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The map label for this gene is mmgC [H]

Identifier: 73540508

GI number: 73540508

Start: 874904

End: 876097

Strand: Reverse

Name: mmgC [H]

Synonym: Reut_A0805

Alternate gene names: 73540508

Gene position: 876097-874904 (Counterclockwise)

Preceding gene: 73540510

Following gene: 73540507

Centisome position: 23.02

GC content: 63.99

Gene sequence:

>1194_bases
ATGGCTGCCAACGCCGAATTCCACTGGGCCGATCCCCTGCTGCTGGACCAGCAACTGACCGCCGACGAGCGCGCCGTGCG
TGACGCCTCCGCGGCGTACTGTCAGGACAAGCTGATGCCGCGCGTGCTCCAGTCGTTCCGCAATGAAAAAACCGACGTGG
AAATCTTCCGCGAGATGGGCGAACTGGGCCTGCTGGGTCCGACCATCCCCGAGCAGTATGGCGGCCCGGGCCTGAACTAC
GTGAGCTATGGCCTGATCGCACGCGAGGTCGAGCGTGTAGATTCGGGCTACCGCTCGATGATGAGCGTGCAGTCGTCGCT
GGTCATGGTGCCGATCTATGAATTCGGCACCGAAGCGCAGAAGCAGAAGTACCTGCCCAAGCTGGCCACCGGCGAGTGGA
TCGGCTGCTTCGGCCTGACCGAGCCGAACCACGGCTCCGACCCGGGCTCGATGGTCACGCGCGCCAAGAAGGTCAATGGC
GGCTACGAGCTGACCGGCGCCAAGATGTGGATCACCAACTCGCCGATCGCCGACGTGTTTGTGGTATGGGCCAAGCTGGC
GGGTGAAGACGGCAAGGAAGATATCCGTGGCTTTATCCTGGAAAAGGGCTGGAAGGGCCTGAGCGCCCCGGCCATCCACG
GCAAGGTCGGCCTGCGTACGTCGATCACCGGCGAAATCGTGCTCGACCAGGTCTTCGTGCCGGAAGAGAACATCATGCCG
GGCGTGAAGGGCCTGAAGGGTCCGTTCACCTGCCTGAACTCCGCCCGCTACGGTATTGCCTGGGGCGCGCTCGGTGCCGC
CGAATTCTGCTGGCACACCGCCCGCCAGTACACGCTGGACCGCAAGCAATTTGGCCGCCCGCTGGCCCAGACTCAACTGG
TGCAGAAGAAGCTGGCCGACATGCAGACCGAGATCACGCTGGGCCTGCAAGGCTGCCTGCGCCTTGGCCGCATGAAAGAC
GAAGGCACGGCCGCCGTGGAAATCACCTCGATCATGAAGCGCAATTCGTGCGGCAAGTCGCTCGACATCGCCCGCGTGGC
GCGTGACATGCTCGGCGGCAACGGCATCTCGGACGAATTCGGCGTGATCCGCCACGTGGTGAACCTGGAAGTGGTCAACA
CCTACGAAGGCACGCACGACATCCACGCGCTGATCCTGGGCCGCGCCCAGACCGGCCTCCAGGCCTTCTTCTGA

Upstream 100 bases:

>100_bases
GCGGAACTTAAAAATTCCACCGATTCCATCGATTGCCGCTGAGGCGGGTGCATCCCAAAGCGCCTGGCAGCGGTTCCCCG
CTCTACCGAAGGAGACCTGC

Downstream 100 bases:

>100_bases
TCCGGAATCGGATATCTGGCACTCGTTTCGTCTCTGCGCAGAAATAAAAAAAGCCCGGCTGGAAAGCCGGGCGAAGCACA
CTACCAAGGAGACGACGGGC

Product: Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MAANAEFHWADPLLLDQQLTADERAVRDASAAYCQDKLMPRVLQSFRNEKTDVEIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVNG
GYELTGAKMWITNSPIADVFVVWAKLAGEDGKEDIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
GVKGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAQTQLVQKKLADMQTEITLGLQGCLRLGRMKD
EGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF

Sequences:

>Translated_397_residues
MAANAEFHWADPLLLDQQLTADERAVRDASAAYCQDKLMPRVLQSFRNEKTDVEIFREMGELGLLGPTIPEQYGGPGLNY
VSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVNG
GYELTGAKMWITNSPIADVFVVWAKLAGEDGKEDIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
GVKGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAQTQLVQKKLADMQTEITLGLQGCLRLGRMKD
EGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF
>Mature_396_residues
AANAEFHWADPLLLDQQLTADERAVRDASAAYCQDKLMPRVLQSFRNEKTDVEIFREMGELGLLGPTIPEQYGGPGLNYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQKQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVNGG
YELTGAKMWITNSPIADVFVVWAKLAGEDGKEDIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMPG
VKGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAQTQLVQKKLADMQTEITLGLQGCLRLGRMKDE
GTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEFGVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=67.5062972292191, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI7669494, Length=377, Percent_Identity=66.3129973474801, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.5106382978723, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=34.2028985507246, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI4557233, Length=357, Percent_Identity=31.6526610644258, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4501859, Length=380, Percent_Identity=29.4736842105263, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI76496475, Length=337, Percent_Identity=33.5311572700297, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4557235, Length=337, Percent_Identity=33.5311572700297, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI21361497, Length=350, Percent_Identity=32.5714285714286, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4557231, Length=400, Percent_Identity=29, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI187960098, Length=400, Percent_Identity=29, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=28.1501340482574, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=28.8, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1786223, Length=337, Percent_Identity=25.5192878338279, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI87081958, Length=342, Percent_Identity=26.6081871345029, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87081702, Length=373, Percent_Identity=25.4691689008043, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17534353, Length=391, Percent_Identity=63.4271099744246, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17508101, Length=381, Percent_Identity=32.0209973753281, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.3529411764706, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=30.1369863013699, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=36.4963503649635, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=30.4, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=370, Percent_Identity=31.3513513513514, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=29.8941798941799, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=33.9285714285714, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=28.6842105263158, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=31.5018315018315, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=24.9329758713137, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=381, Percent_Identity=23.3595800524934, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=354, Percent_Identity=24.2937853107345, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19920834, Length=399, Percent_Identity=62.65664160401, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356377, Length=334, Percent_Identity=33.5329341317365, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=32.3287671232877, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24646207, Length=358, Percent_Identity=32.4022346368715, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=30.9333333333333, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=30.8707124010554, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=30.8988764044944, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43580; Mature: 43448

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANAEFHWADPLLLDQQLTADERAVRDASAAYCQDKLMPRVLQSFRNEKTDVEIFREMG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQ
HCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVNGGYELTGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCCHHHHH
VVWAKLAGEDGKEDIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHEEEHEEECCCCCCCC
GVKGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAQTQLVQKKLAD
CCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHH
MQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
GVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF
HHHHHHHHEEEEECCCCCHHHHHHEEHHHHHHHHHCC
>Mature Secondary Structure 
AANAEFHWADPLLLDQQLTADERAVRDASAAYCQDKLMPRVLQSFRNEKTDVEIFREMG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ELGLLGPTIPEQYGGPGLNYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIYEFGTEAQ
HCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHCCHHH
KQKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRAKKVNGGYELTGAKMWITNSPIADVF
HHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCCHHHHH
VVWAKLAGEDGKEDIRGFILEKGWKGLSAPAIHGKVGLRTSITGEIVLDQVFVPEENIMP
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCHHEEEHEEECCCCCCCC
GVKGLKGPFTCLNSARYGIAWGALGAAEFCWHTARQYTLDRKQFGRPLAQTQLVQKKLAD
CCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHH
MQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKSLDIARVARDMLGGNGISDEF
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
GVIRHVVNLEVVNTYEGTHDIHALILGRAQTGLQAFF
HHHHHHHHEEEEECCCCCHHHHHHEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]