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The map label for this gene is mucB [H]

Identifier: 73541944

GI number: 73541944

Start: 2490623

End: 2491702

Strand: Reverse

Name: mucB [H]

Synonym: Reut_A2257

Alternate gene names: 73541944

Gene position: 2491702-2490623 (Counterclockwise)

Preceding gene: 73541945

Following gene: 73541943

Centisome position: 65.46

GC content: 65.09

Gene sequence:

>1080_bases
ATGCACAAAGGATGGTCGCCCGCCAACGTAGCGGGCGCACCGAGAATGGGGGCCCTGCGTAGGTCCTTTTTTCTGGCCTT
GTGTCTGAGCGCGGCGGCGGCCACGGCCCAGCCCTCGGACAGTTCGCTGAACCGGCGCGACGCGTCCGCCTGGCTCAGCA
AGATCCACCGTGCAGCGCAGCGCGAAAACTATGTCGGCACGCTGATCTATCAGCGCGGCAGTGTGATGCATGCGTCGAAG
ATCCAGCACTACAGCGATCTCGTGCACAACGAGTACGAACGGCTTGAGACGCTCGACGGCAAGCCGCGCGAAGTGCTGCG
GCAGAATGACGTGGTGCACAGCCTGATTCCCGAAGCCAAGCTCGTGGTGGTCGAGAAGCAGGAGGCCAAGGACCGCTTCC
CGGCGCTGCTGGCCACCACCAAGAGCGACGTGCTCGATCTCTACGAGATGCGCAAGCTCCCGGGCGAGCGCGTGGCCGGC
GTGGAATGCGAGGTGTTCTCGCTGGAGCCGCACGATGCGGCCCGCTACGCCGTACGCTTGTGGGCCGAAAAAAATTCGGG
CCTGCTGATGCGGGCGCAGACCATCGGGGACGGCGGCAAGGTGCTGGAGCAGGTTGCCTTTTCGCAGGTCGACATCGGCG
TGCCGTCGGACAAGCAGCGCATCCTCGGGGCCATCAAGAACGCCAGTTCCTGGAATCACTATGAGGTCACGTACCAGCCA
ACCAACGTCGCGGACGAAGGCTGGACCATTGCGGTGCCGCTGAAGGGCTTCCAGAAGATCCGCGAGGTGCGTCGCCCGCT
CGGTGAACTGCGCGCGCCTGCGCAGGGCAGCGGACGCGGCCAGGTGTTCGAGGTGCTCCAGGTCGTCTACAGCGACGGGC
TGACTGGCTTGTCGGTGTTTATCGAACCGGTCTCCGAGCAGCGTGTGCGCCGCGAAGGCGTCGCGTCGCTGGGCGCCACG
CAGGTTGTGGTCCGCCGCATTGCGGACTACTGGATTACAGTGGTGGGCGAAGTGCCCGCCAGCACGGTGCGGCAGTTCGC
GTCGGCCGTGGAATATCGCCCTCCCAAGGCGTTACACTGA

Upstream 100 bases:

>100_bases
ACCGCACGTCCGTCGCAACGGAGGCATTCGTGCCGACCATGCGTACGGTCGCCAACGGTGCCAATTTCTCTCAGGACAAT
TCGCAGGAATAATGCCGGAC

Downstream 100 bases:

>100_bases
GCTCGGGGAAGTGCCGGATACGGGGCTCGCAAGCCCGTGTCCGGTGGCCCCTGTGAGGGCGTCCTGCCGCTTCGTTCCAG
TCGCTACTTCATCATTTGCT

Product: putative sigma-e factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MHKGWSPANVAGAPRMGALRRSFFLALCLSAAAATAQPSDSSLNRRDASAWLSKIHRAAQRENYVGTLIYQRGSVMHASK
IQHYSDLVHNEYERLETLDGKPREVLRQNDVVHSLIPEAKLVVVEKQEAKDRFPALLATTKSDVLDLYEMRKLPGERVAG
VECEVFSLEPHDAARYAVRLWAEKNSGLLMRAQTIGDGGKVLEQVAFSQVDIGVPSDKQRILGAIKNASSWNHYEVTYQP
TNVADEGWTIAVPLKGFQKIREVRRPLGELRAPAQGSGRGQVFEVLQVVYSDGLTGLSVFIEPVSEQRVRREGVASLGAT
QVVVRRIADYWITVVGEVPASTVRQFASAVEYRPPKALH

Sequences:

>Translated_359_residues
MHKGWSPANVAGAPRMGALRRSFFLALCLSAAAATAQPSDSSLNRRDASAWLSKIHRAAQRENYVGTLIYQRGSVMHASK
IQHYSDLVHNEYERLETLDGKPREVLRQNDVVHSLIPEAKLVVVEKQEAKDRFPALLATTKSDVLDLYEMRKLPGERVAG
VECEVFSLEPHDAARYAVRLWAEKNSGLLMRAQTIGDGGKVLEQVAFSQVDIGVPSDKQRILGAIKNASSWNHYEVTYQP
TNVADEGWTIAVPLKGFQKIREVRRPLGELRAPAQGSGRGQVFEVLQVVYSDGLTGLSVFIEPVSEQRVRREGVASLGAT
QVVVRRIADYWITVVGEVPASTVRQFASAVEYRPPKALH
>Mature_359_residues
MHKGWSPANVAGAPRMGALRRSFFLALCLSAAAATAQPSDSSLNRRDASAWLSKIHRAAQRENYVGTLIYQRGSVMHASK
IQHYSDLVHNEYERLETLDGKPREVLRQNDVVHSLIPEAKLVVVEKQEAKDRFPALLATTKSDVLDLYEMRKLPGERVAG
VECEVFSLEPHDAARYAVRLWAEKNSGLLMRAQTIGDGGKVLEQVAFSQVDIGVPSDKQRILGAIKNASSWNHYEVTYQP
TNVADEGWTIAVPLKGFQKIREVRRPLGELRAPAQGSGRGQVFEVLQVVYSDGLTGLSVFIEPVSEQRVRREGVASLGAT
QVVVRRIADYWITVVGEVPASTVRQFASAVEYRPPKALH

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucB causes conversion to mucoidy [H]

COG id: COG3026

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseB family [H]

Homologues:

Organism=Escherichia coli, GI1788924, Length=330, Percent_Identity=24.5454545454545, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005588 [H]

Pfam domain/function: PF03888 MucB_RseB [H]

EC number: NA

Molecular weight: Translated: 39762; Mature: 39762

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKGWSPANVAGAPRMGALRRSFFLALCLSAAAATAQPSDSSLNRRDASAWLSKIHRAAQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RENYVGTLIYQRGSVMHASKIQHYSDLVHNEYERLETLDGKPREVLRQNDVVHSLIPEAK
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHCCCCE
LVVVEKQEAKDRFPALLATTKSDVLDLYEMRKLPGERVAGVECEVFSLEPHDAARYAVRL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHE
WAEKNSGLLMRAQTIGDGGKVLEQVAFSQVDIGVPSDKQRILGAIKNASSWNHYEVTYQP
EEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECC
TNVADEGWTIAVPLKGFQKIREVRRPLGELRAPAQGSGRGQVFEVLQVVYSDGLTGLSVF
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
IEPVSEQRVRREGVASLGATQVVVRRIADYWITVVGEVPASTVRQFASAVEYRPPKALH
HHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHKGWSPANVAGAPRMGALRRSFFLALCLSAAAATAQPSDSSLNRRDASAWLSKIHRAAQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RENYVGTLIYQRGSVMHASKIQHYSDLVHNEYERLETLDGKPREVLRQNDVVHSLIPEAK
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHCCCCE
LVVVEKQEAKDRFPALLATTKSDVLDLYEMRKLPGERVAGVECEVFSLEPHDAARYAVRL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHE
WAEKNSGLLMRAQTIGDGGKVLEQVAFSQVDIGVPSDKQRILGAIKNASSWNHYEVTYQP
EEECCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECC
TNVADEGWTIAVPLKGFQKIREVRRPLGELRAPAQGSGRGQVFEVLQVVYSDGLTGLSVF
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
IEPVSEQRVRREGVASLGATQVVVRRIADYWITVVGEVPASTVRQFASAVEYRPPKALH
HHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 8444793; 10984043 [H]