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The map label for this gene is dxs [H]

Identifier: 73540585

GI number: 73540585

Start: 958926

End: 960842

Strand: Direct

Name: dxs [H]

Synonym: Reut_A0882

Alternate gene names: 73540585

Gene position: 958926-960842 (Clockwise)

Preceding gene: 73540584

Following gene: 73540586

Centisome position: 25.19

GC content: 66.35

Gene sequence:

>1917_bases
ATGACCTACGCACTGCTCAAAAAGATTGACGCCCCCGCAGACCTGCGCAAGCTCGACCGGCGCGAGCTGCGGACACTGGC
CGATGAACTTCGCGCCTACGTGCTGGAGTCGGTCTCGCAGACCGGCGGCCACCTCTCGTCGAATCTCGGCACGGTGGAAC
TGACCATCGCGCTGCACTACGTATTCCATACGCCCGACGACCGTGTCGTCTGGGACGTGGGCCACCAGAGCTATCCGCAC
AAGATCCTGACGGGCCGGCGCGAGCGCATGAATACGCTGCGCCAGTTCGGCGGCATCTCGGGCTTCCCGCGCCGCAGCGA
AAGCCAGTACGACACTTTCGGTACCGCGCATTCGTCGACCTCGATCTCGGCCGCGCTCGGCATGGCGCTGGGCGCGCGCA
CGCTCGGCGAGCAGCGCGTGTCGATCGCCGTGATCGGCGATGGCGCGATGACCGCGGGCATGGCCTTCGAAGCCCTGAAC
AACGCGGGTGTTTACAAGGACCTGCCGCTGGTGGTCGTGCTCAACGACAACGACATGTCGATCTCGCCGCCGGTCGGCGC
GCTCAACAAGCATCTGGCGCGGCTGCTCAGCGGACAGTTCTATGCTGCCACCAAGAAGGGCATCGAGAAGGTGCTGTCGG
TGGCCCCGCCGGTGCTCGAATTCGCCAAGCGCTTCGAGGAACACGCCAAGGGCATGATGGTGCCGGCGACGCTGTTCGAA
GAGTTCGGCTTCAACTACATCGGCCCCATCGACGGCCACGACCTCGACTCGCTGGTGCCGACGCTGCAGAACATCCGCAA
GCGCGCGCTCGAAGGCGCGGGCCCGCAGTTCCTGCACGTGGTGACCAAGAAGGGCCAGGGCTACAAGCTGGCCGAGGCCG
ACCCGATCCTGTATCACGGCCCTGGCAAGTTCAACCCGGCCGAAGGCATCCGCCCGGCCGCGAAGCCCGCGCGCAAGACC
TACACGCAGGTCTTCGGTGAATGGCTGTGCGACATGGCCGCCGCGGACAAGCGCCTGATCGGCATTACGCCGGCAATGCG
CGAAGGCTCGGGCATGGTCGAGTTTGAGAAGCGCTTCCCGGAGCGCTACTATGACGTGGGCATCGCCGAGCAGCATGCCG
TGACGTTCGCGGGCGGCATGGCTTGCGAAGGACTGAAGCCCATCGTGGCGATTTATTCGACGTTCCTGCAGCGTGGCTAT
GACCAGTTGATCCACGACGTGGCGCTGCAGAACCTGCCGGTGGTGTTTGCGCTGGACCGCGCGGGCCTGGTCGGCGCCGA
CGGCGCCACGCACGCGGGTGCCTACGATATCGCCTACCTGCGCTGCATCCCCAACATGATGGTGATGACGCCGTCCGACG
AGAACGAGTGCCGTCAGTTGCTGACGACCGCGTTCCACCAGAACTGCCCGACTGCCGTGCGCTATCCGCGCGGCGCTGGC
CAGGGTGTGGCGACGGAAGCTGTACTGAAGGATGTGCCGGTGGGCAAGGGCGTGATGCGCCGTACGGGCGGCGCACGCTC
GGGCCAGCGCGTGGCGTTCCTGGGTTTTGGTTCGATGGTGCACCCGGCGCTTGGCGCGGCGCAGGCGCTCGACGCCTCGG
TGGCGGACATGCGCTTCGTCAAGCCGCTCGACGTTGAACTCGTCAAGCGACTGGCGGAGGAGCACAACTACCTCGTGACC
GTGGAAGAGGGCAGTGTCATGGGCGGTGCTGGCAGTGCCGTGCTGGAAGCGCTGGCGGAAGCGGGCATCGACATCCCGGT
ACTCGTGCTGGGCCTGCCCGACCGCTTCATCGACCATGGCGATCCAGCCCTGCTGCTGTCGCAGTGCGGGCTCGACGCCG
CCGGCATCGAGCGCTCGGTACGTGAGCGTTTCGGCATCGGCCAGGCACCCGTCGCGGTTGCTTCTCGCGTGGCCTGA

Upstream 100 bases:

>100_bases
GCACGCGCGGGCCGCCTGGCCGATCTGGCGGACCTGATCGTGCTGCGCACACATTGAACACACAAGCCGGACAGCAGAAA
CCGGCGGCCGAACGGACATC

Downstream 100 bases:

>100_bases
TCCACGGCAGGCGCACGGCATCACCCGTACGATCTGTAAGGGTACGGAGCCGCTTTCGGCGGCTCCGTGTGAATTCCCTT
AAACTTCCCGTTTTTGTGTT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MTYALLKKIDAPADLRKLDRRELRTLADELRAYVLESVSQTGGHLSSNLGTVELTIALHYVFHTPDDRVVWDVGHQSYPH
KILTGRRERMNTLRQFGGISGFPRRSESQYDTFGTAHSSTSISAALGMALGARTLGEQRVSIAVIGDGAMTAGMAFEALN
NAGVYKDLPLVVVLNDNDMSISPPVGALNKHLARLLSGQFYAATKKGIEKVLSVAPPVLEFAKRFEEHAKGMMVPATLFE
EFGFNYIGPIDGHDLDSLVPTLQNIRKRALEGAGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPAEGIRPAAKPARKT
YTQVFGEWLCDMAAADKRLIGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGMACEGLKPIVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAYLRCIPNMMVMTPSDENECRQLLTTAFHQNCPTAVRYPRGAG
QGVATEAVLKDVPVGKGVMRRTGGARSGQRVAFLGFGSMVHPALGAAQALDASVADMRFVKPLDVELVKRLAEEHNYLVT
VEEGSVMGGAGSAVLEALAEAGIDIPVLVLGLPDRFIDHGDPALLLSQCGLDAAGIERSVRERFGIGQAPVAVASRVA

Sequences:

>Translated_638_residues
MTYALLKKIDAPADLRKLDRRELRTLADELRAYVLESVSQTGGHLSSNLGTVELTIALHYVFHTPDDRVVWDVGHQSYPH
KILTGRRERMNTLRQFGGISGFPRRSESQYDTFGTAHSSTSISAALGMALGARTLGEQRVSIAVIGDGAMTAGMAFEALN
NAGVYKDLPLVVVLNDNDMSISPPVGALNKHLARLLSGQFYAATKKGIEKVLSVAPPVLEFAKRFEEHAKGMMVPATLFE
EFGFNYIGPIDGHDLDSLVPTLQNIRKRALEGAGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPAEGIRPAAKPARKT
YTQVFGEWLCDMAAADKRLIGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGMACEGLKPIVAIYSTFLQRGY
DQLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAYLRCIPNMMVMTPSDENECRQLLTTAFHQNCPTAVRYPRGAG
QGVATEAVLKDVPVGKGVMRRTGGARSGQRVAFLGFGSMVHPALGAAQALDASVADMRFVKPLDVELVKRLAEEHNYLVT
VEEGSVMGGAGSAVLEALAEAGIDIPVLVLGLPDRFIDHGDPALLLSQCGLDAAGIERSVRERFGIGQAPVAVASRVA
>Mature_637_residues
TYALLKKIDAPADLRKLDRRELRTLADELRAYVLESVSQTGGHLSSNLGTVELTIALHYVFHTPDDRVVWDVGHQSYPHK
ILTGRRERMNTLRQFGGISGFPRRSESQYDTFGTAHSSTSISAALGMALGARTLGEQRVSIAVIGDGAMTAGMAFEALNN
AGVYKDLPLVVVLNDNDMSISPPVGALNKHLARLLSGQFYAATKKGIEKVLSVAPPVLEFAKRFEEHAKGMMVPATLFEE
FGFNYIGPIDGHDLDSLVPTLQNIRKRALEGAGPQFLHVVTKKGQGYKLAEADPILYHGPGKFNPAEGIRPAAKPARKTY
TQVFGEWLCDMAAADKRLIGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGMACEGLKPIVAIYSTFLQRGYD
QLIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAYLRCIPNMMVMTPSDENECRQLLTTAFHQNCPTAVRYPRGAGQ
GVATEAVLKDVPVGKGVMRRTGGARSGQRVAFLGFGSMVHPALGAAQALDASVADMRFVKPLDVELVKRLAEEHNYLVTV
EEGSVMGGAGSAVLEALAEAGIDIPVLVLGLPDRFIDHGDPALLLSQCGLDAAGIERSVRERFGIGQAPVAVASRVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=647, Percent_Identity=23.8021638330757, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4507521, Length=647, Percent_Identity=23.8021638330757, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637463, Length=304, Percent_Identity=27.3026315789474, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI225637459, Length=304, Percent_Identity=27.3026315789474, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI225637461, Length=260, Percent_Identity=27.3076923076923, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI133778974, Length=647, Percent_Identity=23.8021638330757, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI156564403, Length=245, Percent_Identity=26.9387755102041, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=56.4516129032258, Blast_Score=729, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=628, Percent_Identity=23.5668789808917, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=257, Percent_Identity=25.6809338521401, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24666278, Length=640, Percent_Identity=25.3125, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45551847, Length=647, Percent_Identity=24.8840803709428, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550715, Length=647, Percent_Identity=24.8840803709428, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645119, Length=560, Percent_Identity=25.5357142857143, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68748; Mature: 68617

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYALLKKIDAPADLRKLDRRELRTLADELRAYVLESVSQTGGHLSSNLGTVELTIALHY
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEEEE
VFHTPDDRVVWDVGHQSYPHKILTGRRERMNTLRQFGGISGFPRRSESQYDTFGTAHSST
EEECCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCC
SISAALGMALGARTLGEQRVSIAVIGDGAMTAGMAFEALNNAGVYKDLPLVVVLNDNDMS
HHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
ISPPVGALNKHLARLLSGQFYAATKKGIEKVLSVAPPVLEFAKRFEEHAKGMMVPATLFE
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHH
EFGFNYIGPIDGHDLDSLVPTLQNIRKRALEGAGPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCEEEEC
PGKFNPAEGIRPAAKPARKTYTQVFGEWLCDMAAADKRLIGITPAMREGSGMVEFEKRFP
CCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCCHHHHHCC
ERYYDVGIAEQHAVTFAGGMACEGLKPIVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
HHHHCCCCCHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGAYDIAYLRCIPNMMVMTPSDENECRQLLTTAFHQNCPTAVRYPRGAG
CCEECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHCCCCCCC
QGVATEAVLKDVPVGKGVMRRTGGARSGQRVAFLGFGSMVHPALGAAQALDASVADMRFV
CCHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KPLDVELVKRLAEEHNYLVTVEEGSVMGGAGSAVLEALAEAGIDIPVLVLGLPDRFIDHG
CCCCHHHHHHHHHCCCEEEEEECCCEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHCCC
DPALLLSQCGLDAAGIERSVRERFGIGQAPVAVASRVA
CHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure 
TYALLKKIDAPADLRKLDRRELRTLADELRAYVLESVSQTGGHLSSNLGTVELTIALHY
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEEEEE
VFHTPDDRVVWDVGHQSYPHKILTGRRERMNTLRQFGGISGFPRRSESQYDTFGTAHSST
EEECCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCC
SISAALGMALGARTLGEQRVSIAVIGDGAMTAGMAFEALNNAGVYKDLPLVVVLNDNDMS
HHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCC
ISPPVGALNKHLARLLSGQFYAATKKGIEKVLSVAPPVLEFAKRFEEHAKGMMVPATLFE
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHH
EFGFNYIGPIDGHDLDSLVPTLQNIRKRALEGAGPQFLHVVTKKGQGYKLAEADPILYHG
HCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCEEEEC
PGKFNPAEGIRPAAKPARKTYTQVFGEWLCDMAAADKRLIGITPAMREGSGMVEFEKRFP
CCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCCHHHHHCC
ERYYDVGIAEQHAVTFAGGMACEGLKPIVAIYSTFLQRGYDQLIHDVALQNLPVVFALDR
HHHHCCCCCHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGATHAGAYDIAYLRCIPNMMVMTPSDENECRQLLTTAFHQNCPTAVRYPRGAG
CCEECCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHCCCCCCC
QGVATEAVLKDVPVGKGVMRRTGGARSGQRVAFLGFGSMVHPALGAAQALDASVADMRFV
CCHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KPLDVELVKRLAEEHNYLVTVEEGSVMGGAGSAVLEALAEAGIDIPVLVLGLPDRFIDHG
CCCCHHHHHHHHHCCCEEEEEECCCEECCCHHHHHHHHHHCCCCCEEEEEECCHHHHCCC
DPALLLSQCGLDAAGIERSVRERFGIGQAPVAVASRVA
CHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA