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The map label for this gene is envZ [H]

Identifier: 71907608

GI number: 71907608

Start: 2128381

End: 2129682

Strand: Reverse

Name: envZ [H]

Synonym: Daro_1979

Alternate gene names: 71907608

Gene position: 2129682-2128381 (Counterclockwise)

Preceding gene: 71907609

Following gene: 71907601

Centisome position: 47.31

GC content: 61.98

Gene sequence:

>1302_bases
ATGCCGCGCACGCTGCTGGCGCGCACCTTCCTGCTGTTGGCCATGCTGGTGCTGCTGACCACGGCGGCCTGGCTGAGCCT
GTTCCGCTATATCGACGCCGAGCCACGCGCCCGGGAAACCGCCAAGTTGGCGGCTTCGGCCGTCAATCTGATCCGCGCCT
CACTGTTTGCCGCCGCGCCGGAAAAACGCCTGGGTCTGTTTACCGAGTTTTCAACCCGCGAGGGCATCCGTCTGCTACCG
GCCGAACCTGAAGACGAGATCGAGGCGATGCCCGATTCACGCTTTTTTCGGCTGTTGCAGCGCGAACTTCTTTCCCGACT
GGGCGACCACACCCGTGTCGCGGCCAGTGTTGATGGCATTCCCGGATTCTGGGTCAGCTTCCGGCTCGACGATGCTGACG
AAGAAGAGTACTGGCTGGTCCTGCCTCGTGATCGTACCGCCAGGAGTATCGCCAGCCATTGGCTGGCCTGGGGGCTGCTC
GCCATCGTCCTGGCCATGGCAGTCGCGTGGCTGATCGCCTCGCGCATCAGCCGACCACTGAAAGCGATGGCCAAGTCGGC
TGAAACCCTTGGCCGCGGCCAGATACCGGACCCTTTGCCGGAAGATGGCACCGAAGAACTCAGCCGGCTGGCGACTGCAT
TCAATACCATGGCCGCCGATCTTCAACGCCATGAAAAAGACCGTTCCGAAGTGCTGGCCGGTATCTCCCACGATCTACGC
ACGCCGCTGACCCGCCTGCGCCTGGAAGCCGAAATGAGCGTTGCCGATGATGGTGCCCGGCAAGCGGTCGTGACCGACAT
CGAGCAGATGGAGGCGGTCATTTCCCAGTTCATGGACTACGCCCGCGCCGAATCCGGTGAGGCCCCCACCCTGACCGACC
TGTCAGCCCTGCTTGCAAGCCTTGCCGAACGCCAGGCCTATATCGGCCGGCAGATCGTCACCGACATCCAGGCATTGCCG
GAAGCGATGCTCCGCCCGAAAGCAGTCACCCGTGCCATCAACAATCTGCTGGATAACGCGGCAAAATATGGCGGCGGAGA
TATCACCTTGAAAGCAGCCACGATCAATGGCGAAATTCAAATAGACGTTGGTGATCATGGACCGGGTGTTCCGCCTGATG
ACATCGAACGACTGAAGCGCCCGTTTACTCGCCTGGAAGCTGCCAGAACCAATGCCACAGGAACCGGCCTGGGACTGGCC
ATTGTCGAGCGCATCGCCCGCCTGCACGATGGCCGTTTCGACCTGTTACCCAATCAAGGGGGCGGGCTGCTGGCCCGCCT
GTCGCTACCGATCAGGCGATAA

Upstream 100 bases:

>100_bases
AGCTGATCGAAACTGATCCGGCCCAACCGCGCTACCTGCAGACCGTCTGGGGCTTCGGCTACGTCTTCGTGCCGGACGGC
GCCTCCCGGGACTGATGCCA

Downstream 100 bases:

>100_bases
AGGCCTGACAGGTTTCGTCCATTTCCTTCATCACCTGCGGCAGAATACGGGCGATCTTTTCGCTGTCCATCCCCAGGCGC
TGCCAAGCAGTCTGATCCAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MPRTLLARTFLLLAMLVLLTTAAWLSLFRYIDAEPRARETAKLAASAVNLIRASLFAAAPEKRLGLFTEFSTREGIRLLP
AEPEDEIEAMPDSRFFRLLQRELLSRLGDHTRVAASVDGIPGFWVSFRLDDADEEEYWLVLPRDRTARSIASHWLAWGLL
AIVLAMAVAWLIASRISRPLKAMAKSAETLGRGQIPDPLPEDGTEELSRLATAFNTMAADLQRHEKDRSEVLAGISHDLR
TPLTRLRLEAEMSVADDGARQAVVTDIEQMEAVISQFMDYARAESGEAPTLTDLSALLASLAERQAYIGRQIVTDIQALP
EAMLRPKAVTRAINNLLDNAAKYGGGDITLKAATINGEIQIDVGDHGPGVPPDDIERLKRPFTRLEAARTNATGTGLGLA
IVERIARLHDGRFDLLPNQGGGLLARLSLPIRR

Sequences:

>Translated_433_residues
MPRTLLARTFLLLAMLVLLTTAAWLSLFRYIDAEPRARETAKLAASAVNLIRASLFAAAPEKRLGLFTEFSTREGIRLLP
AEPEDEIEAMPDSRFFRLLQRELLSRLGDHTRVAASVDGIPGFWVSFRLDDADEEEYWLVLPRDRTARSIASHWLAWGLL
AIVLAMAVAWLIASRISRPLKAMAKSAETLGRGQIPDPLPEDGTEELSRLATAFNTMAADLQRHEKDRSEVLAGISHDLR
TPLTRLRLEAEMSVADDGARQAVVTDIEQMEAVISQFMDYARAESGEAPTLTDLSALLASLAERQAYIGRQIVTDIQALP
EAMLRPKAVTRAINNLLDNAAKYGGGDITLKAATINGEIQIDVGDHGPGVPPDDIERLKRPFTRLEAARTNATGTGLGLA
IVERIARLHDGRFDLLPNQGGGLLARLSLPIRR
>Mature_432_residues
PRTLLARTFLLLAMLVLLTTAAWLSLFRYIDAEPRARETAKLAASAVNLIRASLFAAAPEKRLGLFTEFSTREGIRLLPA
EPEDEIEAMPDSRFFRLLQRELLSRLGDHTRVAASVDGIPGFWVSFRLDDADEEEYWLVLPRDRTARSIASHWLAWGLLA
IVLAMAVAWLIASRISRPLKAMAKSAETLGRGQIPDPLPEDGTEELSRLATAFNTMAADLQRHEKDRSEVLAGISHDLRT
PLTRLRLEAEMSVADDGARQAVVTDIEQMEAVISQFMDYARAESGEAPTLTDLSALLASLAERQAYIGRQIVTDIQALPE
AMLRPKAVTRAINNLLDNAAKYGGGDITLKAATINGEIQIDVGDHGPGVPPDDIERLKRPFTRLEAARTNATGTGLGLAI
VERIARLHDGRFDLLPNQGGGLLARLSLPIRR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=441, Percent_Identity=31.7460317460317, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1787894, Length=283, Percent_Identity=32.1554770318021, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=29.1044776119403, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=27.6978417266187, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=30.0699300699301, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=26.6211604095563, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=26.2626262626263, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=334, Percent_Identity=25.1497005988024, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=30.1652892561983, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=24.9258160237389, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=290, Percent_Identity=26.2068965517241, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786783, Length=270, Percent_Identity=22.962962962963, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=299, Percent_Identity=28.7625418060201, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=27.1551724137931, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=23.9819004524887, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=293, Percent_Identity=23.2081911262799, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47603; Mature: 47472

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTLLARTFLLLAMLVLLTTAAWLSLFRYIDAEPRARETAKLAASAVNLIRASLFAAAP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
EKRLGLFTEFSTREGIRLLPAEPEDEIEAMPDSRFFRLLQRELLSRLGDHTRVAASVDGI
HHHHHHHHCCCCCCCCEECCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEHCCCCC
PGFWVSFRLDDADEEEYWLVLPRDRTARSIASHWLAWGLLAIVLAMAVAWLIASRISRPL
CCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMAKSAETLGRGQIPDPLPEDGTEELSRLATAFNTMAADLQRHEKDRSEVLAGISHDLR
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLTRLRLEAEMSVADDGARQAVVTDIEQMEAVISQFMDYARAESGEAPTLTDLSALLAS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LAERQAYIGRQIVTDIQALPEAMLRPKAVTRAINNLLDNAAKYGGGDITLKAATINGEIQ
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEE
IDVGDHGPGVPPDDIERLKRPFTRLEAARTNATGTGLGLAIVERIARLHDGRFDLLPNQG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCCC
GGLLARLSLPIRR
CCEEEEECCCCCC
>Mature Secondary Structure 
PRTLLARTFLLLAMLVLLTTAAWLSLFRYIDAEPRARETAKLAASAVNLIRASLFAAAP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
EKRLGLFTEFSTREGIRLLPAEPEDEIEAMPDSRFFRLLQRELLSRLGDHTRVAASVDGI
HHHHHHHHCCCCCCCCEECCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEHCCCCC
PGFWVSFRLDDADEEEYWLVLPRDRTARSIASHWLAWGLLAIVLAMAVAWLIASRISRPL
CCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMAKSAETLGRGQIPDPLPEDGTEELSRLATAFNTMAADLQRHEKDRSEVLAGISHDLR
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPLTRLRLEAEMSVADDGARQAVVTDIEQMEAVISQFMDYARAESGEAPTLTDLSALLAS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LAERQAYIGRQIVTDIQALPEAMLRPKAVTRAINNLLDNAAKYGGGDITLKAATINGEIQ
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEE
IDVGDHGPGVPPDDIERLKRPFTRLEAARTNATGTGLGLAIVERIARLHDGRFDLLPNQG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCCC
GGLLARLSLPIRR
CCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]