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The map label for this gene is ctaB

Identifier: 71907095

GI number: 71907095

Start: 1588286

End: 1589182

Strand: Reverse

Name: ctaB

Synonym: Daro_1463

Alternate gene names: 71907095

Gene position: 1589182-1588286 (Counterclockwise)

Preceding gene: 71907096

Following gene: 71907094

Centisome position: 35.31

GC content: 66.22

Gene sequence:

>897_bases
ATGCAAACCATCGCCACCCCGTCGCTCCCCCTCGGCCAACGCCTCGCCGCCTTCAGCCACCTGTGCAAGCCGCGGGTCAA
CAGCCTGATCGTGTTCACGGCCATGATCGGCATGTGCCTGGCGACACCGGATTTTCCGCCGCTGCTGCGCTTCGGCGTTG
CATCGCTCGGCATTGCGCTGGTCTCCTTCGCGGCCGCTGCCCTCAACTGTCTGGTCGAGCGCACCGTCGATGCCAAGATG
GCGCGCACCAGCTGGCGGGCAACCGCCCGCGGCGACATCTCGCCGCTCGAAACGGTGACGCTGGCCACCGCCCTCGGCGC
CGCCGGGCTCTGGCTGCTGCACGGCTTCATCAACGACCTGACGATGTGGCTGACGCTGGCCACCTTCGTCGGCTACACCG
TCATCTACACGCTGATCCTGAAACCGGCAACGCCGATGAACATCGTCATCGGCGGTGCTTCCGGCGCCATGCCGCCGCTG
CTCGGATGGACGGCAATGACCGGCCAGGTCTCGGCCGAACCGCTGGTTCTCTTCCTGATCATCTTCCTGTGGACGCCGCC
GCATTTCTGGGCACTGGCCTGCTACCGGCGTGACGACTACGCCTGTTCCGGCCTGCCCATGCTGCCGGTCACTCACGGCA
TCGCTTTCACCTGCCAGCACATCCTCTGGTACACGCTGATGCTGGCTGCCGCCAGCCTGATCCCGGTCTCGCTCGGCATG
AGCGGCGGCTTCTACCTGATCGCCATCGGCCTGCTCGACCTCGTCTTCCTCGGCTACGCCATCGCCCTCTGCCGCCGCTA
CAGCGATGCCTTGGCCCGGCGTACCTTCCGCTATTCCATCCTCTACCTGACCCTGCTCTTCGCGGCGCTGTTCGCCGACC
GGCTGATCGTCCTCTAG

Upstream 100 bases:

>100_bases
TTACCCCGCCGAGGTCACCGCCAAGGACATGCGCGCCGACCTCGAACGCCTGCTCAAATTCGCCTGGACCGGTTAGGCCA
CATCGCAAAGGAACCCAGCC

Downstream 100 bases:

>100_bases
GCCGCCATGCGCCTCTACCGCGCCCTGCTGATCGCTGCCGCCCTGCTCGCCCTGATCGTCATCGGCTTGGGCGCCTACGT
CCGGCTGTCCGATGCCGGCC

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQTIATPSLPLGQRLAAFSHLCKPRVNSLIVFTAMIGMCLATPDFPPLLRFGVASLGIALVSFAAAALNCLVERTVDAKM
ARTSWRATARGDISPLETVTLATALGAAGLWLLHGFINDLTMWLTLATFVGYTVIYTLILKPATPMNIVIGGASGAMPPL
LGWTAMTGQVSAEPLVLFLIIFLWTPPHFWALACYRRDDYACSGLPMLPVTHGIAFTCQHILWYTLMLAAASLIPVSLGM
SGGFYLIAIGLLDLVFLGYAIALCRRYSDALARRTFRYSILYLTLLFAALFADRLIVL

Sequences:

>Translated_298_residues
MQTIATPSLPLGQRLAAFSHLCKPRVNSLIVFTAMIGMCLATPDFPPLLRFGVASLGIALVSFAAAALNCLVERTVDAKM
ARTSWRATARGDISPLETVTLATALGAAGLWLLHGFINDLTMWLTLATFVGYTVIYTLILKPATPMNIVIGGASGAMPPL
LGWTAMTGQVSAEPLVLFLIIFLWTPPHFWALACYRRDDYACSGLPMLPVTHGIAFTCQHILWYTLMLAAASLIPVSLGM
SGGFYLIAIGLLDLVFLGYAIALCRRYSDALARRTFRYSILYLTLLFAALFADRLIVL
>Mature_298_residues
MQTIATPSLPLGQRLAAFSHLCKPRVNSLIVFTAMIGMCLATPDFPPLLRFGVASLGIALVSFAAAALNCLVERTVDAKM
ARTSWRATARGDISPLETVTLATALGAAGLWLLHGFINDLTMWLTLATFVGYTVIYTLILKPATPMNIVIGGASGAMPPL
LGWTAMTGQVSAEPLVLFLIIFLWTPPHFWALACYRRDDYACSGLPMLPVTHGIAFTCQHILWYTLMLAAASLIPVSLGM
SGGFYLIAIGLLDLVFLGYAIALCRRYSDALARRTFRYSILYLTLLFAALFADRLIVL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=196, Percent_Identity=38.265306122449, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1786631, Length=243, Percent_Identity=34.9794238683128, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71998235, Length=192, Percent_Identity=32.8125, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=290, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19921064, Length=277, Percent_Identity=32.129963898917, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_DECAR (Q47G19)

Other databases:

- EMBL:   CP000089
- RefSeq:   YP_284682.1
- STRING:   Q47G19
- GeneID:   3569031
- GenomeReviews:   CP000089_GR
- KEGG:   dar:Daro_1463
- NMPDR:   fig|159087.4.peg.1349
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- BioCyc:   DARO159087:DARO_1463-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32324; Mature: 32324

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12ac2254)-; HASH(0x132eb308)-; HASH(0x1335fef8)-; HASH(0x132bf400)-; HASH(0x132bf28c)-; HASH(0x13446ffc)-; HASH(0x130de138)-; HASH(0x134470ec)-; HASH(0x1332c994)-;

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIATPSLPLGQRLAAFSHLCKPRVNSLIVFTAMIGMCLATPDFPPLLRFGVASLGIAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VSFAAAALNCLVERTVDAKMARTSWRATARGDISPLETVTLATALGAAGLWLLHGFINDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TMWLTLATFVGYTVIYTLILKPATPMNIVIGGASGAMPPLLGWTAMTGQVSAEPLVLFLI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHH
IFLWTPPHFWALACYRRDDYACSGLPMLPVTHGIAFTCQHILWYTLMLAAASLIPVSLGM
HHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGGFYLIAIGLLDLVFLGYAIALCRRYSDALARRTFRYSILYLTLLFAALFADRLIVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MQTIATPSLPLGQRLAAFSHLCKPRVNSLIVFTAMIGMCLATPDFPPLLRFGVASLGIAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VSFAAAALNCLVERTVDAKMARTSWRATARGDISPLETVTLATALGAAGLWLLHGFINDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TMWLTLATFVGYTVIYTLILKPATPMNIVIGGASGAMPPLLGWTAMTGQVSAEPLVLFLI
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHH
IFLWTPPHFWALACYRRDDYACSGLPMLPVTHGIAFTCQHILWYTLMLAAASLIPVSLGM
HHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGGFYLIAIGLLDLVFLGYAIALCRRYSDALARRTFRYSILYLTLLFAALFADRLIVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA