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The map label for this gene is engA

Identifier: 73541770

GI number: 73541770

Start: 2288888

End: 2290231

Strand: Reverse

Name: engA

Synonym: Reut_A2082

Alternate gene names: 73541770

Gene position: 2290231-2288888 (Counterclockwise)

Preceding gene: 73541771

Following gene: 73541769

Centisome position: 60.17

GC content: 62.95

Gene sequence:

>1344_bases
ATGAAACCAGTTATTGCACTTGTCGGCCGCCCGAACGTCGGGAAGTCGACGCTATTTAACCGCATGACCCGCTCACGCGA
CGCACTCGTCGCCGACCTGCCGGGCCTGACGCGCGACCGCCACTACGGAGAGGGTCGTATCGGCGATCGTCCGTTCATTG
CCATCGATACCGGCGGCTTCGAGCCGGTGGTCAAGGAAGGCATCGTCGCCGAGATGGCCAAGCAGACCAGGCAAGCCGTG
GTCGAGGCGGACGTTGTCATCTTCATTGTCGATGGCAGGCTGGGCCTGGCCCCGCAGGACCGCGCCATTGCAGACTACCT
GCGCAAGACGGGTCGGCGCGTGATGCTCGCGGTCAACAAGGCCGAGGGCATGAAGTACACCTCGGTCGCCGCCGATTTCT
ATGAACTTGGCATGGGCGATCCGTACGCGATTTCGGCCGCGCACGGCGACGGCGTTCGAGAGCTCGTGGACGAGGCGCTG
GAGCTGGCTGTCCAGGAGCGTCCGGAGCTGGCCGAGGAAGACGCGGACAGTGGCAAGGGCGTGAAGATCGCCATCGTTGG
CCGCCCCAACGTCGGCAAGTCGACGCTGGTCAATACGCTGATCGGCGAAGAGCGCGTGATTGCGTTCGACATGCCTGGCA
CCACGCGCGACGCGATCTACGTGGAGTTCGAGCGCGGCGGCAAGCCGTACACGCTGATCGACACCGCGGGCCTGCGGCGC
CGGGGCAAAGTGTTCGAGGCAATCGAGAAGTTTTCGGTGGTCAAAACGCTGCAGTCGATCGCCGACGCCAATGTCGTCAT
CCTGCTGCTTGATGCGCAGCAGGATATTTCCGACCAGGACGCGCATATTGCCGGTTTCATCGTCGAATCCGGCCGTGCCC
TTGTAGTCGGTGTCAACAAATGGGATGGCCTCGACGGCCATACCCGCGATCGCATCAAGCACGATCTCGAGCGCAAGCTG
CAATTCCTGAGCTTCGCCAATTTCCATTTCGTGTCTGCGCGGGAACGCACAGGCATCGGTGCGCTGATGCGTTCCGTGGA
CGATGCGTATGCCGCGGCCATGGTCAAGCTGCCCACGCCGCAGCTCACGCGGGTGCTACAGGAGGCCGTGGAATTCCAGC
AGCCCAAGCGCGCCGGCGTGTCGCGGCCGAAGCTGCGCTACGCGCACCAGGGTGGCTCCAACCCGCCGATCATCGTGATC
CACGGCAACGCCTTGTCGTCCGTTTCCGAGACCTACCGGCGTTATCTCGAGAACCGCTACCGCGCGGCGTTCAAACTGAA
GGGGACACCGCTTCGCATCGAATTTCGTACGAACAAAAACCCGTATGCGGACTCGAAGGACTGA

Upstream 100 bases:

>100_bases
AGCGGCTGGCCATGCATATTTTGCATAAGGCGCCGTAGGATCAACTGACTCCGGAGTTCCAGGGGGACGGCAGGTGCCGG
CCCCCGTTTCCGTTTATTGC

Downstream 100 bases:

>100_bases
GGTCCTGGCGGGTGCCTGGCGCGGCAAGTTTTCGTTTGCGTTCGTTTGGAACTGCGGCTAAATTTGCGGTAGCAGGGGTT
CTCTGCACGCTGATGCAGCT

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKPVIALVGRPNVGKSTLFNRMTRSRDALVADLPGLTRDRHYGEGRIGDRPFIAIDTGGFEPVVKEGIVAEMAKQTRQAV
VEADVVIFIVDGRLGLAPQDRAIADYLRKTGRRVMLAVNKAEGMKYTSVAADFYELGMGDPYAISAAHGDGVRELVDEAL
ELAVQERPELAEEDADSGKGVKIAIVGRPNVGKSTLVNTLIGEERVIAFDMPGTTRDAIYVEFERGGKPYTLIDTAGLRR
RGKVFEAIEKFSVVKTLQSIADANVVILLLDAQQDISDQDAHIAGFIVESGRALVVGVNKWDGLDGHTRDRIKHDLERKL
QFLSFANFHFVSARERTGIGALMRSVDDAYAAAMVKLPTPQLTRVLQEAVEFQQPKRAGVSRPKLRYAHQGGSNPPIIVI
HGNALSSVSETYRRYLENRYRAAFKLKGTPLRIEFRTNKNPYADSKD

Sequences:

>Translated_447_residues
MKPVIALVGRPNVGKSTLFNRMTRSRDALVADLPGLTRDRHYGEGRIGDRPFIAIDTGGFEPVVKEGIVAEMAKQTRQAV
VEADVVIFIVDGRLGLAPQDRAIADYLRKTGRRVMLAVNKAEGMKYTSVAADFYELGMGDPYAISAAHGDGVRELVDEAL
ELAVQERPELAEEDADSGKGVKIAIVGRPNVGKSTLVNTLIGEERVIAFDMPGTTRDAIYVEFERGGKPYTLIDTAGLRR
RGKVFEAIEKFSVVKTLQSIADANVVILLLDAQQDISDQDAHIAGFIVESGRALVVGVNKWDGLDGHTRDRIKHDLERKL
QFLSFANFHFVSARERTGIGALMRSVDDAYAAAMVKLPTPQLTRVLQEAVEFQQPKRAGVSRPKLRYAHQGGSNPPIIVI
HGNALSSVSETYRRYLENRYRAAFKLKGTPLRIEFRTNKNPYADSKD
>Mature_447_residues
MKPVIALVGRPNVGKSTLFNRMTRSRDALVADLPGLTRDRHYGEGRIGDRPFIAIDTGGFEPVVKEGIVAEMAKQTRQAV
VEADVVIFIVDGRLGLAPQDRAIADYLRKTGRRVMLAVNKAEGMKYTSVAADFYELGMGDPYAISAAHGDGVRELVDEAL
ELAVQERPELAEEDADSGKGVKIAIVGRPNVGKSTLVNTLIGEERVIAFDMPGTTRDAIYVEFERGGKPYTLIDTAGLRR
RGKVFEAIEKFSVVKTLQSIADANVVILLLDAQQDISDQDAHIAGFIVESGRALVVGVNKWDGLDGHTRDRIKHDLERKL
QFLSFANFHFVSARERTGIGALMRSVDDAYAAAMVKLPTPQLTRVLQEAVEFQQPKRAGVSRPKLRYAHQGGSNPPIIVI
HGNALSSVSETYRRYLENRYRAAFKLKGTPLRIEFRTNKNPYADSKD

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=473, Percent_Identity=49.8942917547569, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI2367268, Length=93, Percent_Identity=39.7849462365591, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788919, Length=121, Percent_Identity=34.7107438016529, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=178, Percent_Identity=28.0898876404494, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550813, Length=139, Percent_Identity=33.8129496402878, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_CUPPJ (Q46ZI7)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_296290.1
- HSSP:   O57939
- ProteinModelPortal:   Q46ZI7
- SMR:   Q46ZI7
- GeneID:   3611336
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A2082
- NMPDR:   fig|264198.3.peg.2768
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   REUT264198:REUT_A2082-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49272; Mature: 49272

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVIALVGRPNVGKSTLFNRMTRSRDALVADLPGLTRDRHYGEGRIGDRPFIAIDTGGF
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
EPVVKEGIVAEMAKQTRQAVVEADVVIFIVDGRLGLAPQDRAIADYLRKTGRRVMLAVNK
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEC
AEGMKYTSVAADFYELGMGDPYAISAAHGDGVRELVDEALELAVQERPELAEEDADSGKG
CCCCEEHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
VKIAIVGRPNVGKSTLVNTLIGEERVIAFDMPGTTRDAIYVEFERGGKPYTLIDTAGLRR
EEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCHH
RGKVFEAIEKFSVVKTLQSIADANVVILLLDAQQDISDQDAHIAGFIVESGRALVVGVNK
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEECCC
WDGLDGHTRDRIKHDLERKLQFLSFANFHFVSARERTGIGALMRSVDDAYAAAMVKLPTP
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHCCCHHHHHHHHHHHHHHHEEECCCH
QLTRVLQEAVEFQQPKRAGVSRPKLRYAHQGGSNPPIIVIHGNALSSVSETYRRYLENRY
HHHHHHHHHHHHCCCHHCCCCCCCCHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
RAAFKLKGTPLRIEFRTNKNPYADSKD
HEEEEECCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKPVIALVGRPNVGKSTLFNRMTRSRDALVADLPGLTRDRHYGEGRIGDRPFIAIDTGGF
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
EPVVKEGIVAEMAKQTRQAVVEADVVIFIVDGRLGLAPQDRAIADYLRKTGRRVMLAVNK
CHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEC
AEGMKYTSVAADFYELGMGDPYAISAAHGDGVRELVDEALELAVQERPELAEEDADSGKG
CCCCEEHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
VKIAIVGRPNVGKSTLVNTLIGEERVIAFDMPGTTRDAIYVEFERGGKPYTLIDTAGLRR
EEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCHH
RGKVFEAIEKFSVVKTLQSIADANVVILLLDAQQDISDQDAHIAGFIVESGRALVVGVNK
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEECCC
WDGLDGHTRDRIKHDLERKLQFLSFANFHFVSARERTGIGALMRSVDDAYAAAMVKLPTP
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHCCCHHHHHHHHHHHHHHHEEECCCH
QLTRVLQEAVEFQQPKRAGVSRPKLRYAHQGGSNPPIIVIHGNALSSVSETYRRYLENRY
HHHHHHHHHHHHCCCHHCCCCCCCCHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
RAAFKLKGTPLRIEFRTNKNPYADSKD
HEEEEECCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA