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The map label for this gene is ghrA [H]

Identifier: 73540595

GI number: 73540595

Start: 973819

End: 974748

Strand: Reverse

Name: ghrA [H]

Synonym: Reut_A0892

Alternate gene names: 73540595

Gene position: 974748-973819 (Counterclockwise)

Preceding gene: 73540596

Following gene: 73540587

Centisome position: 25.61

GC content: 68.28

Gene sequence:

>930_bases
ATGGGCATCCTCGTACATCTGCCATCGTTCATGGCCGGCGCCATTGGCGCCGCACTGCGCGAAGCCGCGCCCGACATCCC
GGTCTGGATCGGCCGCGAGAACGCGCCCGCCGACGAAGTCGAAGCGATCATCGCCTGGGGCCTGAAGCCCGGCGTGCTGC
CCGCTTACCGCAACCTGCGCCTGATCTGCAGCGCCGCGGCCGGCGTCGACAAGCTCGTGAGCGCGCCCGATCTGCCCGAA
AGCATGCCAGTCACGCGCGTGGTCGATCCCGGCCAGCAGACTGGCATCGCGCATTACGTGCTTGCGATGGCCCTGCGCCA
TGCGCGTCGCCTCGGAACTTATGCCGAGCAGCAACGCCGTGGCGAATGGAAGCGCCACCCTGCCCCCGACCTCGCGCACT
GCCGCGTGGGCGTGCTTGGCATGGGCGAGATCGGCAGCGCCGTGGCGCGCACGTTCGCGTCCATCGGCTTTCCGGTGGCG
GGATGGAGCCGCAGTGGCAAGGGCATTCCGGGCGTGACCGACTACACCGGTGCCGAGGGCCGGTCGGCCATGCTCGCGCA
GACCGATATTCTCGTCTGCACGCTGCCGCTGACGCCGCAAACCCACGGCCTGCTCAATCGCGAGACGCTGTCGCAGTTGC
CCGCGGGCGCGTTCTTTATCAACGTCGGCCGGGGCGAGCATCTGGTCGAGCCCGACCTGATCGCGCTGATCGACGCAGGC
CATCTGGCCGGTGCGGCGCTCGATGTGTTTTCGAAGGAGCCGCCGGAGCCCGGCGATCCGGTGTGGAACCATCCGCGCAT
CGAAGCGACGCCACACATTGCGTGCGATCCGTCGTATGAACTGGTCGCGCAGCAGTGCGTGGAGAACGTGCGGCGGATGC
GGGATGGCAGGGAGTTGTTGAACCTGGTCGATCGGGCGGCGGGGTACTGA

Upstream 100 bases:

>100_bases
GAACAAGCGCGCCAGGCGACCAAGGGCAAGGGCTCGGGCCTCGCATGGCCGGCGCTGCTGCGTCGCCTGGATCGTATTCA
ACCCGACTTCCGGAACTGAC

Downstream 100 bases:

>100_bases
AGCACACGGCAGCCCCGAGCGGGGCTGCGTGTCAGGCCGTCGATGCCTGCCGCACCATCCAGTTGCGGAATGCGCGCGCT
GCTGCCGGCTCCATGCGATC

Product: 6-phosphogluconate dehydrogenase, NAD-binding:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MGILVHLPSFMAGAIGAALREAAPDIPVWIGRENAPADEVEAIIAWGLKPGVLPAYRNLRLICSAAAGVDKLVSAPDLPE
SMPVTRVVDPGQQTGIAHYVLAMALRHARRLGTYAEQQRRGEWKRHPAPDLAHCRVGVLGMGEIGSAVARTFASIGFPVA
GWSRSGKGIPGVTDYTGAEGRSAMLAQTDILVCTLPLTPQTHGLLNRETLSQLPAGAFFINVGRGEHLVEPDLIALIDAG
HLAGAALDVFSKEPPEPGDPVWNHPRIEATPHIACDPSYELVAQQCVENVRRMRDGRELLNLVDRAAGY

Sequences:

>Translated_309_residues
MGILVHLPSFMAGAIGAALREAAPDIPVWIGRENAPADEVEAIIAWGLKPGVLPAYRNLRLICSAAAGVDKLVSAPDLPE
SMPVTRVVDPGQQTGIAHYVLAMALRHARRLGTYAEQQRRGEWKRHPAPDLAHCRVGVLGMGEIGSAVARTFASIGFPVA
GWSRSGKGIPGVTDYTGAEGRSAMLAQTDILVCTLPLTPQTHGLLNRETLSQLPAGAFFINVGRGEHLVEPDLIALIDAG
HLAGAALDVFSKEPPEPGDPVWNHPRIEATPHIACDPSYELVAQQCVENVRRMRDGRELLNLVDRAAGY
>Mature_308_residues
GILVHLPSFMAGAIGAALREAAPDIPVWIGRENAPADEVEAIIAWGLKPGVLPAYRNLRLICSAAAGVDKLVSAPDLPES
MPVTRVVDPGQQTGIAHYVLAMALRHARRLGTYAEQQRRGEWKRHPAPDLAHCRVGVLGMGEIGSAVARTFASIGFPVAG
WSRSGKGIPGVTDYTGAEGRSAMLAQTDILVCTLPLTPQTHGLLNRETLSQLPAGAFFINVGRGEHLVEPDLIALIDAGH
LAGAALDVFSKEPPEPGDPVWNHPRIEATPHIACDPSYELVAQQCVENVRRMRDGRELLNLVDRAAGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=273, Percent_Identity=27.8388278388278, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=27.5735294117647, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=27.5735294117647, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081824, Length=316, Percent_Identity=35.4430379746835, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87082289, Length=185, Percent_Identity=32.4324324324324, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1789279, Length=164, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=29.8850574712644, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=241, Percent_Identity=26.1410788381743, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=224, Percent_Identity=26.3392857142857, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=179, Percent_Identity=26.2569832402235, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324055, Length=204, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=237, Percent_Identity=27.8481012658228, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574286, Length=224, Percent_Identity=23.6607142857143, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=229, Percent_Identity=23.1441048034935, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574282, Length=229, Percent_Identity=23.1441048034935, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45552429, Length=227, Percent_Identity=23.3480176211454, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28574284, Length=229, Percent_Identity=23.1441048034935, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45551003, Length=229, Percent_Identity=23.1441048034935, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=28.3464566929134, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=28.3464566929134, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=28.3464566929134, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=28.3464566929134, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=28.3464566929134, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33032; Mature: 32901

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILVHLPSFMAGAIGAALREAAPDIPVWIGRENAPADEVEAIIAWGLKPGVLPAYRNLR
CCEEEECHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
LICSAAAGVDKLVSAPDLPESMPVTRVVDPGQQTGIAHYVLAMALRHARRLGTYAEQQRR
HHHHHHHCHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEWKRHPAPDLAHCRVGVLGMGEIGSAVARTFASIGFPVAGWSRSGKGIPGVTDYTGAEG
CCCCCCCCCCHHHHEECEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RSAMLAQTDILVCTLPLTPQTHGLLNRETLSQLPAGAFFINVGRGEHLVEPDLIALIDAG
CCEEEEECCEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECC
HLAGAALDVFSKEPPEPGDPVWNHPRIEATPHIACDPSYELVAQQCVENVRRMRDGRELL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
NLVDRAAGY
HHHHHHCCC
>Mature Secondary Structure 
GILVHLPSFMAGAIGAALREAAPDIPVWIGRENAPADEVEAIIAWGLKPGVLPAYRNLR
CEEEECHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
LICSAAAGVDKLVSAPDLPESMPVTRVVDPGQQTGIAHYVLAMALRHARRLGTYAEQQRR
HHHHHHHCHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEWKRHPAPDLAHCRVGVLGMGEIGSAVARTFASIGFPVAGWSRSGKGIPGVTDYTGAEG
CCCCCCCCCCHHHHEECEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RSAMLAQTDILVCTLPLTPQTHGLLNRETLSQLPAGAFFINVGRGEHLVEPDLIALIDAG
CCEEEEECCEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECC
HLAGAALDVFSKEPPEPGDPVWNHPRIEATPHIACDPSYELVAQQCVENVRRMRDGRELL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
NLVDRAAGY
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA