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The map label for this gene is ndk

Identifier: 73541778

GI number: 73541778

Start: 2298186

End: 2298611

Strand: Reverse

Name: ndk

Synonym: Reut_A2090

Alternate gene names: 73541778

Gene position: 2298611-2298186 (Counterclockwise)

Preceding gene: 73541780

Following gene: 73541777

Centisome position: 60.39

GC content: 61.27

Gene sequence:

>426_bases
ATGGCGATCGAACGCACCCTGTCGATTATCAAGCCGGATGCCGTGGCCAAGAACGTTATCGGCCAGATCTACGCCCGTTT
CGAGGCCGCCGGCCTGAAGATCGTTGCTGCCAAGATGGTGCACCTGTCGCGCGGCGAAGCCGAGCAGTTCTACGCTGTCC
ACAAGGAGCGTCCGTTCTTCAAGGACCTCGTCGACTTCATGGTTTCCGGCCCGGTCATGATCCAGGCGCTGGAAGGTGAA
GGCGCCATCGCCAAGAACCGCGACCTGATGGGCGCCACCGACCCGAAGAAGGCCGACAAGGGCACCATCCGCGCCGACTT
CGCCGACAGCATCGACGCGAACGCCGTGCACGGTTCGGACGCTGCTGAAACTGCCGCTGTGGAAATTGCCTTCTTCTTCC
CGGGCATGAACGTTTATACCCGTTGA

Upstream 100 bases:

>100_bases
CACTTTCGCGAAAGGCTGGCTGCGCTCGAAACCGTCATCGTCTCGTGCTAGAATTGCACGTTTAATCCATTTGTAACCCC
TTCATTTTTCGGAGTTTTTC

Downstream 100 bases:

>100_bases
TTGTCTGGTCAATTCCAAGACTAGACAGACACGGAAGCTGAGTTTGCCGTCATGAACGATCTCGTCAACCTGCTCGACCT
GGATGCGGACGCGCTCACTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAAKMVHLSRGEAEQFYAVHKERPFFKDLVDFMVSGPVMIQALEGE
GAIAKNRDLMGATDPKKADKGTIRADFADSIDANAVHGSDAAETAAVEIAFFFPGMNVYTR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAAKMVHLSRGEAEQFYAVHKERPFFKDLVDFMVSGPVMIQALEGE
GAIAKNRDLMGATDPKKADKGTIRADFADSIDANAVHGSDAAETAAVEIAFFFPGMNVYTR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAAKMVHLSRGEAEQFYAVHKERPFFKDLVDFMVSGPVMIQALEGEG
AIAKNRDLMGATDPKKADKGTIRADFADSIDANAVHGSDAAETAAVEIAFFFPGMNVYTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=43.9393939393939, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=40.4580152671756, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=40.4580152671756, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=40.4580152671756, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=40.4580152671756, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=40.4580152671756, Blast_Score=113, Evalue=5e-26,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=39.6946564885496, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=36.9230769230769, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=38.1294964028777, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=38.1294964028777, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.7664233576642, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI148839372, Length=126, Percent_Identity=34.1269841269841, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=33.8235294117647, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=62.406015037594, Blast_Score=177, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=42.3076923076923, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=41.5384615384615, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=43.8461538461538, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=35.5555555555556, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CUPPJ (Q46ZH9)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296298.1
- ProteinModelPortal:   Q46ZH9
- SMR:   Q46ZH9
- GeneID:   3611344
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2090
- NMPDR:   fig|264198.3.peg.2776
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- ProtClustDB:   PRK00668
- BioCyc:   REUT264198:REUT_A2090-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15277; Mature: 15146

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAAKMVHLSRGEAEQFYAVHKERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHH
KDLVDFMVSGPVMIQALEGEGAIAKNRDLMGATDPKKADKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAAVEIAFFFPGMNVYTR
CCCHHEEEEEEEECCCCCCCC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIVAAKMVHLSRGEAEQFYAVHKERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHH
KDLVDFMVSGPVMIQALEGEGAIAKNRDLMGATDPKKADKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAAVEIAFFFPGMNVYTR
CCCHHEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA