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The map label for this gene is parC [H]

Identifier: 73542042

GI number: 73542042

Start: 2595736

End: 2598078

Strand: Reverse

Name: parC [H]

Synonym: Reut_A2356

Alternate gene names: 73542042

Gene position: 2598078-2595736 (Counterclockwise)

Preceding gene: 73542043

Following gene: 73542041

Centisome position: 68.25

GC content: 66.71

Gene sequence:

>2343_bases
ATGGAACAACAAGACATCACGTTTCAACCCGAAGAGCCCGCGGATTCGCTGACGCTGGCGCGCTACGCCGAGCGGGCTTA
TCTCGACTACGCCGTCAGCGTGGTCAAGGGCCGCGCGTTGCCCGAGGTCGCGGATGGCCAGAAGCCCGTGCAGCGGCGCA
TCCTGTTCGCCATGCACGAGATGGGCCTGCGCGCCGACGCCAAGCCGGTCAAGTCCGCGCGCGTGGTCGGCGACGTGCTC
GGCAAGTACCACCCGCACGGTGACCAGTCGGCGTATGACGCGCTGGTCCGCCTGGCACAGGACTTTTCGCTGCGCTATCC
GCTGATTGACGGCCAGGGCAACTTCGGCTCGCGCGACGGCGACGGTGCGGCGGCAATGCGTTACACCGAAGCGCGCCTCA
CCCCGATCTCACGCCTGCTGCTCGACGAGATCGACCAGGGTACGGTCGACTTCATCGCCAACTACGACGGCTCGATGGAA
GAGCCGAAGCTGCTGCCCGCGCGCATGCCGTTCGTGCTGCTCAACGGCGCGTCGGGCATTGCCGTGGGCATGGCGACCGA
AGTACCGCCGCACAACCTGCGCGAAGTGGCCGGCGCCACGGTGGCGATGATCCGCAACCCGAACATCACGCTGGCCGAAC
TGCTCGCGCTGATGCCGGGCCCGGACTATCCCGGCGGCGGGCAGATCATCTCGCCGGCAGCCGATATCGCCCAGATCTAC
GAGAGCGGCCGCGGCAGCCTCAAGGTGCGCGCGCGCTGGACTATCGAGGAAATGGCGCGCGGCCAGTGGCAGCTCGTGGT
GACCGAACTGCCGCCCGCCACGTCGGCGCAGAAGGTGCTGGAGGAAATCGAGGAGCTGACCAACCCGAAGGTCAAGGCCG
GCAAGAAGGCGCTGACCCCGGAACAGCAGCAGCTCAAGGCCTCGGTGCTGGCCGTGCTGGACGCCGTGCGCGACGAATCG
GGCAAGGATGCGCCGGTGCGGCTCGTGTTCGAGCCCAAGAGCAAGAACATCGAGCAGCAGGAATTCATCCAGACGCTGCT
CGCGCACACGAGCCTGGAGTCGGGCGCGCCGGTCAACCTCGTGATGATCGGCACGGATGGCCGTCCGCGCCAGAAGGGCC
TGCGCGACATCCTGCGCGAGTGGATCGACTTCCGCTTCGCCACCGTCACGCGGCGCACGCGCTATCGCCTGGGCAAGGTG
GAAGACCGCATCCATATCCTCGAAGGCCGGATGCTGGTGCTGCTGAACATCGACGAGGTGATCCGCATCATCCGCGAAAG
CGACGAGCCGAAGCCTGCGCTGATGGAGCGTTTTGGACTGAGCGATCGCCAGGCCGAGGACATCCTCGAAATCCGCCTGC
GTCAGCTGGCCAGGCTCGAAGCCATCCGGATCGAGAAGGAACTCAAGGACCTGCGCGAAGAGCAGGCCGACCTCGACGTG
CTGCTGAAGTCCGACACCATGATGCGCCGTCGCATCATCAAGGAGATCGAGACCGACGCCAAGCAATACAGCCCCGAAGA
CAAGGACCCGCGTCGCACGCTGATCCAGGAAGAGCGTCGCGCCGCCGCCGAGGTGCGCGTGGTCGATGAACCGGTGACGG
TCGTGGTGTCGCAGAAGGGCTGGGTGCGTACGCGCCAGGGCCATGGTCACGATGCGCAGCAGTTCACGTTCAAGGCTGGC
GATGCGCTGTACGACACATTCGAATGCCGCACGATCGATGTGTTGCTGGCCTTTGGCACCAACGGCCGCGTGTATTCGGT
GCCCGTGGCGAGCCTGCCGGGCGGCCGTGGAGACGGCGTGCCGCTGACCACGCTGATCGAGCTTCAGCCGGGCAGCCAGA
TCGCGCATACGTTTGCGGGCAGCGCCGAGCAGCGCATGCTGATCGCGACGCAGGGCGGCAACGGCTTCCTGACCAAGATC
GCGGACATGACGGGCCGGCAGAAGGGCGGCAAGTCGTTCCTGACGCTCGATGACGGCGATGCACCGCTGACGCCCGCGCC
GATCGCGAGCGAGGCCACGCATGTGGCCTGCCTGTCCGGCAACGGCCGCCTGCTGCTGGTTGCGCTCGACGAGGTCAAGG
TGCTGTCGGCCGGCGGCCGCGGCGTCATCCTGATGGAGCTGGAGCCGAAGGAGAAGCTGCTGCAGGCCGTTGGCGTTGGT
GCGCCGGGGCTGGTGGTGTCCGGCACGACGCCGCGAGGTGGCAAGCCTGACACGCAGAAGCTGGCTGGGGCGAACCTGAT
GCCTTATGTCGGCAAGCGGGCGCGCAAGGGCAAGGCGCTGGAGACCAAGCTGAAGGGTGTGCGGATCGATCCGTTCAGGG
TTGTGCCGCCGTCGGGCAACTAA

Upstream 100 bases:

>100_bases
GATCGGCGGACGGCGCAACATGCCCTGACCGAGATACCCGAATAACAAGCCACCCGGCGCGCCGGCTTCACATCATGGCG
CGCCGTCTTCTTGCCAATCC

Downstream 100 bases:

>100_bases
CCCCGACACGGCCGGGTTTCTTTCTCCCCTCTCCCGGTCGTGGGAGAGGGGAGTGCCGCAGCGGCAGATTTAACGCTGCC
ACTGTTGCTTGCCGTTGCTG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MEQQDITFQPEEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHEMGLRADAKPVKSARVVGDVL
GKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLDEIDQGTVDFIANYDGSME
EPKLLPARMPFVLLNGASGIAVGMATEVPPHNLREVAGATVAMIRNPNITLAELLALMPGPDYPGGGQIISPAADIAQIY
ESGRGSLKVRARWTIEEMARGQWQLVVTELPPATSAQKVLEEIEELTNPKVKAGKKALTPEQQQLKASVLAVLDAVRDES
GKDAPVRLVFEPKSKNIEQQEFIQTLLAHTSLESGAPVNLVMIGTDGRPRQKGLRDILREWIDFRFATVTRRTRYRLGKV
EDRIHILEGRMLVLLNIDEVIRIIRESDEPKPALMERFGLSDRQAEDILEIRLRQLARLEAIRIEKELKDLREEQADLDV
LLKSDTMMRRRIIKEIETDAKQYSPEDKDPRRTLIQEERRAAAEVRVVDEPVTVVVSQKGWVRTRQGHGHDAQQFTFKAG
DALYDTFECRTIDVLLAFGTNGRVYSVPVASLPGGRGDGVPLTTLIELQPGSQIAHTFAGSAEQRMLIATQGGNGFLTKI
ADMTGRQKGGKSFLTLDDGDAPLTPAPIASEATHVACLSGNGRLLLVALDEVKVLSAGGRGVILMELEPKEKLLQAVGVG
APGLVVSGTTPRGGKPDTQKLAGANLMPYVGKRARKGKALETKLKGVRIDPFRVVPPSGN

Sequences:

>Translated_780_residues
MEQQDITFQPEEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHEMGLRADAKPVKSARVVGDVL
GKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLDEIDQGTVDFIANYDGSME
EPKLLPARMPFVLLNGASGIAVGMATEVPPHNLREVAGATVAMIRNPNITLAELLALMPGPDYPGGGQIISPAADIAQIY
ESGRGSLKVRARWTIEEMARGQWQLVVTELPPATSAQKVLEEIEELTNPKVKAGKKALTPEQQQLKASVLAVLDAVRDES
GKDAPVRLVFEPKSKNIEQQEFIQTLLAHTSLESGAPVNLVMIGTDGRPRQKGLRDILREWIDFRFATVTRRTRYRLGKV
EDRIHILEGRMLVLLNIDEVIRIIRESDEPKPALMERFGLSDRQAEDILEIRLRQLARLEAIRIEKELKDLREEQADLDV
LLKSDTMMRRRIIKEIETDAKQYSPEDKDPRRTLIQEERRAAAEVRVVDEPVTVVVSQKGWVRTRQGHGHDAQQFTFKAG
DALYDTFECRTIDVLLAFGTNGRVYSVPVASLPGGRGDGVPLTTLIELQPGSQIAHTFAGSAEQRMLIATQGGNGFLTKI
ADMTGRQKGGKSFLTLDDGDAPLTPAPIASEATHVACLSGNGRLLLVALDEVKVLSAGGRGVILMELEPKEKLLQAVGVG
APGLVVSGTTPRGGKPDTQKLAGANLMPYVGKRARKGKALETKLKGVRIDPFRVVPPSGN
>Mature_780_residues
MEQQDITFQPEEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHEMGLRADAKPVKSARVVGDVL
GKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLDEIDQGTVDFIANYDGSME
EPKLLPARMPFVLLNGASGIAVGMATEVPPHNLREVAGATVAMIRNPNITLAELLALMPGPDYPGGGQIISPAADIAQIY
ESGRGSLKVRARWTIEEMARGQWQLVVTELPPATSAQKVLEEIEELTNPKVKAGKKALTPEQQQLKASVLAVLDAVRDES
GKDAPVRLVFEPKSKNIEQQEFIQTLLAHTSLESGAPVNLVMIGTDGRPRQKGLRDILREWIDFRFATVTRRTRYRLGKV
EDRIHILEGRMLVLLNIDEVIRIIRESDEPKPALMERFGLSDRQAEDILEIRLRQLARLEAIRIEKELKDLREEQADLDV
LLKSDTMMRRRIIKEIETDAKQYSPEDKDPRRTLIQEERRAAAEVRVVDEPVTVVVSQKGWVRTRQGHGHDAQQFTFKAG
DALYDTFECRTIDVLLAFGTNGRVYSVPVASLPGGRGDGVPLTTLIELQPGSQIAHTFAGSAEQRMLIATQGGNGFLTKI
ADMTGRQKGGKSFLTLDDGDAPLTPAPIASEATHVACLSGNGRLLLVALDEVKVLSAGGRGVILMELEPKEKLLQAVGVG
APGLVVSGTTPRGGKPDTQKLAGANLMPYVGKRARKGKALETKLKGVRIDPFRVVPPSGN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=370, Percent_Identity=27.8378378378378, Blast_Score=107, Evalue=6e-23,
Organism=Homo sapiens, GI19913406, Length=371, Percent_Identity=26.1455525606469, Blast_Score=95, Evalue=3e-19,
Organism=Escherichia coli, GI1789396, Length=689, Percent_Identity=45.2830188679245, Blast_Score=593, Evalue=1e-170,
Organism=Escherichia coli, GI1788562, Length=767, Percent_Identity=34.5501955671447, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=165, Percent_Identity=37.5757575757576, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212645845, Length=386, Percent_Identity=23.5751295336788, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=179, Percent_Identity=32.9608938547486, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115534553, Length=161, Percent_Identity=33.5403726708075, Blast_Score=85, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=163, Percent_Identity=34.3558282208589, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136538, Length=173, Percent_Identity=34.1040462427746, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85527; Mature: 85527

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQDITFQPEEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRADAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLDEIDQGTVDFIANYDGSMEEPKLLPARMPFVLLNGASGI
CCCHHEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEVPPHNLREVAGATVAMIRNPNITLAELLALMPGPDYPGGGQIISPAADIAQIY
EEEEECCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHH
ESGRGSLKVRARWTIEEMARGQWQLVVTELPPATSAQKVLEEIEELTNPKVKAGKKALTP
HCCCCCEEEEEEEEHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHCCCCCCCC
EQQQLKASVLAVLDAVRDESGKDAPVRLVFEPKSKNIEQQEFIQTLLAHTSLESGAPVNL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
VMIGTDGRPRQKGLRDILREWIDFRFATVTRRTRYRLGKVEDRIHILEGRMLVLLNIDEV
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCEEEEEEHHHH
IRIIRESDEPKPALMERFGLSDRQAEDILEIRLRQLARLEAIRIEKELKDLREEQADLDV
HHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLKSDTMMRRRIIKEIETDAKQYSPEDKDPRRTLIQEERRAAAEVRVVDEPVTVVVSQKG
EECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCC
WVRTRQGHGHDAQQFTFKAGDALYDTFECRTIDVLLAFGTNGRVYSVPVASLPGGRGDGV
CEEECCCCCCCCHHEEEECCCHHHHCCCCEEEEEEEEECCCCEEEEEEHHCCCCCCCCCC
PLTTLIELQPGSQIAHTFAGSAEQRMLIATQGGNGFLTKIADMTGRQKGGKSFLTLDDGD
CEEEEEEECCCCHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCC
APLTPAPIASEATHVACLSGNGRLLLVALDEVKVLSAGGRGVILMELEPKEKLLQAVGVG
CCCCCCCCCCCCCEEEEEECCCEEEEEEECCEEEEECCCCEEEEEEECCHHHHHHHHCCC
APGLVVSGTTPRGGKPDTQKLAGANLMPYVGKRARKGKALETKLKGVRIDPFRVVPPSGN
CCCEEEECCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCHHHHHHCCEEECCEEECCCCCC
>Mature Secondary Structure
MEQQDITFQPEEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMHE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRADAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLDEIDQGTVDFIANYDGSMEEPKLLPARMPFVLLNGASGI
CCCHHEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEVPPHNLREVAGATVAMIRNPNITLAELLALMPGPDYPGGGQIISPAADIAQIY
EEEEECCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHH
ESGRGSLKVRARWTIEEMARGQWQLVVTELPPATSAQKVLEEIEELTNPKVKAGKKALTP
HCCCCCEEEEEEEEHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHCCCCCCCC
EQQQLKASVLAVLDAVRDESGKDAPVRLVFEPKSKNIEQQEFIQTLLAHTSLESGAPVNL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
VMIGTDGRPRQKGLRDILREWIDFRFATVTRRTRYRLGKVEDRIHILEGRMLVLLNIDEV
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCEEEEEEHHHH
IRIIRESDEPKPALMERFGLSDRQAEDILEIRLRQLARLEAIRIEKELKDLREEQADLDV
HHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLKSDTMMRRRIIKEIETDAKQYSPEDKDPRRTLIQEERRAAAEVRVVDEPVTVVVSQKG
EECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCC
WVRTRQGHGHDAQQFTFKAGDALYDTFECRTIDVLLAFGTNGRVYSVPVASLPGGRGDGV
CEEECCCCCCCCHHEEEECCCHHHHCCCCEEEEEEEEECCCCEEEEEEHHCCCCCCCCCC
PLTTLIELQPGSQIAHTFAGSAEQRMLIATQGGNGFLTKIADMTGRQKGGKSFLTLDDGD
CEEEEEEECCCCHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCC
APLTPAPIASEATHVACLSGNGRLLLVALDEVKVLSAGGRGVILMELEPKEKLLQAVGVG
CCCCCCCCCCCCCEEEEEECCCEEEEEEECCEEEEECCCCEEEEEEECCHHHHHHHHCCC
APGLVVSGTTPRGGKPDTQKLAGANLMPYVGKRARKGKALETKLKGVRIDPFRVVPPSGN
CCCEEEECCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCHHHHHHCCEEECCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]