Click here to switch to the map view.

The map label for this gene is fabI [H]

Identifier: 71907564

GI number: 71907564

Start: 2083682

End: 2084479

Strand: Reverse

Name: fabI [H]

Synonym: Daro_1935

Alternate gene names: 71907564

Gene position: 2084479-2083682 (Counterclockwise)

Preceding gene: 71907565

Following gene: 71907560

Centisome position: 46.31

GC content: 60.15

Gene sequence:

>798_bases
ATGGGCTTTCTCGCCGACAAGAAGATTCTAATTACCGGACTGCTGTCCAAGCATTCCATCGCCTATGGCATCGCCAAGGC
ATGCCACCGTGAAGGCGCCCAACTCGCCTTCACCTACCAGAATGAGCGCTTCGAAGATCGAATCAAGAAGTTTGCCGCCG
AGTTCGGCAGCGACATCACCATTCCGGTCGACGTCAGCAGCGATGAGCAGATCGACAACCTTTTCGTCGAACTAGCCAAG
CACTGGGACGGTCTGGATGGCTTGGTTCACTCCATCGCCTACGCTCCGACCGAAGCCATCGAAGGCGATTTCCTGAACGG
CATCACCCGTGACGCCTTCCGCATCGCCCACGAAATCTCGTCGTATAGCTACCCGGCACTGGTCAAGGCCGCTCGCCCGA
TGATGCAGGGTCGCAGGAGCTCAGCCCTTGCGCTCTCCTATCTTGGCGCCGAGCGCACCATGCCGAACTACAACACCATG
GGTCTGGCCAAGGCCAGCCTGGAAGCAGCTACCCGTTACCTGGCTTTCTGCCTCGGCCCTGAAGGCATCCGCGCCAACGC
CATTTCGGCCGGCCCGATCAAGACCCTGGCGGCTTCCGGTATCGGCAATTTTGGCAAGCTGCTCGCCTACAACTCGCACA
ACGCCCCGCTGCGCCGCAACGTGACCATCGATGAAGTCGGCAACGCGGCCGCCTTCATGCTGTCCGATCTGGCCAGCGGC
ATCACCGGTGAAATCATGTACGTCGATGGCGGCATGAACACCGTGGCACTGGGTAATGCGGACCCGCTACCGGCCTAA

Upstream 100 bases:

>100_bases
CCCAATATGTAAGCAGAAACCGGAAACCGCGTTCGCATACCGCGAATCGCGGTTTCCCGGTTTATAATCTTGCGGCTAAA
CCCCTTAGGGAGAACAACAC

Downstream 100 bases:

>100_bases
GTAAATATTTTCGCGGCCAGCGCCGCAAAAAGGCAAAACGCCGATCCGGTTTTATACCGGTCGGCGTTTTTAATTTATGG
TTTGGACAAAACGTGCTGCA

Product: enoyl-[acyl-carrier-protein] reductase [NADH]

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MGFLADKKILITGLLSKHSIAYGIAKACHREGAQLAFTYQNERFEDRIKKFAAEFGSDITIPVDVSSDEQIDNLFVELAK
HWDGLDGLVHSIAYAPTEAIEGDFLNGITRDAFRIAHEISSYSYPALVKAARPMMQGRRSSALALSYLGAERTMPNYNTM
GLAKASLEAATRYLAFCLGPEGIRANAISAGPIKTLAASGIGNFGKLLAYNSHNAPLRRNVTIDEVGNAAAFMLSDLASG
ITGEIMYVDGGMNTVALGNADPLPA

Sequences:

>Translated_265_residues
MGFLADKKILITGLLSKHSIAYGIAKACHREGAQLAFTYQNERFEDRIKKFAAEFGSDITIPVDVSSDEQIDNLFVELAK
HWDGLDGLVHSIAYAPTEAIEGDFLNGITRDAFRIAHEISSYSYPALVKAARPMMQGRRSSALALSYLGAERTMPNYNTM
GLAKASLEAATRYLAFCLGPEGIRANAISAGPIKTLAASGIGNFGKLLAYNSHNAPLRRNVTIDEVGNAAAFMLSDLASG
ITGEIMYVDGGMNTVALGNADPLPA
>Mature_264_residues
GFLADKKILITGLLSKHSIAYGIAKACHREGAQLAFTYQNERFEDRIKKFAAEFGSDITIPVDVSSDEQIDNLFVELAKH
WDGLDGLVHSIAYAPTEAIEGDFLNGITRDAFRIAHEISSYSYPALVKAARPMMQGRRSSALALSYLGAERTMPNYNTMG
LAKASLEAATRYLAFCLGPEGIRANAISAGPIKTLAASGIGNFGKLLAYNSHNAPLRRNVTIDEVGNAAAFMLSDLASGI
TGEIMYVDGGMNTVALGNADPLPA

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=26.6932270916335, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787545, Length=257, Percent_Identity=58.7548638132296, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=28.3464566929134, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=29.6703296703297, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=29.8449612403101, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=25.9842519685039, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28380; Mature: 28248

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLADKKILITGLLSKHSIAYGIAKACHREGAQLAFTYQNERFEDRIKKFAAEFGSDIT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCE
IPVDVSSDEQIDNLFVELAKHWDGLDGLVHSIAYAPTEAIEGDFLNGITRDAFRIAHEIS
EEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHH
SYSYPALVKAARPMMQGRRSSALALSYLGAERTMPNYNTMGLAKASLEAATRYLAFCLGP
CCCCHHHHHHHHHHHHCCCCHHHHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
EGIRANAISAGPIKTLAASGIGNFGKLLAYNSHNAPLRRNVTIDEVGNAAAFMLSDLASG
CCCCCCCCCCCCHHHHHHHCCCCCHHEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHCC
ITGEIMYVDGGMNTVALGNADPLPA
CCCEEEEEECCCCEEEECCCCCCCC
>Mature Secondary Structure 
GFLADKKILITGLLSKHSIAYGIAKACHREGAQLAFTYQNERFEDRIKKFAAEFGSDIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCE
IPVDVSSDEQIDNLFVELAKHWDGLDGLVHSIAYAPTEAIEGDFLNGITRDAFRIAHEIS
EEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHH
SYSYPALVKAARPMMQGRRSSALALSYLGAERTMPNYNTMGLAKASLEAATRYLAFCLGP
CCCCHHHHHHHHHHHHCCCCHHHHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
EGIRANAISAGPIKTLAASGIGNFGKLLAYNSHNAPLRRNVTIDEVGNAAAFMLSDLASG
CCCCCCCCCCCCHHHHHHHCCCCCHHEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHCC
ITGEIMYVDGGMNTVALGNADPLPA
CCCEEEEEECCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]