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The map label for this gene is envZ [H]

Identifier: 73540280

GI number: 73540280

Start: 626638

End: 627927

Strand: Direct

Name: envZ [H]

Synonym: Reut_A0574

Alternate gene names: 73540280

Gene position: 626638-627927 (Clockwise)

Preceding gene: 73540279

Following gene: 73540287

Centisome position: 16.46

GC content: 66.67

Gene sequence:

>1290_bases
ATGACGAGTCCTGACATGAAGTTGCGTATTGATACCCTGTTTGGCCGCATAGCACTGCTGATTGCCGCCGTGCTGGTGAT
CAGCCATTTCTCGTGGCTGGCAATCCTGCGCATGGACCGGCGCCAGCAGCAGGTCGACTATTCGGTCGAGCAGATGCTGT
TCCAGTTCGCCAGCATCCAGCGCGCGCTCGACGCGCGCCCGCCCGTGCCGCTGCCAAGCCTGGTCGAAGTGGCCAGCGAG
GCCAGTGCCGAACAACATACCGTCGTACCCAAGGGCCGCTCGCGACGGCTCGTGGAGCAGTTCATCACGCGGCTGCCGCA
GGGCACCGAGATCCGGGTCGAAGACGAAGCCACGCCGCGGCTGTGGATCAAACTGCCGACGCGCAGCAACTGGATCGCGA
TGCCGATCCTGTGGGTCCACAATCCGCCGCCCGACAACCGCCTGGTGCCGGGCGTGATGCTCGTGGTGGGCGTCGCCATC
ATCTTTGCACTGCTGATTGCATGGCAGATCCAGCGGCCCGTGCGCGATATGGCGGCCGCGGCCGAGCAGCTTTCACGCCA
GCAGCCGGTGGCGCCGCTGCGCGAACGCGGGCCGCATGAACTGCGCCAGCTGATCGAGCGCTTCAACCGCATGGTGGCGG
ACCTCACCCGTATCGACCAGGAGCGCAACACCATGCTGGCCGGCATCGCGCACGACCTGAAAACGCCGCTCGCACGGTTG
CGGCTGCGTGCCGAGATGCTGTCCGACCCGAAGGCCGCGGCAGGCGTCACGCGCGATGTCGAATCCATGTCGGCGATCGT
GGAGCAGTTCCTGAGCTTTGCGCAAAGCAGCGAGCCGACGGCGCGGCCGGTGCCGGTGGATCGGCGTATCCACGAGCTCG
CGGCGTCGCTGGCCGAGCAGGAACGGCAGGTGGTGCTGTCGCTCAATGCCGGCGAGGGCTTCCGCATGATCGCGACGCAG
CTCGACCGCATCGTCGGCAACCTCGTCGACAATGCTTACGCCTACGGCCAGGCGCCGGTGTGCGTGGCGACCTCTCGTAC
GGCCGAAGGCTTCTGCCTTACGGTGGAAGACCAGGGACCGGGCATTCCGGACGCTGACATGGAACGCGTCACACTGCCGT
TCGTGCGGCTCGATCCGGCACGCGGTGGTAACGCGCATTCGGGACTCGGACTGGCGATCGTCGATCGCCTGGTGCGGCAG
GCGGGAGGGAGGTTGTCGCTCCTCAACCGAGCCGAAGGCGGCCTGCGCGTGGAGATGCAGTTCCCGGTGTCGATGGCGCA
GGCAGCCTGA

Upstream 100 bases:

>100_bases
ACCGTGCGCGGACGCGGCTACACGTTCGTACCGGACGAAGCCGAAGAAATTCCGCAGTAACGCCTGTCGCCTCTGTCGCC
CGTCCGGCGGCAGGGCGGCA

Downstream 100 bases:

>100_bases
TCACCCGCGCTCCAGGGAACGCGTTCAGACCTTCTTCTTCTCGCCGATGCGGCTTTCCTTGCCGGTCAGCAGCTTGGCAA
TGTTCTGGCGGTGGCGCGCG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTSPDMKLRIDTLFGRIALLIAAVLVISHFSWLAILRMDRRQQQVDYSVEQMLFQFASIQRALDARPPVPLPSLVEVASE
ASAEQHTVVPKGRSRRLVEQFITRLPQGTEIRVEDEATPRLWIKLPTRSNWIAMPILWVHNPPPDNRLVPGVMLVVGVAI
IFALLIAWQIQRPVRDMAAAAEQLSRQQPVAPLRERGPHELRQLIERFNRMVADLTRIDQERNTMLAGIAHDLKTPLARL
RLRAEMLSDPKAAAGVTRDVESMSAIVEQFLSFAQSSEPTARPVPVDRRIHELAASLAEQERQVVLSLNAGEGFRMIATQ
LDRIVGNLVDNAYAYGQAPVCVATSRTAEGFCLTVEDQGPGIPDADMERVTLPFVRLDPARGGNAHSGLGLAIVDRLVRQ
AGGRLSLLNRAEGGLRVEMQFPVSMAQAA

Sequences:

>Translated_429_residues
MTSPDMKLRIDTLFGRIALLIAAVLVISHFSWLAILRMDRRQQQVDYSVEQMLFQFASIQRALDARPPVPLPSLVEVASE
ASAEQHTVVPKGRSRRLVEQFITRLPQGTEIRVEDEATPRLWIKLPTRSNWIAMPILWVHNPPPDNRLVPGVMLVVGVAI
IFALLIAWQIQRPVRDMAAAAEQLSRQQPVAPLRERGPHELRQLIERFNRMVADLTRIDQERNTMLAGIAHDLKTPLARL
RLRAEMLSDPKAAAGVTRDVESMSAIVEQFLSFAQSSEPTARPVPVDRRIHELAASLAEQERQVVLSLNAGEGFRMIATQ
LDRIVGNLVDNAYAYGQAPVCVATSRTAEGFCLTVEDQGPGIPDADMERVTLPFVRLDPARGGNAHSGLGLAIVDRLVRQ
AGGRLSLLNRAEGGLRVEMQFPVSMAQAA
>Mature_428_residues
TSPDMKLRIDTLFGRIALLIAAVLVISHFSWLAILRMDRRQQQVDYSVEQMLFQFASIQRALDARPPVPLPSLVEVASEA
SAEQHTVVPKGRSRRLVEQFITRLPQGTEIRVEDEATPRLWIKLPTRSNWIAMPILWVHNPPPDNRLVPGVMLVVGVAII
FALLIAWQIQRPVRDMAAAAEQLSRQQPVAPLRERGPHELRQLIERFNRMVADLTRIDQERNTMLAGIAHDLKTPLARLR
LRAEMLSDPKAAAGVTRDVESMSAIVEQFLSFAQSSEPTARPVPVDRRIHELAASLAEQERQVVLSLNAGEGFRMIATQL
DRIVGNLVDNAYAYGQAPVCVATSRTAEGFCLTVEDQGPGIPDADMERVTLPFVRLDPARGGNAHSGLGLAIVDRLVRQA
GGRLSLLNRAEGGLRVEMQFPVSMAQAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=364, Percent_Identity=31.8681318681319, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=30.2631578947368, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=27.1375464684015, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=299, Percent_Identity=30.1003344481605, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=29.5138888888889, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787374, Length=270, Percent_Identity=29.2592592592593, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786600, Length=247, Percent_Identity=28.7449392712551, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788393, Length=268, Percent_Identity=23.5074626865672, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081816, Length=265, Percent_Identity=26.7924528301887, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=265, Percent_Identity=27.5471698113208, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082128, Length=290, Percent_Identity=23.448275862069, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47565; Mature: 47434

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPDMKLRIDTLFGRIALLIAAVLVISHFSWLAILRMDRRQQQVDYSVEQMLFQFASIQ
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALDARPPVPLPSLVEVASEASAEQHTVVPKGRSRRLVEQFITRLPQGTEIRVEDEATPR
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCE
LWIKLPTRSNWIAMPILWVHNPPPDNRLVPGVMLVVGVAIIFALLIAWQIQRPVRDMAAA
EEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQLSRQQPVAPLRERGPHELRQLIERFNRMVADLTRIDQERNTMLAGIAHDLKTPLARL
HHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRAEMLSDPKAAAGVTRDVESMSAIVEQFLSFAQSSEPTARPVPVDRRIHELAASLAEQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
ERQVVLSLNAGEGFRMIATQLDRIVGNLVDNAYAYGQAPVCVATSRTAEGFCLTVEDQGP
HCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCC
GIPDADMERVTLPFVRLDPARGGNAHSGLGLAIVDRLVRQAGGRLSLLNRAEGGLRVEMQ
CCCCCCCCCEEECEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHHCCCCCEEEEEE
FPVSMAQAA
CCHHHHCCC
>Mature Secondary Structure 
TSPDMKLRIDTLFGRIALLIAAVLVISHFSWLAILRMDRRQQQVDYSVEQMLFQFASIQ
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RALDARPPVPLPSLVEVASEASAEQHTVVPKGRSRRLVEQFITRLPQGTEIRVEDEATPR
HHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCE
LWIKLPTRSNWIAMPILWVHNPPPDNRLVPGVMLVVGVAIIFALLIAWQIQRPVRDMAAA
EEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQLSRQQPVAPLRERGPHELRQLIERFNRMVADLTRIDQERNTMLAGIAHDLKTPLARL
HHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRAEMLSDPKAAAGVTRDVESMSAIVEQFLSFAQSSEPTARPVPVDRRIHELAASLAEQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
ERQVVLSLNAGEGFRMIATQLDRIVGNLVDNAYAYGQAPVCVATSRTAEGFCLTVEDQGP
HCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCC
GIPDADMERVTLPFVRLDPARGGNAHSGLGLAIVDRLVRQAGGRLSLLNRAEGGLRVEMQ
CCCCCCCCCEEECEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHHCCCCCEEEEEE
FPVSMAQAA
CCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]