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The map label for this gene is thrS [H]

Identifier: 73540970

GI number: 73540970

Start: 1361019

End: 1362926

Strand: Direct

Name: thrS [H]

Synonym: Reut_A1275

Alternate gene names: 73540970

Gene position: 1361019-1362926 (Clockwise)

Preceding gene: 73540969

Following gene: 73540971

Centisome position: 35.75

GC content: 61.95

Gene sequence:

>1908_bases
ATGATCGCAATCACGCTGCCGGATGGGTCCCGTCGCGAGTTTCCCGGCCCGGTGACGGTCGCCGAAGTGGCGCAAAGCAT
CGGCACGGGTCTGGCCAAGGCCGCGCTGGCTGGCAAGGTGGACGGCAACCTGGTCGACACGAGCTACTCGATCGATCGCG
ATGTGGCGCTGGCCATCATCACGGATAAGGACGCTGACGGCGTCGATGTCATTCGTCACTCCACGGCCCACTTGCTCGCG
TATGCGGTCAAGGAACTGTACCCGGATGCCCAGGTGACGATCGGCCCCGTGATCGAAAACGGCTTCTATTACGACTTCGC
CTACAAGCGTCCCTTCACGCCGGAAGACCTGGCTGCCATCGAAAAGAAGATGACGGAGCTGTCCCGCAAGGACGAGAAGG
TCACGCGCGAGGTCTGGAACCGCGACGAGGCGGTGGCGCTGTTCGAGTCGATGGGCGAGAAGTACAAGGCCGAGATCATC
GCCTCGATTCCGGCGGACCAGGAAATCGGTCTGTATCGCGAAGGCAAGTTCGTCGACCTGTGCCGTGGCCCGCACGTGCC
GTCCACGGGCAAGCTCAAGGTCTTCAAGCTCATGAAGGTGGCCGGCGCCTACTGGCGCGGCGATGCCAACAACGAGATGC
TCCAGCGCATCTACGGTACGGCGTGGGCCAAGAAGGAAGACCAGGAAGCCTACCTGCACATGCTCGAAGAGGCCGAAAAG
CGCGATCACCGCAAACTGGGCAAGTCGCTCGACCTGTTCCACCTGCAGGAAGAGGCGCCGGGCATGGTGTTCTGGCACCC
GAAGGGCTGGCAGGTATGGCAGGCCGTCGAGCAGTACATGCGCGGCCGCCTGACGGCCGCCGGCTATGACGAAGTGCGCA
CGCCGCAGGTGATGGACCGTTCGCTGTGGGAGAAGTCCGGCCACTGGCAGAACTACAAGGAAAACATGTTCGTCACGGAG
TCGGAGAAGCGCGACTACGCGATCAAGCCGATGAACTGCCCGGGACATGTGCAGATCTTCAACCATGGCCTGCGTTCCTA
CCGTGACCTGCCGCTGCGCCTGGCCGAGTTCGGCGCCTGCCATCGCAACGAGCCGTCGGGCGCGCTGCATGGGCTGATGC
GCGTGCGCGGTTTTGTGCAGGATGATGCGCACATCTTCTGCACGGAAGAGCAGATCGTTGCCGAGGCGAAAGCCTTCAAC
GAACTCGCGTTCTCGGTCTATGACGACTTCGGCTTCAAGGATGTGGCGGTGAAGCTGTCGCTGCGTCCGGCACAGCGCGC
TGGCTCGGACGAGGTCTGGGATCACGCCGAAGAAGGCCTGCGCCTGGCGCTGCGCGCCTGTGGCGTGGACTGGGAAGAAC
TGCCCGGCGAGGGCGCATTCTACGGTCCGAAGGTCGAGTACCACATCAAAGATGCCATCGGCCGTTCATGGCAGTGCGGC
ACGCTGCAGCTCGACCTGGTGCTGCCGGAGCGCCTCGGTGCCGAATACGTCGCCGAGGATAATTCGCGCAAGCGTCCGGT
GATGCTGCACCGTGCGATCCTGGGTTCGTTCGAGCGTTTCCTTGGCATCCTGCTCGAAAACCACGCAGGTGCGCTGCCCG
CCTGGCTGGCACCGGAGCAGGTGGTTGTCATGAATATCGCGGAATCGCAGGCTGAATATGCCGAAAATGTCGTGCAATCG
CTGCTAAAACAAGGGTTTAGGGCGAAGGCCGATTTGCGTAACGAGAAAATTACGTATAAAATCCGCGAGCATTCGCTTCA
GAAGATCCCCTACCTGCTGGTGGTGGGCGACAAGGAGCGGGATGCCAATCAAGTGGCCGTGCGTGCCCGTGGCAACGTGG
ATCTGGGTGTGATGCCCGTCTCCGCGTTTGTGGAGCGTCTGCAACAGGACGTCACCAACAAAGCCTGA

Upstream 100 bases:

>100_bases
TCGGTACGCCGCCTGTTTCGGGGTGGGCCGGTGCTACAAAAGATGCAGTTTGATCCGCCCGCCGAGCGCCAGCGCCGGGG
TGGAATCCTGGAGAGTCGAA

Downstream 100 bases:

>100_bases
TGGGTCGGAAGCACGGCTTGTTTTTTTGTCTTCTTGAGGTAACGCAACATCGCTACAGACAAAGGTCATCGCATCAACCG
GGAGATCAGTGCGCCTGAGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MIAITLPDGSRREFPGPVTVAEVAQSIGTGLAKAALAGKVDGNLVDTSYSIDRDVALAIITDKDADGVDVIRHSTAHLLA
YAVKELYPDAQVTIGPVIENGFYYDFAYKRPFTPEDLAAIEKKMTELSRKDEKVTREVWNRDEAVALFESMGEKYKAEII
ASIPADQEIGLYREGKFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDANNEMLQRIYGTAWAKKEDQEAYLHMLEEAEK
RDHRKLGKSLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLTAAGYDEVRTPQVMDRSLWEKSGHWQNYKENMFVTE
SEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGLMRVRGFVQDDAHIFCTEEQIVAEAKAFN
ELAFSVYDDFGFKDVAVKLSLRPAQRAGSDEVWDHAEEGLRLALRACGVDWEELPGEGAFYGPKVEYHIKDAIGRSWQCG
TLQLDLVLPERLGAEYVAEDNSRKRPVMLHRAILGSFERFLGILLENHAGALPAWLAPEQVVVMNIAESQAEYAENVVQS
LLKQGFRAKADLRNEKITYKIREHSLQKIPYLLVVGDKERDANQVAVRARGNVDLGVMPVSAFVERLQQDVTNKA

Sequences:

>Translated_635_residues
MIAITLPDGSRREFPGPVTVAEVAQSIGTGLAKAALAGKVDGNLVDTSYSIDRDVALAIITDKDADGVDVIRHSTAHLLA
YAVKELYPDAQVTIGPVIENGFYYDFAYKRPFTPEDLAAIEKKMTELSRKDEKVTREVWNRDEAVALFESMGEKYKAEII
ASIPADQEIGLYREGKFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDANNEMLQRIYGTAWAKKEDQEAYLHMLEEAEK
RDHRKLGKSLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLTAAGYDEVRTPQVMDRSLWEKSGHWQNYKENMFVTE
SEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGLMRVRGFVQDDAHIFCTEEQIVAEAKAFN
ELAFSVYDDFGFKDVAVKLSLRPAQRAGSDEVWDHAEEGLRLALRACGVDWEELPGEGAFYGPKVEYHIKDAIGRSWQCG
TLQLDLVLPERLGAEYVAEDNSRKRPVMLHRAILGSFERFLGILLENHAGALPAWLAPEQVVVMNIAESQAEYAENVVQS
LLKQGFRAKADLRNEKITYKIREHSLQKIPYLLVVGDKERDANQVAVRARGNVDLGVMPVSAFVERLQQDVTNKA
>Mature_635_residues
MIAITLPDGSRREFPGPVTVAEVAQSIGTGLAKAALAGKVDGNLVDTSYSIDRDVALAIITDKDADGVDVIRHSTAHLLA
YAVKELYPDAQVTIGPVIENGFYYDFAYKRPFTPEDLAAIEKKMTELSRKDEKVTREVWNRDEAVALFESMGEKYKAEII
ASIPADQEIGLYREGKFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDANNEMLQRIYGTAWAKKEDQEAYLHMLEEAEK
RDHRKLGKSLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLTAAGYDEVRTPQVMDRSLWEKSGHWQNYKENMFVTE
SEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGLMRVRGFVQDDAHIFCTEEQIVAEAKAFN
ELAFSVYDDFGFKDVAVKLSLRPAQRAGSDEVWDHAEEGLRLALRACGVDWEELPGEGAFYGPKVEYHIKDAIGRSWQCG
TLQLDLVLPERLGAEYVAEDNSRKRPVMLHRAILGSFERFLGILLENHAGALPAWLAPEQVVVMNIAESQAEYAENVVQS
LLKQGFRAKADLRNEKITYKIREHSLQKIPYLLVVGDKERDANQVAVRARGNVDLGVMPVSAFVERLQQDVTNKA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=632, Percent_Identity=41.4556962025316, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI38570111, Length=614, Percent_Identity=41.042345276873, Blast_Score=478, Evalue=1e-134,
Organism=Homo sapiens, GI20070344, Length=647, Percent_Identity=37.7125193199382, Blast_Score=413, Evalue=1e-115,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=58.0188679245283, Blast_Score=782, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=140, Percent_Identity=31.4285714285714, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984184, Length=634, Percent_Identity=39.1167192429022, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=634, Percent_Identity=39.1167192429022, Blast_Score=473, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=653, Percent_Identity=39.0505359877489, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322654, Length=447, Percent_Identity=36.0178970917226, Blast_Score=293, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=40.5705229793978, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=40.5705229793978, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=40.5705229793978, Blast_Score=494, Evalue=1e-139,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 71652; Mature: 71652

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAITLPDGSRREFPGPVTVAEVAQSIGTGLAKAALAGKVDGNLVDTSYSIDRDVALAII
CEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCCEEEEEE
TDKDADGVDVIRHSTAHLLAYAVKELYPDAQVTIGPVIENGFYYDFAYKRPFTPEDLAAI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHH
EKKMTELSRKDEKVTREVWNRDEAVALFESMGEKYKAEIIASIPADQEIGLYREGKFVDL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHEEEECCCCCCCCCEECCCEEEE
CRGPHVPSTGKLKVFKLMKVAGAYWRGDANNEMLQRIYGTAWAKKEDQEAYLHMLEEAEK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RDHRKLGKSLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLTAAGYDEVRTPQVMDR
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
SLWEKSGHWQNYKENMFVTESEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGAC
HHHHCCCCCCCCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGALHGLMRVRGFVQDDAHIFCTEEQIVAEAKAFNELAFSVYDDFGFKDVAVKLS
CCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
LRPAQRAGSDEVWDHAEEGLRLALRACGVDWEELPGEGAFYGPKVEYHIKDAIGRSWQCG
ECCHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEEEHHHCCCCCCCC
TLQLDLVLPERLGAEYVAEDNSRKRPVMLHRAILGSFERFLGILLENHAGALPAWLAPEQ
EEEEEEECHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VVVMNIAESQAEYAENVVQSLLKQGFRAKADLRNEKITYKIREHSLQKIPYLLVVGDKER
EEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEHHHHHHHCCEEEEECCCCC
DANQVAVRARGNVDLGVMPVSAFVERLQQDVTNKA
CCCEEEEEECCCCCEEEECHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIAITLPDGSRREFPGPVTVAEVAQSIGTGLAKAALAGKVDGNLVDTSYSIDRDVALAII
CEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCEEECCCCCCCCEEEEEE
TDKDADGVDVIRHSTAHLLAYAVKELYPDAQVTIGPVIENGFYYDFAYKRPFTPEDLAAI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHH
EKKMTELSRKDEKVTREVWNRDEAVALFESMGEKYKAEIIASIPADQEIGLYREGKFVDL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHEEEECCCCCCCCCEECCCEEEE
CRGPHVPSTGKLKVFKLMKVAGAYWRGDANNEMLQRIYGTAWAKKEDQEAYLHMLEEAEK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RDHRKLGKSLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLTAAGYDEVRTPQVMDR
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
SLWEKSGHWQNYKENMFVTESEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGAC
HHHHCCCCCCCCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGALHGLMRVRGFVQDDAHIFCTEEQIVAEAKAFNELAFSVYDDFGFKDVAVKLS
CCCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
LRPAQRAGSDEVWDHAEEGLRLALRACGVDWEELPGEGAFYGPKVEYHIKDAIGRSWQCG
ECCHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEEEEEHHHCCCCCCCC
TLQLDLVLPERLGAEYVAEDNSRKRPVMLHRAILGSFERFLGILLENHAGALPAWLAPEQ
EEEEEEECHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VVVMNIAESQAEYAENVVQSLLKQGFRAKADLRNEKITYKIREHSLQKIPYLLVVGDKER
EEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEEHHHHHHHCCEEEEECCCCC
DANQVAVRARGNVDLGVMPVSAFVERLQQDVTNKA
CCCEEEEEECCCCCEEEECHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA