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The map label for this gene is macA [H]

Identifier: 73541506

GI number: 73541506

Start: 1989351

End: 1990568

Strand: Direct

Name: macA [H]

Synonym: Reut_A1817

Alternate gene names: 73541506

Gene position: 1989351-1990568 (Clockwise)

Preceding gene: 73541505

Following gene: 73541507

Centisome position: 52.26

GC content: 68.97

Gene sequence:

>1218_bases
ATGACACTGCCCACACTGCGGGAAACCGCTGACAATGCACCGCCTGAAACTGCCTGCCCGCCACCTGCCGAGCGCGGGAG
GGGGCGCCTCATTCTGGCTGCCGCGGCCGTCCTCGCCTGTGCGCTGGCCGCCGGGATCGTCCCCAGGCTGCACGCGCACG
CTGCACTGGCCCAGCGCACCGCGCAGACGATGGTGCCGGCCGTCAGGATCGTGCGCCCCGGGCATGCGGCGGCGATGCGC
GAAATCGTCCTGCCCGGAGATGTGCGGGCCTATCAGGATGCAGCGGTCTATGCGCGCGTCAACGGCTATTTGCGACGCTG
GTATGCGGACCTCGGTACGCCGGTGAAGAAGGGCCAGTTGCTGGCCGAGATCGACGCGCCGGAAGTGGCTGACCAGTTGC
GCCAGGCACGCGCCGACGAAGCGACCGCCGCCGCCAACTACGCGCTGGCGCGGAGCACTGCGGACCGCTGGAAGGACCTG
CAGGCGTCCAACTCCGTCGCGCAGCAAGAGACCGACCAGAAGATCGCCGACATGCAGGCCAAGGCTGCCGTACTGGCATC
GGCGCGCTCGAATACGTCGCGCCTCGCGCAACTTGCGTCCTACACGGAGATTCGCGCGCCATTCGACGGGGTGATTACCG
CCAGGAATGTCGATACCGGTGCCTTGGTCGATGCCGGCAGCGCCCCCGGCCAGGGCCGTGAACTGTTCCACATCTCGGCG
GGCGGCACGCTGCGGGTCTACATACAGCTTCCCCAGGACGCCAGTGCGATGGTGGGCCCGGACATGCAGGCATGGCTGAC
GCTGCCGCAATCGCCAGGCGAGCGGTTTGCCGCCACGGTGACGCGCAATGCCGGTGCCTTCGATGCCGCCACGCGCAGCC
TGCGGGTCGAACTCGAGGTCGACAGCCACGGCGGCCGCATCCTGCCGGGCGCCTATGCGGAGGTGCACCTGAGCACGAAT
GCGGACACTGCTGGCTTCGACCTGCCGGCCAGCACGCTGGCGTTCCGCCCCGCAGGTCCGAGCGTCGCCGTGGTCGGCAA
GGATGGGCGCGTGGAACTTCGCAACATCACGCTTGGCCGTGACTTCGGTACCCACGTGGAAGTGCTGGGCGGGCTGCAAG
GCACGGAGCAGGTCATCGTCAACCCGGGTGACGGCCTGATGGCTGGCACCCCGGTACGTGTCGTTGCCGACCAGGCCGGT
GCGGCCCGGTCGTCCTGA

Upstream 100 bases:

>100_bases
TGGTCCCGGTCTTCTTCGCGATGCTCCACACCTGGCTCGGCACGCGGTCCGCTGCAACGCCCGCGCATTCGGCACTTGGC
TCTGATGAAAAAGGTCTGGT

Downstream 100 bases:

>100_bases
TCGCTTTGCCATCCCATCATGCTCAACACGTCCGCGACGGAACACCGCAAAAAGCAGCCTGCCAGGCATGGAACACTCAG
ACACCAGGCCGGGCGGGCAC

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTLPTLRETADNAPPETACPPPAERGRGRLILAAAAVLACALAAGIVPRLHAHAALAQRTAQTMVPAVRIVRPGHAAAMR
EIVLPGDVRAYQDAAVYARVNGYLRRWYADLGTPVKKGQLLAEIDAPEVADQLRQARADEATAAANYALARSTADRWKDL
QASNSVAQQETDQKIADMQAKAAVLASARSNTSRLAQLASYTEIRAPFDGVITARNVDTGALVDAGSAPGQGRELFHISA
GGTLRVYIQLPQDASAMVGPDMQAWLTLPQSPGERFAATVTRNAGAFDAATRSLRVELEVDSHGGRILPGAYAEVHLSTN
ADTAGFDLPASTLAFRPAGPSVAVVGKDGRVELRNITLGRDFGTHVEVLGGLQGTEQVIVNPGDGLMAGTPVRVVADQAG
AARSS

Sequences:

>Translated_405_residues
MTLPTLRETADNAPPETACPPPAERGRGRLILAAAAVLACALAAGIVPRLHAHAALAQRTAQTMVPAVRIVRPGHAAAMR
EIVLPGDVRAYQDAAVYARVNGYLRRWYADLGTPVKKGQLLAEIDAPEVADQLRQARADEATAAANYALARSTADRWKDL
QASNSVAQQETDQKIADMQAKAAVLASARSNTSRLAQLASYTEIRAPFDGVITARNVDTGALVDAGSAPGQGRELFHISA
GGTLRVYIQLPQDASAMVGPDMQAWLTLPQSPGERFAATVTRNAGAFDAATRSLRVELEVDSHGGRILPGAYAEVHLSTN
ADTAGFDLPASTLAFRPAGPSVAVVGKDGRVELRNITLGRDFGTHVEVLGGLQGTEQVIVNPGDGLMAGTPVRVVADQAG
AARSS
>Mature_404_residues
TLPTLRETADNAPPETACPPPAERGRGRLILAAAAVLACALAAGIVPRLHAHAALAQRTAQTMVPAVRIVRPGHAAAMRE
IVLPGDVRAYQDAAVYARVNGYLRRWYADLGTPVKKGQLLAEIDAPEVADQLRQARADEATAAANYALARSTADRWKDLQ
ASNSVAQQETDQKIADMQAKAAVLASARSNTSRLAQLASYTEIRAPFDGVITARNVDTGALVDAGSAPGQGRELFHISAG
GTLRVYIQLPQDASAMVGPDMQAWLTLPQSPGERFAATVTRNAGAFDAATRSLRVELEVDSHGGRILPGAYAEVHLSTNA
DTAGFDLPASTLAFRPAGPSVAVVGKDGRVELRNITLGRDFGTHVEVLGGLQGTEQVIVNPGDGLMAGTPVRVVADQAGA
ARSS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=335, Percent_Identity=25.6716417910448, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786668, Length=366, Percent_Identity=25.4098360655738, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082036, Length=340, Percent_Identity=25, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789929, Length=353, Percent_Identity=23.5127478753541, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789665, Length=393, Percent_Identity=26.2086513994911, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42422; Mature: 42291

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPTLRETADNAPPETACPPPAERGRGRLILAAAAVLACALAAGIVPRLHAHAALAQRT
CCCCCCHHHHCCCCCCCCCCCCHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQTMVPAVRIVRPGHAAAMREIVLPGDVRAYQDAAVYARVNGYLRRWYADLGTPVKKGQL
HHHHHHHHEEECCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LAEIDAPEVADQLRQARADEATAAANYALARSTADRWKDLQASNSVAQQETDQKIADMQA
EEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAAVLASARSNTSRLAQLASYTEIRAPFDGVITARNVDTGALVDAGSAPGQGRELFHISA
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCCCCCCCEEEEEEC
GGTLRVYIQLPQDASAMVGPDMQAWLTLPQSPGERFAATVTRNAGAFDAATRSLRVELEV
CCEEEEEEECCCCCCHHCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHCCEEEEEEEEE
DSHGGRILPGAYAEVHLSTNADTAGFDLPASTLAFRPAGPSVAVVGKDGRVELRNITLGR
CCCCCEECCCCEEEEEEECCCCCCCCCCCHHHEEECCCCCCEEEEECCCCEEEEEEEECC
DFGTHVEVLGGLQGTEQVIVNPGDGLMAGTPVRVVADQAGAARSS
CCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
TLPTLRETADNAPPETACPPPAERGRGRLILAAAAVLACALAAGIVPRLHAHAALAQRT
CCCCCHHHHCCCCCCCCCCCCHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQTMVPAVRIVRPGHAAAMREIVLPGDVRAYQDAAVYARVNGYLRRWYADLGTPVKKGQL
HHHHHHHHEEECCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
LAEIDAPEVADQLRQARADEATAAANYALARSTADRWKDLQASNSVAQQETDQKIADMQA
EEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KAAVLASARSNTSRLAQLASYTEIRAPFDGVITARNVDTGALVDAGSAPGQGRELFHISA
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCCCCCCCEEEEEEC
GGTLRVYIQLPQDASAMVGPDMQAWLTLPQSPGERFAATVTRNAGAFDAATRSLRVELEV
CCEEEEEEECCCCCCHHCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHCCEEEEEEEEE
DSHGGRILPGAYAEVHLSTNADTAGFDLPASTLAFRPAGPSVAVVGKDGRVELRNITLGR
CCCCCEECCCCEEEEEEECCCCCCCCCCCHHHEEECCCCCCEEEEECCCCEEEEEEEECC
DFGTHVEVLGGLQGTEQVIVNPGDGLMAGTPVRVVADQAGAARSS
CCCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]