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The map label for this gene is kynA [H]

Identifier: 73540510

GI number: 73540510

Start: 877146

End: 878030

Strand: Reverse

Name: kynA [H]

Synonym: Reut_A0807

Alternate gene names: 73540510

Gene position: 878030-877146 (Counterclockwise)

Preceding gene: 73540511

Following gene: 73540508

Centisome position: 23.07

GC content: 62.71

Gene sequence:

>885_bases
ATGAGCGAATTCAAGGGATGCCCGATGTCGGGCGCGGTACGGCAAGGCGGACAAGGCAAGCAGGGCGACGGCTGGCACGG
CGCGCAGATGGACTTCGCCAAGGACATGAGCTATGGCGACTACCTGGGCCTGGACCAAATTCTGAGCGCGCAGCATCCGC
TGTCGCCCGACCACAACGAGATGCTCTTCATCGTGCAGCACCAGACCACCGAGCTGTGGATGAAGCTGATGCTGCACGAA
CTGCGCGCGGCGCGTGCATCGGTGCGCGAAGACGTCCTGCCGCCGGCCTTCAAGATGCTGACGCGCGTATCGCGCATCAT
GGACCAGCTTGTCCAGGCGTGGAACGTGCTGGCAACCATGACGCCGCCGGAATATTCGGCGATGCGACCCTACCTGGGCA
TGTCGTCCGGCTTCCAGTCGTATCAGTACCGCGAGATCGAGTTCATCCTCGGCAACAAGAACGCGGCCATGCTGCGCCCG
CATTCACACCGGCCGGAACATCTGGAACTGGTGGAGACGGCCCTGAAAACGCCGTCGCTCTATGACGAGGCAATCCGCCT
GATGGCGCGCCGCGGCTTTGCCATCGACGCCAATTGTGTCGAGCGCGACTGGAGCCAGCCGACGACCTACAACGCCTCGG
TCGAAGCGGCGTGGCTTGAGGTCTACCGGAATCCGAACGCGCACTGGGAGCTGTACGAACTCGGCGAGAAGTTTGTCGAC
CTCGAAGACTCGTTCCGCCAATGGCGCTTCCGCCATGTGACCACGGTCGAGCGCGTGATCGGCTTCAAGCGCGGTACCGG
CGGCACCGAAGGCGTCAGCTATCTGCGCAAGATGCTCGACGTGGTGCTGTTCCCGGAACTGTGGAAACTGCGTACGGACC
TGTAA

Upstream 100 bases:

>100_bases
GTGGGACGCCGTGGAAACGCTGCGCGACGTGCTGGATACCGAAACCCACCGGGCCGAGCGCTTCCATACGCGCGGCGCAG
TGACCTGAGCGGAGCGCACC

Downstream 100 bases:

>100_bases
GGCGGCAGCGAGCCAGCAAGGCCGGCGTCAGCCGGCCGGATCCGACAGGCGTGCGGCCAGCGCCTTCAGGGCCGGTGCAA
GGGTTTCGTGGAACACGGAC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSEFKGCPMSGAVRQGGQGKQGDGWHGAQMDFAKDMSYGDYLGLDQILSAQHPLSPDHNEMLFIVQHQTTELWMKLMLHE
LRAARASVREDVLPPAFKMLTRVSRIMDQLVQAWNVLATMTPPEYSAMRPYLGMSSGFQSYQYREIEFILGNKNAAMLRP
HSHRPEHLELVETALKTPSLYDEAIRLMARRGFAIDANCVERDWSQPTTYNASVEAAWLEVYRNPNAHWELYELGEKFVD
LEDSFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRKMLDVVLFPELWKLRTDL

Sequences:

>Translated_294_residues
MSEFKGCPMSGAVRQGGQGKQGDGWHGAQMDFAKDMSYGDYLGLDQILSAQHPLSPDHNEMLFIVQHQTTELWMKLMLHE
LRAARASVREDVLPPAFKMLTRVSRIMDQLVQAWNVLATMTPPEYSAMRPYLGMSSGFQSYQYREIEFILGNKNAAMLRP
HSHRPEHLELVETALKTPSLYDEAIRLMARRGFAIDANCVERDWSQPTTYNASVEAAWLEVYRNPNAHWELYELGEKFVD
LEDSFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRKMLDVVLFPELWKLRTDL
>Mature_293_residues
SEFKGCPMSGAVRQGGQGKQGDGWHGAQMDFAKDMSYGDYLGLDQILSAQHPLSPDHNEMLFIVQHQTTELWMKLMLHEL
RAARASVREDVLPPAFKMLTRVSRIMDQLVQAWNVLATMTPPEYSAMRPYLGMSSGFQSYQYREIEFILGNKNAAMLRPH
SHRPEHLELVETALKTPSLYDEAIRLMARRGFAIDANCVERDWSQPTTYNASVEAAWLEVYRNPNAHWELYELGEKFVDL
EDSFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRKMLDVVLFPELWKLRTDL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=366, Percent_Identity=27.0491803278689, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564651, Length=202, Percent_Identity=29.2079207920792, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17552370, Length=202, Percent_Identity=29.2079207920792, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17530891, Length=329, Percent_Identity=29.483282674772, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 33892; Mature: 33761

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFKGCPMSGAVRQGGQGKQGDGWHGAQMDFAKDMSYGDYLGLDQILSAQHPLSPDHNE
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCCCCCC
MLFIVQHQTTELWMKLMLHELRAARASVREDVLPPAFKMLTRVSRIMDQLVQAWNVLATM
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPEYSAMRPYLGMSSGFQSYQYREIEFILGNKNAAMLRPHSHRPEHLELVETALKTPSL
CCCCHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCHH
YDEAIRLMARRGFAIDANCVERDWSQPTTYNASVEAAWLEVYRNPNAHWELYELGEKFVD
HHHHHHHHHHCCCEECCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHC
LEDSFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRKMLDVVLFPELWKLRTDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEFKGCPMSGAVRQGGQGKQGDGWHGAQMDFAKDMSYGDYLGLDQILSAQHPLSPDHNE
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCCCCCCCC
MLFIVQHQTTELWMKLMLHELRAARASVREDVLPPAFKMLTRVSRIMDQLVQAWNVLATM
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPPEYSAMRPYLGMSSGFQSYQYREIEFILGNKNAAMLRPHSHRPEHLELVETALKTPSL
CCCCHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCHH
YDEAIRLMARRGFAIDANCVERDWSQPTTYNASVEAAWLEVYRNPNAHWELYELGEKFVD
HHHHHHHHHHCCCEECCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHC
LEDSFRQWRFRHVTTVERVIGFKRGTGGTEGVSYLRKMLDVVLFPELWKLRTDL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA