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The map label for this gene is hemH

Identifier: 71906568

GI number: 71906568

Start: 1007548

End: 1008651

Strand: Reverse

Name: hemH

Synonym: Daro_0929

Alternate gene names: 71906568

Gene position: 1008651-1007548 (Counterclockwise)

Preceding gene: 71906569

Following gene: 71906567

Centisome position: 22.41

GC content: 61.14

Gene sequence:

>1104_bases
ATGCCCCGTTTTCTCCCGGAACCGCCGCACCGTCACGGCAACCCGGCGACCACTGCGGTCGTCCTCGTCAATCTCGGCAC
ACCGGATGCGCCGACGGCCCCGGCATTGAAGCGCTATCTCAAGGAGTTCCTGTCCGACCCGCGCGTCGTCGAAATTCCCA
AGCCGGTCTGGTGGCTGATCCTCAACGGCATCATTCTCAATATCCGGCCCAAGAAATCAGCCGCCAAATACGCCTCGGTC
TGGATGCCGGAAGGTTCGCCATTACGCGTCCATACCGAGCGCCAAGCCAAGTTGCTAAAGGGCCTGCTAGGCCAGCGCGG
CCATCACCTGACTGTAACCTCGGCCATGCGCTACGGATCGCCGTCGATTCCGGAGGTCCTCGCCCACCTGAAGGCCGAAG
GGGCCAAGCGCATCCTGCTGGTGCCGATGTACCCGCAATACGCCGCGAGCACAACGGCCACTGTCGTGGATGAAGCGGCC
AACTGGCTGACTAAAATCCGCAATCAGCCAGAAATGCGCTTTGTCCGGAACTTCCATGACCACGAAGGCTATCTGGCTGC
CCTCGAAAAATCGGTTCGTCAGCACTGGCAAACCAACGGATCGTTGGGCGACAACGACCGACTGCTGATCAGTTTCCACG
GCCTGCCCAAGCGCAGCCTGGATCTCGGCGACCCCTATTTCTGCGAATGCCACAAGACCGGCCGCCTGCTAGCCGAGCGC
CTGAACCTCAAGCCGGAACAATTCCAGATCTGCTTCCAGTCACGCTTCGGCAAAGCCGAATGGCTGCAGCCCTACACCGC
GCCGACGCTGCATGAATGGGGTAGCAAAGGCGTCCGCCGCGTCGATGTGATCTGCCCCGGCTTTGTCGCCGACTGCCTGG
AGACGCTGGAAGAAATCGCACAGGAAGGCCGCGACGATTTCCTGAAAGCCGGTGGCAAGGAATATCACTACATTCCCGCA
CTGAACGAAGACGACGCCTGGATCAAGGCACTGGCTGACATCGCCGAGCAGCATCTCGGCGGCTGGTCAACCAAGACTGC
CTTCGACCCGCACGCACTGGAAACCAGCGCCCGAGAAGCCTTCAAATTCGGCGCCCGGGCTTGA

Upstream 100 bases:

>100_bases
TCATCGGACCAACCCGCATGGCCTACGAACGCGTCATCCCCATCGTCGACATTACCGCCCGCCTGCTCTCCAGCGCCCTC
TCCTACAAATCGGACAACTG

Downstream 100 bases:

>100_bases
AATTCGTCAGATGGCACAAATATCAGGACAACCTGATATTTGGAGCCTGAGATGTCCGAAAACCTGCACCTCGTCTGCCC
GCACTGCGCTGCGGTCAATC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MPRFLPEPPHRHGNPATTAVVLVNLGTPDAPTAPALKRYLKEFLSDPRVVEIPKPVWWLILNGIILNIRPKKSAAKYASV
WMPEGSPLRVHTERQAKLLKGLLGQRGHHLTVTSAMRYGSPSIPEVLAHLKAEGAKRILLVPMYPQYAASTTATVVDEAA
NWLTKIRNQPEMRFVRNFHDHEGYLAALEKSVRQHWQTNGSLGDNDRLLISFHGLPKRSLDLGDPYFCECHKTGRLLAER
LNLKPEQFQICFQSRFGKAEWLQPYTAPTLHEWGSKGVRRVDVICPGFVADCLETLEEIAQEGRDDFLKAGGKEYHYIPA
LNEDDAWIKALADIAEQHLGGWSTKTAFDPHALETSAREAFKFGARA

Sequences:

>Translated_367_residues
MPRFLPEPPHRHGNPATTAVVLVNLGTPDAPTAPALKRYLKEFLSDPRVVEIPKPVWWLILNGIILNIRPKKSAAKYASV
WMPEGSPLRVHTERQAKLLKGLLGQRGHHLTVTSAMRYGSPSIPEVLAHLKAEGAKRILLVPMYPQYAASTTATVVDEAA
NWLTKIRNQPEMRFVRNFHDHEGYLAALEKSVRQHWQTNGSLGDNDRLLISFHGLPKRSLDLGDPYFCECHKTGRLLAER
LNLKPEQFQICFQSRFGKAEWLQPYTAPTLHEWGSKGVRRVDVICPGFVADCLETLEEIAQEGRDDFLKAGGKEYHYIPA
LNEDDAWIKALADIAEQHLGGWSTKTAFDPHALETSAREAFKFGARA
>Mature_366_residues
PRFLPEPPHRHGNPATTAVVLVNLGTPDAPTAPALKRYLKEFLSDPRVVEIPKPVWWLILNGIILNIRPKKSAAKYASVW
MPEGSPLRVHTERQAKLLKGLLGQRGHHLTVTSAMRYGSPSIPEVLAHLKAEGAKRILLVPMYPQYAASTTATVVDEAAN
WLTKIRNQPEMRFVRNFHDHEGYLAALEKSVRQHWQTNGSLGDNDRLLISFHGLPKRSLDLGDPYFCECHKTGRLLAERL
NLKPEQFQICFQSRFGKAEWLQPYTAPTLHEWGSKGVRRVDVICPGFVADCLETLEEIAQEGRDDFLKAGGKEYHYIPAL
NEDDAWIKALADIAEQHLGGWSTKTAFDPHALETSAREAFKFGARA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=265, Percent_Identity=24.5283018867925, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI60499021, Length=265, Percent_Identity=24.5283018867925, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786681, Length=321, Percent_Identity=46.417445482866, Blast_Score=283, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=24.9249249249249, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17864156, Length=353, Percent_Identity=22.3796033994334, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_DECAR (Q47HJ6)

Other databases:

- EMBL:   CP000089
- RefSeq:   YP_284155.1
- ProteinModelPortal:   Q47HJ6
- SMR:   Q47HJ6
- STRING:   Q47HJ6
- GeneID:   3570243
- GenomeReviews:   CP000089_GR
- KEGG:   dar:Daro_0929
- NMPDR:   fig|159087.4.peg.1316
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- BioCyc:   DARO159087:DARO_0929-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41259; Mature: 41128

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFLPEPPHRHGNPATTAVVLVNLGTPDAPTAPALKRYLKEFLSDPRVVEIPKPVWWLI
CCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHH
LNGIILNIRPKKSAAKYASVWMPEGSPLRVHTERQAKLLKGLLGQRGHHLTVTSAMRYGS
HCCEEEEEECCHHHHHHHHEECCCCCCEEEECHHHHHHHHHHHCCCCCEEEEEHHHHCCC
PSIPEVLAHLKAEGAKRILLVPMYPQYAASTTATVVDEAANWLTKIRNQPEMRFVRNFHD
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
HEGYLAALEKSVRQHWQTNGSLGDNDRLLISFHGLPKRSLDLGDPYFCECHKTGRLLAER
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHH
LNLKPEQFQICFQSRFGKAEWLQPYTAPTLHEWGSKGVRRVDVICPGFVADCLETLEEIA
HCCCHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
QEGRDDFLKAGGKEYHYIPALNEDDAWIKALADIAEQHLGGWSTKTAFDPHALETSAREA
HHCCHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
FKFGARA
HHCCCCC
>Mature Secondary Structure 
PRFLPEPPHRHGNPATTAVVLVNLGTPDAPTAPALKRYLKEFLSDPRVVEIPKPVWWLI
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHH
LNGIILNIRPKKSAAKYASVWMPEGSPLRVHTERQAKLLKGLLGQRGHHLTVTSAMRYGS
HCCEEEEEECCHHHHHHHHEECCCCCCEEEECHHHHHHHHHHHCCCCCEEEEEHHHHCCC
PSIPEVLAHLKAEGAKRILLVPMYPQYAASTTATVVDEAANWLTKIRNQPEMRFVRNFHD
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHC
HEGYLAALEKSVRQHWQTNGSLGDNDRLLISFHGLPKRSLDLGDPYFCECHKTGRLLAER
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHH
LNLKPEQFQICFQSRFGKAEWLQPYTAPTLHEWGSKGVRRVDVICPGFVADCLETLEEIA
HCCCHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
QEGRDDFLKAGGKEYHYIPALNEDDAWIKALADIAEQHLGGWSTKTAFDPHALETSAREA
HHCCHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
FKFGARA
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA