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The map label for this gene is cyp18 [H]

Identifier: 71906555

GI number: 71906555

Start: 991621

End: 992193

Strand: Reverse

Name: cyp18 [H]

Synonym: Daro_0916

Alternate gene names: 71906555

Gene position: 992193-991621 (Counterclockwise)

Preceding gene: 71906556

Following gene: 71906554

Centisome position: 22.04

GC content: 54.45

Gene sequence:

>573_bases
ATGTTGAAAAAAATTTCTGTTCTCGCCGCTGGCCTGCTGGCTTCAGCAATGGTGTGGGCTGCCCCAACCGTCGAAATGAC
GACCAATCTGGGCAAGTTCACGCTTGAACTGTTCCCGGAAAAGGCCCCGAAAACGGTTGAAATGTTTCTCTATAACGCCA
AGCACGGTTTTTATGAGGCGACCATCTTCCACCGCGTGATTGATGGCTTCATGATCCAGGGTGGCGGTTTCAGCCGGGCC
ATGGAAGAGAAAAAGACCCTGACCCCGGCGCTGCAGAACGAAGCCACCAACGGCCTGACCAATGACCGTGGCACGGTGGC
CATGGCACGCACGCAGGACCCGCATTCAGCTCGCGTCCAGTTCTTCATCAATCTGAAGGACAACGAGTTCCTGAACCATC
GCAACTCTACCGACCCACGCGGCTGGGGCTATGCCGTCTTTGGCAAAGTGACCCAGGGCATGGATGTCGTCGACAAGATT
GCCAAGGTGCCGACCGGCAACGCTGGCTATTACGAAAACGTTCCGACGACACCGGTTGTCATTCAGAACGTCAAAATCAT
CTCTGAAAAATAA

Upstream 100 bases:

>100_bases
AGGATTACCGCAGCAACAACCTGAACAACCAGATGAAGAAGCGTCAGTACTGGCAGCGCGAAGATGGCAAGTGGAAAATC
ATTTACGAAGGAAGTGCCTG

Downstream 100 bases:

>100_bases
GGTTTCTCCATGATCAAGCTCACCACCAACCACGGTGTAATCACCCTCAACCTGGATGCCGAGAAGGCGCCAAAGACGGT
TGCAAACTTCATCTCCTACG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MLKKISVLAAGLLASAMVWAAPTVEMTTNLGKFTLELFPEKAPKTVEMFLYNAKHGFYEATIFHRVIDGFMIQGGGFSRA
MEEKKTLTPALQNEATNGLTNDRGTVAMARTQDPHSARVQFFINLKDNEFLNHRNSTDPRGWGYAVFGKVTQGMDVVDKI
AKVPTGNAGYYENVPTTPVVIQNVKIISEK

Sequences:

>Translated_190_residues
MLKKISVLAAGLLASAMVWAAPTVEMTTNLGKFTLELFPEKAPKTVEMFLYNAKHGFYEATIFHRVIDGFMIQGGGFSRA
MEEKKTLTPALQNEATNGLTNDRGTVAMARTQDPHSARVQFFINLKDNEFLNHRNSTDPRGWGYAVFGKVTQGMDVVDKI
AKVPTGNAGYYENVPTTPVVIQNVKIISEK
>Mature_190_residues
MLKKISVLAAGLLASAMVWAAPTVEMTTNLGKFTLELFPEKAPKTVEMFLYNAKHGFYEATIFHRVIDGFMIQGGGFSRA
MEEKKTLTPALQNEATNGLTNDRGTVAMARTQDPHSARVQFFINLKDNEFLNHRNSTDPRGWGYAVFGKVTQGMDVVDKI
AKVPTGNAGYYENVPTTPVVIQNVKIISEK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=180, Percent_Identity=31.1111111111111, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=31.3253012048193, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI24308049, Length=138, Percent_Identity=34.0579710144928, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI10863927, Length=144, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI22547215, Length=142, Percent_Identity=32.3943661971831, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI22547212, Length=142, Percent_Identity=32.3943661971831, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI7657473, Length=142, Percent_Identity=32.3943661971831, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=189, Percent_Identity=51.8518518518518, Blast_Score=184, Evalue=3e-48,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=54.601226993865, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17532641, Length=186, Percent_Identity=28.494623655914, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=32.0987654320988, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=166, Percent_Identity=31.3253012048193, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=140, Percent_Identity=33.5714285714286, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=31.2925170068027, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922912, Length=167, Percent_Identity=33.5329341317365, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922376, Length=184, Percent_Identity=24.4565217391304, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=173, Percent_Identity=28.9017341040462, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21001; Mature: 21001

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKISVLAAGLLASAMVWAAPTVEMTTNLGKFTLELFPEKAPKTVEMFLYNAKHGFYEA
CCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCHHH
TIFHRVIDGFMIQGGGFSRAMEEKKTLTPALQNEATNGLTNDRGTVAMARTQDPHSARVQ
HHHHHHHHHEEECCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEE
FFINLKDNEFLNHRNSTDPRGWGYAVFGKVTQGMDVVDKIAKVPTGNAGYYENVPTTPVV
EEEEECCCCHHCCCCCCCCCCCCEEEEHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEE
IQNVKIISEK
EEEEEEEECC
>Mature Secondary Structure
MLKKISVLAAGLLASAMVWAAPTVEMTTNLGKFTLELFPEKAPKTVEMFLYNAKHGFYEA
CCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCHHH
TIFHRVIDGFMIQGGGFSRAMEEKKTLTPALQNEATNGLTNDRGTVAMARTQDPHSARVQ
HHHHHHHHHEEECCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEE
FFINLKDNEFLNHRNSTDPRGWGYAVFGKVTQGMDVVDKIAKVPTGNAGYYENVPTTPVV
EEEEECCCCHHCCCCCCCCCCCCEEEEHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEE
IQNVKIISEK
EEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]