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The map label for this gene is hyi [H]

Identifier: 73542975

GI number: 73542975

Start: 3601112

End: 3601894

Strand: Direct

Name: hyi [H]

Synonym: Reut_A3292

Alternate gene names: 73542975

Gene position: 3601112-3601894 (Clockwise)

Preceding gene: 73542974

Following gene: 73542976

Centisome position: 94.6

GC content: 62.96

Gene sequence:

>783_bases
ATGACCAAACTTGCGGCAAACCTCACCATGCTGTTCAACGAAGTGGGCTTTCTCGACCGCTTCGAAGCCGCCGCACGCGC
GGGCTTCCGCGGCGTGGAATTCCTGTTTCCGTATGCGTTCCACGCGGACCAGATCGCGGACCGCCTGAACCGCTTCCAGC
TGGACCTGGTGTTGCATAACCTGCCGGCCGGCAAGTGGGATGCGGGCGAGCGCGGCATTGCGTGCCACCCGGATCGCGTG
AGCGAGTTCCAGGACGGTGTGGGCGAGGCCATCAAGTACGCCAAGGTGCTCGGCGTGCGCCAGCTCAACTGCCTGGTCGG
CATCCAGCCGCAGAACGTGAAGCGCGAGCAGGCGCAGGAAACGCTGGTGGAAAACCTGCGCTTCGCCGCCAATGCGCTCG
CCGGCGAGCATATCGACCTGCTGATCGAGCCGATCAACACGTTCGATATCCCGGGCTTCTTCCTGTCGCGCACGCAGCAG
GCGGTGGACCTGATCAACCAGGTCAACGTGCCGAATCTGTACGTGCAGTACGACATCTATCACATGCAGCGCATGGAAGG
CGAGATCGCCAACACGATCAAGGCCAACCTGCCGAAGATCAAGCATGTGCAGCTGGCCGACAACCCGGGCCGCAACGAGC
CGGGCACGGGCGAGCTGAACTACCAGTTCCTGTTCAAGTACCTGGACGAAATCGGCTACACCGGCTGGATCGGCTGCGAA
TACAAGCCGAAGACCACCACTGAAGCCGGCCTGGGCTGGCGCGCCGCCCACGGCGTGCAGTAA

Upstream 100 bases:

>100_bases
CCCGCGCTGCTGTCAGCGCCCCCTGTTTTTGCAGCAGAAACGAAAGCAGTAGCGGCTCCGCACCGGCGGAGCGACAACCA
CAATTAAACCGGAGAGATTC

Downstream 100 bases:

>100_bases
CAGCGTGCAGTAACGGGTTACCGCACACGCAATCCATCACAGACTTAACATCCAATCGGAGACATCAACATGGCAAACCA
ACGCAACGTCGGCTTCATCG

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTKLAANLTMLFNEVGFLDRFEAAARAGFRGVEFLFPYAFHADQIADRLNRFQLDLVLHNLPAGKWDAGERGIACHPDRV
SEFQDGVGEAIKYAKVLGVRQLNCLVGIQPQNVKREQAQETLVENLRFAANALAGEHIDLLIEPINTFDIPGFFLSRTQQ
AVDLINQVNVPNLYVQYDIYHMQRMEGEIANTIKANLPKIKHVQLADNPGRNEPGTGELNYQFLFKYLDEIGYTGWIGCE
YKPKTTTEAGLGWRAAHGVQ

Sequences:

>Translated_260_residues
MTKLAANLTMLFNEVGFLDRFEAAARAGFRGVEFLFPYAFHADQIADRLNRFQLDLVLHNLPAGKWDAGERGIACHPDRV
SEFQDGVGEAIKYAKVLGVRQLNCLVGIQPQNVKREQAQETLVENLRFAANALAGEHIDLLIEPINTFDIPGFFLSRTQQ
AVDLINQVNVPNLYVQYDIYHMQRMEGEIANTIKANLPKIKHVQLADNPGRNEPGTGELNYQFLFKYLDEIGYTGWIGCE
YKPKTTTEAGLGWRAAHGVQ
>Mature_259_residues
TKLAANLTMLFNEVGFLDRFEAAARAGFRGVEFLFPYAFHADQIADRLNRFQLDLVLHNLPAGKWDAGERGIACHPDRVS
EFQDGVGEAIKYAKVLGVRQLNCLVGIQPQNVKREQAQETLVENLRFAANALAGEHIDLLIEPINTFDIPGFFLSRTQQA
VDLINQVNVPNLYVQYDIYHMQRMEGEIANTIKANLPKIKHVQLADNPGRNEPGTGELNYQFLFKYLDEIGYTGWIGCEY
KPKTTTEAGLGWRAAHGVQ

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=258, Percent_Identity=40.6976744186046, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=39.917695473251, Blast_Score=168, Evalue=4e-42,
Organism=Escherichia coli, GI1786718, Length=253, Percent_Identity=59.6837944664032, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI1789095, Length=253, Percent_Identity=39.5256916996047, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=37.0833333333333, Blast_Score=163, Evalue=8e-41,
Organism=Drosophila melanogaster, GI17530883, Length=264, Percent_Identity=34.8484848484849, Blast_Score=148, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29251; Mature: 29119

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLAANLTMLFNEVGFLDRFEAAARAGFRGVEFLFPYAFHADQIADRLNRFQLDLVLHN
CCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPAGKWDAGERGIACHPDRVSEFQDGVGEAIKYAKVLGVRQLNCLVGIQPQNVKREQAQE
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHH
TLVENLRFAANALAGEHIDLLIEPINTFDIPGFFLSRTQQAVDLINQVNVPNLYVQYDIY
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHH
HMQRMEGEIANTIKANLPKIKHVQLADNPGRNEPGTGELNYQFLFKYLDEIGYTGWIGCE
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCC
YKPKTTTEAGLGWRAAHGVQ
CCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
TKLAANLTMLFNEVGFLDRFEAAARAGFRGVEFLFPYAFHADQIADRLNRFQLDLVLHN
CCHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPAGKWDAGERGIACHPDRVSEFQDGVGEAIKYAKVLGVRQLNCLVGIQPQNVKREQAQE
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHH
TLVENLRFAANALAGEHIDLLIEPINTFDIPGFFLSRTQQAVDLINQVNVPNLYVQYDIY
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHH
HMQRMEGEIANTIKANLPKIKHVQLADNPGRNEPGTGELNYQFLFKYLDEIGYTGWIGCE
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCC
YKPKTTTEAGLGWRAAHGVQ
CCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]