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The map label for this gene is maeB [H]

Identifier: 73542127

GI number: 73542127

Start: 2675955

End: 2678288

Strand: Reverse

Name: maeB [H]

Synonym: Reut_A2441

Alternate gene names: 73542127

Gene position: 2678288-2675955 (Counterclockwise)

Preceding gene: 73542128

Following gene: 73542120

Centisome position: 70.36

GC content: 65.6

Gene sequence:

>2334_bases
ATGAGCAGCAAGACCAGCGGTGACGCACCGCAACACGCCCCGAACAGTCCTGAAGCGCAATTGCGCCTCGCTGCGCTGGA
ATACCACCGCAGTCCCACCAAGGGGAAGATCCAGGTAACCGCCACGAAGGCGCTGTCCAACCAGCGCGATCTGTCGCTGG
CGTACTCGCCGGGCGTGGCCTATGCCTGCGAGGAGATTGCCAAGGATCCGTCGACGGCTGCCGAATACACCTCTCGCGCC
AACCTGGTGGCCGTGATCACCAACGGTACCGCGGTGCTGGGCCTGGGCGACATTGGTCCGCTGGCCGGTAAGCCGGTGAT
GGAAGGCAAGGGCTGCCTGTTCAAGAAGTTCGCCGGCATCGACGTGTTCGACATCGAGCTCGACGCGCGCGACCCGGACA
AGATCGTGGAAATCGTCGCCGCGCTGGAACCCACGCTCGGCGGCGTGAACCTCGAAGACATCAAGGCGCCAGAATGCTTC
TACATCGAGCAGAAGCTGCGCGAGCGCATGAATATCCCCGTCTTCCATGACGACCAGCACGGCACTGCCATTATCTCGGC
CGCGGCACTGCTGAACGGCCTGAAGGTGGTCGGCAAGGACATCGCCAAGGTCAAGCTGGCGGTGTCGGGTGCCGGCGCTG
CGGCCATCGCTTGCCTGGATACCATGGTGAGCCTGGGCGTGAAGCGCGAAAACGTCTCGGTGGTGGACTCGAAGGGCGTG
ATCTATGTCGGCCGCGACGCCAACATGGAAGCCAACAAGGCCCGCTACGCGCAGGACACCTCGGCCCGTACGCTGGCCGA
CATCGTCAACGGCGCAGACGTTTTCCTGGGCTGCTCGACCGCCGGCGTGCTGACCGGCGACATGGTCAAGACCATGGCCG
ACAAGCCGATCATCCTGGCGCTGGCTAACCCCGAACCGGAAATCCGCCCGGAAGTGGCCAAGGCCGCGCGTCCGGACTGC
ATCATCGCCACGGGCCGTTCGGACTACCCGAACCAGGTCAACAACGTGCTGTGCTTCCCGTACATCTTCCGCGGCGCGCT
CGACTGCGGCGCGACGAAGATCACGGAAGCGATGAAGCTGGCCTGCGTGAAGGCGATCGCCGAGCTGGCCGAAGCCGAGC
TCAACGACGCCGTCGCCGCTGCCTACGGTGGCCGTGAACTGAAGTTCGGCCCCGACTACATCATCCCGACGCCGTTCGAC
CAGCGCCTGATCGAAAAGATCGCGCCGGCCGTGGCCAAGGCTGCCGAAGAATCGGGCGTGGCAACGCGTCCGATTCAGGA
CCTGGACGCCTATCGCCAGCAGCTGTCGACCTACGTCTACCACACCGGCATGATCATGAAGCCGGTGTTCTCGGCCGCCA
AGGCTTCGCCCAAGCGCGTCGCCTATGCCGAAGGCGAAGAAGAGCGCGTGCTGCGCGCGGTGCAGAGCGTGGTCGACGAA
GGCCTCGCACGTCCGATCCTGATCGGCCGTCCGCACGTGATCCAGATGCGCATCGAAAAGGCCGGCCTGCGTCTCAAGGC
CGGCGTCGATTTCGAGCTGATCAACCCGGAAGACGATCCGCGCTACCGCGCCTACCACGAGGCCTACCACGCGCTGCGCG
GCCGCGACGGCGTGACGCCCGACATGGCCAAGGTGGCGCTGCGCCGCTCCAACACGCTGATCGGCACCATGCTCATGCAT
ATGGGCGATGCCGACGCGCTGCTGTGTGGCACGGTGGGCCGCTTCGAGGCGCACCTCGAACACGTGAGCGACGTCATCGG
CCTGGCACCCGGTGCGAAGGTCTTCGCTGCGCTGAACGCGCTGATGCTCGAGAAGCACACGCTGTTCATCACGGATGCCT
TCGTCAACGACGATCCGAACGCCGAAGAGCTGGCCGCGATCACGCAGCTTGCCGCTGAGGAAATCCGCCGCTTCGGCCTG
CACCCGAAGGTCGCGCTGATGTCGCACTCGATGTTCGGCTCGTCGACGCGTCCGTCTGCGCGCAAGATGCGCGAAGCGGC
CGAGATCCTGGCCAAGGTGGCGCCGCATCTCGAGGTGGAAGGCGAGATGCAGGGCGACGCCGCGCTCGACGAGGACGTGC
GGCGCCACTTCCTGCCGTCGACCAAGCTGGCCGGCAGCGCGAACCTGCTGGTGATGCCGACGCTGGACGCTGCCAATATC
GCGTTCAACCTGCTCAAGATGACGGGCGGGCAGGGCGTGACGGTGGGCCCGATCCTGCTCGGCGCGGCCAAGCCGGTGCA
CATCCTGAACCCGCAGGCCACGACGCGCCGTATCGTCAATATGACGGCAGTCGCGGTGGCTGAGGCCAACGCCAACGCCA
GCGTGCAGCAGTAA

Upstream 100 bases:

>100_bases
CCGTCAGGATGCTGCCCCTCGCTGCCGGCCGTCGTGCCTGCTGCGTCGTTGGCGGGATGCGCTCGGGCCCCGGCAAGAAG
GCCATTTTCCGGACGAGCCA

Downstream 100 bases:

>100_bases
GCGCGGCGTCACACAGGCATGAAAAAGGCCGGGTCAATGACCCGGCCTTATTTTCTTGCTGTGGCGCATCAAAGGTGCGC
CACACCCGGTTGTTATTGCA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MSSKTSGDAPQHAPNSPEAQLRLAALEYHRSPTKGKIQVTATKALSNQRDLSLAYSPGVAYACEEIAKDPSTAAEYTSRA
NLVAVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGIDVFDIELDARDPDKIVEIVAALEPTLGGVNLEDIKAPECF
YIEQKLRERMNIPVFHDDQHGTAIISAAALLNGLKVVGKDIAKVKLAVSGAGAAAIACLDTMVSLGVKRENVSVVDSKGV
IYVGRDANMEANKARYAQDTSARTLADIVNGADVFLGCSTAGVLTGDMVKTMADKPIILALANPEPEIRPEVAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKLACVKAIAELAEAELNDAVAAAYGGRELKFGPDYIIPTPFD
QRLIEKIAPAVAKAAEESGVATRPIQDLDAYRQQLSTYVYHTGMIMKPVFSAAKASPKRVAYAEGEEERVLRAVQSVVDE
GLARPILIGRPHVIQMRIEKAGLRLKAGVDFELINPEDDPRYRAYHEAYHALRGRDGVTPDMAKVALRRSNTLIGTMLMH
MGDADALLCGTVGRFEAHLEHVSDVIGLAPGAKVFAALNALMLEKHTLFITDAFVNDDPNAEELAAITQLAAEEIRRFGL
HPKVALMSHSMFGSSTRPSARKMREAAEILAKVAPHLEVEGEMQGDAALDEDVRRHFLPSTKLAGSANLLVMPTLDAANI
AFNLLKMTGGQGVTVGPILLGAAKPVHILNPQATTRRIVNMTAVAVAEANANASVQQ

Sequences:

>Translated_777_residues
MSSKTSGDAPQHAPNSPEAQLRLAALEYHRSPTKGKIQVTATKALSNQRDLSLAYSPGVAYACEEIAKDPSTAAEYTSRA
NLVAVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGIDVFDIELDARDPDKIVEIVAALEPTLGGVNLEDIKAPECF
YIEQKLRERMNIPVFHDDQHGTAIISAAALLNGLKVVGKDIAKVKLAVSGAGAAAIACLDTMVSLGVKRENVSVVDSKGV
IYVGRDANMEANKARYAQDTSARTLADIVNGADVFLGCSTAGVLTGDMVKTMADKPIILALANPEPEIRPEVAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKLACVKAIAELAEAELNDAVAAAYGGRELKFGPDYIIPTPFD
QRLIEKIAPAVAKAAEESGVATRPIQDLDAYRQQLSTYVYHTGMIMKPVFSAAKASPKRVAYAEGEEERVLRAVQSVVDE
GLARPILIGRPHVIQMRIEKAGLRLKAGVDFELINPEDDPRYRAYHEAYHALRGRDGVTPDMAKVALRRSNTLIGTMLMH
MGDADALLCGTVGRFEAHLEHVSDVIGLAPGAKVFAALNALMLEKHTLFITDAFVNDDPNAEELAAITQLAAEEIRRFGL
HPKVALMSHSMFGSSTRPSARKMREAAEILAKVAPHLEVEGEMQGDAALDEDVRRHFLPSTKLAGSANLLVMPTLDAANI
AFNLLKMTGGQGVTVGPILLGAAKPVHILNPQATTRRIVNMTAVAVAEANANASVQQ
>Mature_776_residues
SSKTSGDAPQHAPNSPEAQLRLAALEYHRSPTKGKIQVTATKALSNQRDLSLAYSPGVAYACEEIAKDPSTAAEYTSRAN
LVAVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGIDVFDIELDARDPDKIVEIVAALEPTLGGVNLEDIKAPECFY
IEQKLRERMNIPVFHDDQHGTAIISAAALLNGLKVVGKDIAKVKLAVSGAGAAAIACLDTMVSLGVKRENVSVVDSKGVI
YVGRDANMEANKARYAQDTSARTLADIVNGADVFLGCSTAGVLTGDMVKTMADKPIILALANPEPEIRPEVAKAARPDCI
IATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKLACVKAIAELAEAELNDAVAAAYGGRELKFGPDYIIPTPFDQ
RLIEKIAPAVAKAAEESGVATRPIQDLDAYRQQLSTYVYHTGMIMKPVFSAAKASPKRVAYAEGEEERVLRAVQSVVDEG
LARPILIGRPHVIQMRIEKAGLRLKAGVDFELINPEDDPRYRAYHEAYHALRGRDGVTPDMAKVALRRSNTLIGTMLMHM
GDADALLCGTVGRFEAHLEHVSDVIGLAPGAKVFAALNALMLEKHTLFITDAFVNDDPNAEELAAITQLAAEEIRRFGLH
PKVALMSHSMFGSSTRPSARKMREAAEILAKVAPHLEVEGEMQGDAALDEDVRRHFLPSTKLAGSANLLVMPTLDAANIA
FNLLKMTGGQGVTVGPILLGAAKPVHILNPQATTRRIVNMTAVAVAEANANASVQQ

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=403, Percent_Identity=26.0545905707196, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI4505143, Length=398, Percent_Identity=23.8693467336683, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI62420882, Length=409, Percent_Identity=24.4498777506112, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI62420880, Length=409, Percent_Identity=24.4498777506112, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI239049447, Length=409, Percent_Identity=24.4498777506112, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI270265879, Length=368, Percent_Identity=26.3586956521739, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788806, Length=752, Percent_Identity=63.2978723404255, Blast_Score=979, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=321, Percent_Identity=28.3489096573209, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI1788800, Length=343, Percent_Identity=30.0291545189504, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87081919, Length=459, Percent_Identity=21.5686274509804, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17537199, Length=404, Percent_Identity=25.2475247524752, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=353, Percent_Identity=27.1954674220963, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356279, Length=503, Percent_Identity=26.441351888668, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=26.3713080168776, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=26.3713080168776, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646388, Length=349, Percent_Identity=29.2263610315186, Blast_Score=89, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=29.5652173913043, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82981; Mature: 82850

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKTSGDAPQHAPNSPEAQLRLAALEYHRSPTKGKIQVTATKALSNQRDLSLAYSPGVA
CCCCCCCCCCCCCCCCCHHHEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCEEEEECCCHH
YACEEIAKDPSTAAEYTSRANLVAVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGI
HHHHHHHCCCCHHHHHHCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
DVFDIELDARDPDKIVEIVAALEPTLGGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCC
GTAIISAAALLNGLKVVGKDIAKVKLAVSGAGAAAIACLDTMVSLGVKRENVSVVDSKGV
CHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCE
IYVGRDANMEANKARYAQDTSARTLADIVNGADVFLGCSTAGVLTGDMVKTMADKPIILA
EEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEE
LANPEPEIRPEVAKAARPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKL
ECCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHH
ACVKAIAELAEAELNDAVAAAYGGRELKFGPDYIIPTPFDQRLIEKIAPAVAKAAEESGV
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ATRPIQDLDAYRQQLSTYVYHTGMIMKPVFSAAKASPKRVAYAEGEEERVLRAVQSVVDE
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
GLARPILIGRPHVIQMRIEKAGLRLKAGVDFELINPEDDPRYRAYHEAYHALRGRDGVTP
HCCCCEEECCCCEEEEEEECCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCH
DMAKVALRRSNTLIGTMLMHMGDADALLCGTVGRFEAHLEHVSDVIGLAPGAKVFAALNA
HHHHHHHHHCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LMLEKHTLFITDAFVNDDPNAEELAAITQLAAEEIRRFGLHPKVALMSHSMFGSSTRPSA
HHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
RKMREAAEILAKVAPHLEVEGEMQGDAALDEDVRRHFLPSTKLAGSANLLVMPTLDAANI
HHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHH
AFNLLKMTGGQGVTVGPILLGAAKPVHILNPQATTRRIVNMTAVAVAEANANASVQQ
HHHHHHCCCCCCCEEHHEEECCCCCEEEECCCHHHHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
SSKTSGDAPQHAPNSPEAQLRLAALEYHRSPTKGKIQVTATKALSNQRDLSLAYSPGVA
CCCCCCCCCCCCCCCCHHHEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCEEEEECCCHH
YACEEIAKDPSTAAEYTSRANLVAVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGI
HHHHHHHCCCCHHHHHHCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
DVFDIELDARDPDKIVEIVAALEPTLGGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCC
GTAIISAAALLNGLKVVGKDIAKVKLAVSGAGAAAIACLDTMVSLGVKRENVSVVDSKGV
CHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCE
IYVGRDANMEANKARYAQDTSARTLADIVNGADVFLGCSTAGVLTGDMVKTMADKPIILA
EEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEE
LANPEPEIRPEVAKAARPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKL
ECCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHH
ACVKAIAELAEAELNDAVAAAYGGRELKFGPDYIIPTPFDQRLIEKIAPAVAKAAEESGV
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ATRPIQDLDAYRQQLSTYVYHTGMIMKPVFSAAKASPKRVAYAEGEEERVLRAVQSVVDE
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
GLARPILIGRPHVIQMRIEKAGLRLKAGVDFELINPEDDPRYRAYHEAYHALRGRDGVTP
HCCCCEEECCCCEEEEEEECCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCH
DMAKVALRRSNTLIGTMLMHMGDADALLCGTVGRFEAHLEHVSDVIGLAPGAKVFAALNA
HHHHHHHHHCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LMLEKHTLFITDAFVNDDPNAEELAAITQLAAEEIRRFGLHPKVALMSHSMFGSSTRPSA
HHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
RKMREAAEILAKVAPHLEVEGEMQGDAALDEDVRRHFLPSTKLAGSANLLVMPTLDAANI
HHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHH
AFNLLKMTGGQGVTVGPILLGAAKPVHILNPQATTRRIVNMTAVAVAEANANASVQQ
HHHHHHCCCCCCCEEHHEEECCCCCEEEECCCHHHHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]