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The map label for this gene is coaE

Identifier: 73542647

GI number: 73542647

Start: 3249397

End: 3250023

Strand: Direct

Name: coaE

Synonym: Reut_A2963

Alternate gene names: 73542647

Gene position: 3249397-3250023 (Clockwise)

Preceding gene: 73542646

Following gene: 73542648

Centisome position: 85.36

GC content: 67.78

Gene sequence:

>627_bases
ATGCTGGAGATCGGACTGACTGGCGGTATCGGCAGCGGCAAGACCCGCGTAGCCGACATGTTCGCCGCGCGCGGCGCCGC
CATCATCGACACTGACCTGCTGGCCCACGAGATCACTGCCCCGGGCGGGCAGGCCATCCCCGCGCTGGTCGAGGCCTTCG
GCCCGCAGTGCCTGCGCCCCGACGGCGCCATGGACCGCGACGCCATGCGCGCGGTGGTCTTTGCGGACCCGGCCGCCAAG
GCACGGCTCGAAGGCATCACCCATCCGCTGATCCGCGAACTGACCACGTCACGCGCCGCCGAGATCGCGCACGCCGGTGA
GCATCCCTATCTGATCTACGTCGTGCCGCTGCTGGTTGAATCGGGCGCATGGCTCAATCGCGTGGGGCGCGTGCTGGTCG
TGGACTGCAGCGAGGACACGCAGATCGCCCGTGTCATGTCGCGCAACGGATTCAGCCGCGAGCAGGTGCTGGCCATCATG
GCTAAGCAGGCAACGCGTGCACAGCGCCTGGCAGTCGCCCATGACGTGATCGACAACGATGGGCCGGTTGAGGCACTGAC
GGCACAGGTGGATCAGCTTGATCGCACCTATCGTGCACTGTCCGCCGCCGGCGTCACGCAAGCGTGA

Upstream 100 bases:

>100_bases
CGGGTGTGCTGCCGCTGCTATTCATGCCGTAAGCGGCGCCAGAGGACCGGAGAAGCGCCAAGCTGGTATCGTTTGGGGCA
TTGCACCCACGGAACCTGAC

Downstream 100 bases:

>100_bases
GCCGGAGCACGACCGGGCACCGGACCACTCCAGAACACGGCGCACCGTTCACATTGCATTGTCCTCTCAGCCCGTCTCGC
ATAGAATGCGCTGGAACATG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLEIGLTGGIGSGKTRVADMFAARGAAIIDTDLLAHEITAPGGQAIPALVEAFGPQCLRPDGAMDRDAMRAVVFADPAAK
ARLEGITHPLIRELTTSRAAEIAHAGEHPYLIYVVPLLVESGAWLNRVGRVLVVDCSEDTQIARVMSRNGFSREQVLAIM
AKQATRAQRLAVAHDVIDNDGPVEALTAQVDQLDRTYRALSAAGVTQA

Sequences:

>Translated_208_residues
MLEIGLTGGIGSGKTRVADMFAARGAAIIDTDLLAHEITAPGGQAIPALVEAFGPQCLRPDGAMDRDAMRAVVFADPAAK
ARLEGITHPLIRELTTSRAAEIAHAGEHPYLIYVVPLLVESGAWLNRVGRVLVVDCSEDTQIARVMSRNGFSREQVLAIM
AKQATRAQRLAVAHDVIDNDGPVEALTAQVDQLDRTYRALSAAGVTQA
>Mature_208_residues
MLEIGLTGGIGSGKTRVADMFAARGAAIIDTDLLAHEITAPGGQAIPALVEAFGPQCLRPDGAMDRDAMRAVVFADPAAK
ARLEGITHPLIRELTTSRAAEIAHAGEHPYLIYVVPLLVESGAWLNRVGRVLVVDCSEDTQIARVMSRNGFSREQVLAIM
AKQATRAQRLAVAHDVIDNDGPVEALTAQVDQLDRTYRALSAAGVTQA

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=190, Percent_Identity=34.7368421052632, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI191252795, Length=190, Percent_Identity=34.7368421052632, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI110227607, Length=174, Percent_Identity=32.183908045977, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI110227605, Length=176, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI110227603, Length=176, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI110227601, Length=176, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI205277394, Length=176, Percent_Identity=31.8181818181818, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786292, Length=204, Percent_Identity=42.6470588235294, Blast_Score=158, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17554944, Length=206, Percent_Identity=31.0679611650485, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=31.3131313131313, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644728, Length=184, Percent_Identity=29.8913043478261, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658602, Length=198, Percent_Identity=26.7676767676768, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CUPPJ (Q46X10)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_297167.1
- ProteinModelPortal:   Q46X10
- SMR:   Q46X10
- GeneID:   3608985
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2963
- NMPDR:   fig|264198.3.peg.2913
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   REUT264198:REUT_A2963-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22089; Mature: 22089

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEIGLTGGIGSGKTRVADMFAARGAAIIDTDLLAHEITAPGGQAIPALVEAFGPQCLRP
CEEEEECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
DGAMDRDAMRAVVFADPAAKARLEGITHPLIRELTTSRAAEIAHAGEHPYLIYVVPLLVE
CCCCCHHHHEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHC
SGAWLNRVGRVLVVDCSEDTQIARVMSRNGFSREQVLAIMAKQATRAQRLAVAHDVIDND
CCHHHHHCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPVEALTAQVDQLDRTYRALSAAGVTQA
CCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLEIGLTGGIGSGKTRVADMFAARGAAIIDTDLLAHEITAPGGQAIPALVEAFGPQCLRP
CEEEEECCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCC
DGAMDRDAMRAVVFADPAAKARLEGITHPLIRELTTSRAAEIAHAGEHPYLIYVVPLLVE
CCCCCHHHHEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHC
SGAWLNRVGRVLVVDCSEDTQIARVMSRNGFSREQVLAIMAKQATRAQRLAVAHDVIDND
CCHHHHHCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPVEALTAQVDQLDRTYRALSAAGVTQA
CCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA