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The map label for this gene is acdA [H]

Identifier: 71907972

GI number: 71907972

Start: 2536988

End: 2538124

Strand: Reverse

Name: acdA [H]

Synonym: Daro_2353

Alternate gene names: 71907972

Gene position: 2538124-2536988 (Counterclockwise)

Preceding gene: 71907973

Following gene: 71907971

Centisome position: 56.39

GC content: 61.57

Gene sequence:

>1137_bases
ATGGACTTTTCCCTCACTGAAGAGCAACGCATGATCCAGGACTTGGCCCGGGAGTTCGCCGATCGCGAAATCGCGCCCCT
GGCGGCCCAGGCCGATGTGGACAAAGTATTTCCGCTCGCTGTCCAGCAAAAGGCGCTGGAACTGGGCTTGCTGAACATCG
TCCTGCCCACCGAATACGGTGGTGCCGGCCTCGGTTGTCTGGAGGTTGCCCTGATTACCGAGCAGTTTTGTCGGGCCTGC
CTGGGCATTGGAACGACGCTATGCATCAATGCCCTGGCTGCCGAACCCATAGTGCTGGCTGGCAACGAAGCGCAAAAGCG
CAAGTATTTTTCACGTCTGGCGGCCGGCGAATTTGCCAGCTTTGCGCTGACCGAGCCGGCAGCAGGTTCCGACTCCGCGG
CGATTCGTACTTCGGCCAAACGGGTCGCCGGTGGCTACGAGCTGACCGGCAGCAAAATCTGGATTTCCAATGCCTCGCTG
GCCAGCTTCATGGTGGTCTTTGCCAAGACCGATCCGGCCGCCGGGCACAAGGGCATCAGCGCCTTCATCGTCGAGCGCGA
ATCGGCTGGTCTTTCCGTCGGCGAGCCCCTGGGCAAGCTGGGCCAGCGGGCAGCGCCGACCTGCGAAGTGTTTTTCGATC
AGGTCTTCGTGCCCGAAGAAAATCGTCTCGGGGCGGAGGGTGAGGGCTTCTCGATCGCCATGCGCACCTTCGACCAGTCG
CGGCCGATGGTCGCTGCCTTCGGCCTGGGCCTGACCCAGCGTTGCATCGACGAATCGCTGGCCTATGCCTGTGAACGCCA
GTCGATGGGCAAACGCCTGATCGACCATCAGGTGATCGCGCACCGCCTAGCCGACATGCGCATTCGTCTCGAAGCCTCAC
GCCTGCTGACCTACCAGTCGGCCTGGCTGGCTGACCAGGGCTTGCGCAATACCAGCCAGGCCTCGATTGCCAAGGCCTTT
ACCTCGGATGCCGCGATGTGGGCCGCAACCGAGGCCATCCAGATTTTTGGCGGCATGGGTTACAGCACCGAGTACCCCGT
CGAAAAACTCTTCCGCGACGCCAAGGTGCTGCAAATCTACGAAGGCACCAGTGAAATTCAACGCAACATCATCGCCCGGG
ACATGGAACGGGCCTGA

Upstream 100 bases:

>100_bases
CTGCCGAGAGGCGGTTCGGCAAGTTATTACCTAACGCTAAAACATGACCTGAATGGGGTCAATGGGGCTTGTTCGCCCAA
AATTTTGGAGAAACACACCG

Downstream 100 bases:

>100_bases
GCCTGTTCCTCCCGTATTCATCGCAAAGGAATCAACATGCAGAATTCTCAAGATCCGGTCATCCTGGCCGCCGTCCGTAC
CCCGTTTGGCCGCCGCAATG

Product: Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MDFSLTEEQRMIQDLAREFADREIAPLAAQADVDKVFPLAVQQKALELGLLNIVLPTEYGGAGLGCLEVALITEQFCRAC
LGIGTTLCINALAAEPIVLAGNEAQKRKYFSRLAAGEFASFALTEPAAGSDSAAIRTSAKRVAGGYELTGSKIWISNASL
ASFMVVFAKTDPAAGHKGISAFIVERESAGLSVGEPLGKLGQRAAPTCEVFFDQVFVPEENRLGAEGEGFSIAMRTFDQS
RPMVAAFGLGLTQRCIDESLAYACERQSMGKRLIDHQVIAHRLADMRIRLEASRLLTYQSAWLADQGLRNTSQASIAKAF
TSDAAMWAATEAIQIFGGMGYSTEYPVEKLFRDAKVLQIYEGTSEIQRNIIARDMERA

Sequences:

>Translated_378_residues
MDFSLTEEQRMIQDLAREFADREIAPLAAQADVDKVFPLAVQQKALELGLLNIVLPTEYGGAGLGCLEVALITEQFCRAC
LGIGTTLCINALAAEPIVLAGNEAQKRKYFSRLAAGEFASFALTEPAAGSDSAAIRTSAKRVAGGYELTGSKIWISNASL
ASFMVVFAKTDPAAGHKGISAFIVERESAGLSVGEPLGKLGQRAAPTCEVFFDQVFVPEENRLGAEGEGFSIAMRTFDQS
RPMVAAFGLGLTQRCIDESLAYACERQSMGKRLIDHQVIAHRLADMRIRLEASRLLTYQSAWLADQGLRNTSQASIAKAF
TSDAAMWAATEAIQIFGGMGYSTEYPVEKLFRDAKVLQIYEGTSEIQRNIIARDMERA
>Mature_378_residues
MDFSLTEEQRMIQDLAREFADREIAPLAAQADVDKVFPLAVQQKALELGLLNIVLPTEYGGAGLGCLEVALITEQFCRAC
LGIGTTLCINALAAEPIVLAGNEAQKRKYFSRLAAGEFASFALTEPAAGSDSAAIRTSAKRVAGGYELTGSKIWISNASL
ASFMVVFAKTDPAAGHKGISAFIVERESAGLSVGEPLGKLGQRAAPTCEVFFDQVFVPEENRLGAEGEGFSIAMRTFDQS
RPMVAAFGLGLTQRCIDESLAYACERQSMGKRLIDHQVIAHRLADMRIRLEASRLLTYQSAWLADQGLRNTSQASIAKAF
TSDAAMWAATEAIQIFGGMGYSTEYPVEKLFRDAKVLQIYEGTSEIQRNIIARDMERA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=44.6808510638298, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=44.6808510638298, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=40.3743315508021, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=41.7553191489362, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=37.3684210526316, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=38.0952380952381, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI21361497, Length=352, Percent_Identity=38.9204545454545, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=37.7005347593583, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4557235, Length=383, Percent_Identity=38.3812010443864, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=38.3812010443864, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=30.5851063829787, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4503943, Length=374, Percent_Identity=30.4812834224599, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=30.1104972375691, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI48976061, Length=349, Percent_Identity=30.3724928366762, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI211971008, Length=349, Percent_Identity=30.3724928366762, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI38505218, Length=372, Percent_Identity=29.3010752688172, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=28.4574468085106, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=31.2335958005249, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082384, Length=275, Percent_Identity=28.3636363636364, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=377, Percent_Identity=45.0928381962865, Blast_Score=327, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=42.7440633245383, Blast_Score=314, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=44.6194225721785, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=38.6486486486486, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=38.0053908355795, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=35.4166666666667, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=346, Percent_Identity=36.1271676300578, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=37.3239436619718, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=33.7801608579088, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=34.5588235294118, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=38.695652173913, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=31.4516129032258, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=291, Percent_Identity=36.426116838488, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=30.0531914893617, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=31.0160427807487, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=33.0543933054393, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562446, Length=353, Percent_Identity=28.0453257790368, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531913, Length=174, Percent_Identity=30.4597701149425, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=27.9569892473118, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=27.9569892473118, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=46.8421052631579, Blast_Score=339, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=40, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=40.7008086253369, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=36.6310160427808, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI281363737, Length=391, Percent_Identity=36.8286445012788, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=36.7875647668394, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=29.287598944591, Blast_Score=147, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40958; Mature: 40958

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSLTEEQRMIQDLAREFADREIAPLAAQADVDKVFPLAVQQKALELGLLNIVLPTEYG
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCC
GAGLGCLEVALITEQFCRACLGIGTTLCINALAAEPIVLAGNEAQKRKYFSRLAAGEFAS
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCHHH
FALTEPAAGSDSAAIRTSAKRVAGGYELTGSKIWISNASLASFMVVFAKTDPAAGHKGIS
HEECCCCCCCCCHHHHHHHHHHCCCEEECCCEEEEECCHHHHEEEEEEECCCCCCCCCCE
AFIVERESAGLSVGEPLGKLGQRAAPTCEVFFDQVFVPEENRLGAEGEGFSIAMRTFDQS
EEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCC
RPMVAAFGLGLTQRCIDESLAYACERQSMGKRLIDHQVIAHRLADMRIRLEASRLLTYQS
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
AWLADQGLRNTSQASIAKAFTSDAAMWAATEAIQIFGGMGYSTEYPVEKLFRDAKVLQIY
HHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHEEEE
EGTSEIQRNIIARDMERA
CCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSLTEEQRMIQDLAREFADREIAPLAAQADVDKVFPLAVQQKALELGLLNIVLPTEYG
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHEEEEEECCCC
GAGLGCLEVALITEQFCRACLGIGTTLCINALAAEPIVLAGNEAQKRKYFSRLAAGEFAS
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCHHH
FALTEPAAGSDSAAIRTSAKRVAGGYELTGSKIWISNASLASFMVVFAKTDPAAGHKGIS
HEECCCCCCCCCHHHHHHHHHHCCCEEECCCEEEEECCHHHHEEEEEEECCCCCCCCCCE
AFIVERESAGLSVGEPLGKLGQRAAPTCEVFFDQVFVPEENRLGAEGEGFSIAMRTFDQS
EEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCC
RPMVAAFGLGLTQRCIDESLAYACERQSMGKRLIDHQVIAHRLADMRIRLEASRLLTYQS
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
AWLADQGLRNTSQASIAKAFTSDAAMWAATEAIQIFGGMGYSTEYPVEKLFRDAKVLQIY
HHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHEEEE
EGTSEIQRNIIARDMERA
CCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]