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The map label for this gene is degP [H]

Identifier: 73541943

GI number: 73541943

Start: 2489008

End: 2490504

Strand: Reverse

Name: degP [H]

Synonym: Reut_A2256

Alternate gene names: 73541943

Gene position: 2490504-2489008 (Counterclockwise)

Preceding gene: 73541944

Following gene: 73541942

Centisome position: 65.43

GC content: 65.46

Gene sequence:

>1497_bases
ATGACGTTCAGATCCCCAGCCCTGGCGCGTGCCGTGGTCATGGCTGCCATATTGATTCTCGGCCCGGCGGTTGCCGAAGT
GGGCCACGCCCAGGCCGCCGCGTCCAATTACAACCTGCCCGACTTTACCGACCTGGTGGAAAAGGCCAGCCCCGCCGTGG
TCAACATCCGGACCACCGAGCGCATTCGCTCGCGCGGTGGTTCAGGCGGCGACGACGACGAGATGGCTGAGTTCTTCCGG
CGTTTCTTCGGGGTTCCGATGCCAGGCGCTCCGACGCCGGGGGCCCCAAATGCGCCGCGCCGCGGCCAGCCGCCGCAGGG
CGAGGAACAGAGCCGCGGCGTCGGTTCCGGATTCATCATCAGCCAGGACGGCTATGTGATGACAAATGCCCATGTGGTGG
CTGACGCGGAAACCATCTATGTCACGCTGCCTGACAAGCGCGAGTTCAAGGCCAAGCTGATTGGCTCGGACAAGCGTACC
GACGTGGCGCTGATCAAGATTGAAGCGACAGGCTTGCCAAAGCTGGTGCTTGGGGATTCCGACAAGGTTCGTGCCGGAGA
GTGGGTGCTCGCGATCGGTTCGCCGTTCGGCCTCGACAACAGCGTGACCGCCGGCATCGTGTCCGCCAAGGGCCGTGATA
CCGGCGACTACCTGCCGTTCATCCAGACCGACGTGGCGGTCAACCCAGGCAATTCGGGCGGCCCGCTGATCAACCTGCGC
GGTGAAGTCATCGGCATCAACTCGCAGATTTACAGCCGCAGCGGTGGCTACATGGGCATTTCGTTCGCGATCCCGATCGA
CGAGGCCATGCGCGTCACCGAGCAGTTGAAGACGTCGGGCCGCGTCACGCGCGGGCGGATTGCCGTGGCGATCGGCGATG
TGACCAAGGAAGTGGCCGATTCACTCGGCCTGGGCCGTGCGCGCGGGGCACTGGTCGGCAGCGTGGAGCCGGGCGGACCG
GCGGAAAAGGCCGGCATCGAGCCCGGTGACATCATCCTGAAGTTCAACGGCCGCGAGATCGAAAAGGCGTCCGACCTGCC
GCGCATGGTTGGCGATACCAAGCCGGGCACGCGCGTGCCGATTCAGTTGTGGCGCAAGGGCGCCACCCGCGATGTGTCGA
TCACCGTGACGGAGTTGGAGCCGGAAGCCCGCGCGAAGGCGCGCAATGCCCCCTCGTCCAAGGATGACGCCAGTGCGCAG
GCACCTAAACCTAACGCGCTCGGTCTGATCGTCAACGACATTCCCGACGCTCGCCTGAAGGAGCTTAAGGTAAGGTCCGG
CGTGGAGGTCGAGGTCGCGGATGGCCCGGCCATGCGTGCAGGCATTCGTCCTGGCGACATCATCCTGCGGCTTGGCGATA
CTGACGTGACCGGCGCGCGCCAGTTCAATGATCTGGTGAAGGGGTTGGACAAGAGCCGCATCGCCGCCGTGTTCGTGCGT
CGTGGCGATGCCACCCAGGTCCTGACGCTGCGTCCGGGGGCGACCGCCGCCCGCTGA

Upstream 100 bases:

>100_bases
TACGGGGCTCGCAAGCCCGTGTCCGGTGGCCCCTGTGAGGGCGTCCTGCCGCTTCGTTCCAGTCGCTACTTCATCATTTG
CTGAATCCCGGGAGTTGTCG

Downstream 100 bases:

>100_bases
CCGTCGTCATGCTGCCGCTCACGGGGAAGGGATCCCTGTGAGCTTTGCCACGACTTCCTCTATGTCGTGGCCCTTCGGGT
GTGGCATGCGTCGCAGCAGG

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTFRSPALARAVVMAAILILGPAVAEVGHAQAAASNYNLPDFTDLVEKASPAVVNIRTTERIRSRGGSGGDDDEMAEFFR
RFFGVPMPGAPTPGAPNAPRRGQPPQGEEQSRGVGSGFIISQDGYVMTNAHVVADAETIYVTLPDKREFKAKLIGSDKRT
DVALIKIEATGLPKLVLGDSDKVRAGEWVLAIGSPFGLDNSVTAGIVSAKGRDTGDYLPFIQTDVAVNPGNSGGPLINLR
GEVIGINSQIYSRSGGYMGISFAIPIDEAMRVTEQLKTSGRVTRGRIAVAIGDVTKEVADSLGLGRARGALVGSVEPGGP
AEKAGIEPGDIILKFNGREIEKASDLPRMVGDTKPGTRVPIQLWRKGATRDVSITVTELEPEARAKARNAPSSKDDASAQ
APKPNALGLIVNDIPDARLKELKVRSGVEVEVADGPAMRAGIRPGDIILRLGDTDVTGARQFNDLVKGLDKSRIAAVFVR
RGDATQVLTLRPGATAAR

Sequences:

>Translated_498_residues
MTFRSPALARAVVMAAILILGPAVAEVGHAQAAASNYNLPDFTDLVEKASPAVVNIRTTERIRSRGGSGGDDDEMAEFFR
RFFGVPMPGAPTPGAPNAPRRGQPPQGEEQSRGVGSGFIISQDGYVMTNAHVVADAETIYVTLPDKREFKAKLIGSDKRT
DVALIKIEATGLPKLVLGDSDKVRAGEWVLAIGSPFGLDNSVTAGIVSAKGRDTGDYLPFIQTDVAVNPGNSGGPLINLR
GEVIGINSQIYSRSGGYMGISFAIPIDEAMRVTEQLKTSGRVTRGRIAVAIGDVTKEVADSLGLGRARGALVGSVEPGGP
AEKAGIEPGDIILKFNGREIEKASDLPRMVGDTKPGTRVPIQLWRKGATRDVSITVTELEPEARAKARNAPSSKDDASAQ
APKPNALGLIVNDIPDARLKELKVRSGVEVEVADGPAMRAGIRPGDIILRLGDTDVTGARQFNDLVKGLDKSRIAAVFVR
RGDATQVLTLRPGATAAR
>Mature_497_residues
TFRSPALARAVVMAAILILGPAVAEVGHAQAAASNYNLPDFTDLVEKASPAVVNIRTTERIRSRGGSGGDDDEMAEFFRR
FFGVPMPGAPTPGAPNAPRRGQPPQGEEQSRGVGSGFIISQDGYVMTNAHVVADAETIYVTLPDKREFKAKLIGSDKRTD
VALIKIEATGLPKLVLGDSDKVRAGEWVLAIGSPFGLDNSVTAGIVSAKGRDTGDYLPFIQTDVAVNPGNSGGPLINLRG
EVIGINSQIYSRSGGYMGISFAIPIDEAMRVTEQLKTSGRVTRGRIAVAIGDVTKEVADSLGLGRARGALVGSVEPGGPA
EKAGIEPGDIILKFNGREIEKASDLPRMVGDTKPGTRVPIQLWRKGATRDVSITVTELEPEARAKARNAPSSKDDASAQA
PKPNALGLIVNDIPDARLKELKVRSGVEVEVADGPAMRAGIRPGDIILRLGDTDVTGARQFNDLVKGLDKSRIAAVFVRR
GDATQVLTLRPGATAAR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=366, Percent_Identity=35.792349726776, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI22129776, Length=350, Percent_Identity=35.4285714285714, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=37.6, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI7019477, Length=295, Percent_Identity=37.9661016949153, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1786356, Length=484, Percent_Identity=35.1239669421488, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789629, Length=459, Percent_Identity=33.9869281045752, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789630, Length=296, Percent_Identity=37.5, Blast_Score=180, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24646839, Length=262, Percent_Identity=36.6412213740458, Blast_Score=160, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52461; Mature: 52330

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRSPALARAVVMAAILILGPAVAEVGHAQAAASNYNLPDFTDLVEKASPAVVNIRTTE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHCCCCEEEEEEHH
RIRSRGGSGGDDDEMAEFFRRFFGVPMPGAPTPGAPNAPRRGQPPQGEEQSRGVGSGFII
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEE
SQDGYVMTNAHVVADAETIYVTLPDKREFKAKLIGSDKRTDVALIKIEATGLPKLVLGDS
ECCCEEEECCEEEEECEEEEEECCCCCCCHHHCCCCCCCCEEEEEEEECCCCCEEEECCC
DKVRAGEWVLAIGSPFGLDNSVTAGIVSAKGRDTGDYLPFIQTDVAVNPGNSGGPLINLR
CCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEECEEECCCCCCCCEEEEC
GEVIGINSQIYSRSGGYMGISFAIPIDEAMRVTEQLKTSGRVTRGRIAVAIGDVTKEVAD
CCEEEECHHEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCEEECEEEEEECHHHHHHHH
SLGLGRARGALVGSVEPGGPAEKAGIEPGDIILKFNGREIEKASDLPRMVGDTKPGTRVP
HCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEECCCCCHHHHCCHHHHCCCCCCCCCC
IQLWRKGATRDVSITVTELEPEARAKARNAPSSKDDASAQAPKPNALGLIVNDIPDARLK
HHHHCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHH
ELKVRSGVEVEVADGPAMRAGIRPGDIILRLGDTDVTGARQFNDLVKGLDKSRIAAVFVR
HHHHHCCCEEEECCCCHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEE
RGDATQVLTLRPGATAAR
CCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
TFRSPALARAVVMAAILILGPAVAEVGHAQAAASNYNLPDFTDLVEKASPAVVNIRTTE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHCCCCEEEEEEHH
RIRSRGGSGGDDDEMAEFFRRFFGVPMPGAPTPGAPNAPRRGQPPQGEEQSRGVGSGFII
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEE
SQDGYVMTNAHVVADAETIYVTLPDKREFKAKLIGSDKRTDVALIKIEATGLPKLVLGDS
ECCCEEEECCEEEEECEEEEEECCCCCCCHHHCCCCCCCCEEEEEEEECCCCCEEEECCC
DKVRAGEWVLAIGSPFGLDNSVTAGIVSAKGRDTGDYLPFIQTDVAVNPGNSGGPLINLR
CCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEECEEECCCCCCCCEEEEC
GEVIGINSQIYSRSGGYMGISFAIPIDEAMRVTEQLKTSGRVTRGRIAVAIGDVTKEVAD
CCEEEECHHEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCEEECEEEEEECHHHHHHHH
SLGLGRARGALVGSVEPGGPAEKAGIEPGDIILKFNGREIEKASDLPRMVGDTKPGTRVP
HCCCCCCCCCEEECCCCCCCHHHCCCCCCCEEEEECCCCCHHHHCCHHHHCCCCCCCCCC
IQLWRKGATRDVSITVTELEPEARAKARNAPSSKDDASAQAPKPNALGLIVNDIPDARLK
HHHHCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHH
ELKVRSGVEVEVADGPAMRAGIRPGDIILRLGDTDVTGARQFNDLVKGLDKSRIAAVFVR
HHHHHCCCEEEECCCCHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEE
RGDATQVLTLRPGATAAR
CCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]