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The map label for this gene is fadA [H]

Identifier: 71907971

GI number: 71907971

Start: 2535764

End: 2536951

Strand: Reverse

Name: fadA [H]

Synonym: Daro_2352

Alternate gene names: 71907971

Gene position: 2536951-2535764 (Counterclockwise)

Preceding gene: 71907972

Following gene: 71907970

Centisome position: 56.36

GC content: 63.97

Gene sequence:

>1188_bases
ATGCAGAATTCTCAAGATCCGGTCATCCTGGCCGCCGTCCGTACCCCGTTTGGCCGCCGCAATGGGGCCTTCCGTCAGAC
CCGTCCCGATGAACTGCTGGCCGGTATTGTCAGTGAAGCCGTCAAGCGTTCCGGCGTTTCGGTGTCTGGTGTTGCCGACG
TCATTGCCGGCTGTGTCAGTCAGGCTGGCGAGCAGGGGGCCAACATTGCCCGCCAGGCCTTGCTGCTGGCCGGTCTGCCA
GCCGAGATTCCCGGTGTCAGCCTGAACCGGATGTGCGGATCGAGTCAGTATGCGGTACATGCGGCTGCCCAGTCGATTCT
GGCGGGCGATGCGGAATTTTCGGTAGGCTGCGGCGTCGAGAACATGAGCCGGGTGCCAATGTTTCTCGACCTGACCCTGG
GCAAAGGCGATTTCAAGGGCTTCGACAACCTGCACCCGGGTATCACGGCCCGCTTCGCCATCCCGCATCAGGTCGAGAGC
GCCGAACTGATCGGCGACCACTGGCAGATCAGCCGCGCCGAGTGCGACGAATTTGCCCGCGAAAGCCATCGTCGCGCCCA
TGCCGCCCGGCTGGCCGGCGTGCATAAGGAAATCGTGGCGACGGCCGGCGTCGACAAGGAGGGCAACGCGATTACCCTCG
ATTACGACGAGGGCGTTCGCCCGGTGATTGATGTCGATAAGATGTCGGCCATGCTGCCGGTGTTCCGCACGCCTGAAACC
GGTGTCGTGACGGCCGCCAACGCCAGCCAGATGTCCGACGGCGCGGCAGCGGTCGTGCTCGGCAGTGCCGAATCTGCCGC
TCGCCTGGGCCTGAAGCCGAAGGCTCGTTTCAAGGCGCGGGTCGTGGTCGGCTCCGATCCGGTCATGCAGTTGACCGGCG
TCATCCCGGCGACTCGTCTGGCACTGAAGAAGGCCGGCCTGAGTATTGCTGATCTGGACTGGATCGAAGTCAATGAAGCC
TTTGCCACTGTGGCGATAGCCTGGGCGCGCGAGTTTTCTCCCAATATGGATAAACTTAACCCGTGGGGCGGGGCGATTGC
CCACGGGCATCCGCTGGGTGGCACCGGCGCCGGCCTGATGGCCAAGATGCTGTCCGGGCTGGAGTCGTGCAACGGCCGTT
TCGGCCTGCAGGTCATGTGCATCGGCCACGGCATGGCGACCGCCACCATCATCGAACGTCTGGCCTGA

Upstream 100 bases:

>100_bases
AATCTACGAAGGCACCAGTGAAATTCAACGCAACATCATCGCCCGGGACATGGAACGGGCCTGAGCCTGTTCCTCCCGTA
TTCATCGCAAAGGAATCAAC

Downstream 100 bases:

>100_bases
TTGCGGAGCATTCTCATGGAGCACAAATTGACACCGGAAATCAAACAAAGCATTCGCAACACGCTGGGCGACGCCCTGCA
GCGCTCGGTTCGCCGCTGGC

Product: thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MQNSQDPVILAAVRTPFGRRNGAFRQTRPDELLAGIVSEAVKRSGVSVSGVADVIAGCVSQAGEQGANIARQALLLAGLP
AEIPGVSLNRMCGSSQYAVHAAAQSILAGDAEFSVGCGVENMSRVPMFLDLTLGKGDFKGFDNLHPGITARFAIPHQVES
AELIGDHWQISRAECDEFARESHRRAHAARLAGVHKEIVATAGVDKEGNAITLDYDEGVRPVIDVDKMSAMLPVFRTPET
GVVTAANASQMSDGAAAVVLGSAESAARLGLKPKARFKARVVVGSDPVMQLTGVIPATRLALKKAGLSIADLDWIEVNEA
FATVAIAWAREFSPNMDKLNPWGGAIAHGHPLGGTGAGLMAKMLSGLESCNGRFGLQVMCIGHGMATATIIERLA

Sequences:

>Translated_395_residues
MQNSQDPVILAAVRTPFGRRNGAFRQTRPDELLAGIVSEAVKRSGVSVSGVADVIAGCVSQAGEQGANIARQALLLAGLP
AEIPGVSLNRMCGSSQYAVHAAAQSILAGDAEFSVGCGVENMSRVPMFLDLTLGKGDFKGFDNLHPGITARFAIPHQVES
AELIGDHWQISRAECDEFARESHRRAHAARLAGVHKEIVATAGVDKEGNAITLDYDEGVRPVIDVDKMSAMLPVFRTPET
GVVTAANASQMSDGAAAVVLGSAESAARLGLKPKARFKARVVVGSDPVMQLTGVIPATRLALKKAGLSIADLDWIEVNEA
FATVAIAWAREFSPNMDKLNPWGGAIAHGHPLGGTGAGLMAKMLSGLESCNGRFGLQVMCIGHGMATATIIERLA
>Mature_395_residues
MQNSQDPVILAAVRTPFGRRNGAFRQTRPDELLAGIVSEAVKRSGVSVSGVADVIAGCVSQAGEQGANIARQALLLAGLP
AEIPGVSLNRMCGSSQYAVHAAAQSILAGDAEFSVGCGVENMSRVPMFLDLTLGKGDFKGFDNLHPGITARFAIPHQVES
AELIGDHWQISRAECDEFARESHRRAHAARLAGVHKEIVATAGVDKEGNAITLDYDEGVRPVIDVDKMSAMLPVFRTPET
GVVTAANASQMSDGAAAVVLGSAESAARLGLKPKARFKARVVVGSDPVMQLTGVIPATRLALKKAGLSIADLDWIEVNEA
FATVAIAWAREFSPNMDKLNPWGGAIAHGHPLGGTGAGLMAKMLSGLESCNGRFGLQVMCIGHGMATATIIERLA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=39.6984924623116, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=35.0383631713555, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4501853, Length=404, Percent_Identity=35.1485148514851, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=33.0808080808081, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=31.002331002331, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI194353979, Length=119, Percent_Identity=39.4957983193277, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI48994986, Length=395, Percent_Identity=41.7721518987342, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=38.7254901960784, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=36.1323155216285, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1788554, Length=395, Percent_Identity=36.9620253164557, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1788683, Length=407, Percent_Identity=29.97542997543, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=36.6412213740458, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=34.4387755102041, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=32.6530612244898, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=30.0925925925926, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=29.1044776119403, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=32.3456790123457, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=409, Percent_Identity=31.0513447432763, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=36.8020304568528, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=32.3076923076923, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=35.1145038167939, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=30.9468822170901, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41349; Mature: 41349

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSQDPVILAAVRTPFGRRNGAFRQTRPDELLAGIVSEAVKRSGVSVSGVADVIAGCVS
CCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QAGEQGANIARQALLLAGLPAEIPGVSLNRMCGSSQYAVHAAAQSILAGDAEFSVGCGVE
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCC
NMSRVPMFLDLTLGKGDFKGFDNLHPGITARFAIPHQVESAELIGDHWQISRAECDEFAR
CCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHH
ESHRRAHAARLAGVHKEIVATAGVDKEGNAITLDYDEGVRPVIDVDKMSAMLPVFRTPET
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHCCCCCCCCC
GVVTAANASQMSDGAAAVVLGSAESAARLGLKPKARFKARVVVGSDPVMQLTGVIPATRL
CEEEECCHHHCCCCCEEEEEECCCHHHHCCCCCCCCEEEEEEECCCCHHHHHCCCHHHHH
ALKKAGLSIADLDWIEVNEAFATVAIAWAREFSPNMDKLNPWGGAIAHGHPLGGTGAGLM
HHHHCCCCEECCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AKMLSGLESCNGRFGLQVMCIGHGMATATIIERLA
HHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHC
>Mature Secondary Structure
MQNSQDPVILAAVRTPFGRRNGAFRQTRPDELLAGIVSEAVKRSGVSVSGVADVIAGCVS
CCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QAGEQGANIARQALLLAGLPAEIPGVSLNRMCGSSQYAVHAAAQSILAGDAEFSVGCGVE
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCC
NMSRVPMFLDLTLGKGDFKGFDNLHPGITARFAIPHQVESAELIGDHWQISRAECDEFAR
CCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHH
ESHRRAHAARLAGVHKEIVATAGVDKEGNAITLDYDEGVRPVIDVDKMSAMLPVFRTPET
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEHHHHHHHCCCCCCCCC
GVVTAANASQMSDGAAAVVLGSAESAARLGLKPKARFKARVVVGSDPVMQLTGVIPATRL
CEEEECCHHHCCCCCEEEEEECCCHHHHCCCCCCCCEEEEEEECCCCHHHHHCCCHHHHH
ALKKAGLSIADLDWIEVNEAFATVAIAWAREFSPNMDKLNPWGGAIAHGHPLGGTGAGLM
HHHHCCCCEECCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AKMLSGLESCNGRFGLQVMCIGHGMATATIIERLA
HHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA