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The map label for this gene is fppS [H]

Identifier: 73540584

GI number: 73540584

Start: 957998

End: 958882

Strand: Direct

Name: fppS [H]

Synonym: Reut_A0881

Alternate gene names: 73540584

Gene position: 957998-958882 (Clockwise)

Preceding gene: 73540583

Following gene: 73540585

Centisome position: 25.17

GC content: 68.36

Gene sequence:

>885_bases
ATGACCGAATTCGCAAGCTGGATGCGGGCGCAGGGGGCCCGGACCGAGGCCGCGCTGGACCAAACGTTGCCAAATGCCGA
CACCGTGCCGCATACACTGCATGAGGCCATGCGCTATGCTGTGCTCGGCGGTGGCAAGCGCGTGCGGCCGCTGCTGGTGC
ATGCCGCCGGTGAAGTGACGGGTGCGAGCGCCGAGGCCTGCGACGCCGCAGCCTGCGCGGTGGAGATGATCCACGCCTAC
TCGCTTGTACACGACGACATGCCCTGCATGGATGACGACGACCTGCGCCGCGGCCGCCCGACCGTGCACAAGGCCTATGA
CGAAGCCACGGCGCTGCTCGTCGGCGACGCGCTGCAGACGCAGGCGTTCATCGTGCTGGCGCAGGCACAATCGGTACAGG
CCGAGGCGCGGCTGAAGCTCGTGGCCGAACTGGCCGTGGCATCTGGCTCGGTCGGCATGGCCGGTGGCCAGGCCATCGAC
CTGCAGAACGTGGGCAAGGCCATGTCGCGCGATGCGCTGGAGGCCATGCACCGCATGAAGACCGGTGCGCTGCTGCGCGC
AAGCGTGCGCATGGGCGCGCTCTGTGGTGAAATCGACGCGCAGGGACTGTCGGCGCTGGACCGGTATGCCGCAGCCGTGG
GTTTGGCGTTTCAGGTAGTAGACGATATTCTGGACGTCACCGCCGATACCGCCACGCTTGGCAAGACCGCCGGCAAGGAC
GCCGCGCATGACAAGCCGACCTATGTCTCGCTGATGGGGCTGGAAGCGGCGCGCGCACTGGCGGCCGAGCTGCGCGAGTC
CGCGCATGCGGCACTGGCCGGTTTCGGCGCACGCGCGGGCCGCCTGGCCGATCTGGCGGACCTGATCGTGCTGCGCACAC
ATTGA

Upstream 100 bases:

>100_bases
AGCAGCAGGTCAGGGTACTCGAAGGCGACGTGCTGAAGCCCATGGCCGGTGATGCCGGAAACGCCGGAAACGCCGGAAAC
GCCAACGGCATGGAGCAGGA

Downstream 100 bases:

>100_bases
ACACACAAGCCGGACAGCAGAAACCGGCGGCCGAACGGACATCATGACCTACGCACTGCTCAAAAAGATTGACGCCCCCG
CAGACCTGCGCAAGCTCGAC

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTEFASWMRAQGARTEAALDQTLPNADTVPHTLHEAMRYAVLGGGKRVRPLLVHAAGEVTGASAEACDAAACAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQTQAFIVLAQAQSVQAEARLKLVAELAVASGSVGMAGGQAID
LQNVGKAMSRDALEAMHRMKTGALLRASVRMGALCGEIDAQGLSALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
AAHDKPTYVSLMGLEAARALAAELRESAHAALAGFGARAGRLADLADLIVLRTH

Sequences:

>Translated_294_residues
MTEFASWMRAQGARTEAALDQTLPNADTVPHTLHEAMRYAVLGGGKRVRPLLVHAAGEVTGASAEACDAAACAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQTQAFIVLAQAQSVQAEARLKLVAELAVASGSVGMAGGQAID
LQNVGKAMSRDALEAMHRMKTGALLRASVRMGALCGEIDAQGLSALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
AAHDKPTYVSLMGLEAARALAAELRESAHAALAGFGARAGRLADLADLIVLRTH
>Mature_293_residues
TEFASWMRAQGARTEAALDQTLPNADTVPHTLHEAMRYAVLGGGKRVRPLLVHAAGEVTGASAEACDAAACAVEMIHAYS
LVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQTQAFIVLAQAQSVQAEARLKLVAELAVASGSVGMAGGQAIDL
QNVGKAMSRDALEAMHRMKTGALLRASVRMGALCGEIDAQGLSALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKDA
AHDKPTYVSLMGLEAARALAAELRESAHAALAGFGARAGRLADLADLIVLRTH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=220, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786623, Length=265, Percent_Identity=52.8301886792453, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789578, Length=214, Percent_Identity=33.6448598130841, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24651612, Length=212, Percent_Identity=26.4150943396226, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30694; Mature: 30563

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFASWMRAQGARTEAALDQTLPNADTVPHTLHEAMRYAVLGGGKRVRPLLVHAAGEVT
CCHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHEEEECCCCC
GASAEACDAAACAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFIVLAQAQSVQAEARLKLVAELAVASGSVGMAGGQAIDLQNVGKAMSRDALEAMHRMK
HHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
TGALLRASVRMGALCGEIDAQGLSALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
AAHDKPTYVSLMGLEAARALAAELRESAHAALAGFGARAGRLADLADLIVLRTH
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECC
>Mature Secondary Structure 
TEFASWMRAQGARTEAALDQTLPNADTVPHTLHEAMRYAVLGGGKRVRPLLVHAAGEVT
CHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHEEEECCCCC
GASAEACDAAACAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHKAYDEATALLVGDALQT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFIVLAQAQSVQAEARLKLVAELAVASGSVGMAGGQAIDLQNVGKAMSRDALEAMHRMK
HHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHH
TGALLRASVRMGALCGEIDAQGLSALDRYAAAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
AAHDKPTYVSLMGLEAARALAAELRESAHAALAGFGARAGRLADLADLIVLRTH
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]