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The map label for this gene is ung [H]

Identifier: 73542712

GI number: 73542712

Start: 3329854

End: 3330621

Strand: Direct

Name: ung [H]

Synonym: Reut_A3028

Alternate gene names: 73542712

Gene position: 3329854-3330621 (Clockwise)

Preceding gene: 73542711

Following gene: 73542714

Centisome position: 87.48

GC content: 69.01

Gene sequence:

>768_bases
ATGCAAGCCGATCTTTTTGCTCCCGAGACTGACACCGCCCCACCGTCGTCCGCAGCCGCCGGGCTGCAAGCACAAGCCGA
CGCCCTGCCCGCCGCGTGGCGTGCCTTGCTCGCGCCGTGTCTGACGGCGCCCGCCTGGCAGGAATTGTCTACTTTCGTCG
ATGGCGAGCGCGCCGCCGGCAAGCCGGTCTTCCCGCATCACGTCTTCCACGCGCTGCACCTGACGCCCCCGGACGCGGTC
AAGGTCGTGATCCTCGGCCAGGACCCATACCACGGCACCGGCGTCGTCGGCGGCATGGAACTGCCGCAGGCGCATGGCCT
GGCGTTCTCGGTGCCGGACGGCATCAAGGTCCCGCCGAGCCTGCGCAACATCTTCAAGGAAATCGCGGCCGAATACGGCG
ACAGCCCGGCGCCGCGCACGTCCGGCAACCTGGAAGGCTGGGCGCGCCAGGGCGTGCTGCTGCTAAACACGGTGCTGACG
GTGGAACAAGGCCAGGCTGCCAGCCACGCGCGCCGCGGCTGGGAGGCCGTGACCGACTGCGTGATCCACGCGCTGGCCGC
AAGCCATCCCAATCTGGTGTTCCTGCTGTGGGGCAGCCATGCACAGGCCAAGAAGCCGTTGCTGACGGACAGCCATTGCG
TGCTTGAGGCCCCGCATCCGTCGCCGTTGTCGGCGCATCGCGGGTTCCTTGGCTGCGGGCATTTCCGCGCGGCTAACCGG
TGGCTGGAAGCGCATGGCCGGACGCCCATTGACTGGCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
ACGCCGTCCGATCTCAGCAAGGCCGCGCGCGGCTACCGGCTCGCCGGTGTCGACAACGCCTGAACCCTCCTTCCCTGCCA
TCCCGCGCCAATCCGTACGC

Downstream 100 bases:

>100_bases
TCTTTGATCTCGCCAGCGCTGTCTGACGGCAACGTCAGCTACAACGTCGGCCGCAAATCGAAATCCTCGAACTTCCCCTG
GCCCGGCTCGACATCCACAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MQADLFAPETDTAPPSSAAAGLQAQADALPAAWRALLAPCLTAPAWQELSTFVDGERAAGKPVFPHHVFHALHLTPPDAV
KVVILGQDPYHGTGVVGGMELPQAHGLAFSVPDGIKVPPSLRNIFKEIAAEYGDSPAPRTSGNLEGWARQGVLLLNTVLT
VEQGQAASHARRGWEAVTDCVIHALAASHPNLVFLLWGSHAQAKKPLLTDSHCVLEAPHPSPLSAHRGFLGCGHFRAANR
WLEAHGRTPIDWLAA

Sequences:

>Translated_255_residues
MQADLFAPETDTAPPSSAAAGLQAQADALPAAWRALLAPCLTAPAWQELSTFVDGERAAGKPVFPHHVFHALHLTPPDAV
KVVILGQDPYHGTGVVGGMELPQAHGLAFSVPDGIKVPPSLRNIFKEIAAEYGDSPAPRTSGNLEGWARQGVLLLNTVLT
VEQGQAASHARRGWEAVTDCVIHALAASHPNLVFLLWGSHAQAKKPLLTDSHCVLEAPHPSPLSAHRGFLGCGHFRAANR
WLEAHGRTPIDWLAA
>Mature_255_residues
MQADLFAPETDTAPPSSAAAGLQAQADALPAAWRALLAPCLTAPAWQELSTFVDGERAAGKPVFPHHVFHALHLTPPDAV
KVVILGQDPYHGTGVVGGMELPQAHGLAFSVPDGIKVPPSLRNIFKEIAAEYGDSPAPRTSGNLEGWARQGVLLLNTVLT
VEQGQAASHARRGWEAVTDCVIHALAASHPNLVFLLWGSHAQAKKPLLTDSHCVLEAPHPSPLSAHRGFLGCGHFRAANR
WLEAHGRTPIDWLAA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=224, Percent_Identity=47.3214285714286, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI6224979, Length=224, Percent_Identity=47.3214285714286, Blast_Score=181, Evalue=4e-46,
Organism=Escherichia coli, GI1788934, Length=225, Percent_Identity=52.8888888888889, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17556304, Length=225, Percent_Identity=43.5555555555556, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323620, Length=249, Percent_Identity=40.9638554216867, Blast_Score=165, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 27067; Mature: 27067

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQADLFAPETDTAPPSSAAAGLQAQADALPAAWRALLAPCLTAPAWQELSTFVDGERAAG
CCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
KPVFPHHVFHALHLTPPDAVKVVILGQDPYHGTGVVGGMELPQAHGLAFSVPDGIKVPPS
CCCCHHHHHHEEECCCCCCEEEEEECCCCCCCCCEECCCCCCHHCCEEEECCCCCCCCHH
LRNIFKEIAAEYGDSPAPRTSGNLEGWARQGVLLLNTVLTVEQGQAASHARRGWEAVTDC
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHH
VIHALAASHPNLVFLLWGSHAQAKKPLLTDSHCVLEAPHPSPLSAHRGFLGCGHFRAANR
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCEECCHHHHHHH
WLEAHGRTPIDWLAA
HHHHCCCCCHHHHCC
>Mature Secondary Structure
MQADLFAPETDTAPPSSAAAGLQAQADALPAAWRALLAPCLTAPAWQELSTFVDGERAAG
CCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
KPVFPHHVFHALHLTPPDAVKVVILGQDPYHGTGVVGGMELPQAHGLAFSVPDGIKVPPS
CCCCHHHHHHEEECCCCCCEEEEEECCCCCCCCCEECCCCCCHHCCEEEECCCCCCCCHH
LRNIFKEIAAEYGDSPAPRTSGNLEGWARQGVLLLNTVLTVEQGQAASHARRGWEAVTDC
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHH
VIHALAASHPNLVFLLWGSHAQAKKPLLTDSHCVLEAPHPSPLSAHRGFLGCGHFRAANR
HHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCEECCHHHHHHH
WLEAHGRTPIDWLAA
HHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]