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The map label for this gene is atoC [H]

Identifier: 71908213

GI number: 71908213

Start: 2799848

End: 2801194

Strand: Reverse

Name: atoC [H]

Synonym: Daro_2600

Alternate gene names: 71908213

Gene position: 2801194-2799848 (Counterclockwise)

Preceding gene: 71908214

Following gene: 71908204

Centisome position: 62.23

GC content: 55.9

Gene sequence:

>1347_bases
ATGGCAACACCGTCTGAAATCCGCCCACATCTTTGCCTGATCGAGGACGACGAGATCATGGGCGAGTCGCTTTCCCAGCG
CTTCCAGTTAGAAGGCTTCGATGTCGATTGGTGGCGGACGGCTCGCGAAGCATCGGCAGCGTTGGAAAGTCGGCGCTATG
GCGTCGTCGTCAGCGATATCCGCCTGCCTGACCGTAACGGCGGAGAACTTTTTCTCGATCTGACCAAACGCCTGCCGATG
TTGCCGCCTTTTTTGTTCATGACCGGTTACGGGAGCATTGATCGAGCCGTCGAATTGCTCAAGGCAGGCGCTGCCGACTA
CATTACCAAGCCATTCGATACCGATGCCCTTGTTGAAAAAGTATGCGGTCTCGCCGAATGCTATGGCGCCCGCGGTACGA
ATGAGGGAGATGCACTGGGCGTTTCTCCTGTCATGCAGCGTATTGCGGAGAGCTTGCCCCGGTTGGCTCGCCACGCGTCG
GCGCTATTGATCACTGGCGAGTCAGGTGTTGGCAAGGAGCACGTAGCCAAGGAATTCCACCGCCATGCCGTCGGCAATTC
AGCCCCTTTTGTTGCGGTGAACTGCGCTGCGATACCGGACTCATTACTGGAAGCAGAGCTTTTCGGCTACGAAAAAGGTG
CTTTCACCGGGGCAGTTAAAGCCAAGCGTGGATATTTCGAGTTAGCCAACAATGGCACGCTTTTTCTCGACGAAATCGGT
GAGATGCCACCGTCGATGCAGGCCAAACTGCTGCGCGTAATCCAGGAGCGTACTTTGGTACGGTTAGGGGGGGAGTCAGT
TGTTGCCGTCAATTTTCGGCTGGTCTGTGCTACCCATCAGGACTTGAAGGCAATGGTCGAGATGGGCGACTTTCGAGAGG
ATTTGTACTACCGGATCAACGTTATTCAATTGCGCATTCCACCCCTTCGAGAGCGTCAGGACGATATACGCTGGTTCGTA
CGGCACTACGTGGAAATCTTCAATCGAGCCAACCCATCGGAATCCCGTCGGCTTGATCCGCGAACCGAGCAGGTTCTCAC
CAGTTATCTCTGGCCAGGCAATGTCCGTGAGTTGAAGCACGCTGTAGAACGGGCTTGCATCCTCTCCCCCGGGCCCCTAT
TGGGGGCTGAGGCCTTTTTTGGAGACAGTCTGGAATGTGGCGAATCGGCGGGGGAGATTTCCCCATCGCTAGCCGACTAC
CTGATGGCTTGCGAGCGTGACTATCTTCAGGTCGCGCTGGACAAACATGGCTGGCACATGACCCAGACAGCCGAAGCCCT
TGGCATTTCCAGAAAGACGCTCTGGGAAAAGTTGCGGAGGATGGGAATACACGCAGAGGAGGGATAA

Upstream 100 bases:

>100_bases
CTGGGTTTGTGGATCGTTTATCAGATCGTTCAGCAACTGGGTGGCGAAATCGAGGTCGAGAGCCTGCCCGGCTACACTAC
TTTCAAGGTTGATATTCCTT

Downstream 100 bases:

>100_bases
TTTGCGGTTTCAAGAGTTTCGGTATCGTCCCCTGTACTCAGGTCAATATGGGTGTTGACAGCCCATTCGCGGGCGATTCG
TCATCCGCGTAGATGAAAAC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MATPSEIRPHLCLIEDDEIMGESLSQRFQLEGFDVDWWRTAREASAALESRRYGVVVSDIRLPDRNGGELFLDLTKRLPM
LPPFLFMTGYGSIDRAVELLKAGAADYITKPFDTDALVEKVCGLAECYGARGTNEGDALGVSPVMQRIAESLPRLARHAS
ALLITGESGVGKEHVAKEFHRHAVGNSAPFVAVNCAAIPDSLLEAELFGYEKGAFTGAVKAKRGYFELANNGTLFLDEIG
EMPPSMQAKLLRVIQERTLVRLGGESVVAVNFRLVCATHQDLKAMVEMGDFREDLYYRINVIQLRIPPLRERQDDIRWFV
RHYVEIFNRANPSESRRLDPRTEQVLTSYLWPGNVRELKHAVERACILSPGPLLGAEAFFGDSLECGESAGEISPSLADY
LMACERDYLQVALDKHGWHMTQTAEALGISRKTLWEKLRRMGIHAEEG

Sequences:

>Translated_448_residues
MATPSEIRPHLCLIEDDEIMGESLSQRFQLEGFDVDWWRTAREASAALESRRYGVVVSDIRLPDRNGGELFLDLTKRLPM
LPPFLFMTGYGSIDRAVELLKAGAADYITKPFDTDALVEKVCGLAECYGARGTNEGDALGVSPVMQRIAESLPRLARHAS
ALLITGESGVGKEHVAKEFHRHAVGNSAPFVAVNCAAIPDSLLEAELFGYEKGAFTGAVKAKRGYFELANNGTLFLDEIG
EMPPSMQAKLLRVIQERTLVRLGGESVVAVNFRLVCATHQDLKAMVEMGDFREDLYYRINVIQLRIPPLRERQDDIRWFV
RHYVEIFNRANPSESRRLDPRTEQVLTSYLWPGNVRELKHAVERACILSPGPLLGAEAFFGDSLECGESAGEISPSLADY
LMACERDYLQVALDKHGWHMTQTAEALGISRKTLWEKLRRMGIHAEEG
>Mature_447_residues
ATPSEIRPHLCLIEDDEIMGESLSQRFQLEGFDVDWWRTAREASAALESRRYGVVVSDIRLPDRNGGELFLDLTKRLPML
PPFLFMTGYGSIDRAVELLKAGAADYITKPFDTDALVEKVCGLAECYGARGTNEGDALGVSPVMQRIAESLPRLARHASA
LLITGESGVGKEHVAKEFHRHAVGNSAPFVAVNCAAIPDSLLEAELFGYEKGAFTGAVKAKRGYFELANNGTLFLDEIGE
MPPSMQAKLLRVIQERTLVRLGGESVVAVNFRLVCATHQDLKAMVEMGDFREDLYYRINVIQLRIPPLRERQDDIRWFVR
HYVEIFNRANPSESRRLDPRTEQVLTSYLWPGNVRELKHAVERACILSPGPLLGAEAFFGDSLECGESAGEISPSLADYL
MACERDYLQVALDKHGWHMTQTAEALGISRKTLWEKLRRMGIHAEEG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=38.8026607538803, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1790299, Length=462, Percent_Identity=38.0952380952381, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=38.5487528344671, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1788905, Length=441, Percent_Identity=36.0544217687075, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082117, Length=331, Percent_Identity=40.785498489426, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1789233, Length=315, Percent_Identity=39.0476190476191, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786524, Length=320, Percent_Identity=42.5, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789087, Length=333, Percent_Identity=37.2372372372372, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=37.4603174603175, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=37.9746835443038, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI87081872, Length=323, Percent_Identity=35.9133126934984, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=35.8333333333333, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87081858, Length=307, Percent_Identity=28.9902280130293, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789402, Length=125, Percent_Identity=29.6, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790552, Length=125, Percent_Identity=31.2, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50012; Mature: 49881

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPSEIRPHLCLIEDDEIMGESLSQRFQLEGFDVDWWRTAREASAALESRRYGVVVSDI
CCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
RLPDRNGGELFLDLTKRLPMLPPFLFMTGYGSIDRAVELLKAGAADYITKPFDTDALVEK
ECCCCCCCEEEEEHHHCCCCCCCHHHHCCCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHH
VCGLAECYGARGTNEGDALGVSPVMQRIAESLPRLARHASALLITGESGVGKEHVAKEFH
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
RHAVGNSAPFVAVNCAAIPDSLLEAELFGYEKGAFTGAVKAKRGYFELANNGTLFLDEIG
HHHCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCCEEEEEHHC
EMPPSMQAKLLRVIQERTLVRLGGESVVAVNFRLVCATHQDLKAMVEMGDFREDLYYRIN
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHHHHHHHHHEEEEE
VIQLRIPPLRERQDDIRWFVRHYVEIFNRANPSESRRLDPRTEQVLTSYLWPGNVRELKH
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCHHHHHH
AVERACILSPGPLLGAEAFFGDSLECGESAGEISPSLADYLMACERDYLQVALDKHGWHM
HHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
TQTAEALGISRKTLWEKLRRMGIHAEEG
HHHHHHHCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATPSEIRPHLCLIEDDEIMGESLSQRFQLEGFDVDWWRTAREASAALESRRYGVVVSDI
CCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
RLPDRNGGELFLDLTKRLPMLPPFLFMTGYGSIDRAVELLKAGAADYITKPFDTDALVEK
ECCCCCCCEEEEEHHHCCCCCCCHHHHCCCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHH
VCGLAECYGARGTNEGDALGVSPVMQRIAESLPRLARHASALLITGESGVGKEHVAKEFH
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHH
RHAVGNSAPFVAVNCAAIPDSLLEAELFGYEKGAFTGAVKAKRGYFELANNGTLFLDEIG
HHHCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCCEEEEEHHC
EMPPSMQAKLLRVIQERTLVRLGGESVVAVNFRLVCATHQDLKAMVEMGDFREDLYYRIN
CCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHHHHHHHHHEEEEE
VIQLRIPPLRERQDDIRWFVRHYVEIFNRANPSESRRLDPRTEQVLTSYLWPGNVRELKH
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCHHHHHH
AVERACILSPGPLLGAEAFFGDSLECGESAGEISPSLADYLMACERDYLQVALDKHGWHM
HHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
TQTAEALGISRKTLWEKLRRMGIHAEEG
HHHHHHHCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]