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The map label for this gene is kynU [H]

Identifier: 73540511

GI number: 73540511

Start: 878043

End: 879299

Strand: Reverse

Name: kynU [H]

Synonym: Reut_A0808

Alternate gene names: 73540511

Gene position: 879299-878043 (Counterclockwise)

Preceding gene: 73540512

Following gene: 73540510

Centisome position: 23.1

GC content: 66.43

Gene sequence:

>1257_bases
ATGACTGCACTGACCCGCGAGCAATGCCTGTTGCTCGACCAGCAAGACCCCCTGCGCGCATTGCGCGACCAGTTCGCGCT
ACCTGACGGCGTGATCTACCTCGATGGCAATTCGCTGGGCGCCCGCCCGCGCGCAGCTGCGGCACGTGCCGCCGAAGTCG
TCAGCGAGGAATGGGGCACTGGCCTGATCCGCAGCTGGAACACCGCGGGCTGGTTCGACCTGCCGCAGCGCCTCGGAAAC
ATGCTGGCTCCGCTGATTGGCGCCGGCGAGAACGAGGTGGTGGTCACCGATACCACGTCGATCAACCTGTTCAAGGTGCT
GGCCGCCGCGCTGCGCGTGCAGGCCACGCGAGATCCGTCGCGCAAGGTGATCGTGTCTGAAGCAAGCAATTTCCCGACCG
ACCTGTATATCGCGCAAGGTCTGGCGGATCTGCTGCAGCAAGGCTATTCGCTGCGCCTGGTGAACTCGCCGGCCGAGATC
GATGCCGCCGTCGGCGCCGACACCGCCGTGCTGATGCTCACGCACGTGAACTACAAGAGCGGCGAGATGCTCGACATGGC
CGCGCTGACCGAACTCGCCCATGCGCGCGGCGCGTTGACCGTGTGGGACCTCTGCCATTCGGCAGGCGCCGTGCCCGTGG
CACTGAACGCGTCGAAGGCTGACTACGCGATCGGCTGCACCTACAAGTACCTCAACGGCGGCCCGGGTTCGCCGGCCTTC
GTGTGGGTCGCGCCGGCGCTGCGCGATGCCTTCTGGCAGCCGCTGTCGGGCTGGTGGGGCCACGCCGCGCCGTTCGCGAT
GGATCCGCAATACCGCCCTGTCGAAGGTGTGCGCCGTTTCCTGTGCGGCACGCAGCCGATCACGTCGATGGCGATGGTCG
AATGCGGACTCGACATCTACGCACAAACCGACATGGCGGCGCTGCGCGCCAAGTCGCTTCAACTTACCGACCTGTTCATC
GCGCTCGTGGAATCGCGTTGCGGCCACCACCCGCTCACGCTGGTCACGCCGCGCGAGCACGCACGCCGCGGCAGCCAGGT
CAGCTTCGAACATCCGCAAGGCTATGCCGTGATGCAGGCACTGATCGAGCGCGGCGTGATCGGCGATTACCGCGAGCCGC
GCATCATCCGTTTCGGCTTCACGCCGCTGTACACGAGCTTCACCGAAGTGTGGGACGCCGTGGAAACGCTGCGCGACGTG
CTGGATACCGAAACCCACCGGGCCGAGCGCTTCCATACGCGCGGCGCAGTGACCTGA

Upstream 100 bases:

>100_bases
CGCTGCCGCTGCGCTTTACCGGGCTCGACGCAAGCCCGGTGCGTGCCGTGCTGCGCAGCCTTGACTGAACACCCCCCGTA
ATCCTTTGCCTCTTTCCGAC

Downstream 100 bases:

>100_bases
GCGGAGCGCACCATGAGCGAATTCAAGGGATGCCCGATGTCGGGCGCGGTACGGCAAGGCGGACAAGGCAAGCAGGGCGA
CGGCTGGCACGGCGCGCAGA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTALTREQCLLLDQQDPLRALRDQFALPDGVIYLDGNSLGARPRAAAARAAEVVSEEWGTGLIRSWNTAGWFDLPQRLGN
MLAPLIGAGENEVVVTDTTSINLFKVLAAALRVQATRDPSRKVIVSEASNFPTDLYIAQGLADLLQQGYSLRLVNSPAEI
DAAVGADTAVLMLTHVNYKSGEMLDMAALTELAHARGALTVWDLCHSAGAVPVALNASKADYAIGCTYKYLNGGPGSPAF
VWVAPALRDAFWQPLSGWWGHAAPFAMDPQYRPVEGVRRFLCGTQPITSMAMVECGLDIYAQTDMAALRAKSLQLTDLFI
ALVESRCGHHPLTLVTPREHARRGSQVSFEHPQGYAVMQALIERGVIGDYREPRIIRFGFTPLYTSFTEVWDAVETLRDV
LDTETHRAERFHTRGAVT

Sequences:

>Translated_418_residues
MTALTREQCLLLDQQDPLRALRDQFALPDGVIYLDGNSLGARPRAAAARAAEVVSEEWGTGLIRSWNTAGWFDLPQRLGN
MLAPLIGAGENEVVVTDTTSINLFKVLAAALRVQATRDPSRKVIVSEASNFPTDLYIAQGLADLLQQGYSLRLVNSPAEI
DAAVGADTAVLMLTHVNYKSGEMLDMAALTELAHARGALTVWDLCHSAGAVPVALNASKADYAIGCTYKYLNGGPGSPAF
VWVAPALRDAFWQPLSGWWGHAAPFAMDPQYRPVEGVRRFLCGTQPITSMAMVECGLDIYAQTDMAALRAKSLQLTDLFI
ALVESRCGHHPLTLVTPREHARRGSQVSFEHPQGYAVMQALIERGVIGDYREPRIIRFGFTPLYTSFTEVWDAVETLRDV
LDTETHRAERFHTRGAVT
>Mature_417_residues
TALTREQCLLLDQQDPLRALRDQFALPDGVIYLDGNSLGARPRAAAARAAEVVSEEWGTGLIRSWNTAGWFDLPQRLGNM
LAPLIGAGENEVVVTDTTSINLFKVLAAALRVQATRDPSRKVIVSEASNFPTDLYIAQGLADLLQQGYSLRLVNSPAEID
AAVGADTAVLMLTHVNYKSGEMLDMAALTELAHARGALTVWDLCHSAGAVPVALNASKADYAIGCTYKYLNGGPGSPAFV
WVAPALRDAFWQPLSGWWGHAAPFAMDPQYRPVEGVRRFLCGTQPITSMAMVECGLDIYAQTDMAALRAKSLQLTDLFIA
LVESRCGHHPLTLVTPREHARRGSQVSFEHPQGYAVMQALIERGVIGDYREPRIIRFGFTPLYTSFTEVWDAVETLRDVL
DTETHRAERFHTRGAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=436, Percent_Identity=27.2935779816514, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI74101437, Length=254, Percent_Identity=24.8031496062992, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550466, Length=431, Percent_Identity=25.2900232018561, Blast_Score=141, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=28.0701754385965, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45739; Mature: 45607

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALTREQCLLLDQQDPLRALRDQFALPDGVIYLDGNSLGARPRAAAARAAEVVSEEWGT
CCCCCCCHHHEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
GLIRSWNTAGWFDLPQRLGNMLAPLIGAGENEVVVTDTTSINLFKVLAAALRVQATRDPS
CHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCC
RKVIVSEASNFPTDLYIAQGLADLLQQGYSLRLVNSPAEIDAAVGADTAVLMLTHVNYKS
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEEEEECCCCC
GEMLDMAALTELAHARGALTVWDLCHSAGAVPVALNASKADYAIGCTYKYLNGGPGSPAF
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEE
VWVAPALRDAFWQPLSGWWGHAAPFAMDPQYRPVEGVRRFLCGTQPITSMAMVECGLDIY
EEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCHHE
AQTDMAALRAKSLQLTDLFIALVESRCGHHPLTLVTPREHARRGSQVSFEHPQGYAVMQA
ECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCCCCCCHHHHHH
LIERGVIGDYREPRIIRFGFTPLYTSFTEVWDAVETLRDVLDTETHRAERFHTRGAVT
HHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TALTREQCLLLDQQDPLRALRDQFALPDGVIYLDGNSLGARPRAAAARAAEVVSEEWGT
CCCCCCHHHEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
GLIRSWNTAGWFDLPQRLGNMLAPLIGAGENEVVVTDTTSINLFKVLAAALRVQATRDPS
CHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCC
RKVIVSEASNFPTDLYIAQGLADLLQQGYSLRLVNSPAEIDAAVGADTAVLMLTHVNYKS
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEEEEECCCCC
GEMLDMAALTELAHARGALTVWDLCHSAGAVPVALNASKADYAIGCTYKYLNGGPGSPAF
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEE
VWVAPALRDAFWQPLSGWWGHAAPFAMDPQYRPVEGVRRFLCGTQPITSMAMVECGLDIY
EEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCHHE
AQTDMAALRAKSLQLTDLFIALVESRCGHHPLTLVTPREHARRGSQVSFEHPQGYAVMQA
ECCHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCCCCCCHHHHHH
LIERGVIGDYREPRIIRFGFTPLYTSFTEVWDAVETLRDVLDTETHRAERFHTRGAVT
HHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA