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The map label for this gene is xapA [H]

Identifier: 73540862

GI number: 73540862

Start: 1250279

End: 1251142

Strand: Direct

Name: xapA [H]

Synonym: Reut_A1163

Alternate gene names: 73540862

Gene position: 1250279-1251142 (Clockwise)

Preceding gene: 73540861

Following gene: 73540864

Centisome position: 32.85

GC content: 59.38

Gene sequence:

>864_bases
ATGACTCTCACGCTGCCATCGTCGGCGGACGCGCCTGATCAGACCGAACAGGCAGTTCAACGAATTCGTCAACACGTCGG
CGAATTCCGTCCCCAGATTGGCCTGATTCTTGGCTCCGGGCTCGGTGGTTTGGCGCGAGCGATCGAAAATGCCATTGCCA
TTCCCTATGCGGCGCTGCCGGGATTCCCGCAATCCCTGGTTGAAGGCCACGCCGGTGAAGTCGTTCTGGGTCGGTTGGGT
GGGGTGGAATTGATGTGCATGCGAGGGCGGCAGCATTTCTATGAAGGGCATGGCACGACGGGTATGACGCAGGCGGTCCG
TACAATGAAACGGATGGGATGCGACCGGTTATTCGTGACCTGTGCAGCTGGCTCGCTCCACCCCGAATTGGAACCTGGCC
GGTTGGTAGCGATCAAGGACCATATTAATCTGCTCCCCGGCAATCCATTGATCGGCCCCAACGATGACCAAATCGGGCCC
CGTTTCTGCTCTATGGCGAACGCGTACGACACGGTCTTACGGCAAGGGTTGCAAGATGTCGCGCAGGCGCTGGGACTGCC
TTGGGCCGAAGGCGTCTACGTTGCGTTCAGCGGCCCGACATTCGAGACCGCTGCCGAGATCCGAATGATGCAAGTCATCG
GTGGCGACGTCGTGGGCATGTCGACAGTTCCGGAGGTGATCAGCGCACGGCATTGTGGCCTGCGCGTGCTTGCCATTGCT
TGCATTACCAACCTGGGCGAGGGGATCGGAAATGAAGTCCTGTCTCACGAGCTGACGTTGCAGTATGGATCCATGGCCTT
GGTAGACCTGCAGCGCCTGATAGTGGGCTGGTTCGAACAACAGGCCGCCACAGCTAAGCGTTGA

Upstream 100 bases:

>100_bases
CGCCTGTGCCAAGCATTGCTGCCTCGGCCGCTCTTGCTTCCACCGAAAAGCGAGCGATGCCATTTGATGATACCAACCTC
GACATACGGGAGCAGGTGCC

Downstream 100 bases:

>100_bases
GAGCGGGACATATCTGGCGATTTCCTCTCGCCTCCATTGCGCCAACCAATCTGCCGAATAGAGCCACCAGAATCGCCGGT
CATGTTTCGTCTTCCGGTTC

Product: purine nucleoside phosphorylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTLTLPSSADAPDQTEQAVQRIRQHVGEFRPQIGLILGSGLGGLARAIENAIAIPYAALPGFPQSLVEGHAGEVVLGRLG
GVELMCMRGRQHFYEGHGTTGMTQAVRTMKRMGCDRLFVTCAAGSLHPELEPGRLVAIKDHINLLPGNPLIGPNDDQIGP
RFCSMANAYDTVLRQGLQDVAQALGLPWAEGVYVAFSGPTFETAAEIRMMQVIGGDVVGMSTVPEVISARHCGLRVLAIA
CITNLGEGIGNEVLSHELTLQYGSMALVDLQRLIVGWFEQQAATAKR

Sequences:

>Translated_287_residues
MTLTLPSSADAPDQTEQAVQRIRQHVGEFRPQIGLILGSGLGGLARAIENAIAIPYAALPGFPQSLVEGHAGEVVLGRLG
GVELMCMRGRQHFYEGHGTTGMTQAVRTMKRMGCDRLFVTCAAGSLHPELEPGRLVAIKDHINLLPGNPLIGPNDDQIGP
RFCSMANAYDTVLRQGLQDVAQALGLPWAEGVYVAFSGPTFETAAEIRMMQVIGGDVVGMSTVPEVISARHCGLRVLAIA
CITNLGEGIGNEVLSHELTLQYGSMALVDLQRLIVGWFEQQAATAKR
>Mature_286_residues
TLTLPSSADAPDQTEQAVQRIRQHVGEFRPQIGLILGSGLGGLARAIENAIAIPYAALPGFPQSLVEGHAGEVVLGRLGG
VELMCMRGRQHFYEGHGTTGMTQAVRTMKRMGCDRLFVTCAAGSLHPELEPGRLVAIKDHINLLPGNPLIGPNDDQIGPR
FCSMANAYDTVLRQGLQDVAQALGLPWAEGVYVAFSGPTFETAAEIRMMQVIGGDVVGMSTVPEVISARHCGLRVLAIAC
ITNLGEGIGNEVLSHELTLQYGSMALVDLQRLIVGWFEQQAATAKR

Specific function: The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI157168362, Length=253, Percent_Identity=45.8498023715415, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI47132622, Length=222, Percent_Identity=30.1801801801802, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788746, Length=264, Percent_Identity=57.1969696969697, Blast_Score=310, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI17541190, Length=263, Percent_Identity=38.7832699619772, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323238, Length=268, Percent_Identity=42.1641791044776, Blast_Score=182, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24656090, Length=246, Percent_Identity=41.869918699187, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24656093, Length=220, Percent_Identity=45.9090909090909, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI45552887, Length=220, Percent_Identity=45.9090909090909, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI45552885, Length=220, Percent_Identity=45.9090909090909, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24762376, Length=257, Percent_Identity=30.7392996108949, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI221459247, Length=271, Percent_Identity=25.830258302583, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130079, Length=256, Percent_Identity=27.34375, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011268
- InterPro:   IPR000845
- InterPro:   IPR010943
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.-

Molecular weight: Translated: 30664; Mature: 30533

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTLPSSADAPDQTEQAVQRIRQHVGEFRPQIGLILGSGLGGLARAIENAIAIPYAALP
CEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCHHHCC
GFPQSLVEGHAGEVVLGRLGGVELMCMRGRQHFYEGHGTTGMTQAVRTMKRMGCDRLFVT
CCCHHHHCCCCCCEEEECCCCEEEEEHHCHHHHHCCCCCCHHHHHHHHHHHCCCHHEEEE
CAAGSLHPELEPGRLVAIKDHINLLPGNPLIGPNDDQIGPRFCSMANAYDTVLRQGLQDV
EECCCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AQALGLPWAEGVYVAFSGPTFETAAEIRMMQVIGGDVVGMSTVPEVISARHCGLRVLAIA
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHH
CITNLGEGIGNEVLSHELTLQYGSMALVDLQRLIVGWFEQQAATAKR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLTLPSSADAPDQTEQAVQRIRQHVGEFRPQIGLILGSGLGGLARAIENAIAIPYAALP
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCHHHCC
GFPQSLVEGHAGEVVLGRLGGVELMCMRGRQHFYEGHGTTGMTQAVRTMKRMGCDRLFVT
CCCHHHHCCCCCCEEEECCCCEEEEEHHCHHHHHCCCCCCHHHHHHHHHHHCCCHHEEEE
CAAGSLHPELEPGRLVAIKDHINLLPGNPLIGPNDDQIGPRFCSMANAYDTVLRQGLQDV
EECCCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AQALGLPWAEGVYVAFSGPTFETAAEIRMMQVIGGDVVGMSTVPEVISARHCGLRVLAIA
HHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHH
CITNLGEGIGNEVLSHELTLQYGSMALVDLQRLIVGWFEQQAATAKR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7559336; 9205837; 9278503 [H]