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The map label for this gene is ttuB [H]

Identifier: 73541118

GI number: 73541118

Start: 1540377

End: 1541741

Strand: Reverse

Name: ttuB [H]

Synonym: Reut_A1424

Alternate gene names: 73541118

Gene position: 1541741-1540377 (Counterclockwise)

Preceding gene: 73541119

Following gene: 73541117

Centisome position: 40.5

GC content: 63.22

Gene sequence:

>1365_bases
GTGAATCCCAACCAACCCGCGGCCAGCGTGCCCGCCTACGACAGCCTGGGCGCCAATGCCCGGCTCGATGCCGACGCCCA
GGTCGAAAAACGCGCCTATAACAAGGTGTTCTGGCGCATCATGCCTTTCCTGATGCTGTGCTACGTGATCGCGTACCTCG
ATCGCGTCAATGTCGGCTTCGCCAAGCTGCAGATGGGCCAGGACCTGGCCTTTTCCGAGACCGTGTTCGGCCTTGGCGCC
GGTCTTTTCTTCATCGGCTACTTCCTGTTCGAGTTGCCTAGCAACCTGCTGATGCACAAGCTCGGCGCGCGCATATGGAT
AGCGCGCATCATGATCACGTGGGGCATCATCTCGTCACTGTTCATGTTCGTGCAGACGCCGACACAGTTCTACGTGATGC
GCTTCCTGCTCGGCCTGGCCGAAGCAGGCTTCTACCCGGGTGTGATCCTGTACCTGACCTACTGGTACCCGGCCAACCGT
CGCGCGAAGATGATCGCCCTTTTCATGTCGGGCATTCCAGTGGCCGGCATGTTCGGCAACCCGCTGTCGGGATGGATCAT
GGACGCGTTCAACGATACCCACGGCCTGCGCGGCTGGCAATGGATGTTCGTGATCGAAGCCCTGCCCGCATTCGTGATCG
GCGTGGTAACCGTCTTCGTGCTGCGCGACGGCATCGACAAGGCGCCGTGGCTCGACGCCGACGAGAAGCGCGTGCTCAAG
CGCAATATCGAGGAAGACCAGCAGAACGCGGGCGCGGCCTCCGGCAAGGCGCATGGCCATTCGCTCGGCGCCGTCTTCAG
CGACAGCCGCGTCTGGTGGATGTGCCTGATCTACTTCTGCTTCGTCACCGGCCAGTACGCGCTGACGTTCTGGATGCCCA
CGCTGGTCAAGGCGAGCGGCGTGACCGGCAACTTCAATATCGGCCTGCTGTCGGCGATTCCGTTTCTGTGTGCGGTCGTC
GTGATGAATATCCTCGGCCACAGCGCCGACGCGCGCCGCGAGCGCCGCTGGCACCTGATCGTGCCTGCGCTGATGGGTGC
CGCGGGCTTTGCGGTTGCGGCTTCGTTTACCGACAATACGACCGTGGCCATCGCCGCGCTGTCCGTGGCTGCCGCTGGCG
TACTGACCTGCGCGCCGCTGTTCTGGTCGCTGCCGACCGCGTTTCTGTCGGGCATCGCCGCGGCCTCGGGCATCGCGGTG
GTCAACTCGGTGGGCAACCTGGCCGGTTTCGTGTCGCCGTACATGATCGGTGCGCTGAAAGACATGACCCACAGCACGCA
GCTGCCCATGTATGTGCTTTCCGCGATCCTGGTCATTGGCGCGGTGCTCGTGTGGCTGACGCCGGCCAAACTGGTCAACC
GCTGA

Upstream 100 bases:

>100_bases
AGCAGTACCCCACTAATACAGACGCGATCCCGTGCGCAGCAGCCACAAGGCTGCCGCGCGGAGAACACGCGCGCCCTCGA
AACCCGAACCGGAGACCACC

Downstream 100 bases:

>100_bases
TCCGCCGCTTTAAAGACTCACAACTGGAATCCAACCATGCCGCGTTTCGCCGCCAACCTTTCGATGATGTACACGGAGCA
CGACTTCCTGGACCGCTTCG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNPNQPAASVPAYDSLGANARLDADAQVEKRAYNKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMGQDLAFSETVFGLGA
GLFFIGYFLFELPSNLLMHKLGARIWIARIMITWGIISSLFMFVQTPTQFYVMRFLLGLAEAGFYPGVILYLTYWYPANR
RAKMIALFMSGIPVAGMFGNPLSGWIMDAFNDTHGLRGWQWMFVIEALPAFVIGVVTVFVLRDGIDKAPWLDADEKRVLK
RNIEEDQQNAGAASGKAHGHSLGAVFSDSRVWWMCLIYFCFVTGQYALTFWMPTLVKASGVTGNFNIGLLSAIPFLCAVV
VMNILGHSADARRERRWHLIVPALMGAAGFAVAASFTDNTTVAIAALSVAAAGVLTCAPLFWSLPTAFLSGIAAASGIAV
VNSVGNLAGFVSPYMIGALKDMTHSTQLPMYVLSAILVIGAVLVWLTPAKLVNR

Sequences:

>Translated_454_residues
MNPNQPAASVPAYDSLGANARLDADAQVEKRAYNKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMGQDLAFSETVFGLGA
GLFFIGYFLFELPSNLLMHKLGARIWIARIMITWGIISSLFMFVQTPTQFYVMRFLLGLAEAGFYPGVILYLTYWYPANR
RAKMIALFMSGIPVAGMFGNPLSGWIMDAFNDTHGLRGWQWMFVIEALPAFVIGVVTVFVLRDGIDKAPWLDADEKRVLK
RNIEEDQQNAGAASGKAHGHSLGAVFSDSRVWWMCLIYFCFVTGQYALTFWMPTLVKASGVTGNFNIGLLSAIPFLCAVV
VMNILGHSADARRERRWHLIVPALMGAAGFAVAASFTDNTTVAIAALSVAAAGVLTCAPLFWSLPTAFLSGIAAASGIAV
VNSVGNLAGFVSPYMIGALKDMTHSTQLPMYVLSAILVIGAVLVWLTPAKLVNR
>Mature_454_residues
MNPNQPAASVPAYDSLGANARLDADAQVEKRAYNKVFWRIMPFLMLCYVIAYLDRVNVGFAKLQMGQDLAFSETVFGLGA
GLFFIGYFLFELPSNLLMHKLGARIWIARIMITWGIISSLFMFVQTPTQFYVMRFLLGLAEAGFYPGVILYLTYWYPANR
RAKMIALFMSGIPVAGMFGNPLSGWIMDAFNDTHGLRGWQWMFVIEALPAFVIGVVTVFVLRDGIDKAPWLDADEKRVLK
RNIEEDQQNAGAASGKAHGHSLGAVFSDSRVWWMCLIYFCFVTGQYALTFWMPTLVKASGVTGNFNIGLLSAIPFLCAVV
VMNILGHSADARRERRWHLIVPALMGAAGFAVAASFTDNTTVAIAALSVAAAGVLTCAPLFWSLPTAFLSGIAAASGIAV
VNSVGNLAGFVSPYMIGALKDMTHSTQLPMYVLSAILVIGAVLVWLTPAKLVNR

Specific function: Component of the tartrate utilization system and may allow entry of tartrate and tartrate dehydrogenase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI9966811, Length=399, Percent_Identity=23.5588972431078, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI21322234, Length=402, Percent_Identity=23.8805970149254, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI6912666, Length=406, Percent_Identity=22.9064039408867, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082071, Length=423, Percent_Identity=36.8794326241135, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1789515, Length=422, Percent_Identity=22.9857819905213, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI2367379, Length=445, Percent_Identity=22.0224719101124, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789152, Length=427, Percent_Identity=24.5901639344262, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87082320, Length=433, Percent_Identity=21.7090069284065, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322025, Length=231, Percent_Identity=26.8398268398268, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321698, Length=327, Percent_Identity=21.7125382262997, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319876, Length=181, Percent_Identity=27.6243093922652, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319250, Length=321, Percent_Identity=22.7414330218069, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323032, Length=267, Percent_Identity=25.0936329588015, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322612, Length=275, Percent_Identity=22.9090909090909, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324410, Length=164, Percent_Identity=25, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584153, Length=366, Percent_Identity=24.3169398907104, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24583789, Length=379, Percent_Identity=25.3298153034301, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49651; Mature: 49651

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure
MNPNQPAASVPAYDSLGANARLDADAQVEKRAYNKVFWRIMPFLMLCYVIAYLDRVNVGF
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AKLQMGQDLAFSETVFGLGAGLFFIGYFLFELPSNLLMHKLGARIWIARIMITWGIISSL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMFVQTPTQFYVMRFLLGLAEAGFYPGVILYLTYWYPANRRAKMIALFMSGIPVAGMFGN
HHHHHCCHHHHHHHHHHHHHHCCCCCCEEHEEEEECCCCCCHHHHHHHHCCCCCCCCCCC
PLSGWIMDAFNDTHGLRGWQWMFVIEALPAFVIGVVTVFVLRDGIDKAPWLDADEKRVLK
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RNIEEDQQNAGAASGKAHGHSLGAVFSDSRVWWMCLIYFCFVTGQYALTFWMPTLVKASG
HCCHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
VTGNFNIGLLSAIPFLCAVVVMNILGHSADARRERRWHLIVPALMGAAGFAVAASFTDNT
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEHHHHHCCHHHHEEEECCCCC
TVAIAALSVAAAGVLTCAPLFWSLPTAFLSGIAAASGIAVVNSVGNLAGFVSPYMIGALK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMTHSTQLPMYVLSAILVIGAVLVWLTPAKLVNR
HHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]