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The map label for this gene is qor [C]

Identifier: 73541293

GI number: 73541293

Start: 1725825

End: 1726820

Strand: Direct

Name: qor [C]

Synonym: Reut_A1603

Alternate gene names: 73541293

Gene position: 1725825-1726820 (Clockwise)

Preceding gene: 73541292

Following gene: 73541294

Centisome position: 45.34

GC content: 63.86

Gene sequence:

>996_bases
ATGAAGGCGATCTGGTACGAAAAACAAGGGCGGGCGGAAGAGGTGCTGGCCTTCGGCGAGCTACCCACGCCGCAACCGGC
CCCTGGCGAGGTCCGCGTGCGCCTCCACGCATCGGCCGTTAACCCGGCAGATGCAAACCGGCGCGCCGGACGCATGCATG
GTGGCATGGAGTTCCCGCGCATCATTCCGAATAGCGATGGCGCGGGTGTGATCGACGCGCTTGGGCATGGCGTCGACCAG
AAGATGCTGGGCACGCGGATTTGGCTGCATTTCGGACAGCGCGGGCGTCCGTTCGGTACAGCGGCAGAGTACATCTGCGT
GCCACACGAATTGACGTCACCACTGCCCGAGCATCTGGACTTCGCGCAGGGCGCATGCCTGGGCATTCCTGCAATGACGG
CATATATCGCCCTGTTCCAGCGCGGAGCGATCAAAGGCAAGTACGTCCTCGTGACCGGCGGTGCGGGAGCCGTTGGGCAC
TACGCAGTGCAACTCGCCAAGTGGGGCGGCGCGCATGTCATTGCCACCGCCAGCTCCGCACGCAAGGCGGCTCACGCCGC
AGCGGGTGGCGCCGATGCAGTGGTCGACTACCGTGCTCCCGATGCTGCGCAGCAGATTCTCGATGCCACTCACGGGCAAG
GCGTAGACCACATCGTCGATGTCAATGCCATCGACAATTCCAGGCTGTGCTTCGAAGCAGCCGCTAACCATGCGCAGTGG
GTCTCGTATGCAAGCGGTGCCGGCCTCGAACAGGCGGTTCCGCTGGTCACGCTGATTCGCAAGAACCTCTGCCTGCAGGG
ACTCTACCTGCCGGGATTGCCCTACGAGATGCGCTGGATTGCGCAGGAGGGCTTGTCGCGCTGGATGCACGACGTCCCGA
ATGCCATCCACGCTGTCGACAGCGTCTTCGACCTGCAAGACACCGAGAAGGCTCATCAGGCCGTCGAGGCCGGCGCGAAG
CTCGGCACCGTTGTGGTTCAGTGTGTCGCGCAATAG

Upstream 100 bases:

>100_bases
GATGGAGCGCGCGGGAATAGTGGGTGATATCCCATACTGATTCGAAACTGGGCCAGCAGAACGACTTGATGCGCGCCATG
CGCAACGGCACAAGGGCACC

Downstream 100 bases:

>100_bases
ATCACCAGCGCCGTGCTCGCTGGCGGACATGACAGTGAGTTTTCCAATCAAACGAGGAGTGTAAATCCCATGACATCCGG
AAATCAGCCAACCGTTGTGA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKAIWYEKQGRAEEVLAFGELPTPQPAPGEVRVRLHASAVNPADANRRAGRMHGGMEFPRIIPNSDGAGVIDALGHGVDQ
KMLGTRIWLHFGQRGRPFGTAAEYICVPHELTSPLPEHLDFAQGACLGIPAMTAYIALFQRGAIKGKYVLVTGGAGAVGH
YAVQLAKWGGAHVIATASSARKAAHAAAGGADAVVDYRAPDAAQQILDATHGQGVDHIVDVNAIDNSRLCFEAAANHAQW
VSYASGAGLEQAVPLVTLIRKNLCLQGLYLPGLPYEMRWIAQEGLSRWMHDVPNAIHAVDSVFDLQDTEKAHQAVEAGAK
LGTVVVQCVAQ

Sequences:

>Translated_331_residues
MKAIWYEKQGRAEEVLAFGELPTPQPAPGEVRVRLHASAVNPADANRRAGRMHGGMEFPRIIPNSDGAGVIDALGHGVDQ
KMLGTRIWLHFGQRGRPFGTAAEYICVPHELTSPLPEHLDFAQGACLGIPAMTAYIALFQRGAIKGKYVLVTGGAGAVGH
YAVQLAKWGGAHVIATASSARKAAHAAAGGADAVVDYRAPDAAQQILDATHGQGVDHIVDVNAIDNSRLCFEAAANHAQW
VSYASGAGLEQAVPLVTLIRKNLCLQGLYLPGLPYEMRWIAQEGLSRWMHDVPNAIHAVDSVFDLQDTEKAHQAVEAGAK
LGTVVVQCVAQ
>Mature_331_residues
MKAIWYEKQGRAEEVLAFGELPTPQPAPGEVRVRLHASAVNPADANRRAGRMHGGMEFPRIIPNSDGAGVIDALGHGVDQ
KMLGTRIWLHFGQRGRPFGTAAEYICVPHELTSPLPEHLDFAQGACLGIPAMTAYIALFQRGAIKGKYVLVTGGAGAVGH
YAVQLAKWGGAHVIATASSARKAAHAAAGGADAVVDYRAPDAAQQILDATHGQGVDHIVDVNAIDNSRLCFEAAANHAQW
VSYASGAGLEQAVPLVTLIRKNLCLQGLYLPGLPYEMRWIAQEGLSRWMHDVPNAIHAVDSVFDLQDTEKAHQAVEAGAK
LGTVVVQCVAQ

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=338, Percent_Identity=28.1065088757396, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI22538444, Length=338, Percent_Identity=28.1065088757396, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI194239674, Length=230, Percent_Identity=32.1739130434783, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13236495, Length=230, Percent_Identity=32.1739130434783, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI194239676, Length=210, Percent_Identity=32.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI28557745, Length=272, Percent_Identity=28.3088235294118, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI24308257, Length=327, Percent_Identity=22.0183486238532, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI47519420, Length=228, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI18379349, Length=192, Percent_Identity=31.25, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790485, Length=333, Percent_Identity=26.4264264264264, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=218, Percent_Identity=33.9449541284404, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71987554, Length=204, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=335, Percent_Identity=24.1791044776119, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581339, Length=366, Percent_Identity=25.1366120218579, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24581341, Length=366, Percent_Identity=25.1366120218579, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35204; Mature: 35204

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIWYEKQGRAEEVLAFGELPTPQPAPGEVRVRLHASAVNPADANRRAGRMHGGMEFPR
CCCEEECCCCCHHHHHEECCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCC
IIPNSDGAGVIDALGHGVDQKMLGTRIWLHFGQRGRPFGTAAEYICVPHELTSPLPEHLD
CCCCCCCCCHHHHHCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEECCHHHCCCCHHHHH
FAQGACLGIPAMTAYIALFQRGAIKGKYVLVTGGAGAVGHYAVQLAKWGGAHVIATASSA
HHCCCHHCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECHHH
RKAAHAAAGGADAVVDYRAPDAAQQILDATHGQGVDHIVDVNAIDNSRLCFEAAANHAQW
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCHHHH
VSYASGAGLEQAVPLVTLIRKNLCLQGLYLPGLPYEMRWIAQEGLSRWMHDVPNAIHAVD
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVFDLQDTEKAHQAVEAGAKLGTVVVQCVAQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAIWYEKQGRAEEVLAFGELPTPQPAPGEVRVRLHASAVNPADANRRAGRMHGGMEFPR
CCCEEECCCCCHHHHHEECCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCC
IIPNSDGAGVIDALGHGVDQKMLGTRIWLHFGQRGRPFGTAAEYICVPHELTSPLPEHLD
CCCCCCCCCHHHHHCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEECCHHHCCCCHHHHH
FAQGACLGIPAMTAYIALFQRGAIKGKYVLVTGGAGAVGHYAVQLAKWGGAHVIATASSA
HHCCCHHCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECHHH
RKAAHAAAGGADAVVDYRAPDAAQQILDATHGQGVDHIVDVNAIDNSRLCFEAAANHAQW
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCHHHH
VSYASGAGLEQAVPLVTLIRKNLCLQGLYLPGLPYEMRWIAQEGLSRWMHDVPNAIHAVD
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVFDLQDTEKAHQAVEAGAKLGTVVVQCVAQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA