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The map label for this gene is aroE

Identifier: 73542540

GI number: 73542540

Start: 3128339

End: 3129223

Strand: Reverse

Name: aroE

Synonym: Reut_A2855

Alternate gene names: 73542540

Gene position: 3129223-3128339 (Counterclockwise)

Preceding gene: 73542541

Following gene: 73542539

Centisome position: 82.21

GC content: 67.8

Gene sequence:

>885_bases
ATGACATCCACCGAATCCTCCCAGCCGGCTGACCGCTACGTCGTGGTCGGCAACCCCGTCGCGCACAGCCGTTCGCCGTT
CATCCACGCCGCGTTTGCCAGGCAGACCGGCGAAGCCGTCGAATACGGTCGCCTGGAAGCGCCGCTCGACGCGTTCGCAG
ACACCATGCGCGCGTTCCTTGCTGAAGGCGGCTATGGCTTCAACGTGACCGTGCCGTTCAAGCTGCAGGCCTATGATCTG
GCCGACCGCCTGACGCCGCGCGCGGAAGCCGCCGGCGCGGTCAACACGATGTGGATCGAGGATGGCCTGATCCACGGCGA
CAATACCGACGGCATCGGCCTCGTGCGCGATATCCAGGACAATCTCGACACCCTGCTCGAAGACAAGCGTGTGCTGCTGC
TCGGCGCGGGCGGCGCGGCCATGGGCGCGATGCTGCCGCTGATTGAATGCCGGCCCTCGCGCATTGTGGTGGCCAACCGC
ACGGCCTCGCGCGCGAGCGACATGCTCGAAGAGTTCGTGGAAGCGGCCGATTCGTTCGGCGTGGAGTTGTGGGGCGGTGG
CCTCGATGCGCTTGAGCAGCTGTCCGAAGACGATGTCTGCGACGTCGTCATCAACGCATCGTCGAGCAGCCTGCATGGCG
AAGTGCCGCCGGTGCCGGCGTTCCTGCTCGGCGACGGCGTGCTCGCCTACGACATGATGTACGGCGCCGAGCCGACCGTA
TTCCTGCAGCACGCTGCGCAATGCGGCGCGCGCACGGCCGACGGTCTCGGCATGCTGGTCGAACAGGCGGCTGAAGCGTT
CTACATCTGGCGCGGCGTGCGTCCGCGCACCGCGCCCGTGCTGGCCGACCTGCGCGCCGCGCTGCAGGCCGAGCGCAAGG
GCTGA

Upstream 100 bases:

>100_bases
CGTTCACGGCCGAGATGGCTGCGCGCCAGGACATTCTCGAAGTGATTTCCACATTCAAGTTTTCGCGCAGCGGGCTGGAA
ACCCGCTTGCAGGCACGCTG

Downstream 100 bases:

>100_bases
TCGCCGCCAGTGCCCGTGGCCACCCGACAGCGCTCCGCGCGCGCCGCCGGCACGGCATTCTCCCCGCTGCGCTGGATCGG
TTTCCTGCTCGGCTGCATCG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTSTESSQPADRYVVVGNPVAHSRSPFIHAAFARQTGEAVEYGRLEAPLDAFADTMRAFLAEGGYGFNVTVPFKLQAYDL
ADRLTPRAEAAGAVNTMWIEDGLIHGDNTDGIGLVRDIQDNLDTLLEDKRVLLLGAGGAAMGAMLPLIECRPSRIVVANR
TASRASDMLEEFVEAADSFGVELWGGGLDALEQLSEDDVCDVVINASSSSLHGEVPPVPAFLLGDGVLAYDMMYGAEPTV
FLQHAAQCGARTADGLGMLVEQAAEAFYIWRGVRPRTAPVLADLRAALQAERKG

Sequences:

>Translated_294_residues
MTSTESSQPADRYVVVGNPVAHSRSPFIHAAFARQTGEAVEYGRLEAPLDAFADTMRAFLAEGGYGFNVTVPFKLQAYDL
ADRLTPRAEAAGAVNTMWIEDGLIHGDNTDGIGLVRDIQDNLDTLLEDKRVLLLGAGGAAMGAMLPLIECRPSRIVVANR
TASRASDMLEEFVEAADSFGVELWGGGLDALEQLSEDDVCDVVINASSSSLHGEVPPVPAFLLGDGVLAYDMMYGAEPTV
FLQHAAQCGARTADGLGMLVEQAAEAFYIWRGVRPRTAPVLADLRAALQAERKG
>Mature_293_residues
TSTESSQPADRYVVVGNPVAHSRSPFIHAAFARQTGEAVEYGRLEAPLDAFADTMRAFLAEGGYGFNVTVPFKLQAYDLA
DRLTPRAEAAGAVNTMWIEDGLIHGDNTDGIGLVRDIQDNLDTLLEDKRVLLLGAGGAAMGAMLPLIECRPSRIVVANRT
ASRASDMLEEFVEAADSFGVELWGGGLDALEQLSEDDVCDVVINASSSSLHGEVPPVPAFLLGDGVLAYDMMYGAEPTVF
LQHAAQCGARTADGLGMLVEQAAEAFYIWRGVRPRTAPVLADLRAALQAERKG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=286, Percent_Identity=44.4055944055944, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1787983, Length=275, Percent_Identity=30.5454545454545, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320332, Length=186, Percent_Identity=29.5698924731183, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_CUPPJ (Q46XB7)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_297060.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q46XB7
- SMR:   Q46XB7
- GeneID:   3611866
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2855
- NMPDR:   fig|264198.3.peg.3461
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- ProtClustDB:   PRK00258
- BioCyc:   REUT264198:REUT_A2855-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31385; Mature: 31254

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: ACT_SITE 74-74

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTESSQPADRYVVVGNPVAHSRSPFIHAAFARQTGEAVEYGRLEAPLDAFADTMRAFL
CCCCCCCCCCCCEEEECCCCCCCCCCCEEEHHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
AEGGYGFNVTVPFKLQAYDLADRLTPRAEAAGAVNTMWIEDGLIHGDNTDGIGLVRDIQD
HCCCCCEEEEEEEEEEEEHHHHHCCCCHHHCCCEEEEEEECCEEECCCCCCCHHHHHHHH
NLDTLLEDKRVLLLGAGGAAMGAMLPLIECRPSRIVVANRTASRASDMLEEFVEAADSFG
HHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
VELWGGGLDALEQLSEDDVCDVVINASSSSLHGEVPPVPAFLLGDGVLAYDMMYGAEPTV
EEEECCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCHH
FLQHAAQCGARTADGLGMLVEQAAEAFYIWRGVRPRTAPVLADLRAALQAERKG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSTESSQPADRYVVVGNPVAHSRSPFIHAAFARQTGEAVEYGRLEAPLDAFADTMRAFL
CCCCCCCCCCCEEEECCCCCCCCCCCEEEHHHHHCCCHHHHCCCCCCHHHHHHHHHHHH
AEGGYGFNVTVPFKLQAYDLADRLTPRAEAAGAVNTMWIEDGLIHGDNTDGIGLVRDIQD
HCCCCCEEEEEEEEEEEEHHHHHCCCCHHHCCCEEEEEEECCEEECCCCCCCHHHHHHHH
NLDTLLEDKRVLLLGAGGAAMGAMLPLIECRPSRIVVANRTASRASDMLEEFVEAADSFG
HHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCC
VELWGGGLDALEQLSEDDVCDVVINASSSSLHGEVPPVPAFLLGDGVLAYDMMYGAEPTV
EEEECCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCHH
FLQHAAQCGARTADGLGMLVEQAAEAFYIWRGVRPRTAPVLADLRAALQAERKG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA