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The map label for this gene is asd [H]

Identifier: 73541996

GI number: 73541996

Start: 2548860

End: 2549996

Strand: Reverse

Name: asd [H]

Synonym: Reut_A2310

Alternate gene names: 73541996

Gene position: 2549996-2548860 (Counterclockwise)

Preceding gene: 73541997

Following gene: 73541995

Centisome position: 66.99

GC content: 63.76

Gene sequence:

>1137_bases
ATGATTGTAGGTCTCGTCGGTTGGCGGGGAATGGTCGGTAGCGTCCTGATGCAACGCATGCAGGAAGAGCGTGATTTCGA
CCATATCGAGCCCGTCTTCTTCAGCACGTCCAATGCCGGCGGCAAGGCGCCCGCCATGGCCAAGAACGAAACCACGCTCA
AGGATGCCAACGACATCGACGCGCTGAAGAAGTGCGACGTGGTGCTGACCGCCCAGGGCGGCGACTATACCAACGAAGTC
TTCCCGAAGCTGCGCGCAGCGGGCTGGAAGGGCTACTGGATCGACGCGGCTTCGTCGCTGCGTATGAAGGACGATGCCAT
CATCGTGCTGGATCCGGTGAACCAGGGTGTGATCAAGGATGCCCTGTCCAAGGGCGTGAAGAATTTCATCGGCGGCAACT
GCACGGTCAGCTGCATGCTGATCGGCCTCGGCGGCCTGTTCCAGGCCGACCTGGTCGAGTGGATGACTTCGATGACCTAC
CAGGCCGCCTCGGGCGGCGGTGCGCAGCATATGCGCGAACTGCTGACGCAGTTCGGTACGCTGAACGCATCGGTCAAGTC
GCTGCTGGATAACCCGGCATCGGCCATCCTGGAAATCGACCGCCAGATCCTGGCGACGCAGCATGGCCTGTCCGCCGAAG
AAACCAAGCAGTTCGGCGTGCCGCTGGCCGGCAATCTGATTCCCTGGATCGACAAGGACCTGGGCAACGGCCAGTCGAAG
GAAGAATGGAAGGGCGGCGCCGAGACCAACAAGATCCTGGGTCGCGGCGAAGGCTTCCTGGGTGCGACCGGCGCCACGCC
GATCGCCGTCGACGGCTTGTGCGTGCGCATTGGCGCCATGCGCTGCCATTCGCAGGCGCTGACCATCAAGCTGCGCAAGG
ACGTGCCGCTGGACGAGATCGAAGGCATGCTCGCGGCGGCCAACCAGTGGGCCAAGGTGGTGCCGAACACGCGTGAAGCC
AGTATGACCGACCTGACCCCGGCTGCCGTGACGGGCACGCTGACCATTCCGGTCGGGCGCCTGCGCAAGATGCAGATGGG
CGGCGAGTACCTGTCGGCCTTCACGGTTGGCGACCAGCTGCTGTGGGGCGCGGCCGAGCCGCTGCGCCGTATGCTGCGCA
TTTTGATCGAGTCCTGA

Upstream 100 bases:

>100_bases
GATCGCCTAGATCCGTTCGTCGTGCCTGCCCGTCTTCCCCGCGCAGCCACGCCGGGCGAGGAAAATGGCGGGGAAGTAAA
AATCACATCCGAGGTAAATC

Downstream 100 bases:

>100_bases
TCCCGGGGAGCGACGTTGCTGATGCCTGGAGGCTTTCGTTGCAGCCAGGCAACAGAAACAACAGCTTTGTCCGTGACGCC
GCGCCCGTGCGCGGCGTTGT

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MIVGLVGWRGMVGSVLMQRMQEERDFDHIEPVFFSTSNAGGKAPAMAKNETTLKDANDIDALKKCDVVLTAQGGDYTNEV
FPKLRAAGWKGYWIDAASSLRMKDDAIIVLDPVNQGVIKDALSKGVKNFIGGNCTVSCMLIGLGGLFQADLVEWMTSMTY
QAASGGGAQHMRELLTQFGTLNASVKSLLDNPASAILEIDRQILATQHGLSAEETKQFGVPLAGNLIPWIDKDLGNGQSK
EEWKGGAETNKILGRGEGFLGATGATPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEIEGMLAAANQWAKVVPNTREA
SMTDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQLLWGAAEPLRRMLRILIES

Sequences:

>Translated_378_residues
MIVGLVGWRGMVGSVLMQRMQEERDFDHIEPVFFSTSNAGGKAPAMAKNETTLKDANDIDALKKCDVVLTAQGGDYTNEV
FPKLRAAGWKGYWIDAASSLRMKDDAIIVLDPVNQGVIKDALSKGVKNFIGGNCTVSCMLIGLGGLFQADLVEWMTSMTY
QAASGGGAQHMRELLTQFGTLNASVKSLLDNPASAILEIDRQILATQHGLSAEETKQFGVPLAGNLIPWIDKDLGNGQSK
EEWKGGAETNKILGRGEGFLGATGATPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEIEGMLAAANQWAKVVPNTREA
SMTDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQLLWGAAEPLRRMLRILIES
>Mature_378_residues
MIVGLVGWRGMVGSVLMQRMQEERDFDHIEPVFFSTSNAGGKAPAMAKNETTLKDANDIDALKKCDVVLTAQGGDYTNEV
FPKLRAAGWKGYWIDAASSLRMKDDAIIVLDPVNQGVIKDALSKGVKNFIGGNCTVSCMLIGLGGLFQADLVEWMTSMTY
QAASGGGAQHMRELLTQFGTLNASVKSLLDNPASAILEIDRQILATQHGLSAEETKQFGVPLAGNLIPWIDKDLGNGQSK
EEWKGGAETNKILGRGEGFLGATGATPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEIEGMLAAANQWAKVVPNTREA
SMTDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQLLWGAAEPLRRMLRILIES

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=374, Percent_Identity=67.1122994652406, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40623; Mature: 40623

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGLVGWRGMVGSVLMQRMQEERDFDHIEPVFFSTSNAGGKAPAMAKNETTLKDANDID
CEEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHH
ALKKCDVVLTAQGGDYTNEVFPKLRAAGWKGYWIDAASSLRMKDDAIIVLDPVNQGVIKD
HHHHCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCCHHHHH
ALSKGVKNFIGGNCTVSCMLIGLGGLFQADLVEWMTSMTYQAASGGGAQHMRELLTQFGT
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
LNASVKSLLDNPASAILEIDRQILATQHGLSAEETKQFGVPLAGNLIPWIDKDLGNGQSK
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCH
EEWKGGAETNKILGRGEGFLGATGATPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEI
HHHCCCCCHHHHHCCCCCCEECCCCCCEEECHHHHHHHHHHHCCCEEEEEEECCCCHHHH
EGMLAAANQWAKVVPNTREASMTDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQL
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEEECHHHHHHHHHCCHHHHHHHHHHHH
LWGAAEPLRRMLRILIES
HHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVGLVGWRGMVGSVLMQRMQEERDFDHIEPVFFSTSNAGGKAPAMAKNETTLKDANDID
CEEEEECHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHH
ALKKCDVVLTAQGGDYTNEVFPKLRAAGWKGYWIDAASSLRMKDDAIIVLDPVNQGVIKD
HHHHCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCCHHHHH
ALSKGVKNFIGGNCTVSCMLIGLGGLFQADLVEWMTSMTYQAASGGGAQHMRELLTQFGT
HHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
LNASVKSLLDNPASAILEIDRQILATQHGLSAEETKQFGVPLAGNLIPWIDKDLGNGQSK
CCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCH
EEWKGGAETNKILGRGEGFLGATGATPIAVDGLCVRIGAMRCHSQALTIKLRKDVPLDEI
HHHCCCCCHHHHHCCCCCCEECCCCCCEEECHHHHHHHHHHHCCCEEEEEEECCCCHHHH
EGMLAAANQWAKVVPNTREASMTDLTPAAVTGTLTIPVGRLRKMQMGGEYLSAFTVGDQL
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEEEEECHHHHHHHHHCCHHHHHHHHHHHH
LWGAAEPLRRMLRILIES
HHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]