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The map label for this gene is hemN [H]

Identifier: 73543005

GI number: 73543005

Start: 3630928

End: 3632397

Strand: Reverse

Name: hemN [H]

Synonym: Reut_A3323

Alternate gene names: 73543005

Gene position: 3632397-3630928 (Counterclockwise)

Preceding gene: 73543007

Following gene: 73543001

Centisome position: 95.43

GC content: 65.58

Gene sequence:

>1470_bases
ATGAATTCCCCCGCAACATCATCCCCGGCGCTCGACCGCCGTGCCCTGTCCGACTTCCGTGCGCTGGCTGGCCGCATCGA
TGGGAACGGCCCGCGCTACACCTCGTATCCCACGGCGGACCGCTTCCACAACAAACTCGGCGAGGCCGGCTACCACGCTT
CGCTGGCGGACTGCCGCGCCGCCGCGCCCGCGCCGTTGTCGCTGTATCTGCACATCCCGTTCTGCGAGAACATCTGTTAC
TACTGCGGCTGCAACAAGGTCATCACGCGCGATCACGGCCGCAGCGCCAAGTACGTCCACTATCTGGCCAAGGAAATGGC
CCTGGCGGCTGCGCACATTGGCGGGCGTCGCCAGGTGCTGCAGTCACACTGGGGCGGCGGCACGCCGACTTTCTTGAACC
CGGAAGAGATGCGGCGCGTGATGGTGTCGCTGCACGAGCATTTCGACCTGCCGGCCGAGGGCGAGCACTCGATCGAGATC
GATCCGCGCCGCGTCGACCACGCGCGCATGGCGCTGCTGGCCGAGCTGGGATTCAACCGCGTGAGCCTCGGCGTGCAGGA
TTTCGATCCAGAAGTGCAGCAGGCCATCCACCGCGTGCAGCCGTTCGAGGAAACCCGCGCCGTCGTGGATGCCGCGCGTG
AGCTCGGATTCCGCTCGGTGAGCCTGGACCTGATCTATGGTCTGCCGCACCAGACCACGGCGCGCTTCAATGCCACGGTG
GAACAGGTGCTGACGCTGCGGCCCGACCGGCTCTCGGTCTACAGCTACGCGCACTTGCCTCACGTCTTCAAGCCACAACG
GCGTATCGATGAGAATGCGCTGCCGAGCGCAGGCGAGAAGCTCGACATCCTCGTCTCGACGATCGAACGCCTGACCGCCG
CCGGTTATGTCTACATCGGCATGGACCACTTTGCGCTGCCCGATGACGACCTCGCCGTAGCGCAACGCGAAGGCCGGCTG
CAGCGCAATTTCCAGGGCTATTCCACGCATGCGGGCTACGACCAGCTCGGCTTCGGCATTTCCGCGATCGGCGCCGTGGC
GGGCCGCTACGTGCAGAACGCGCGCACGCTCGACGAATACTATGCGTCGCTCGATGCCGGCCATCTGCCAGTGATGCGTG
GCTTCGCGATGAATCAGGATGACCACCTGCGACGCGAGATCATCGGCGCGCTGATGTGCAACGGGGTACTCGACATCACG
CAGATCGAGGCACGCCATGGCATCGATTTCGCGCACGCCTTCGCAGCCGAACTCGCGGATCTCGACCGCCTCGCCGAAGA
TGGTCTGGTGCGTCGCGATCCGCGCCGGATCGAGGTGACCTTGCTTGGCCGCTTGCTGGTTCGCCGCGTGGCCATGGTGT
TCGACCGCTACCTGCGCGAAGACGCCGCACGACCGCCTGCCGTGCAACCGGCCGCCAACGACGGCGCGCAGCCTGTCCGG
TTCGTACCGAAGTATTCCCGTGTAGTCTGA

Upstream 100 bases:

>100_bases
CTGCGCGCATGCCATGGCTGCCGCGCTTGATGCGCGTCAATTCCCCATTGGCCTAGGGGCTCTAGCATGGGCCGTCAAAC
TCCCCGGTAAGTCCGCCCCC

Downstream 100 bases:

>100_bases
GGCCGAGGCGCAACGACGCCAGAACGACGGACGAAAAAAAGCCCGCGAACATGTCGCGGGCTTTTCTGTATCCGAAGCCG
GAATTACTTGGCGGCGTTGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNSPATSSPALDRRALSDFRALAGRIDGNGPRYTSYPTADRFHNKLGEAGYHASLADCRAAAPAPLSLYLHIPFCENICY
YCGCNKVITRDHGRSAKYVHYLAKEMALAAAHIGGRRQVLQSHWGGGTPTFLNPEEMRRVMVSLHEHFDLPAEGEHSIEI
DPRRVDHARMALLAELGFNRVSLGVQDFDPEVQQAIHRVQPFEETRAVVDAARELGFRSVSLDLIYGLPHQTTARFNATV
EQVLTLRPDRLSVYSYAHLPHVFKPQRRIDENALPSAGEKLDILVSTIERLTAAGYVYIGMDHFALPDDDLAVAQREGRL
QRNFQGYSTHAGYDQLGFGISAIGAVAGRYVQNARTLDEYYASLDAGHLPVMRGFAMNQDDHLRREIIGALMCNGVLDIT
QIEARHGIDFAHAFAAELADLDRLAEDGLVRRDPRRIEVTLLGRLLVRRVAMVFDRYLREDAARPPAVQPAANDGAQPVR
FVPKYSRVV

Sequences:

>Translated_489_residues
MNSPATSSPALDRRALSDFRALAGRIDGNGPRYTSYPTADRFHNKLGEAGYHASLADCRAAAPAPLSLYLHIPFCENICY
YCGCNKVITRDHGRSAKYVHYLAKEMALAAAHIGGRRQVLQSHWGGGTPTFLNPEEMRRVMVSLHEHFDLPAEGEHSIEI
DPRRVDHARMALLAELGFNRVSLGVQDFDPEVQQAIHRVQPFEETRAVVDAARELGFRSVSLDLIYGLPHQTTARFNATV
EQVLTLRPDRLSVYSYAHLPHVFKPQRRIDENALPSAGEKLDILVSTIERLTAAGYVYIGMDHFALPDDDLAVAQREGRL
QRNFQGYSTHAGYDQLGFGISAIGAVAGRYVQNARTLDEYYASLDAGHLPVMRGFAMNQDDHLRREIIGALMCNGVLDIT
QIEARHGIDFAHAFAAELADLDRLAEDGLVRRDPRRIEVTLLGRLLVRRVAMVFDRYLREDAARPPAVQPAANDGAQPVR
FVPKYSRVV
>Mature_489_residues
MNSPATSSPALDRRALSDFRALAGRIDGNGPRYTSYPTADRFHNKLGEAGYHASLADCRAAAPAPLSLYLHIPFCENICY
YCGCNKVITRDHGRSAKYVHYLAKEMALAAAHIGGRRQVLQSHWGGGTPTFLNPEEMRRVMVSLHEHFDLPAEGEHSIEI
DPRRVDHARMALLAELGFNRVSLGVQDFDPEVQQAIHRVQPFEETRAVVDAARELGFRSVSLDLIYGLPHQTTARFNATV
EQVLTLRPDRLSVYSYAHLPHVFKPQRRIDENALPSAGEKLDILVSTIERLTAAGYVYIGMDHFALPDDDLAVAQREGRL
QRNFQGYSTHAGYDQLGFGISAIGAVAGRYVQNARTLDEYYASLDAGHLPVMRGFAMNQDDHLRREIIGALMCNGVLDIT
QIEARHGIDFAHAFAAELADLDRLAEDGLVRRDPRRIEVTLLGRLLVRRVAMVFDRYLREDAARPPAVQPAANDGAQPVR
FVPKYSRVV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=191, Percent_Identity=29.3193717277487, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI87082341, Length=442, Percent_Identity=48.6425339366516, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1789325, Length=295, Percent_Identity=29.8305084745763, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54512; Mature: 54512

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPATSSPALDRRALSDFRALAGRIDGNGPRYTSYPTADRFHNKLGEAGYHASLADCRA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHC
AAPAPLSLYLHIPFCENICYYCGCNKVITRDHGRSAKYVHYLAKEMALAAAHIGGRRQVL
CCCCCEEEEEECCHHHCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
QSHWGGGTPTFLNPEEMRRVMVSLHEHFDLPAEGEHSIEIDPRRVDHARMALLAELGFNR
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCC
VSLGVQDFDPEVQQAIHRVQPFEETRAVVDAARELGFRSVSLDLIYGLPHQTTARFNATV
EECCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHH
EQVLTLRPDRLSVYSYAHLPHVFKPQRRIDENALPSAGEKLDILVSTIERLTAAGYVYIG
HHHHHCCCCCEEHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEC
MDHFALPDDDLAVAQREGRLQRNFQGYSTHAGYDQLGFGISAIGAVAGRYVQNARTLDEY
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YASLDAGHLPVMRGFAMNQDDHLRREIIGALMCNGVLDITQIEARHGIDFAHAFAAELAD
HHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHH
LDRLAEDGLVRRDPRRIEVTLLGRLLVRRVAMVFDRYLREDAARPPAVQPAANDGAQPVR
HHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
FVPKYSRVV
ECCHHHCCC
>Mature Secondary Structure
MNSPATSSPALDRRALSDFRALAGRIDGNGPRYTSYPTADRFHNKLGEAGYHASLADCRA
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHC
AAPAPLSLYLHIPFCENICYYCGCNKVITRDHGRSAKYVHYLAKEMALAAAHIGGRRQVL
CCCCCEEEEEECCHHHCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
QSHWGGGTPTFLNPEEMRRVMVSLHEHFDLPAEGEHSIEIDPRRVDHARMALLAELGFNR
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCC
VSLGVQDFDPEVQQAIHRVQPFEETRAVVDAARELGFRSVSLDLIYGLPHQTTARFNATV
EECCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHH
EQVLTLRPDRLSVYSYAHLPHVFKPQRRIDENALPSAGEKLDILVSTIERLTAAGYVYIG
HHHHHCCCCCEEHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEC
MDHFALPDDDLAVAQREGRLQRNFQGYSTHAGYDQLGFGISAIGAVAGRYVQNARTLDEY
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
YASLDAGHLPVMRGFAMNQDDHLRREIIGALMCNGVLDITQIEARHGIDFAHAFAAELAD
HHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHH
LDRLAEDGLVRRDPRRIEVTLLGRLLVRRVAMVFDRYLREDAARPPAVQPAANDGAQPVR
HHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
FVPKYSRVV
ECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]