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The map label for this gene is yedX [C]

Identifier: 73542120

GI number: 73542120

Start: 2669553

End: 2669906

Strand: Reverse

Name: yedX [C]

Synonym: Reut_A2434

Alternate gene names: 73542120

Gene position: 2669906-2669553 (Counterclockwise)

Preceding gene: 73542127

Following gene: 73542119

Centisome position: 70.14

GC content: 64.12

Gene sequence:

>354_bases
ATGGGACGCTTGACCACCCACGTTCTCGACACCGCTGCCGGCACCCCGGGCCAGGGCATGTCGATTACTCTCCATAAAAT
TGTCGACAATCGCCGCGAAACGCTGAAAACCGTGGTCACCAACTACGACGGCCGCTGCGACCAACCCCTGCTGGAAGGCG
CCGACCTGGTTGCCGGCGTGTACGAGCTGGAATTCGCCGCCGGCGACTACTTCCGCGCGCAAGGCGTGAAGCTGCCGGAA
CCGGCCTTCCTCGACGTCGTGCCGCTGCGTTTCGGCATTGCAAACACCGACGCGCACTACCACGTGCCGCTCCTGGTTTC
GCCCTGGTCGTACTCGACCTACCGCGGCAGCTGA

Upstream 100 bases:

>100_bases
GGATGCGTTACATGACGTACCGAGCGGGCACCATTCCCAGATATGGTGCTAGTGAAGGCAGCGGCGCCCCTCACAACCCA
ATCGCAAAAGGACAAATACG

Downstream 100 bases:

>100_bases
ATTCGTGGTCTAGGGAAACAGGAGACAAGACATGGAAGGCTATATCCTCGACTGGGCCAATATGCTGTTGCGGTGGGTGC
ACGTCATCACCGCCATTGCA

Product: transthyretin

Products: NA

Alternate protein names: HIU hydrolase; HIUHase [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MGRLTTHVLDTAAGTPGQGMSITLHKIVDNRRETLKTVVTNYDGRCDQPLLEGADLVAGVYELEFAAGDYFRAQGVKLPE
PAFLDVVPLRFGIANTDAHYHVPLLVSPWSYSTYRGS

Sequences:

>Translated_117_residues
MGRLTTHVLDTAAGTPGQGMSITLHKIVDNRRETLKTVVTNYDGRCDQPLLEGADLVAGVYELEFAAGDYFRAQGVKLPE
PAFLDVVPLRFGIANTDAHYHVPLLVSPWSYSTYRGS
>Mature_116_residues
GRLTTHVLDTAAGTPGQGMSITLHKIVDNRRETLKTVVTNYDGRCDQPLLEGADLVAGVYELEFAAGDYFRAQGVKLPEP
AFLDVVPLRFGIANTDAHYHVPLLVSPWSYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=114, Percent_Identity=38.5964912280702, Blast_Score=84, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115534555, Length=116, Percent_Identity=35.3448275862069, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115532922, Length=114, Percent_Identity=34.2105263157895, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532920, Length=116, Percent_Identity=33.6206896551724, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652571, Length=116, Percent_Identity=32.7586206896552, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 12823; Mature: 12691

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLTTHVLDTAAGTPGQGMSITLHKIVDNRRETLKTVVTNYDGRCDQPLLEGADLVAGV
CCCCHHHHHHHCCCCCCCCCEEEHHHHHCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHH
YELEFAAGDYFRAQGVKLPEPAFLDVVPLRFGIANTDAHYHVPLLVSPWSYSTYRGS
EEEEECCCCEEEECCCCCCCCCCEEEEEHEEEECCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GRLTTHVLDTAAGTPGQGMSITLHKIVDNRRETLKTVVTNYDGRCDQPLLEGADLVAGV
CCCHHHHHHHCCCCCCCCCEEEHHHHHCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHH
YELEFAAGDYFRAQGVKLPEPAFLDVVPLRFGIANTDAHYHVPLLVSPWSYSTYRGS
EEEEECCCCEEEECCCCCCCCCCEEEEEHEEEECCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]