Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 73541939

GI number: 73541939

Start: 2484719

End: 2485489

Strand: Reverse

Name: rnc [H]

Synonym: Reut_A2252

Alternate gene names: 73541939

Gene position: 2485489-2484719 (Counterclockwise)

Preceding gene: 73541940

Following gene: 73541938

Centisome position: 65.3

GC content: 62.52

Gene sequence:

>771_bases
ATGAACCTCGACGCCTTGCAGCAACGTCTCGGCTACCGTTTCAGCAAGCCTGAGTTGCTGCAGCAGGCGCTGACGCACCG
CAGCCACAGCGCCCAGCACAACGAACGCCTCGAATTCCTGGGCGACTCGGTGCTGAACTGCGCCGTGGCCGACATGCTGT
TTGGCATGTTCGGCAAACTCGATGAAGGCGACCTGTCGCGCGTGCGCGCGAACCTGGTCAAGCAGCAGGCGTTGTACGAA
ATTGCACAGATGCTGCAGTTGTCCGAAGTGCTGCGCCTGGGCGAGGGCGAACTGAAGAGCGGTGGATTCCGCCGCCCGTC
GATTCTCGCCGATGCGCTTGAAGCCATTGTCGGAGCGGTGTTCCTCGATGCCGGTTTCGAAGCCGCGCGCACGCTGATCC
GCAAGTTGTATATCCCCATCCTGGAGCAAGTCGATCCACGCACGCTCGGTAAGGATGCCAAGACGCTGCTCCAGGAATAC
TTGCAGGGCCACAAGATCGCCCTGCCTCAATATAACGTAATCGCCACTCACGGCGCCGCGCACAGCCAGCAGTTTGAAGT
CGAGTGCATGGTGCCTAAACTGGAAGTCCGGGTGTTCGGCACCGGTGCCTCCCGCCGAGCCGCGGAGCAGGCGGCGGCCA
AGCTGGCGCTCGATGAAGTCCAGAAGCTCGTGCCGCAGCTGCTCAAGCGCAGCCGCGCCGAGCGCACCGGCAAGACCCGC
AAGCAGCCGGTACCGCCGGACCCACAGTTGTCTCTCAGGTTGAAGGAATGA

Upstream 100 bases:

>100_bases
AATGGAACGATCCAGTCGGTCGATTTTGCCTACCGGACCGAAGTTCCTGTCTACGGTCCACTGAGCTTACTGATTACTTA
TTCGGGAACGCAGCACTGAT

Downstream 100 bases:

>100_bases
CCGAATCCCATGATTCGCAGCAGCCCGCTGCGGATACCCAAGCCAAGGCGTTCCGCTGCGGCACCGTGGCCATTGTTGGC
CGCCCCAACGTCGGCAAGTC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLSEVLRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFEAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYNVIATHGAAHSQQFEVECMVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
KQPVPPDPQLSLRLKE

Sequences:

>Translated_256_residues
MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLSEVLRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFEAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYNVIATHGAAHSQQFEVECMVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
KQPVPPDPQLSLRLKE
>Mature_256_residues
MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLSEVLRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFEAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYNVIATHGAAHSQQFEVECMVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
KQPVPPDPQLSLRLKE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=240, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI155030236, Length=240, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1788920, Length=204, Percent_Identity=53.4313725490196, Blast_Score=220, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17506883, Length=199, Percent_Identity=31.1557788944724, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=199, Percent_Identity=31.1557788944724, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323895, Length=202, Percent_Identity=29.7029702970297, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137682, Length=243, Percent_Identity=27.9835390946502, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28529; Mature: 28529

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKL
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLQLSEVLRLGEGELKSGGFRRPSILADALEAIVGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDAGFEAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAA
HHHCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
HSQQFEVECMVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
CCCCEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KQPVPPDPQLSLRLKE
CCCCCCCCCCCEEECC
>Mature Secondary Structure
MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKL
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLQLSEVLRLGEGELKSGGFRRPSILADALEAIVGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDAGFEAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAA
HHHCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
HSQQFEVECMVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
CCCCEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KQPVPPDPQLSLRLKE
CCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA