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The map label for this gene is gluP [H]

Identifier: 71908004

GI number: 71908004

Start: 2570383

End: 2571459

Strand: Reverse

Name: gluP [H]

Synonym: Daro_2385

Alternate gene names: 71908004

Gene position: 2571459-2570383 (Counterclockwise)

Preceding gene: 71908005

Following gene: 71908003

Centisome position: 57.13

GC content: 57.01

Gene sequence:

>1077_bases
ATGCCTTCACTTCACGATCAGCTTCGCCATGCCATGCCGCAATTGCACCTGACGCCGCTGCTGATCGCGGCTAACGTCCT
GATTTTCGTGGCGATGTTGCTCAATGGCGCAAGTCTGTGGCATGCGCAAAACACCATCCAGCTAGCCTGGGGCGCCAATT
TCGGGCCTGCAACACAGGATGGAGAATGGTGGCGCCTGGGTAGTGCGCTCTTTCTGCATTTCGGTATCCTGCACCTGCTC
CTGAACATGGCGGCTTTGTGGGATGTCGGTCAGTGGGTCGAGCGCATGTACGGCACCCTGCGATTCGCGGTGATCTACCT
GACTGCCGGCCTGACCGGAAATCTACTGTCGCTGGTGGCGAATGCCGGGGCAGCCGTGTCCGGAGGAGCATCCGGCGCCA
TTTTCGGCATTTACGGTGCGCTACTCAGTTATCTGTGGCTGGAACGTTCGAGTATCCATCGCGGCGAGTTCCGCTGGTTG
TTCTGGGCCGCGATCGGTTTTTCCGGGGCGACTATTATTTTCGGATTGCTGGTTCCCGGCATCGACAATGCCGCCCACGT
TGGTGGATGGATTGCCGGTGTTCTGATGGGCGTGCTGCTGATCAGGTCCGAGCCTGGCATTGTGGCCGGGCCTCAACTTG
GTAGATGGGTGTCGGGGCTGTTTTTTCTCTTTCTCGTCGCGGTTATCGTGGGCCAGATTCCAAAGCCAGCCTATCGCTGG
AGCGAAGAAAAGCAGATTCGCGGGGAGGTCTTCGAGTTCCTTCAGGAAGATGCGGCGATTACTCGAAATTGGGACAATCT
TTTGTGGCAAGGCGGCAAAAAGGGTGTCTCCGCCGACGAACTGGCCGATGCGATTGAGAGCATGGTGGCCGAGCGATACG
ACCAAAGTTTTGAGGAGCTTTTGGCCTTACCGATCGATGAAAATTTGCCGTCTGCGCCGACGGTTGAACATTTGAAGCTC
TATGCCGAACAGCGGCGTGACGCATCGCGGGCGATGGTCGAAGGATTGCGGGCCCGGGATAAATCAAAGATCAAAAAAGC
ACTGGATCAGGCGCGCCAGTCCGGCAAAGTCAATTAA

Upstream 100 bases:

>100_bases
GGGCTCCCGTTTTTATTGATGCGAGCTTTGTTGGTCAGCCTCTTGAGCCAACAGACGCGCATAATTCAAGTTTGGGTGCT
CATTGATTTCTGCAGAGACC

Downstream 100 bases:

>100_bases
CGGGAGGCGCCATTTTCTTCAGATGGCCTGATGGGGGTGAGGTTATTCCAATCCTGATCAAGGAAATGGACTGGGAGGAT
CGGCAAAATCGCTATCGATT

Product: rhomboid-like protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MPSLHDQLRHAMPQLHLTPLLIAANVLIFVAMLLNGASLWHAQNTIQLAWGANFGPATQDGEWWRLGSALFLHFGILHLL
LNMAALWDVGQWVERMYGTLRFAVIYLTAGLTGNLLSLVANAGAAVSGGASGAIFGIYGALLSYLWLERSSIHRGEFRWL
FWAAIGFSGATIIFGLLVPGIDNAAHVGGWIAGVLMGVLLIRSEPGIVAGPQLGRWVSGLFFLFLVAVIVGQIPKPAYRW
SEEKQIRGEVFEFLQEDAAITRNWDNLLWQGGKKGVSADELADAIESMVAERYDQSFEELLALPIDENLPSAPTVEHLKL
YAEQRRDASRAMVEGLRARDKSKIKKALDQARQSGKVN

Sequences:

>Translated_358_residues
MPSLHDQLRHAMPQLHLTPLLIAANVLIFVAMLLNGASLWHAQNTIQLAWGANFGPATQDGEWWRLGSALFLHFGILHLL
LNMAALWDVGQWVERMYGTLRFAVIYLTAGLTGNLLSLVANAGAAVSGGASGAIFGIYGALLSYLWLERSSIHRGEFRWL
FWAAIGFSGATIIFGLLVPGIDNAAHVGGWIAGVLMGVLLIRSEPGIVAGPQLGRWVSGLFFLFLVAVIVGQIPKPAYRW
SEEKQIRGEVFEFLQEDAAITRNWDNLLWQGGKKGVSADELADAIESMVAERYDQSFEELLALPIDENLPSAPTVEHLKL
YAEQRRDASRAMVEGLRARDKSKIKKALDQARQSGKVN
>Mature_357_residues
PSLHDQLRHAMPQLHLTPLLIAANVLIFVAMLLNGASLWHAQNTIQLAWGANFGPATQDGEWWRLGSALFLHFGILHLLL
NMAALWDVGQWVERMYGTLRFAVIYLTAGLTGNLLSLVANAGAAVSGGASGAIFGIYGALLSYLWLERSSIHRGEFRWLF
WAAIGFSGATIIFGLLVPGIDNAAHVGGWIAGVLMGVLLIRSEPGIVAGPQLGRWVSGLFFLFLVAVIVGQIPKPAYRWS
EEKQIRGEVFEFLQEDAAITRNWDNLLWQGGKKGVSADELADAIESMVAERYDQSFEELLALPIDENLPSAPTVEHLKLY
AEQRRDASRAMVEGLRARDKSKIKKALDQARQSGKVN

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI190341097, Length=146, Percent_Identity=37.6712328767123, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534507, Length=137, Percent_Identity=29.1970802919708, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 39336; Mature: 39205

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLHDQLRHAMPQLHLTPLLIAANVLIFVAMLLNGASLWHAQNTIQLAWGANFGPATQD
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCEEEEEECCCCCCCCCC
GEWWRLGSALFLHFGILHLLLNMAALWDVGQWVERMYGTLRFAVIYLTAGLTGNLLSLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NAGAAVSGGASGAIFGIYGALLSYLWLERSSIHRGEFRWLFWAAIGFSGATIIFGLLVPG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCC
IDNAAHVGGWIAGVLMGVLLIRSEPGIVAGPQLGRWVSGLFFLFLVAVIVGQIPKPAYRW
CCCHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHCC
SEEKQIRGEVFEFLQEDAAITRNWDNLLWQGGKKGVSADELADAIESMVAERYDQSFEEL
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LALPIDENLPSAPTVEHLKLYAEQRRDASRAMVEGLRARDKSKIKKALDQARQSGKVN
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSLHDQLRHAMPQLHLTPLLIAANVLIFVAMLLNGASLWHAQNTIQLAWGANFGPATQD
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCEEEEEECCCCCCCCCC
GEWWRLGSALFLHFGILHLLLNMAALWDVGQWVERMYGTLRFAVIYLTAGLTGNLLSLVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
NAGAAVSGGASGAIFGIYGALLSYLWLERSSIHRGEFRWLFWAAIGFSGATIIFGLLVPG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCC
IDNAAHVGGWIAGVLMGVLLIRSEPGIVAGPQLGRWVSGLFFLFLVAVIVGQIPKPAYRW
CCCHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHCC
SEEKQIRGEVFEFLQEDAAITRNWDNLLWQGGKKGVSADELADAIESMVAERYDQSFEEL
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LALPIDENLPSAPTVEHLKLYAEQRRDASRAMVEGLRARDKSKIKKALDQARQSGKVN
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]