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The map label for this gene is maeB [H]

Identifier: 73542532

GI number: 73542532

Start: 3119179

End: 3121503

Strand: Reverse

Name: maeB [H]

Synonym: Reut_A2847

Alternate gene names: 73542532

Gene position: 3121503-3119179 (Counterclockwise)

Preceding gene: 73542536

Following gene: 73542531

Centisome position: 82.0

GC content: 65.08

Gene sequence:

>2325_bases
ATGACCAGCCCTCAGCAGTCCCCGTCCCAAGACGATCTGAAACAGCAGCAGCGTGAGGCGCTGCGCAAAGCGGCGCTCGA
GTATCACGAGTTTCCGACTCCCGGGAAGATCTCCGTTACGCCGACCAAGCCGCTGTCGAACCAGCGCGACCTGGCCCTGG
CCTATTCGCCGGGCGTGGCAGCTGCCTGCGAGGAGATCGTCGCCGACCCCGCCAACTCCTTCCGCTACACCGCGCGCGGC
AACCTGGTGGCGGTAATCACCAATGGCACCGCCGTGCTGGGCCTGGGCGACATTGGCGCCGCGGCGTCCAAGCCGGTCAT
GGAAGGCAAGGCCGGCCTGTTCAAGAAATTCGCCGGCATCGACGTCTTTGACATCGAAATCGACGAAAAAGACCCCGAAA
AGCTCGTGCAGGTCATTGCCGCGCTGGAGCCGACCTTCGGCGGCATCAACCTCGAAGACATCAAGGCACCGGAGTGCTTC
TACGTCGAGCGCAAGCTGCGCGAGAAGATGAAGATCCCGGTCTTCCACGATGACCAGCACGGTACCGCCATCGTCGTGGC
TGCCGCCGTCATCAACGGCCTGAAGGTCGTCGGCAAGGACATCAAGAGCGTCAAGCTGGTGGCCTCGGGCGCCGGCGCCG
CCGCGCTGGCCTGCCTGGATCTGCTGGTGGACCTGGGCCTGCCCATCGAGAACATCTGGGTGACGGACCTGGCCGGCGTG
GTCTACGAAGGCCGTACCGAATTGATGGACCCGGAGAAGGCCCGCTTCTGCCAGAAGACCGACAAGCGCAAGCTTGGCGA
GGTGATCGATGGCGCCGACATTTTCCTGGGCCTGTCCGCCGCCGGCGTGCTCAAGCAGGACATGGTCCAGCGCATGGGCG
AGAAGCCGCTGGTGCTGGCCCTGGCCAACCCGAACCCGGAAATCGCACCGGAACTGGTCAAGGAAGTCCGCCCGGACGCC
ATCATGGCGACCGGCCGTACCGACTACCCGAACCAGGTCAATAACGTCCTGTGCTTCCCGTTCATCTTCCGCGGCGCGCT
CGATTGCGGTGCGACCACCATCACGCGTGAGATGGAGATCGCCGCCGCCAACGCGATCGCCGAGCTGGCGCGCCAGGAGC
AGAGCGATATCGTGGCCACGGCCTACGGCATCCAGGACCTGGCGTTCGGCCCGGAATACCTGATCCCGAAGCCGTTCGAT
CCGCGCCTGATCGTGTGGGTGGCACCGGCTGTGGCGGAAGCCGCCATGAAATCTGGCGTGGCCTCGCGTCCGATCGAGGA
CATGGACGCCTACCGCCTGCAGTTGCAGCAGTTCGTGTACCACTCCGGCACGCTGATGAAGCCGATCTACGCCGCCGCCC
GCAAGGTCGAGATGGCGAAGAAGCGCATCGTCTTTGCCGAGGGCGAGGAGGAGCGCGTGCTGCGCGCCGTGCAGGTGGTC
GTCGATGAAAAGCTGGCCAACCCGATCCTGATCGGCCGCCCGGCGGTGTTGCAGCATCGCATTGAGCGTTTCGGCCTGCG
CCTGCGCCCGGGCGTGGACTTCGCCGTGGTCAACCCCGAGCACGACGAGCGCTTCCGCGATTATTCCGACGCGTATTACC
GCATGATGGCGCGCGAAGGCGTTACGCCGCAGTACGCCAAGCTCGAACTGCGCCGCCGCACCACGCTGATTGGCGCCATG
CTGGTCAAGAGGGGCGAGGCCGATGGCATGATCTGCGGTACCGTCAGCAACACCGCCGCACACCTGCGCTACATCGACCA
GGTTCTGGGTGGGACCAGCAAGGTCTACGCAGCCATGAACGGCCTGGTGCTGCCGGGCCGCCAGATCTTCCTGGTGGATA
CCCACGTGAACGTGGATCCGACCGCCGATGAACTGGCCGAGATCACGCTGATGGCGGCTGAAGAGCTCAAGCGCTTCGGC
ATCGAGCCCAAGGTGGGGCTGCTGTCGCACTCGAATTTCGGGTCGTCCGAAGCGCCTTCGGCCCGCAAGATGCGCGATAC
GCTCGCGATCCTGCGCGAACGCGCACCGGAGCTCGAAGTCGACGGCGAAATGCACGGCGACAGCGCGCTGGACGAGAAGC
TGCGCAATACCCTGGTGCCGGACGGCACGCTCAAGGGCGAGGCGAACCTGCTGGTCTGCCCGAACATCGACGCGGCCAAT
ATCTCGTACAACCTGCTGAAGGTTGCGGCGGGCAACAACGTCGCCATCGGGCCGATTTTGCTCGGCGTGAAGGCGCCGGT
GCACATCCTGACCCCGTCGGCAACGGTGCGCCGCATCGTCAACATGACCTCGCTGGTCGTGGTCGACGCTGCTGCCAAGC
GCTAA

Upstream 100 bases:

>100_bases
TGCCGGGTCCAGAGGAAGAGATTGGCGGGCACGTGGAGCCGGTCCGCCAATCATCCGAAGCCCTGTCAAATGACGGCTCC
ACCGATTGGAATATGCGCCG

Downstream 100 bases:

>100_bases
GCCGCAGTACGGTTCAATGTGGCGGAAAAGCCGGGCTTGCCCGGCTTTTTTTCGCTTTGCGGCTGCCAGTTAGTATGCGC
ACACATCCTATTAACACATT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MTSPQQSPSQDDLKQQQREALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVADPANSFRYTARG
NLVAVITNGTAVLGLGDIGAAASKPVMEGKAGLFKKFAGIDVFDIEIDEKDPEKLVQVIAALEPTFGGINLEDIKAPECF
YVERKLREKMKIPVFHDDQHGTAIVVAAAVINGLKVVGKDIKSVKLVASGAGAAALACLDLLVDLGLPIENIWVTDLAGV
VYEGRTELMDPEKARFCQKTDKRKLGEVIDGADIFLGLSAAGVLKQDMVQRMGEKPLVLALANPNPEIAPELVKEVRPDA
IMATGRTDYPNQVNNVLCFPFIFRGALDCGATTITREMEIAAANAIAELARQEQSDIVATAYGIQDLAFGPEYLIPKPFD
PRLIVWVAPAVAEAAMKSGVASRPIEDMDAYRLQLQQFVYHSGTLMKPIYAAARKVEMAKKRIVFAEGEEERVLRAVQVV
VDEKLANPILIGRPAVLQHRIERFGLRLRPGVDFAVVNPEHDERFRDYSDAYYRMMAREGVTPQYAKLELRRRTTLIGAM
LVKRGEADGMICGTVSNTAAHLRYIDQVLGGTSKVYAAMNGLVLPGRQIFLVDTHVNVDPTADELAEITLMAAEELKRFG
IEPKVGLLSHSNFGSSEAPSARKMRDTLAILRERAPELEVDGEMHGDSALDEKLRNTLVPDGTLKGEANLLVCPNIDAAN
ISYNLLKVAAGNNVAIGPILLGVKAPVHILTPSATVRRIVNMTSLVVVDAAAKR

Sequences:

>Translated_774_residues
MTSPQQSPSQDDLKQQQREALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVADPANSFRYTARG
NLVAVITNGTAVLGLGDIGAAASKPVMEGKAGLFKKFAGIDVFDIEIDEKDPEKLVQVIAALEPTFGGINLEDIKAPECF
YVERKLREKMKIPVFHDDQHGTAIVVAAAVINGLKVVGKDIKSVKLVASGAGAAALACLDLLVDLGLPIENIWVTDLAGV
VYEGRTELMDPEKARFCQKTDKRKLGEVIDGADIFLGLSAAGVLKQDMVQRMGEKPLVLALANPNPEIAPELVKEVRPDA
IMATGRTDYPNQVNNVLCFPFIFRGALDCGATTITREMEIAAANAIAELARQEQSDIVATAYGIQDLAFGPEYLIPKPFD
PRLIVWVAPAVAEAAMKSGVASRPIEDMDAYRLQLQQFVYHSGTLMKPIYAAARKVEMAKKRIVFAEGEEERVLRAVQVV
VDEKLANPILIGRPAVLQHRIERFGLRLRPGVDFAVVNPEHDERFRDYSDAYYRMMAREGVTPQYAKLELRRRTTLIGAM
LVKRGEADGMICGTVSNTAAHLRYIDQVLGGTSKVYAAMNGLVLPGRQIFLVDTHVNVDPTADELAEITLMAAEELKRFG
IEPKVGLLSHSNFGSSEAPSARKMRDTLAILRERAPELEVDGEMHGDSALDEKLRNTLVPDGTLKGEANLLVCPNIDAAN
ISYNLLKVAAGNNVAIGPILLGVKAPVHILTPSATVRRIVNMTSLVVVDAAAKR
>Mature_773_residues
TSPQQSPSQDDLKQQQREALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVADPANSFRYTARGN
LVAVITNGTAVLGLGDIGAAASKPVMEGKAGLFKKFAGIDVFDIEIDEKDPEKLVQVIAALEPTFGGINLEDIKAPECFY
VERKLREKMKIPVFHDDQHGTAIVVAAAVINGLKVVGKDIKSVKLVASGAGAAALACLDLLVDLGLPIENIWVTDLAGVV
YEGRTELMDPEKARFCQKTDKRKLGEVIDGADIFLGLSAAGVLKQDMVQRMGEKPLVLALANPNPEIAPELVKEVRPDAI
MATGRTDYPNQVNNVLCFPFIFRGALDCGATTITREMEIAAANAIAELARQEQSDIVATAYGIQDLAFGPEYLIPKPFDP
RLIVWVAPAVAEAAMKSGVASRPIEDMDAYRLQLQQFVYHSGTLMKPIYAAARKVEMAKKRIVFAEGEEERVLRAVQVVV
DEKLANPILIGRPAVLQHRIERFGLRLRPGVDFAVVNPEHDERFRDYSDAYYRMMAREGVTPQYAKLELRRRTTLIGAML
VKRGEADGMICGTVSNTAAHLRYIDQVLGGTSKVYAAMNGLVLPGRQIFLVDTHVNVDPTADELAEITLMAAEELKRFGI
EPKVGLLSHSNFGSSEAPSARKMRDTLAILRERAPELEVDGEMHGDSALDEKLRNTLVPDGTLKGEANLLVCPNIDAANI
SYNLLKVAAGNNVAIGPILLGVKAPVHILTPSATVRRIVNMTSLVVVDAAAKR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=398, Percent_Identity=25.8793969849246, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI62420882, Length=352, Percent_Identity=26.9886363636364, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI62420880, Length=352, Percent_Identity=26.9886363636364, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI239049447, Length=352, Percent_Identity=26.9886363636364, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI4505145, Length=403, Percent_Identity=26.0545905707196, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI270265879, Length=369, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=62.9287598944591, Blast_Score=978, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=347, Percent_Identity=28.2420749279539, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788800, Length=318, Percent_Identity=32.0754716981132, Blast_Score=144, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17537199, Length=412, Percent_Identity=24.0291262135922, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=275, Percent_Identity=28, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362674, Length=473, Percent_Identity=27.061310782241, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281362672, Length=473, Percent_Identity=27.061310782241, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356279, Length=473, Percent_Identity=27.061310782241, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646388, Length=424, Percent_Identity=26.6509433962264, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646386, Length=424, Percent_Identity=26.6509433962264, Blast_Score=86, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 84029; Mature: 83898

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPQQSPSQDDLKQQQREALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCHH
AACEEIVADPANSFRYTARGNLVAVITNGTAVLGLGDIGAAASKPVMEGKAGLFKKFAGI
HHHHHHHCCCCCCCEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCC
DVFDIEIDEKDPEKLVQVIAALEPTFGGINLEDIKAPECFYVERKLREKMKIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEECCCC
GTAIVVAAAVINGLKVVGKDIKSVKLVASGAGAAALACLDLLVDLGLPIENIWVTDLAGV
CCHHHHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VYEGRTELMDPEKARFCQKTDKRKLGEVIDGADIFLGLSAAGVLKQDMVQRMGEKPLVLA
HCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHCCCCCEEEE
LANPNPEIAPELVKEVRPDAIMATGRTDYPNQVNNVLCFPFIFRGALDCGATTITREMEI
ECCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHH
AAANAIAELARQEQSDIVATAYGIQDLAFGPEYLIPKPFDPRLIVWVAPAVAEAAMKSGV
HHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCC
ASRPIEDMDAYRLQLQQFVYHSGTLMKPIYAAARKVEMAKKRIVFAEGEEERVLRAVQVV
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHH
VDEKLANPILIGRPAVLQHRIERFGLRLRPGVDFAVVNPEHDERFRDYSDAYYRMMAREG
HHHHHCCCEEECCCHHHHHHHHHCCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
VTPQYAKLELRRRTTLIGAMLVKRGEADGMICGTVSNTAAHLRYIDQVLGGTSKVYAAMN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHC
GLVLPGRQIFLVDTHVNVDPTADELAEITLMAAEELKRFGIEPKVGLLSHSNFGSSEAPS
CEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCH
ARKMRDTLAILRERAPELEVDGEMHGDSALDEKLRNTLVPDGTLKGEANLLVCPNIDAAN
HHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
ISYNLLKVAAGNNVAIGPILLGVKAPVHILTPSATVRRIVNMTSLVVVDAAAKR
CEEEEEEEECCCCEEEHHEEEECCCCEEEECCCHHHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure 
TSPQQSPSQDDLKQQQREALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCHH
AACEEIVADPANSFRYTARGNLVAVITNGTAVLGLGDIGAAASKPVMEGKAGLFKKFAGI
HHHHHHHCCCCCCCEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCC
DVFDIEIDEKDPEKLVQVIAALEPTFGGINLEDIKAPECFYVERKLREKMKIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEECCCC
GTAIVVAAAVINGLKVVGKDIKSVKLVASGAGAAALACLDLLVDLGLPIENIWVTDLAGV
CCHHHHHHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VYEGRTELMDPEKARFCQKTDKRKLGEVIDGADIFLGLSAAGVLKQDMVQRMGEKPLVLA
HCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHCCCCCEEEE
LANPNPEIAPELVKEVRPDAIMATGRTDYPNQVNNVLCFPFIFRGALDCGATTITREMEI
ECCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHH
AAANAIAELARQEQSDIVATAYGIQDLAFGPEYLIPKPFDPRLIVWVAPAVAEAAMKSGV
HHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCC
ASRPIEDMDAYRLQLQQFVYHSGTLMKPIYAAARKVEMAKKRIVFAEGEEERVLRAVQVV
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHH
VDEKLANPILIGRPAVLQHRIERFGLRLRPGVDFAVVNPEHDERFRDYSDAYYRMMAREG
HHHHHCCCEEECCCHHHHHHHHHCCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
VTPQYAKLELRRRTTLIGAMLVKRGEADGMICGTVSNTAAHLRYIDQVLGGTSKVYAAMN
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHC
GLVLPGRQIFLVDTHVNVDPTADELAEITLMAAEELKRFGIEPKVGLLSHSNFGSSEAPS
CEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCH
ARKMRDTLAILRERAPELEVDGEMHGDSALDEKLRNTLVPDGTLKGEANLLVCPNIDAAN
HHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
ISYNLLKVAAGNNVAIGPILLGVKAPVHILTPSATVRRIVNMTSLVVVDAAAKR
CEEEEEEEECCCCEEEHHEEEECCCCEEEECCCHHHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]