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The map label for this gene is ppiB [H]

Identifier: 71906554

GI number: 71906554

Start: 991120

End: 991611

Strand: Reverse

Name: ppiB [H]

Synonym: Daro_0915

Alternate gene names: 71906554

Gene position: 991611-991120 (Counterclockwise)

Preceding gene: 71906555

Following gene: 71906553

Centisome position: 22.03

GC content: 57.52

Gene sequence:

>492_bases
ATGATCAAGCTCACCACCAACCACGGTGTAATCACCCTCAACCTGGATGCCGAGAAGGCGCCAAAGACGGTTGCAAACTT
CATCTCCTACGTTGAAGCCGGCCACTACAACAACACCATCTTCCACCGCGTCATCAAGAACTTCATGATCCAGGGTGGCG
GCATGGAACCGGGCATGGGCCAGAAGCCCTGCCAGGCACCGATCGAGAATGAGGCCGCCAATGGCCTCAAGAACAAGCGC
GGCACGATTGCCATGGCTCGCACCAACGATCCGCACTCGGCCACTGCCCAGTTCTTCATCAATACCGTCGATAACGACTT
CCTCGACTTCAAGTCGCCGTCCGGCCAGGGCTGGGGCTACTGCGTGTTCGGCGAAGTGGTTGAAGGCATGGACGTCGTCG
ACAAGATTCGCGCCGTCAAGACCGGCAACAAGGGCTTCCATCAGGACGTTCCGGCTGAAGATGTGATCATCGAGAAGGCC
GAGATCGTTTGA

Upstream 100 bases:

>100_bases
CAAGGTGCCGACCGGCAACGCTGGCTATTACGAAAACGTTCCGACGACACCGGTTGTCATTCAGAACGTCAAAATCATCT
CTGAAAAATAAGGTTTCTCC

Downstream 100 bases:

>100_bases
TCCTCTTCATCTCCGATCTGCATCTGTCGCCCCGGTCACCCGGGGCGACTGCTTTGTTCCTCCGCTTTTTGTCGGGCCGC
GCCCGCCAGGCCGAGGCTTT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MIKLTTNHGVITLNLDAEKAPKTVANFISYVEAGHYNNTIFHRVIKNFMIQGGGMEPGMGQKPCQAPIENEAANGLKNKR
GTIAMARTNDPHSATAQFFINTVDNDFLDFKSPSGQGWGYCVFGEVVEGMDVVDKIRAVKTGNKGFHQDVPAEDVIIEKA
EIV

Sequences:

>Translated_163_residues
MIKLTTNHGVITLNLDAEKAPKTVANFISYVEAGHYNNTIFHRVIKNFMIQGGGMEPGMGQKPCQAPIENEAANGLKNKR
GTIAMARTNDPHSATAQFFINTVDNDFLDFKSPSGQGWGYCVFGEVVEGMDVVDKIRAVKTGNKGFHQDVPAEDVIIEKA
EIV
>Mature_163_residues
MIKLTTNHGVITLNLDAEKAPKTVANFISYVEAGHYNNTIFHRVIKNFMIQGGGMEPGMGQKPCQAPIENEAANGLKNKR
GTIAMARTNDPHSATAQFFINTVDNDFLDFKSPSGQGWGYCVFGEVVEGMDVVDKIRAVKTGNKGFHQDVPAEDVIIEKA
EIV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=36.5853658536585, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI19557636, Length=162, Percent_Identity=33.9506172839506, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4758950, Length=155, Percent_Identity=38.0645161290323, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=38.2165605095541, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.9268292682927, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.9268292682927, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.9268292682927, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI27735045, Length=149, Percent_Identity=32.2147651006711, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI64276486, Length=128, Percent_Identity=35.9375, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI4505991, Length=139, Percent_Identity=35.9712230215827, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=67.2839506172839, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=56.1728395061728, Blast_Score=177, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17532641, Length=166, Percent_Identity=36.144578313253, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=148, Percent_Identity=35.8108108108108, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=148, Percent_Identity=35.8108108108108, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=36.7088607594937, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=140, Percent_Identity=37.8571428571429, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506307, Length=155, Percent_Identity=35.4838709677419, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=34.5679012345679, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551282, Length=147, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=147, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=162, Percent_Identity=32.7160493827161, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552784, Length=150, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=156, Percent_Identity=38.4615384615385, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=161, Percent_Identity=34.1614906832298, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=169, Percent_Identity=33.7278106508876, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=32.5301204819277, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136360, Length=161, Percent_Identity=34.1614906832298, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922912, Length=157, Percent_Identity=35.031847133758, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45549139, Length=139, Percent_Identity=40.2877697841727, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17811; Mature: 17811

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLTTNHGVITLNLDAEKAPKTVANFISYVEAGHYNNTIFHRVIKNFMIQGGGMEPGMG
CEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
QKPCQAPIENEAANGLKNKRGTIAMARTNDPHSATAQFFINTVDNDFLDFKSPSGQGWGY
CCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHEEEEECCCCCCCCCCCCCCCCCEE
CVFGEVVEGMDVVDKIRAVKTGNKGFHQDVPAEDVIIEKAEIV
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHCCC
>Mature Secondary Structure
MIKLTTNHGVITLNLDAEKAPKTVANFISYVEAGHYNNTIFHRVIKNFMIQGGGMEPGMG
CEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
QKPCQAPIENEAANGLKNKRGTIAMARTNDPHSATAQFFINTVDNDFLDFKSPSGQGWGY
CCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCHHHEEEEECCCCCCCCCCCCCCCCCEE
CVFGEVVEGMDVVDKIRAVKTGNKGFHQDVPAEDVIIEKAEIV
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]