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The map label for this gene is aslA [H]

Identifier: 73542578

GI number: 73542578

Start: 3171181

End: 3172884

Strand: Reverse

Name: aslA [H]

Synonym: Reut_A2893

Alternate gene names: 73542578

Gene position: 3172884-3171181 (Counterclockwise)

Preceding gene: 73542579

Following gene: 73542577

Centisome position: 83.35

GC content: 62.79

Gene sequence:

>1704_bases
ATGCTGGCCATGGCCGCCGCCGTGTTCACGTTGGCGGGCTGCGGCAAGAAGGAAACGCCGCCCAAGGAACAGCAGCCAGC
GGCACAGGCGCCCGCGCCCGCGCCTGTGGCGCAGGCTCCGGTGCCTGCAAAGGAAAACCCGCCCGTGGCGGCCAGTGCGC
CAGTTGACGCGGCATCGGCGCCGGCGCTGGCGGCTACCTCGTCGTCCGGCAAGAAGCCGAACATCCTCGTCATCTTCGGC
GATGACATCGGGCAGACCAACATCAGCGCCTACAGTCACGGCGTGGTGGGCTATCGCACGCCCAACATCGACCGCATCGC
CAATGAAGGCATGATGCTCACCGACTACTACGGCGAGAACAGCTGCACGGCAGGCCGCTCCACGTTCATTACCGGTGAGG
TTGGCTTGCGCACCGGTCTGCTGAAGGTCGGCATTCCCGGCGCACCGGTCGGTCTGCAGGCGCAGAACGTGACGATCGCA
CAGGCGCTCAAGCCGCTCGGCTATGCGACCGGCCAGTTTGGCAAGAATCACCTGGGCGACCGCAACGAGTACCTGCCGAC
CGCGCACGGCTTCGACGAGTTCTTCGGCAACCTCTACCACTTGAACGCGGAAGAGGAACCCGAGCGTCCGTACTACCCGA
AGAACGATACGGCATGGGTCAAGGCAAACGCGCCGCGTGGCGTGCTCCATACGTACGCCGACGGCAAGATCGAAGATACC
GGTCCGCTGAACCGCAAGCGCATGGAGACCATCGATGACGAAACCACGGCGGCGGCGATCGGCTTCATGGAGAAGCAGGT
CAAGGCCGACAAGCCGTTCTTCGTGTGGATGAATACCACGCGCATGCACGCGTTCACGCACGTGCGCGAGTCGATGCGCG
GACAGAGCGGCATGCCCGGTAACGATTATGCGGACGGCATGCTCGAACATGATGGCGATGTCGGCAAGCTGCTCAAGTCG
CTCGACGACCTGAAGGTTGCCGACAACACTATCGTTATTTACACGACCGACAACGGGCCGAACCAGTGGTCCTGGCCGGA
CGCCGCAACAACGCCGTTCCGCAGCGAGAAGGACACCAACTGGGAAGGTGCGTTCCGCGTGCCTGCAATGGTGCGCTGGC
CGGGCAGGATCAAGCCTGGCACGGTGTCAACGACCATGATGTCCGGCCTCGACTGGTTCCCGACGCTGCTTGCGGCGGCT
GGCGATGGCGACATCAAGGACCGGCTGCTCAAGGGCGCGAGCATTGGCGGCAAGTCCTTCAAGGTGCACCTCGACGGCTA
TAACTTCCTGCCATACCTGACCGGACAGACTAATGTCGGACCGCGCCAGGACTTCTTCTATTTCAACGATGACGGCGTGC
TGGTCGCCATGCGCCACAACGACTGGAAATTTGTGTTCTGCGAGCAGCGACACCCGGGCGGCTTCGAGGTATGGGCGAAT
CCCTTTACCTGCCTGCGCGTGCCAAAGGCGTTCAACCTCCGCATGGACCCGTATGAGCGTGCGGATATCGTCTCCGATCA
GTACTATGACTGGACGGCGAAAAACGCCTACATGATCAGCTACGCGTCATCGCGGGTCGCACCGTTCCTCCAGACGTTCA
AGGACTACCCGCCCAGCCAGCGTCCGGCGAGCTTCACGATCGACCAGATGACGGAGGCGGTGATGAAGTCCATTGACAAG
GGGGCTGCCGGGGCCGGGAAGTAA

Upstream 100 bases:

>100_bases
AACAGCAGCACGAAGCTGGCAATCATGGGTCGACAAACGGAGGCAGGACATGCACCGAGTTGAAGAAGGCAGTAGCAGAG
GAAGGGGCACCAGGCTGGTG

Downstream 100 bases:

>100_bases
TTCCAGCAGCAATGGTTGGCCGGGCTGTCCCGGCCAACCGCTTCACAGGATCGCGACATGAGAGAAGCGCATGCCGGCAC
GGACGCCGGCAAACAGCAAG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MLAMAAAVFTLAGCGKKETPPKEQQPAAQAPAPAPVAQAPVPAKENPPVAASAPVDAASAPALAATSSSGKKPNILVIFG
DDIGQTNISAYSHGVVGYRTPNIDRIANEGMMLTDYYGENSCTAGRSTFITGEVGLRTGLLKVGIPGAPVGLQAQNVTIA
QALKPLGYATGQFGKNHLGDRNEYLPTAHGFDEFFGNLYHLNAEEEPERPYYPKNDTAWVKANAPRGVLHTYADGKIEDT
GPLNRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHAFTHVRESMRGQSGMPGNDYADGMLEHDGDVGKLLKS
LDDLKVADNTIVIYTTDNGPNQWSWPDAATTPFRSEKDTNWEGAFRVPAMVRWPGRIKPGTVSTTMMSGLDWFPTLLAAA
GDGDIKDRLLKGASIGGKSFKVHLDGYNFLPYLTGQTNVGPRQDFFYFNDDGVLVAMRHNDWKFVFCEQRHPGGFEVWAN
PFTCLRVPKAFNLRMDPYERADIVSDQYYDWTAKNAYMISYASSRVAPFLQTFKDYPPSQRPASFTIDQMTEAVMKSIDK
GAAGAGK

Sequences:

>Translated_567_residues
MLAMAAAVFTLAGCGKKETPPKEQQPAAQAPAPAPVAQAPVPAKENPPVAASAPVDAASAPALAATSSSGKKPNILVIFG
DDIGQTNISAYSHGVVGYRTPNIDRIANEGMMLTDYYGENSCTAGRSTFITGEVGLRTGLLKVGIPGAPVGLQAQNVTIA
QALKPLGYATGQFGKNHLGDRNEYLPTAHGFDEFFGNLYHLNAEEEPERPYYPKNDTAWVKANAPRGVLHTYADGKIEDT
GPLNRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHAFTHVRESMRGQSGMPGNDYADGMLEHDGDVGKLLKS
LDDLKVADNTIVIYTTDNGPNQWSWPDAATTPFRSEKDTNWEGAFRVPAMVRWPGRIKPGTVSTTMMSGLDWFPTLLAAA
GDGDIKDRLLKGASIGGKSFKVHLDGYNFLPYLTGQTNVGPRQDFFYFNDDGVLVAMRHNDWKFVFCEQRHPGGFEVWAN
PFTCLRVPKAFNLRMDPYERADIVSDQYYDWTAKNAYMISYASSRVAPFLQTFKDYPPSQRPASFTIDQMTEAVMKSIDK
GAAGAGK
>Mature_567_residues
MLAMAAAVFTLAGCGKKETPPKEQQPAAQAPAPAPVAQAPVPAKENPPVAASAPVDAASAPALAATSSSGKKPNILVIFG
DDIGQTNISAYSHGVVGYRTPNIDRIANEGMMLTDYYGENSCTAGRSTFITGEVGLRTGLLKVGIPGAPVGLQAQNVTIA
QALKPLGYATGQFGKNHLGDRNEYLPTAHGFDEFFGNLYHLNAEEEPERPYYPKNDTAWVKANAPRGVLHTYADGKIEDT
GPLNRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHAFTHVRESMRGQSGMPGNDYADGMLEHDGDVGKLLKS
LDDLKVADNTIVIYTTDNGPNQWSWPDAATTPFRSEKDTNWEGAFRVPAMVRWPGRIKPGTVSTTMMSGLDWFPTLLAAA
GDGDIKDRLLKGASIGGKSFKVHLDGYNFLPYLTGQTNVGPRQDFFYFNDDGVLVAMRHNDWKFVFCEQRHPGGFEVWAN
PFTCLRVPKAFNLRMDPYERADIVSDQYYDWTAKNAYMISYASSRVAPFLQTFKDYPPSQRPASFTIDQMTEAVMKSIDK
GAAGAGK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=533, Percent_Identity=29.0806754221388, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI146229331, Length=411, Percent_Identity=31.3868613138686, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI146229329, Length=411, Percent_Identity=31.3868613138686, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI6005990, Length=411, Percent_Identity=31.3868613138686, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI146229324, Length=411, Percent_Identity=31.3868613138686, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI45430057, Length=386, Percent_Identity=29.0155440414508, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI109389362, Length=486, Percent_Identity=27.7777777777778, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI53831991, Length=514, Percent_Identity=24.9027237354086, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI157266309, Length=485, Percent_Identity=26.1855670103093, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI38569405, Length=479, Percent_Identity=26.7223382045929, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI58743319, Length=442, Percent_Identity=26.9230769230769, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI146229327, Length=321, Percent_Identity=30.5295950155763, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI38569407, Length=374, Percent_Identity=28.3422459893048, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI31742482, Length=448, Percent_Identity=25.8928571428571, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI59797060, Length=475, Percent_Identity=25.4736842105263, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI71852584, Length=549, Percent_Identity=24.2258652094718, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI71852586, Length=160, Percent_Identity=36.25, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1790233, Length=511, Percent_Identity=29.9412915851272, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI87081924, Length=389, Percent_Identity=24.1645244215938, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI115533416, Length=418, Percent_Identity=25.5980861244019, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI115533418, Length=387, Percent_Identity=25.8397932816537, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559078, Length=242, Percent_Identity=28.5123966942149, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666175, Length=408, Percent_Identity=28.4313725490196, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24666109, Length=422, Percent_Identity=27.4881516587678, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI281366397, Length=352, Percent_Identity=27.5568181818182, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281366395, Length=352, Percent_Identity=27.5568181818182, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24666163, Length=352, Percent_Identity=27.5568181818182, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281363223, Length=135, Percent_Identity=36.2962962962963, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 61956; Mature: 61956

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMAAAVFTLAGCGKKETPPKEQQPAAQAPAPAPVAQAPVPAKENPPVAASAPVDAASA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCC
PALAATSSSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDRIANEGMMLTDYYGEN
CCEEECCCCCCCCCEEEEECCCCCCCCCHHHHCCEEEEECCCHHHHHCCCEEEEEECCCC
SCTAGRSTFITGEVGLRTGLLKVGIPGAPVGLQAQNVTIAQALKPLGYATGQFGKNHLGD
CCCCCCCEEEEECCCHHCCEEEECCCCCCCCCEECCEEHHHHHHHCCCCCCCCCCCCCCC
RNEYLPTAHGFDEFFGNLYHLNAEEEPERPYYPKNDTAWVKANAPRGVLHTYADGKIEDT
CCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCEECCC
GPLNRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHAFTHVRESMRGQSGMPG
CCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCC
NDYADGMLEHDGDVGKLLKSLDDLKVADNTIVIYTTDNGPNQWSWPDAATTPFRSEKDTN
CCHHCCHHHCCCHHHHHHHHHHCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
WEGAFRVPAMVRWPGRIKPGTVSTTMMSGLDWFPTLLAAAGDGDIKDRLLKGASIGGKSF
CCCEEECCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEE
KVHLDGYNFLPYLTGQTNVGPRQDFFYFNDDGVLVAMRHNDWKFVFCEQRHPGGFEVWAN
EEEECCCCCCEEECCCCCCCCCCCEEEECCCCEEEEEEECCEEEEEEECCCCCCEEEECC
PFTCLRVPKAFNLRMDPYERADIVSDQYYDWTAKNAYMISYASSRVAPFLQTFKDYPPSQ
CEEEEECCCHHCCCCCCCHHHHHCCCCCCCEECCCEEEEEECCHHHHHHHHHHHCCCCCC
RPASFTIDQMTEAVMKSIDKGAAGAGK
CCCCEEHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLAMAAAVFTLAGCGKKETPPKEQQPAAQAPAPAPVAQAPVPAKENPPVAASAPVDAASA
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCC
PALAATSSSGKKPNILVIFGDDIGQTNISAYSHGVVGYRTPNIDRIANEGMMLTDYYGEN
CCEEECCCCCCCCCEEEEECCCCCCCCCHHHHCCEEEEECCCHHHHHCCCEEEEEECCCC
SCTAGRSTFITGEVGLRTGLLKVGIPGAPVGLQAQNVTIAQALKPLGYATGQFGKNHLGD
CCCCCCCEEEEECCCHHCCEEEECCCCCCCCCEECCEEHHHHHHHCCCCCCCCCCCCCCC
RNEYLPTAHGFDEFFGNLYHLNAEEEPERPYYPKNDTAWVKANAPRGVLHTYADGKIEDT
CCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCEECCC
GPLNRKRMETIDDETTAAAIGFMEKQVKADKPFFVWMNTTRMHAFTHVRESMRGQSGMPG
CCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCCC
NDYADGMLEHDGDVGKLLKSLDDLKVADNTIVIYTTDNGPNQWSWPDAATTPFRSEKDTN
CCHHCCHHHCCCHHHHHHHHHHCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
WEGAFRVPAMVRWPGRIKPGTVSTTMMSGLDWFPTLLAAAGDGDIKDRLLKGASIGGKSF
CCCEEECCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEE
KVHLDGYNFLPYLTGQTNVGPRQDFFYFNDDGVLVAMRHNDWKFVFCEQRHPGGFEVWAN
EEEECCCCCCEEECCCCCCCCCCCEEEECCCCEEEEEEECCEEEEEEECCCCCCEEEECC
PFTCLRVPKAFNLRMDPYERADIVSDQYYDWTAKNAYMISYASSRVAPFLQTFKDYPPSQ
CEEEEECCCHHCCCCCCCHHHHHCCCCCCCEECCCEEEEEECCHHHHHHHHHHHCCCCCC
RPASFTIDQMTEAVMKSIDKGAAGAGK
CCCCEEHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]