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The map label for this gene is folE2

Identifier: 73540586

GI number: 73540586

Start: 961077

End: 961889

Strand: Direct

Name: folE2

Synonym: Reut_A0883

Alternate gene names: 73540586

Gene position: 961077-961889 (Clockwise)

Preceding gene: 73540585

Following gene: 73540588

Centisome position: 25.25

GC content: 62.12

Gene sequence:

>813_bases
ATGAATGACATCAATCCTGCCTTCGTGATGCCCGACGTCCAGTCGAGCCGTGACACCCGCCAGATTCCCATCCAGCGTGT
CGGTGTCAAGGGCGTGCGCTATCCCGTCTCGCTGAAGACGCCGGCCGGCGTGGTTCCGAGCGTGGGCACCTTCAATCTCG
ACGTGCATCTGCCTGCCGAAGTCAAAGGTACGCACATGTCGCGCTTTGTCGCGCTGCTCGAAGAAGAGCGCGCGCCGCTG
GAGCTAGCGAGCTTCCGCGTGCTGCTCGACAAGATGCTCGAAAAGCTCGAAGCCGAGGCCGGTCGCATCGAGGTCACGTT
CCCGTACTTCATCAGCAAGATCGCGCCTGTGTCGGGGGTGGAGTCGCTGATGGACTACGAGGTCACGCTGACCGGCGAGA
TCCGCAACGGCGTGACGCGCGTGTTCCTGAAGGCACTGGTGCCGGTGACGAGCCTGTGCCCGTGCTCCAAGAAGATCTCG
CAGTACGGCGCGCACAACCAGCGCTCGCACATCACCATGAATGTCGAGCTGGCGGGCGAACTGCCGGTGGAAGCGCTGGT
GCGCATGGCGGAAGAAGAGGCGTCGTGCGAGCTGTGGGGCCTGCTCAAACGTCCGGACGAGAAGTTCGTGACCGAGCGTG
CGTACGAAAACCCGAAGTTCGTGGAAGACCTGGTGCGCGATATCGCCATGCGGCTCAATGCCGATGAGCGCATCGTGGCG
TACGTGCTCGAAGCCGAGAACTTCGAGTCCATCCACAACCACAGCGCTTACGCCGTGATTGAACGCGACAAACGGCTTGA
GCCGACTGCGTAA

Upstream 100 bases:

>100_bases
CGTGGTTTCACACTCGTTGCGCGGCATGGATGGACTGCGAAAATGCCGCGACCGTAAGGACCTGTGCCGTCGCCTGGTGC
ACTCCTGGAGGAAACCGTAG

Downstream 100 bases:

>100_bases
GTCGGTTTGAGTGCAAACAGAAAGGCCACCTTCGCGGTGGCCTTTCTGTTTTCAGCGTCGGCATGTTCAGGCGGCCGAAG
GCAGGCGGATATCAGCCAGA

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNDINPAFVMPDVQSSRDTRQIPIQRVGVKGVRYPVSLKTPAGVVPSVGTFNLDVHLPAEVKGTHMSRFVALLEEERAPL
ELASFRVLLDKMLEKLEAEAGRIEVTFPYFISKIAPVSGVESLMDYEVTLTGEIRNGVTRVFLKALVPVTSLCPCSKKIS
QYGAHNQRSHITMNVELAGELPVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADERIVA
YVLEAENFESIHNHSAYAVIERDKRLEPTA

Sequences:

>Translated_270_residues
MNDINPAFVMPDVQSSRDTRQIPIQRVGVKGVRYPVSLKTPAGVVPSVGTFNLDVHLPAEVKGTHMSRFVALLEEERAPL
ELASFRVLLDKMLEKLEAEAGRIEVTFPYFISKIAPVSGVESLMDYEVTLTGEIRNGVTRVFLKALVPVTSLCPCSKKIS
QYGAHNQRSHITMNVELAGELPVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADERIVA
YVLEAENFESIHNHSAYAVIERDKRLEPTA
>Mature_270_residues
MNDINPAFVMPDVQSSRDTRQIPIQRVGVKGVRYPVSLKTPAGVVPSVGTFNLDVHLPAEVKGTHMSRFVALLEEERAPL
ELASFRVLLDKMLEKLEAEAGRIEVTFPYFISKIAPVSGVESLMDYEVTLTGEIRNGVTRVFLKALVPVTSLCPCSKKIS
QYGAHNQRSHITMNVELAGELPVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADERIVA
YVLEAENFESIHNHSAYAVIERDKRLEPTA

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_CUPPJ (Q474C1)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_295106.1
- ProteinModelPortal:   Q474C1
- SMR:   Q474C1
- GeneID:   3611765
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0883
- NMPDR:   fig|264198.3.peg.1440
- HOGENOM:   HBG626871
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- BioCyc:   REUT264198:REUT_A0883-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 30293; Mature: 30293

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDINPAFVMPDVQSSRDTRQIPIQRVGVKGVRYPVSLKTPAGVVPSVGTFNLDVHLPAE
CCCCCCEEEECCCCCCCCCCCCCHHHHCCCCEECEEEECCCCCCCCCCCEEEEEEEECCC
VKGTHMSRFVALLEEERAPLELASFRVLLDKMLEKLEAEAGRIEVTFPYFISKIAPVSGV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHH
ESLMDYEVTLTGEIRNGVTRVFLKALVPVTSLCPCSKKISQYGAHNQRSHITMNVELAGE
HHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEEECCC
LPVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADERIVA
CCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
YVLEAENFESIHNHSAYAVIERDKRLEPTA
EEECCCCHHHHHCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MNDINPAFVMPDVQSSRDTRQIPIQRVGVKGVRYPVSLKTPAGVVPSVGTFNLDVHLPAE
CCCCCCEEEECCCCCCCCCCCCCHHHHCCCCEECEEEECCCCCCCCCCCEEEEEEEECCC
VKGTHMSRFVALLEEERAPLELASFRVLLDKMLEKLEAEAGRIEVTFPYFISKIAPVSGV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHH
ESLMDYEVTLTGEIRNGVTRVFLKALVPVTSLCPCSKKISQYGAHNQRSHITMNVELAGE
HHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEEEECCC
LPVEALVRMAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDIAMRLNADERIVA
CCHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
YVLEAENFESIHNHSAYAVIERDKRLEPTA
EEECCCCHHHHHCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA