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The map label for this gene is hemA [H]

Identifier: 161611253

GI number: 161611253

Start: 3346980

End: 3348284

Strand: Direct

Name: hemA [H]

Synonym: Reut_A3043

Alternate gene names: 161611253

Gene position: 3346980-3348284 (Clockwise)

Preceding gene: 73542725

Following gene: 73542728

Centisome position: 87.93

GC content: 66.82

Gene sequence:

>1305_bases
ATGCAACTGCTCGCGATCGGCATCAATCACACGACGGCACCAGTCTCGCTTCGCGAGCGGGTGGCGTTTCCGCTTGAGCA
GATCAAACCCGCACTTGGGGCGCTGCGCACACATCTGGCCGGGCGCAATGGTACCGAAGCTGCCATCCTTTCCACCTGCA
ATCGCACCGAAATCTACTGCGCGACGGACATCCTGAAGCCGGGCGCCGAAGGTTTCGAGCACACGTTGCGGTGGCTGTCG
CAGCACCACAACGTGCCGGCGTCCGACCTGGCACCGCACCTGTATTCCCTGCCCCAGTCCGAAGCCGTACGGCACGCGTT
CCGCGTCGCCAGCGGGCTCGACTCGATGGTGCTTGGCGAAACCCAGATCCTGGGCCAGCTCAAGGACGCGGTGCGCACGG
CCGGCGAAGCCGGCTCGCTCGGCACCTACCTGAACCAGCTGTTCCAGCGCACGTTCGCGGTCGCCAAGGAAGTCCGCGGC
CAGACCGAGATCGGCGCGCATTCGGTGTCGATGGCGGCCGCGGCGGTACGGCTGGCACAACGGATTTTTGAAAGCGTCTC
GACGCAGCGCGTGCTGTTCATCGGCGCGGGCGAGATGATTGAGCTGTGCGCGACGCACTTCGCCGCGCAGAAGCCGCGCC
AGGTGGTGGTGGCCAACCGCACCGTCGAGCGTGGCGAGAAGCTGGCGGAGCAACTTGCCGAACAGGGCCTGACGACGCAG
GCGATCCGCCTGCAGGAACTGGGCGAGCGACTCCATGAGTTCGATATCGTGGTGTCGTGCACGGCGAGCTCGCTGCCGAT
CATCGGGCTTGGCGCCGTGGAACGCGCGGTCAAGCGCCGCAAGCACCGCCCGATCATGATGGTCGACCTGGCCGTGCCGC
GCGACGTCGAGCCGGAGGTTGCACGCCTCGACGACGTGTTCCTCTACACCGTCGACGATCTCGGCGCTGTCGTGCGCGAA
GGCAACGCCCTTCGCCAGGCTGCCGTGGCGCAGGCCGAGGCCATCATCGAAAGCCGTGTGCAGAATTTCATGCACTGGCT
GGAGACGCGCAGCGTGGTGCCGGTCATCCGCGAACTGCAGACTGCCGGCGAGTCGATTCGTCAGGCCGAACTCGAACGCG
CGCGCCGCATGCTGGCGCGTGGCGACGATCCGGAAGCCGTGCTCGAAGCGCTGTCCGGCGCGCTCACGCGCAAGTTTCTG
CATGGCCCGACCCATGCGCTGAACCATATGCAGGGCGAGGACCGCGAGGCGCTGGTGCGCCTGGTGCCCGGCCTGTTCCG
CCAAAGCAGCCACTCCGAGCGCTAG

Upstream 100 bases:

>100_bases
CACTGGCCTCTGGCCGCCGCGCCTGCCTGCAAGATCCGATCCCGACGTTATAATGGCAATCGGGGCGCACACGCTGCGGA
CCCGGTACCAGTCCCTACAA

Downstream 100 bases:

>100_bases
CCGCGCTGATCGCTGCGCCCGCGCGCAATGCGCGCCGGCAACCGCCGCCGCCCCGATCGGGGCCCGGTATCCTGCCTTCC
CCACCCGGAATCCCATGAAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MQLLAIGINHTTAPVSLRERVAFPLEQIKPALGALRTHLAGRNGTEAAILSTCNRTEIYCATDILKPGAEGFEHTLRWLS
QHHNVPASDLAPHLYSLPQSEAVRHAFRVASGLDSMVLGETQILGQLKDAVRTAGEAGSLGTYLNQLFQRTFAVAKEVRG
QTEIGAHSVSMAAAAVRLAQRIFESVSTQRVLFIGAGEMIELCATHFAAQKPRQVVVANRTVERGEKLAEQLAEQGLTTQ
AIRLQELGERLHEFDIVVSCTASSLPIIGLGAVERAVKRRKHRPIMMVDLAVPRDVEPEVARLDDVFLYTVDDLGAVVRE
GNALRQAAVAQAEAIIESRVQNFMHWLETRSVVPVIRELQTAGESIRQAELERARRMLARGDDPEAVLEALSGALTRKFL
HGPTHALNHMQGEDREALVRLVPGLFRQSSHSER

Sequences:

>Translated_434_residues
MQLLAIGINHTTAPVSLRERVAFPLEQIKPALGALRTHLAGRNGTEAAILSTCNRTEIYCATDILKPGAEGFEHTLRWLS
QHHNVPASDLAPHLYSLPQSEAVRHAFRVASGLDSMVLGETQILGQLKDAVRTAGEAGSLGTYLNQLFQRTFAVAKEVRG
QTEIGAHSVSMAAAAVRLAQRIFESVSTQRVLFIGAGEMIELCATHFAAQKPRQVVVANRTVERGEKLAEQLAEQGLTTQ
AIRLQELGERLHEFDIVVSCTASSLPIIGLGAVERAVKRRKHRPIMMVDLAVPRDVEPEVARLDDVFLYTVDDLGAVVRE
GNALRQAAVAQAEAIIESRVQNFMHWLETRSVVPVIRELQTAGESIRQAELERARRMLARGDDPEAVLEALSGALTRKFL
HGPTHALNHMQGEDREALVRLVPGLFRQSSHSER
>Mature_434_residues
MQLLAIGINHTTAPVSLRERVAFPLEQIKPALGALRTHLAGRNGTEAAILSTCNRTEIYCATDILKPGAEGFEHTLRWLS
QHHNVPASDLAPHLYSLPQSEAVRHAFRVASGLDSMVLGETQILGQLKDAVRTAGEAGSLGTYLNQLFQRTFAVAKEVRG
QTEIGAHSVSMAAAAVRLAQRIFESVSTQRVLFIGAGEMIELCATHFAAQKPRQVVVANRTVERGEKLAEQLAEQGLTTQ
AIRLQELGERLHEFDIVVSCTASSLPIIGLGAVERAVKRRKHRPIMMVDLAVPRDVEPEVARLDDVFLYTVDDLGAVVRE
GNALRQAAVAQAEAIIESRVQNFMHWLETRSVVPVIRELQTAGESIRQAELERARRMLARGDDPEAVLEALSGALTRKFL
HGPTHALNHMQGEDREALVRLVPGLFRQSSHSER

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=409, Percent_Identity=44.7432762836186, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 47659; Mature: 47659

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLAIGINHTTAPVSLRERVAFPLEQIKPALGALRTHLAGRNGTEAAILSTCNRTEIYC
CCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEE
ATDILKPGAEGFEHTLRWLSQHHNVPASDLAPHLYSLPQSEAVRHAFRVASGLDSMVLGE
EHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHH
TQILGQLKDAVRTAGEAGSLGTYLNQLFQRTFAVAKEVRGQTEIGAHSVSMAAAAVRLAQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHH
RIFESVSTQRVLFIGAGEMIELCATHFAAQKPRQVVVANRTVERGEKLAEQLAEQGLTTQ
HHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHH
AIRLQELGERLHEFDIVVSCTASSLPIIGLGAVERAVKRRKHRPIMMVDLAVPRDVEPEV
HHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
ARLDDVFLYTVDDLGAVVREGNALRQAAVAQAEAIIESRVQNFMHWLETRSVVPVIRELQ
HHHHHHHEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TAGESIRQAELERARRMLARGDDPEAVLEALSGALTRKFLHGPTHALNHMQGEDREALVR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHH
LVPGLFRQSSHSER
HHHHHHHCCCCCCC
>Mature Secondary Structure
MQLLAIGINHTTAPVSLRERVAFPLEQIKPALGALRTHLAGRNGTEAAILSTCNRTEIYC
CCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEE
ATDILKPGAEGFEHTLRWLSQHHNVPASDLAPHLYSLPQSEAVRHAFRVASGLDSMVLGE
EHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHH
TQILGQLKDAVRTAGEAGSLGTYLNQLFQRTFAVAKEVRGQTEIGAHSVSMAAAAVRLAQ
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHH
RIFESVSTQRVLFIGAGEMIELCATHFAAQKPRQVVVANRTVERGEKLAEQLAEQGLTTQ
HHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHH
AIRLQELGERLHEFDIVVSCTASSLPIIGLGAVERAVKRRKHRPIMMVDLAVPRDVEPEV
HHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
ARLDDVFLYTVDDLGAVVREGNALRQAAVAQAEAIIESRVQNFMHWLETRSVVPVIRELQ
HHHHHHHEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TAGESIRQAELERARRMLARGDDPEAVLEALSGALTRKFLHGPTHALNHMQGEDREALVR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHH
LVPGLFRQSSHSER
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA