQQRIRMQLAQQSRFLAA
VSHDLRTPLTRMSLRLEGIADNPVQYRLRQDLAEMNGLIDSTLYYLRDRDEAAGPRQRVDVLALLQAVVDDAAELGHEVL
LNGQAAPLLAYPAELRRAVVNLVENAQRYGERAHIVLTDSAQRVRIDICDEGPGIPPEELARVLEPFYRLESSRSRATGG
VGMGLSIAADIVARHGGELTIANREAGGLRVRIDLPRA
>Mature_357_residues
ARFARYDSMFLRLFVVMATIMLCVHLLGVTVIESLFPRPGGHHVPHEMRGNPPPGAPGPPQGSRPPPPPPGLRGIWPPHL
GMLFQLAAIVAASWAGARLLARPVQQLASGAGRLAQDVHAPPLDEHTGPAEARAAAQAFNHMQQRIRMQLAQQSRFLAAV
SHDLRTPLTRMSLRLEGIADNPVQYRLRQDLAEMNGLIDSTLYYLRDRDEAAGPRQRVDVLALLQAVVDDAAELGHEVLL
NGQAAPLLAYPAELRRAVVNLVENAQRYGERAHIVLTDSAQRVRIDICDEGPGIPPEELARVLEPFYRLESSRSRATGGV
GMGLSIAADIVARHGGELTIANREAGGLRVRIDLPRA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=273, Percent_Identity=34.4322344322344, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=29.5880149812734, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1787894, Length=258, Percent_Identity=34.1085271317829, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=29.9270072992701, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=30.4659498207885, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786783, Length=294, Percent_Identity=28.2312925170068, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=33.1818181818182, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=31.6964285714286, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=223, Percent_Identity=29.5964125560538, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=27.5510204081633, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789403, Length=247, Percent_Identity=29.1497975708502, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789149, Length=212, Percent_Identity=27.8301886792453, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=27.0491803278689, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38988; Mature: 38856

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFARYDSMFLRLFVVMATIMLCVHLLGVTVIESLFPRPGGHHVPHEMRGNPPPGAPGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC
PQGSRPPPPPPGLRGIWPPHLGMLFQLAAIVAASWAGARLLARPVQQLASGAGRLAQDVH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APPLDEHTGPAEARAAAQAFNHMQQRIRMQLAQQSRFLAAVSHDLRTPLTRMSLRLEGIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
DNPVQYRLRQDLAEMNGLIDSTLYYLRDRDEAAGPRQRVDVLALLQAVVDDAAELGHEVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHE
LNGQAAPLLAYPAELRRAVVNLVENAQRYGERAHIVLTDSAQRVRIDICDEGPGIPPEEL
ECCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCHHHH
ARVLEPFYRLESSRSRATGGVGMGLSIAADIVARHGGELTIANREAGGLRVRIDLPRA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure 
ARFARYDSMFLRLFVVMATIMLCVHLLGVTVIESLFPRPGGHHVPHEMRGNPPPGAPGP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCC
PQGSRPPPPPPGLRGIWPPHLGMLFQLAAIVAASWAGARLLARPVQQLASGAGRLAQDVH
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APPLDEHTGPAEARAAAQAFNHMQQRIRMQLAQQSRFLAAVSHDLRTPLTRMSLRLEGIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
DNPVQYRLRQDLAEMNGLIDSTLYYLRDRDEAAGPRQRVDVLALLQAVVDDAAELGHEVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHE
LNGQAAPLLAYPAELRRAVVNLVENAQRYGERAHIVLTDSAQRVRIDICDEGPGIPPEEL
ECCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCHHHH
ARVLEPFYRLESSRSRATGGVGMGLSIAADIVARHGGELTIANREAGGLRVRIDLPRA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]