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The map label for this gene is hom [H]

Identifier: 71908005

GI number: 71908005

Start: 2571595

End: 2572905

Strand: Reverse

Name: hom [H]

Synonym: Daro_2386

Alternate gene names: 71908005

Gene position: 2572905-2571595 (Counterclockwise)

Preceding gene: 71908006

Following gene: 71908004

Centisome position: 57.16

GC content: 57.67

Gene sequence:

>1311_bases
ATGAAACCCATCAATGTTGGCCTTATCGGCATCGGCACCGTCGGCGGTGGCACCTGGACCGTTCTTAAGCGCAACGAGGA
AGAGATTACCCGTCGTGCCGGTCGGCCGATTCGCATCACCGCTGTGGCCGACAAGAACGTTGAACTCGCCAAGCAGATTA
CTGGTGGTGCAGCCCGTGTTACCGACGATGCCTTTTCGTTGGTCAATGACCCGGAAATCGATATCATCGTCGAACTGATC
GGCGGTTATGGTGTTGCCAAGGAAGTGGTCATGCAGGCCATCGCCAACGGCAAACATGTCGTGACGGCCAACAAGGCACT
GCTTGCCGTGCATGGCACTGAAATCTTTACGGCCGCTCAACAAAAGGGCGTGATGGTCGCTTTCGAAGCGGCAGTAGCCG
GCGGCATTCCCATCATCAAGGCATTGCGCGAGGGCCTGACGGCCAATCGCATCGAGTGGGCGGCCGGCATTATCAATGGT
ACGACCAACTTCATCCTGTCTGAAATGCGCGACAAGGGCCTGTCCTTTGGCGATGTGCTGAAAGAAGCTCAGCGTCTTGG
TTATGCCGAAGCAGATCCGACTTTCGACATCGAAGGTGTCGATGCGGCCCACAAGGCGACATTGATTGCTTCGATTGCCT
ATGGCATTCCGGTCCAGTTCGACAAGGCTTACATCGAAGGCATCACCAAGCTGGAAGCCTCCGATATCAAGTATGCCGAA
CAGCTCGGTTACCGCATCAAGCTGCTTGGCATCGCCAAGCGTCGCGAGAAGGGTATCGAGTTGCGCGTCCATCCGACCCT
GATCCCGGCAAAGCGCCTGCTGGCCAATGTCGAAGGTGCGATGAATGCCGTCATGGTCAAGGGCGACGCGGTTGGCATCA
CCCTGTATTACGGCAAGGGGGCTGGTGCTGAGCCGACCGCTTCCGCCGTGGTGGCTGATCTGGTCGATGTTGCTCGTCTG
GCCACCGCTGATGCCGCGCACCGCGTGCCGCACCTGGCCTTCCAGCCGGACGCCATGTCCAACCTGCCGATCCTGCCAAT
GAGCGAAGTCGAGACTGGTTATTACCTGCGTTTGCGCGTTGAAGACAAGCCTGGGGTACTGGCAGATATCACTCGCATCC
TGGCCGATCAGGGTATTTCTATCGATGCCATGCTGCAGCGCGAGCCGGAAGAGGGTGAGGGCGAGACCGACATTATCATC
CTGACCCACATCTGCAAGGAAAGTGCGGCCGATGCGGCGATTGCCAAGATCGAAGGCTTGTCTGCGCAAAAGGGCAAGGT
CAAGCGTATTCGCCTGGAAGAGCTGCAATAA

Upstream 100 bases:

>100_bases
CGCACGAGGATGACCTGCGGGAAGCAGTCGCACGTATTGCCCGCTTTCTTGAAAATTATCGCAAACGTCACAACACCAAC
CAACTTATCAAAGACTGAAC

Downstream 100 bases:

>100_bases
GCCAGGTTTCTCCAAGGCACTGAAACGGGAGCTACGGGCTCCCGTTTTTATTGATGCGAGCTTTGTTGGTCAGCCTCTTG
AGCCAACAGACGCGCATAAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKPINVGLIGIGTVGGGTWTVLKRNEEEITRRAGRPIRITAVADKNVELAKQITGGAARVTDDAFSLVNDPEIDIIVELI
GGYGVAKEVVMQAIANGKHVVTANKALLAVHGTEIFTAAQQKGVMVAFEAAVAGGIPIIKALREGLTANRIEWAAGIING
TTNFILSEMRDKGLSFGDVLKEAQRLGYAEADPTFDIEGVDAAHKATLIASIAYGIPVQFDKAYIEGITKLEASDIKYAE
QLGYRIKLLGIAKRREKGIELRVHPTLIPAKRLLANVEGAMNAVMVKGDAVGITLYYGKGAGAEPTASAVVADLVDVARL
ATADAAHRVPHLAFQPDAMSNLPILPMSEVETGYYLRLRVEDKPGVLADITRILADQGISIDAMLQREPEEGEGETDIII
LTHICKESAADAAIAKIEGLSAQKGKVKRIRLEELQ

Sequences:

>Translated_436_residues
MKPINVGLIGIGTVGGGTWTVLKRNEEEITRRAGRPIRITAVADKNVELAKQITGGAARVTDDAFSLVNDPEIDIIVELI
GGYGVAKEVVMQAIANGKHVVTANKALLAVHGTEIFTAAQQKGVMVAFEAAVAGGIPIIKALREGLTANRIEWAAGIING
TTNFILSEMRDKGLSFGDVLKEAQRLGYAEADPTFDIEGVDAAHKATLIASIAYGIPVQFDKAYIEGITKLEASDIKYAE
QLGYRIKLLGIAKRREKGIELRVHPTLIPAKRLLANVEGAMNAVMVKGDAVGITLYYGKGAGAEPTASAVVADLVDVARL
ATADAAHRVPHLAFQPDAMSNLPILPMSEVETGYYLRLRVEDKPGVLADITRILADQGISIDAMLQREPEEGEGETDIII
LTHICKESAADAAIAKIEGLSAQKGKVKRIRLEELQ
>Mature_436_residues
MKPINVGLIGIGTVGGGTWTVLKRNEEEITRRAGRPIRITAVADKNVELAKQITGGAARVTDDAFSLVNDPEIDIIVELI
GGYGVAKEVVMQAIANGKHVVTANKALLAVHGTEIFTAAQQKGVMVAFEAAVAGGIPIIKALREGLTANRIEWAAGIING
TTNFILSEMRDKGLSFGDVLKEAQRLGYAEADPTFDIEGVDAAHKATLIASIAYGIPVQFDKAYIEGITKLEASDIKYAE
QLGYRIKLLGIAKRREKGIELRVHPTLIPAKRLLANVEGAMNAVMVKGDAVGITLYYGKGAGAEPTASAVVADLVDVARL
ATADAAHRVPHLAFQPDAMSNLPILPMSEVETGYYLRLRVEDKPGVLADITRILADQGISIDAMLQREPEEGEGETDIII
LTHICKESAADAAIAKIEGLSAQKGKVKRIRLEELQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=275, Percent_Identity=25.4545454545455, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=133, Percent_Identity=34.5864661654135, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46550; Mature: 46550

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPINVGLIGIGTVGGGTWTVLKRNEEEITRRAGRPIRITAVADKNVELAKQITGGAARV
CCCEEEEEEEEEECCCCEEEEEECCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEE
TDDAFSLVNDPEIDIIVELIGGYGVAKEVVMQAIANGKHVVTANKALLAVHGTEIFTAAQ
CHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHHHHH
QKGVMVAFEAAVAGGIPIIKALREGLTANRIEWAAGIINGTTNFILSEMRDKGLSFGDVL
HCCEEEEEECHHHCCCHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQRLGYAEADPTFDIEGVDAAHKATLIASIAYGIPVQFDKAYIEGITKLEASDIKYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHCCHHHHHHHH
QLGYRIKLLGIAKRREKGIELRVHPTLIPAKRLLANVEGAMNAVMVKGDAVGITLYYGKG
HCCCEEEEEEEHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCEEEEEEEECCC
AGAEPTASAVVADLVDVARLATADAAHRVPHLAFQPDAMSNLPILPMSEVETGYYLRLRV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCEEEEEEE
EDKPGVLADITRILADQGISIDAMLQREPEEGEGETDIIILTHICKESAADAAIAKIEGL
CCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCC
SAQKGKVKRIRLEELQ
CCCCCCEEEEEHHCCC
>Mature Secondary Structure
MKPINVGLIGIGTVGGGTWTVLKRNEEEITRRAGRPIRITAVADKNVELAKQITGGAARV
CCCEEEEEEEEEECCCCEEEEEECCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEE
TDDAFSLVNDPEIDIIVELIGGYGVAKEVVMQAIANGKHVVTANKALLAVHGTEIFTAAQ
CHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECCHHHHHHH
QKGVMVAFEAAVAGGIPIIKALREGLTANRIEWAAGIINGTTNFILSEMRDKGLSFGDVL
HCCEEEEEECHHHCCCHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQRLGYAEADPTFDIEGVDAAHKATLIASIAYGIPVQFDKAYIEGITKLEASDIKYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHCCHHHHHHHH
QLGYRIKLLGIAKRREKGIELRVHPTLIPAKRLLANVEGAMNAVMVKGDAVGITLYYGKG
HCCCEEEEEEEHHHHCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCEEEEEEEECCC
AGAEPTASAVVADLVDVARLATADAAHRVPHLAFQPDAMSNLPILPMSEVETGYYLRLRV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCEEEEEEE
EDKPGVLADITRILADQGISIDAMLQREPEEGEGETDIIILTHICKESAADAAIAKIEGL
CCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHCCC
SAQKGKVKRIRLEELQ
CCCCCCEEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]