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The map label for this gene is ppx [H]

Identifier: 73541847

GI number: 73541847

Start: 2380087

End: 2381619

Strand: Reverse

Name: ppx [H]

Synonym: Reut_A2159

Alternate gene names: 73541847

Gene position: 2381619-2380087 (Counterclockwise)

Preceding gene: 73541849

Following gene: 73541843

Centisome position: 62.57

GC content: 64.71

Gene sequence:

>1533_bases
ATGAACAACACTCCACGCCTGCTGGCCGCCGTCGACATGGGTTCGAACAGCTTCCGCCTCATGATCGGGCGGGTGGACGA
AACCCCCACTAGCAACGGCCCGGCCAGCCAGATCTTCCAGGTCGACGCGCTGCGCGAGCCGGTGAGGCTCGCAGCAGGCC
TGACACCGGACAAGTATCTCGACCAGCCGGCACGGCGCCGCGGCATCGACGCGCTGCGCCGCTTCGGCGACCGGCTGCGC
GACTTCTCCCCGGATCAGGTGCGTGCCGTGGCGACCAACACGCTGCGCGTGGCCAAGAATGCATCGGAATTCCTGATCGA
GGCGGAAGCGGCGCTTGGCTTCCCGATCGAAGTCATCGCAGGCCGTGAAGAAGCGCGCCTGATTTACCTGGGCGCATCGC
ACGATGCACCGGTGTGCCAGGGCAATCGCCTTGTCGTGGACATTGGTGGCGGTTCGACCGAATTCATCATCGGCAGCGGC
TACCAGTCGAAGCTGATGGAAAGCCTCTACATCGGCTGCGTGTCGCACAGCCGCCAGTTCTTTCCGAGCGGCAACGTCGA
CGAGTATGCGATGAAGCAGGCCGAACTCGCCGCACGCCGAGAGATCCAGGTGCTGGTGCGCCAGTATCGCGCGGCGGGAT
GGGAGCAGGCGGTCGGTTCATCGGGTACGGCGCGTGCGTTGGCCGAACTGATCGAGCTCAATGGCATGAACGACAGCGCG
GCCGAGCATGGCATCACGCGCGAAGGGCTCGAACGGCTCAAGCGCGCGTTGGTCAAGGCCGAGAACGCGAACCGCGTCAA
GCTGACCGGCCTGAAGGCCGACCGTATTCCGGTGCTGCCAGGCGGGCTCTCGATCATGCTGGGCGTATTCGCCGAACTCG
ACATCGATCGTATGGACGTGACCGACGGCGCTTTGCGGCTCGGCGTGCTTTATGACCTGCTGGGACGCAGTCATCACGAG
GACATGCGCACCGTGACGGTGGACCAGTTCATGCGACGCTACGGAGTAGACCGGGCTCAGGCGACTCGCGTGCGCCGCGC
GGCGACCATCTTGCTGTCGCAGTTTCCGCAGCCGCGCCATGAGCGGCGCGAGGACAACCTCGGGCTGCTGGGCTGGGCCG
CGAGCCTGCATGAAGTTGGCATGTCGATTTCCCATAGCGGCTACCACAAGCACTCGGCGTATATCGCGACGCATGCGGAT
ATGCCGGGCTTCTCCAAGACGGATCAGGCTCGCCTGGCGGCACTGCTGCTTGGCCATGCGGGGAAGCTCGGCAAGCTTTC
TGGCAGCGGCAAGTTCCTCGACTGGCGCATGCTATTCAGCCTTCGGCTTGCCTTCGTGCTGTGCCGGCGGCGCTCGGACT
CCCCGCTGCCCGACATCAAGGTCTCGCAGCGCTCGGATGCGCTGGATGAGGGCTTCGAGGTGCGTGTGCCCAAGGTCTGG
ATCGAAGCCAATCCGCTGGTCGAATACAGCCTGGCGCAGGAAGCCGATGAATGGCAGCGCATCGGCAAGCGCTACAAGGT
CGTGTACGCCTGA

Upstream 100 bases:

>100_bases
GACATAATTTTCTGGGGTGCCAGCCGCCCCCGGGCGGAGCGTCCATCTCGTCTGATGCGGCCTCCCGGCGCCCTCTGCGT
TTCAGTTTTCCAGATACCGA

Downstream 100 bases:

>100_bases
GTCGCGGCGCCGAACGTCAACGGAAACGGCGGCCAAGGGCCGCCGTTTTCATTTCGCCGGAGTGCTTCAGGCATGCCTGT
TTCAGGCGGTCTTGTTGTTC

Product: guanosine-5'-triphosphate,3'-diphosphate diphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNNTPRLLAAVDMGSNSFRLMIGRVDETPTSNGPASQIFQVDALREPVRLAAGLTPDKYLDQPARRRGIDALRRFGDRLR
DFSPDQVRAVATNTLRVAKNASEFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPVCQGNRLVVDIGGGSTEFIIGSG
YQSKLMESLYIGCVSHSRQFFPSGNVDEYAMKQAELAARREIQVLVRQYRAAGWEQAVGSSGTARALAELIELNGMNDSA
AEHGITREGLERLKRALVKAENANRVKLTGLKADRIPVLPGGLSIMLGVFAELDIDRMDVTDGALRLGVLYDLLGRSHHE
DMRTVTVDQFMRRYGVDRAQATRVRRAATILLSQFPQPRHERREDNLGLLGWAASLHEVGMSISHSGYHKHSAYIATHAD
MPGFSKTDQARLAALLLGHAGKLGKLSGSGKFLDWRMLFSLRLAFVLCRRRSDSPLPDIKVSQRSDALDEGFEVRVPKVW
IEANPLVEYSLAQEADEWQRIGKRYKVVYA

Sequences:

>Translated_510_residues
MNNTPRLLAAVDMGSNSFRLMIGRVDETPTSNGPASQIFQVDALREPVRLAAGLTPDKYLDQPARRRGIDALRRFGDRLR
DFSPDQVRAVATNTLRVAKNASEFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPVCQGNRLVVDIGGGSTEFIIGSG
YQSKLMESLYIGCVSHSRQFFPSGNVDEYAMKQAELAARREIQVLVRQYRAAGWEQAVGSSGTARALAELIELNGMNDSA
AEHGITREGLERLKRALVKAENANRVKLTGLKADRIPVLPGGLSIMLGVFAELDIDRMDVTDGALRLGVLYDLLGRSHHE
DMRTVTVDQFMRRYGVDRAQATRVRRAATILLSQFPQPRHERREDNLGLLGWAASLHEVGMSISHSGYHKHSAYIATHAD
MPGFSKTDQARLAALLLGHAGKLGKLSGSGKFLDWRMLFSLRLAFVLCRRRSDSPLPDIKVSQRSDALDEGFEVRVPKVW
IEANPLVEYSLAQEADEWQRIGKRYKVVYA
>Mature_510_residues
MNNTPRLLAAVDMGSNSFRLMIGRVDETPTSNGPASQIFQVDALREPVRLAAGLTPDKYLDQPARRRGIDALRRFGDRLR
DFSPDQVRAVATNTLRVAKNASEFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPVCQGNRLVVDIGGGSTEFIIGSG
YQSKLMESLYIGCVSHSRQFFPSGNVDEYAMKQAELAARREIQVLVRQYRAAGWEQAVGSSGTARALAELIELNGMNDSA
AEHGITREGLERLKRALVKAENANRVKLTGLKADRIPVLPGGLSIMLGVFAELDIDRMDVTDGALRLGVLYDLLGRSHHE
DMRTVTVDQFMRRYGVDRAQATRVRRAATILLSQFPQPRHERREDNLGLLGWAASLHEVGMSISHSGYHKHSAYIATHAD
MPGFSKTDQARLAALLLGHAGKLGKLSGSGKFLDWRMLFSLRLAFVLCRRRSDSPLPDIKVSQRSDALDEGFEVRVPKVW
IEANPLVEYSLAQEADEWQRIGKRYKVVYA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=514, Percent_Identity=38.5214007782101, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI48994966, Length=504, Percent_Identity=35.3174603174603, Blast_Score=291, Evalue=7e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56461; Mature: 56461

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTPRLLAAVDMGSNSFRLMIGRVDETPTSNGPASQIFQVDALREPVRLAAGLTPDKYL
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHHEEHHHHHHHHHHHCCCCCHHHH
DQPARRRGIDALRRFGDRLRDFSPDQVRAVATNTLRVAKNASEFLIEAEAALGFPIEVIA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHEEEHHHHCCCCEEEEC
GREEARLIYLGASHDAPVCQGNRLVVDIGGGSTEFIIGSGYQSKLMESLYIGCVSHSRQF
CCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
FPSGNVDEYAMKQAELAARREIQVLVRQYRAAGWEQAVGSSGTARALAELIELNGMNDSA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCHH
AEHGITREGLERLKRALVKAENANRVKLTGLKADRIPVLPGGLSIMLGVFAELDIDRMDV
HHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
TDGALRLGVLYDLLGRSHHEDMRTVTVDQFMRRYGVDRAQATRVRRAATILLSQFPQPRH
CHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
ERREDNLGLLGWAASLHEVGMSISHSGYHKHSAYIATHADMPGFSKTDQARLAALLLGHA
HHCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCC
GKLGKLSGSGKFLDWRMLFSLRLAFVLCRRRSDSPLPDIKVSQRSDALDEGFEVRVPKVW
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHCCCCEEECCEEE
IEANPLVEYSLAQEADEWQRIGKRYKVVYA
EECCCCEEHHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure
MNNTPRLLAAVDMGSNSFRLMIGRVDETPTSNGPASQIFQVDALREPVRLAAGLTPDKYL
CCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHHEEHHHHHHHHHHHCCCCCHHHH
DQPARRRGIDALRRFGDRLRDFSPDQVRAVATNTLRVAKNASEFLIEAEAALGFPIEVIA
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHEEEHHHHCCCCEEEEC
GREEARLIYLGASHDAPVCQGNRLVVDIGGGSTEFIIGSGYQSKLMESLYIGCVSHSRQF
CCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
FPSGNVDEYAMKQAELAARREIQVLVRQYRAAGWEQAVGSSGTARALAELIELNGMNDSA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCHH
AEHGITREGLERLKRALVKAENANRVKLTGLKADRIPVLPGGLSIMLGVFAELDIDRMDV
HHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
TDGALRLGVLYDLLGRSHHEDMRTVTVDQFMRRYGVDRAQATRVRRAATILLSQFPQPRH
CHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
ERREDNLGLLGWAASLHEVGMSISHSGYHKHSAYIATHADMPGFSKTDQARLAALLLGHA
HHCCCCCCEEHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCC
GKLGKLSGSGKFLDWRMLFSLRLAFVLCRRRSDSPLPDIKVSQRSDALDEGFEVRVPKVW
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHCCCCEEECCEEE
IEANPLVEYSLAQEADEWQRIGKRYKVVYA
EECCCCEEHHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]