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The map label for this gene is phoR [H]

Identifier: 73541849

GI number: 73541849

Start: 2383992

End: 2385326

Strand: Reverse

Name: phoR [H]

Synonym: Reut_A2161

Alternate gene names: 73541849

Gene position: 2385326-2383992 (Counterclockwise)

Preceding gene: 73541850

Following gene: 73541847

Centisome position: 62.66

GC content: 63.6

Gene sequence:

>1335_bases
ATGAATGTCATCTGGGCCCGCTCCGTGGCCATCCTGATCAGCCTGGTGGTGGTTGCCGTCGGGGTCTATCTTCTGGCGGG
GGCGGTGCCTGCGCTGGCGGTGATGAGTGTGTCGCTGCTTTGCCTGGTGGCATTCCACCTGTACCAGATCAACCGGCTGT
GGAAAGTGCTGGACGCGCCAGCGTATGGTGAAATTCCCAGCGCGCCGGGCCTGTGGGGCGAGGTCTATTACCGCCTGCAC
CGGCTGGTCAAGCGTTGGCGCCTGCAGGTACTGCAAGTGGAGCAGCAGCACACGCGCTTTATCCAGGCGATCCAGGCTTC
GCCCAACGGCGTGCTGATGCTGGACGACGCCGACCAGATCGAGTGGTGCAACAGCGTGGCTGAACTGCACCTCGGCTTGA
ATGCACGGCGCGATGTGCGCCAGCGCATTACGCACCTGATTCGCCGTCCCGAGTTCGTTCACTACCTGACACGCCAGCGC
TTTGATGAGCCATTGGCCATGCGCGACATGGGCGAGCACAAGCAGGGCGTGATCTCGGTGCAGGTGCTGCCGTATGGCGA
CAACCGCAAGCTGGTCATCACGCAGGACATCACCAAGCTCGAGAATACGGAAGCCATGCGGCGCGACTTTGTCGCCAACG
TTTCGCATGAGTTGAAGACGCCGCTCACCGTGCTGACCGGCTTCCTGGAAACCGTGCGTGACCTGCCGGTTTCCGAGGAA
GACCGTCAGCGCTATGTCGACATGATGCTGGTGCAGTCCATGCGCATGCAGAGCATCGTGGAAGACCTGCTGGCGCTGGC
CAAGCTGGAAAGCGATGCGCAACCGCCCGGGCAGGATCTCGTCCCGGTCCGCGAGATGGTGGATCATCTCGTCCACGATG
CGGAGGCGCTGTCACAAGGCCGCCATCATATCGCTGCGGAGATCGATCCGACCGTGGAGCTGCGCGGCACCGAGTCCGAA
CTGATGTCGGCGCTGGGCAACCTGGTATCGAATGCCGTGCGCTATACGCCCGCCGGCGGGCGAATCACGGTCCGGCTCGG
CTGGGATGATGGACATGCCGTGTTTTCGGTCGCGGATACCGGGCTGGGCATCGCGCCCGAGCATATTCCCCGGCTAACCG
AGCGTTTCTACCGTGTCGACCGCAGCCGGTCGCGTGACACCGGCGGTACCGGGCTTGGCCTGGCAATCGTCAAGCATGTG
GTCTCGCGCCATCATGCCGAGCTGCGCGTGAACAGCGAAGTGGGGCGGGGCAGCGTGTTTCGGATCATTTTTCCGATCGA
GCGCAGCGTGCGCGAGGTGGCGGACACTGCCGATCCTTCGCGCCGCGCTGCCTGA

Upstream 100 bases:

>100_bases
TTGCGTGGCCAGTTGTCACGGATTCGTGGCAAACTCTGCCGCAACGGCGGTTCCCCCGCCACTTGCCCGCACCGCGGGTT
CCTGAGTCTCCTTTGCGCGC

Downstream 100 bases:

>100_bases
GCGCTGCTGGCGGCTATTTGCCGCTGGCAACCATCCTTTCCCTTGGAAAAATGGCCCGCACAAGCGGGCCATTTCTTTCT
GGCGGAGCCTGGCTTATGCG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MNVIWARSVAILISLVVVAVGVYLLAGAVPALAVMSVSLLCLVAFHLYQINRLWKVLDAPAYGEIPSAPGLWGEVYYRLH
RLVKRWRLQVLQVEQQHTRFIQAIQASPNGVLMLDDADQIEWCNSVAELHLGLNARRDVRQRITHLIRRPEFVHYLTRQR
FDEPLAMRDMGEHKQGVISVQVLPYGDNRKLVITQDITKLENTEAMRRDFVANVSHELKTPLTVLTGFLETVRDLPVSEE
DRQRYVDMMLVQSMRMQSIVEDLLALAKLESDAQPPGQDLVPVREMVDHLVHDAEALSQGRHHIAAEIDPTVELRGTESE
LMSALGNLVSNAVRYTPAGGRITVRLGWDDGHAVFSVADTGLGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
VSRHHAELRVNSEVGRGSVFRIIFPIERSVREVADTADPSRRAA

Sequences:

>Translated_444_residues
MNVIWARSVAILISLVVVAVGVYLLAGAVPALAVMSVSLLCLVAFHLYQINRLWKVLDAPAYGEIPSAPGLWGEVYYRLH
RLVKRWRLQVLQVEQQHTRFIQAIQASPNGVLMLDDADQIEWCNSVAELHLGLNARRDVRQRITHLIRRPEFVHYLTRQR
FDEPLAMRDMGEHKQGVISVQVLPYGDNRKLVITQDITKLENTEAMRRDFVANVSHELKTPLTVLTGFLETVRDLPVSEE
DRQRYVDMMLVQSMRMQSIVEDLLALAKLESDAQPPGQDLVPVREMVDHLVHDAEALSQGRHHIAAEIDPTVELRGTESE
LMSALGNLVSNAVRYTPAGGRITVRLGWDDGHAVFSVADTGLGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
VSRHHAELRVNSEVGRGSVFRIIFPIERSVREVADTADPSRRAA
>Mature_444_residues
MNVIWARSVAILISLVVVAVGVYLLAGAVPALAVMSVSLLCLVAFHLYQINRLWKVLDAPAYGEIPSAPGLWGEVYYRLH
RLVKRWRLQVLQVEQQHTRFIQAIQASPNGVLMLDDADQIEWCNSVAELHLGLNARRDVRQRITHLIRRPEFVHYLTRQR
FDEPLAMRDMGEHKQGVISVQVLPYGDNRKLVITQDITKLENTEAMRRDFVANVSHELKTPLTVLTGFLETVRDLPVSEE
DRQRYVDMMLVQSMRMQSIVEDLLALAKLESDAQPPGQDLVPVREMVDHLVHDAEALSQGRHHIAAEIDPTVELRGTESE
LMSALGNLVSNAVRYTPAGGRITVRLGWDDGHAVFSVADTGLGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
VSRHHAELRVNSEVGRGSVFRIIFPIERSVREVADTADPSRRAA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=432, Percent_Identity=38.1944444444444, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=34.7639484978541, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=31.1355311355311, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI145693157, Length=343, Percent_Identity=28.5714285714286, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994928, Length=409, Percent_Identity=25.1833740831296, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788713, Length=277, Percent_Identity=27.7978339350181, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=34.5794392523364, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=218, Percent_Identity=28.4403669724771, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082128, Length=243, Percent_Identity=28.8065843621399, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788549, Length=396, Percent_Identity=22.7272727272727, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=29.1139240506329, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790551, Length=217, Percent_Identity=31.3364055299539, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=31.0502283105023, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=222, Percent_Identity=30.1801801801802, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=238, Percent_Identity=27.7310924369748, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=218, Percent_Identity=26.605504587156, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=23.7668161434978, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=263, Percent_Identity=23.9543726235741, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=26.1044176706827, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=26.3392857142857, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49891; Mature: 49891

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIWARSVAILISLVVVAVGVYLLAGAVPALAVMSVSLLCLVAFHLYQINRLWKVLDAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AYGEIPSAPGLWGEVYYRLHRLVKRWRLQVLQVEQQHTRFIQAIQASPNGVLMLDDADQI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNSVAELHLGLNARRDVRQRITHLIRRPEFVHYLTRQRFDEPLAMRDMGEHKQGVISV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEE
QVLPYGDNRKLVITQDITKLENTEAMRRDFVANVSHELKTPLTVLTGFLETVRDLPVSEE
EEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHH
DRQRYVDMMLVQSMRMQSIVEDLLALAKLESDAQPPGQDLVPVREMVDHLVHDAEALSQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
RHHIAAEIDPTVELRGTESELMSALGNLVSNAVRYTPAGGRITVRLGWDDGHAVFSVADT
CCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEECC
GLGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVVSRHHAELRVNSEVGRGSVF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEE
RIIFPIERSVREVADTADPSRRAA
EEEEHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNVIWARSVAILISLVVVAVGVYLLAGAVPALAVMSVSLLCLVAFHLYQINRLWKVLDAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AYGEIPSAPGLWGEVYYRLHRLVKRWRLQVLQVEQQHTRFIQAIQASPNGVLMLDDADQI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
EWCNSVAELHLGLNARRDVRQRITHLIRRPEFVHYLTRQRFDEPLAMRDMGEHKQGVISV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEE
QVLPYGDNRKLVITQDITKLENTEAMRRDFVANVSHELKTPLTVLTGFLETVRDLPVSEE
EEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHH
DRQRYVDMMLVQSMRMQSIVEDLLALAKLESDAQPPGQDLVPVREMVDHLVHDAEALSQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
RHHIAAEIDPTVELRGTESELMSALGNLVSNAVRYTPAGGRITVRLGWDDGHAVFSVADT
CCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEECC
GLGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVVSRHHAELRVNSEVGRGSVF
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEE
RIIFPIERSVREVADTADPSRRAA
EEEEHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]