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The map label for this gene is era [H]

Identifier: 73541938

GI number: 73541938

Start: 2483787

End: 2484722

Strand: Reverse

Name: era [H]

Synonym: Reut_A2251

Alternate gene names: 73541938

Gene position: 2484722-2483787 (Counterclockwise)

Preceding gene: 73541939

Following gene: 73541937

Centisome position: 65.28

GC content: 62.82

Gene sequence:

>936_bases
ATGACCGAATCCCATGATTCGCAGCAGCCCGCTGCGGATACCCAAGCCAAGGCGTTCCGCTGCGGCACCGTGGCCATTGT
TGGCCGCCCCAACGTCGGCAAGTCCACGCTGATGAATGCGCTGGTCGGCCAGAAGATCAGCATCACGTCGCGCAAGGCGC
AGACCACGCGTCACCGCCTGGTCGGCATCCAGACCACGGATGACGCGCAGTATGTCTTCGTCGACACGCCAGGTTTTCAG
ACCCGCCACGCCAGTGCGCTGAACCGCTCGCTCAACCGCGCAGTCACCTCCACGCTGTCGTCGGTGGACCTGGTGCTGTT
CGTCGTGGAAGCCGGCTACTATGGCGCCGATGACGAAAAGGTGCTCGCGCTGCTGCCGAAGAACACGCCGGTGCTGCTGG
TGACCAACAAGCTCGACCGCGTGACTGACGACCGCGCCGGGGTGATGATGCCCTTCCTCGAAAAGATGGGCCAGCTGTTC
CCGTTCCGGGAAGTGGTGCCGATGTCGGCCAAGACGCGCGACCATATCGCGCGCCTGTTCGAGATCATCCGGCCTTACCT
GCCGGAAGGCGAACCGATGTACGACGCCGACGCGATGACCGACCGCAGCGAGCGTTTCCTCGCCTCGGAAATTATCCGCG
AGAAGGTGTTCCGCTGGACCGGCGACGAACTGCCGTACACGAGCACCGTCATCATCGACAAGTTCGAGACGGAAGGGCGC
CTGCGCCGCGTGTTTGCCACGATCCTGGTCGAGCGCGACGCGCACAAGGCCATGATCATCGGCAACAAGGGCAGCAAGCT
GAAGCAGATCTCCACCGAGGCGCGCCTCGACATGGAAAAGCTGTTCGACGGCAAGGTCTACCTGGAAATGTGGATCAAGG
TGAAAAGCGGCTGGGCCGATAACGAAGCCGGACTGCGCGCATACGGCTACGAGTGA

Upstream 100 bases:

>100_bases
TCGTGCCGCAGCTGCTCAAGCGCAGCCGCGCCGAGCGCACCGGCAAGACCCGCAAGCAGCCGGTACCGCCGGACCCACAG
TTGTCTCTCAGGTTGAAGGA

Downstream 100 bases:

>100_bases
GCAAAATGCCTGACTTCGCGCGTGGGCCTGCGAAGGCCCGCCGCGCCGATCCGGTCGTGGACGAGGCCGCGGAGCTGCTG
GACAGCCGCGCGCTGCCCGG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTESHDSQQPAADTQAKAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRLVGIQTTDDAQYVFVDTPGFQ
TRHASALNRSLNRAVTSTLSSVDLVLFVVEAGYYGADDEKVLALLPKNTPVLLVTNKLDRVTDDRAGVMMPFLEKMGQLF
PFREVVPMSAKTRDHIARLFEIIRPYLPEGEPMYDADAMTDRSERFLASEIIREKVFRWTGDELPYTSTVIIDKFETEGR
LRRVFATILVERDAHKAMIIGNKGSKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWADNEAGLRAYGYE

Sequences:

>Translated_311_residues
MTESHDSQQPAADTQAKAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRLVGIQTTDDAQYVFVDTPGFQ
TRHASALNRSLNRAVTSTLSSVDLVLFVVEAGYYGADDEKVLALLPKNTPVLLVTNKLDRVTDDRAGVMMPFLEKMGQLF
PFREVVPMSAKTRDHIARLFEIIRPYLPEGEPMYDADAMTDRSERFLASEIIREKVFRWTGDELPYTSTVIIDKFETEGR
LRRVFATILVERDAHKAMIIGNKGSKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWADNEAGLRAYGYE
>Mature_310_residues
TESHDSQQPAADTQAKAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRLVGIQTTDDAQYVFVDTPGFQT
RHASALNRSLNRAVTSTLSSVDLVLFVVEAGYYGADDEKVLALLPKNTPVLLVTNKLDRVTDDRAGVMMPFLEKMGQLFP
FREVVPMSAKTRDHIARLFEIIRPYLPEGEPMYDADAMTDRSERFLASEIIREKVFRWTGDELPYTSTVIIDKFETEGRL
RRVFATILVERDAHKAMIIGNKGSKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWADNEAGLRAYGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=323, Percent_Identity=25.6965944272446, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=50.3424657534247, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI87082120, Length=177, Percent_Identity=28.2485875706215, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=164, Percent_Identity=29.2682926829268, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24646434, Length=305, Percent_Identity=26.8852459016393, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34988; Mature: 34856

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESHDSQQPAADTQAKAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRL
CCCCCCCCCCCCCCHHHEEECCEEEEEECCCCCHHHHHHHHHCCEEEECCHHHHHHHHHE
VGIQTTDDAQYVFVDTPGFQTRHASALNRSLNRAVTSTLSSVDLVLFVVEAGYYGADDEK
EEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCE
VLALLPKNTPVLLVTNKLDRVTDDRAGVMMPFLEKMGQLFPFREVVPMSAKTRDHIARLF
EEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
EIIRPYLPEGEPMYDADAMTDRSERFLASEIIREKVFRWTGDELPYTSTVIIDKFETEGR
HHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHH
LRRVFATILVERDAHKAMIIGNKGSKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWAD
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHCCEEEEEEEEEEECCCCC
NEAGLRAYGYE
CCCCCEECCCC
>Mature Secondary Structure 
TESHDSQQPAADTQAKAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRL
CCCCCCCCCCCCCHHHEEECCEEEEEECCCCCHHHHHHHHHCCEEEECCHHHHHHHHHE
VGIQTTDDAQYVFVDTPGFQTRHASALNRSLNRAVTSTLSSVDLVLFVVEAGYYGADDEK
EEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCE
VLALLPKNTPVLLVTNKLDRVTDDRAGVMMPFLEKMGQLFPFREVVPMSAKTRDHIARLF
EEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
EIIRPYLPEGEPMYDADAMTDRSERFLASEIIREKVFRWTGDELPYTSTVIIDKFETEGR
HHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHH
LRRVFATILVERDAHKAMIIGNKGSKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWAD
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHCCEEEEEEEEEEECCCCC
NEAGLRAYGYE
CCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]