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The map label for this gene is map [H]

Identifier: 73541571

GI number: 73541571

Start: 2058991

End: 2059809

Strand: Direct

Name: map [H]

Synonym: Reut_A1882

Alternate gene names: 73541571

Gene position: 2058991-2059809 (Clockwise)

Preceding gene: 73541554

Following gene: 73541572

Centisome position: 54.09

GC content: 64.35

Gene sequence:

>819_bases
ATGAGCATCCACCTGAATACCGCCGAAGACGTCGCCCAAATGCGCGTGGCTTGCCGCCTTGCCTCGGAAGTCCTCGACTA
CATCACGCCGTTCGTGAAGCCTGGTGTGACGACCGGCGAACTCGACCGGCTGTGCCACGCCTACATGCGTGACGTACAGG
GCACCGTACCGGCCCCGCTAAATTATGCGCCTCCGGGCTACCCGCCTTTCCCCGGCGCGATCTGCACTTCGGTCAATGAC
GTGATCTGCCACGGCATTCCTGGTGACCGCGTGCTCAAGGCCGGCGATGCCATCAACCTGGATATCACCGTCATCACCAA
GGAAGGCTACTACGGCGACACCAGCCGCATGTTCATCGTTGGCGAGGGCTCGATCCTCGCCAAGCGCCTGGCCCAAGTGA
CTTACGAGTGCATGTGGAAGGGCATCGCGCAAGTCCGCCATGGCGCGCGCCTCGGCGACATCGGCCACGCCATCCAGGTG
CATGCCGAAGCGGCCGGCTACAGCGTGGTGCGCGAGTACTGCGGCCACGGCATCGGCAAGAACTTCCATGAAGATCCGCA
GATCCTGCACTACGGCCGCGCGGGTACGGGCGCCGAGATCAAGGCAGGCATGATCTTCACGGTCGAGCCGATGATCAACG
CCGGCAAGCGCGACATCCGCACCATGCCTGACCAGTGGACGGTCAAGACCCGCGACCGCAGCCTGTCCGCGCAGTGGGAA
CATACCGTGCTCGTGACCGAAACCGGCTACGAGGTGCTGACGGTCTCCGCCGGCACGCCGGCGCCGCCCGCATTCATTAC
GGAATCGGTCGCGGCCTGA

Upstream 100 bases:

>100_bases
GATCGCTGCGATCAGGCGCCGATGGTGCGATAATCCCACATTACCCTATCGATTCCGGCGCGGCCTGTGGCCTCGCCATC
ACTTATTCTGGCGAAGCAGC

Downstream 100 bases:

>100_bases
GCCGCAACATCGTTGGGGGGCGCCTGACAGGCGCCTTTCTTTTTCCAGCCGTGCCCACGAACCTTCCTGCCCTGCCCATG
GACACCACGCCGGAACTCCT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSIHLNTAEDVAQMRVACRLASEVLDYITPFVKPGVTTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVND
VICHGIPGDRVLKAGDAINLDITVITKEGYYGDTSRMFIVGEGSILAKRLAQVTYECMWKGIAQVRHGARLGDIGHAIQV
HAEAAGYSVVREYCGHGIGKNFHEDPQILHYGRAGTGAEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTVLVTETGYEVLTVSAGTPAPPAFITESVAA

Sequences:

>Translated_272_residues
MSIHLNTAEDVAQMRVACRLASEVLDYITPFVKPGVTTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVND
VICHGIPGDRVLKAGDAINLDITVITKEGYYGDTSRMFIVGEGSILAKRLAQVTYECMWKGIAQVRHGARLGDIGHAIQV
HAEAAGYSVVREYCGHGIGKNFHEDPQILHYGRAGTGAEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTVLVTETGYEVLTVSAGTPAPPAFITESVAA
>Mature_271_residues
SIHLNTAEDVAQMRVACRLASEVLDYITPFVKPGVTTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVNDV
ICHGIPGDRVLKAGDAINLDITVITKEGYYGDTSRMFIVGEGSILAKRLAQVTYECMWKGIAQVRHGARLGDIGHAIQVH
AEAAGYSVVREYCGHGIGKNFHEDPQILHYGRAGTGAEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
TVLVTETGYEVLTVSAGTPAPPAFITESVAA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=267, Percent_Identity=47.1910112359551, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI40385867, Length=255, Percent_Identity=39.6078431372549, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786364, Length=263, Percent_Identity=54.3726235741445, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=27.34375, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71996291, Length=260, Percent_Identity=45.3846153846154, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=43.7007874015748, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21355531, Length=258, Percent_Identity=44.9612403100775, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=37.1541501976285, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29467; Mature: 29336

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIHLNTAEDVAQMRVACRLASEVLDYITPFVKPGVTTGELDRLCHAYMRDVQGTVPAPL
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPGAICTSVNDVICHGIPGDRVLKAGDAINLDITVITKEGYYGDTSRMFIV
CCCCCCCCCCCCHHHHCCCHHEECCCCCCCEEECCCEEEEEEEEEEECCCCCCCCEEEEE
GEGSILAKRLAQVTYECMWKGIAQVRHGARLGDIGHAIQVHAEAAGYSVVREYCGHGIGK
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCC
NFHEDPQILHYGRAGTGAEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
CCCCCCCEEEECCCCCCCEEECCEEEEECHHHCCCCHHHHCCCCCEEEEECCCCCCCCCC
HTVLVTETGYEVLTVSAGTPAPPAFITESVAA
EEEEEEECCCEEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SIHLNTAEDVAQMRVACRLASEVLDYITPFVKPGVTTGELDRLCHAYMRDVQGTVPAPL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPGAICTSVNDVICHGIPGDRVLKAGDAINLDITVITKEGYYGDTSRMFIV
CCCCCCCCCCCCHHHHCCCHHEECCCCCCCEEECCCEEEEEEEEEEECCCCCCCCEEEEE
GEGSILAKRLAQVTYECMWKGIAQVRHGARLGDIGHAIQVHAEAAGYSVVREYCGHGIGK
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCC
NFHEDPQILHYGRAGTGAEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
CCCCCCCEEEECCCCCCCEEECCEEEEECHHHCCCCHHHHCCCCCEEEEECCCCCCCCCC
HTVLVTETGYEVLTVSAGTPAPPAFITESVAA
EEEEEEECCCEEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]