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The map label for this gene is pgi

Identifier: 71906221

GI number: 71906221

Start: 648738

End: 650318

Strand: Reverse

Name: pgi

Synonym: Daro_0581

Alternate gene names: 71906221

Gene position: 650318-648738 (Counterclockwise)

Preceding gene: 71906222

Following gene: 71906220

Centisome position: 14.45

GC content: 63.95

Gene sequence:

>1581_bases
ATGAACCCTATCGACTCCCCGGCCTGGCGGGCGCTCGCCGCCCACGCCGAGGCTATCCGCCCGCTGCATCTGCGCGACCT
GTTCGCGACCGATCCGCAGCGCTTCGAGCTTTTTTCTCTACACCACGATGGCCTGTTGCTCGACTATTCGAAGCAACGCG
TCAGTGTCGAAACGATGGCCCTGCTCCGCGCCTATGCCGAGACGGCCGATGTCACCGGCTGGCGCCGCAGGATGCTGGAC
GGCGAGAGCATCAACCACACTGAAGGCCGCGCTGTCCGCCACATGAGCTTGCGTGCCGGCGACCAGGCGCCGGCCGAAGT
CCGTGCCGCACTGGCCCGCCAGCAGGCGTTCTGCGAAAGCATCCATAACGGCGTTTGGCGCGGTTTTTCCGGCGAGCGGA
TCACCGATGTCGTCAATATTGGCATCGGCGGCTCCGACCTTGGTCCGCGCATGGCGGCCCTGGCCCTGTCGGCGCGGCAA
CAACCGGATATCGCGGTGCATTTCATCGCCAATGTCGACAGCGCCGACATCGCGCCGCTGCTCGCCAGCCTGAACCCGCG
TACCACGCTGTTCATCGTCGCCAGCAAGACTTTCACGACGCTGGAAACCCTGACCAATGCCCGCACTGCCCGCGACTGGC
TACTCGCCACGGCCGGCCAGGAGAGCGCCATTGCCCGCCATTTCGTCGCCATCTCGACCAATCTCGAATTAACCAAGCAA
TTCGGCATTGCCGACGACAACGTCTTCGAGTTCTGGGACTGGGTTGGTGGCCGTTTCTCGATCTGGTCGGCCATCGGTCT
CTCGCTGGCCCTCGCCATCGGCTGGAAGAACTTCGAGCAACTGCAGGCCGGCGCCCGGGCCATGGACCGGCACTTCATCG
ACACCCCGGCCGACGAGAACCTGCCGCTGACGCTGGCCCTGCTCAGCCTGTGGAACACCAATTTCCTCGGTGCCTCGACC
GAGGCCATGCTGCCCTACAGTCAGTCGCTGCATCTGTTCCCAGCCTATCTGCAGCAACTGGAAATGGAGAGCAACGGCAA
GCAGATCGACCGCGACGGCAAGCCGCTGAACATCGCGACCAGCCCGGTGATCTGGGGCGAGTCCGGCACCAATGGCCAGC
ACTCGTTCTACCAGCTCTTCCATCAGGGCGGCCACCTCATCCCGGCCGACTTCGTGGCGCTGCGCGAAGCTGATTTCCCC
CTGCCCGGCCATCACGCCTCGCTGCTGGCCAATTGCCTGGCCCAGTCCGCCGCCCTGGCTTTTGGTCAAACGGCTGAAGA
AGTCCGTGCCGCAGGCATTCCGGAGGCCCTGATTCCCTACAAGGTGTTCCCCGGCAATCAGCCGTCGAACACCCTGCTGC
TGCCCTCACTCGATCCCTACACGCTGGGGCAGTTGCTTGCCCTGTTCGAGCACAAGGTCTTCTGCCTGGGTGTGCTGTGG
AACCTGAATGCTTTCGACCAATGGGGCGTCGAACTCGGCAAACAACTGGCCGGCCAGCTGACCCCGCTGATCGAGGGCAA
CGGCGATCTGTCAGCCTTCGACAGCTCGACACGCGGCCTGATCACGGCCCTGAAAGGATAA

Upstream 100 bases:

>100_bases
TGACGCCGGAACTGTGCGGCAAGCTGGAATACCGCATCCGTATCTTCCCGACCCATGCGTCACTGACCCACCCTCTTGAA
ACCGGATTGATGATCTGGCT

Downstream 100 bases:

>100_bases
TCATGAGCTCGCTCTCGATTCTCTTTGCCACCTCCGAAATGGCCCCCTGGGTCAAGACCGGTGGTCTCGGCGATGTCGCC
GCCGCCCTGCCTGCCGCCTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MNPIDSPAWRALAAHAEAIRPLHLRDLFATDPQRFELFSLHHDGLLLDYSKQRVSVETMALLRAYAETADVTGWRRRMLD
GESINHTEGRAVRHMSLRAGDQAPAEVRAALARQQAFCESIHNGVWRGFSGERITDVVNIGIGGSDLGPRMAALALSARQ
QPDIAVHFIANVDSADIAPLLASLNPRTTLFIVASKTFTTLETLTNARTARDWLLATAGQESAIARHFVAISTNLELTKQ
FGIADDNVFEFWDWVGGRFSIWSAIGLSLALAIGWKNFEQLQAGARAMDRHFIDTPADENLPLTLALLSLWNTNFLGAST
EAMLPYSQSLHLFPAYLQQLEMESNGKQIDRDGKPLNIATSPVIWGESGTNGQHSFYQLFHQGGHLIPADFVALREADFP
LPGHHASLLANCLAQSAALAFGQTAEEVRAAGIPEALIPYKVFPGNQPSNTLLLPSLDPYTLGQLLALFEHKVFCLGVLW
NLNAFDQWGVELGKQLAGQLTPLIEGNGDLSAFDSSTRGLITALKG

Sequences:

>Translated_526_residues
MNPIDSPAWRALAAHAEAIRPLHLRDLFATDPQRFELFSLHHDGLLLDYSKQRVSVETMALLRAYAETADVTGWRRRMLD
GESINHTEGRAVRHMSLRAGDQAPAEVRAALARQQAFCESIHNGVWRGFSGERITDVVNIGIGGSDLGPRMAALALSARQ
QPDIAVHFIANVDSADIAPLLASLNPRTTLFIVASKTFTTLETLTNARTARDWLLATAGQESAIARHFVAISTNLELTKQ
FGIADDNVFEFWDWVGGRFSIWSAIGLSLALAIGWKNFEQLQAGARAMDRHFIDTPADENLPLTLALLSLWNTNFLGAST
EAMLPYSQSLHLFPAYLQQLEMESNGKQIDRDGKPLNIATSPVIWGESGTNGQHSFYQLFHQGGHLIPADFVALREADFP
LPGHHASLLANCLAQSAALAFGQTAEEVRAAGIPEALIPYKVFPGNQPSNTLLLPSLDPYTLGQLLALFEHKVFCLGVLW
NLNAFDQWGVELGKQLAGQLTPLIEGNGDLSAFDSSTRGLITALKG
>Mature_526_residues
MNPIDSPAWRALAAHAEAIRPLHLRDLFATDPQRFELFSLHHDGLLLDYSKQRVSVETMALLRAYAETADVTGWRRRMLD
GESINHTEGRAVRHMSLRAGDQAPAEVRAALARQQAFCESIHNGVWRGFSGERITDVVNIGIGGSDLGPRMAALALSARQ
QPDIAVHFIANVDSADIAPLLASLNPRTTLFIVASKTFTTLETLTNARTARDWLLATAGQESAIARHFVAISTNLELTKQ
FGIADDNVFEFWDWVGGRFSIWSAIGLSLALAIGWKNFEQLQAGARAMDRHFIDTPADENLPLTLALLSLWNTNFLGAST
EAMLPYSQSLHLFPAYLQQLEMESNGKQIDRDGKPLNIATSPVIWGESGTNGQHSFYQLFHQGGHLIPADFVALREADFP
LPGHHASLLANCLAQSAALAFGQTAEEVRAAGIPEALIPYKVFPGNQPSNTLLLPSLDPYTLGQLLALFEHKVFCLGVLW
NLNAFDQWGVELGKQLAGQLTPLIEGNGDLSAFDSSTRGLITALKG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=527, Percent_Identity=49.5256166982922, Blast_Score=527, Evalue=1e-150,
Organism=Homo sapiens, GI296080693, Length=527, Percent_Identity=46.2998102466793, Blast_Score=471, Evalue=1e-133,
Organism=Escherichia coli, GI1790457, Length=543, Percent_Identity=50.6445672191529, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71996708, Length=539, Percent_Identity=47.8664192949907, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71996703, Length=539, Percent_Identity=47.8664192949907, Blast_Score=509, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319673, Length=537, Percent_Identity=46.1824953445065, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24651916, Length=530, Percent_Identity=49.622641509434, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24651914, Length=530, Percent_Identity=49.622641509434, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI17737445, Length=530, Percent_Identity=49.622641509434, Blast_Score=520, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_DECAR (Q47IJ3)

Other databases:

- EMBL:   CP000089
- RefSeq:   YP_283808.1
- ProteinModelPortal:   Q47IJ3
- SMR:   Q47IJ3
- STRING:   Q47IJ3
- GeneID:   3568807
- GenomeReviews:   CP000089_GR
- KEGG:   dar:Daro_0581
- NMPDR:   fig|159087.4.peg.430
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- BioCyc:   DARO159087:DARO_0581-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57500; Mature: 57500

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 343-343 ACT_SITE 374-374 ACT_SITE 494-494

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIDSPAWRALAAHAEAIRPLHLRDLFATDPQRFELFSLHHDGLLLDYSKQRVSVETMA
CCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEECCCEEEECCCHHHHHHHHH
LLRAYAETADVTGWRRRMLDGESINHTEGRAVRHMSLRAGDQAPAEVRAALARQQAFCES
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHEEEHHCCCCCCHHHHHHHHHHHHHHHHH
IHNGVWRGFSGERITDVVNIGIGGSDLGPRMAALALSARQQPDIAVHFIANVDSADIAPL
HHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
LASLNPRTTLFIVASKTFTTLETLTNARTARDWLLATAGQESAIARHFVAISTNLELTKQ
HHCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHEEECCCHHHHHHEEEEEECCCEEHHH
FGIADDNVFEFWDWVGGRFSIWSAIGLSLALAIGWKNFEQLQAGARAMDRHFIDTPADEN
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
LPLTLALLSLWNTNFLGASTEAMLPYSQSLHLFPAYLQQLEMESNGKQIDRDGKPLNIAT
CCHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEC
SPVIWGESGTNGQHSFYQLFHQGGHLIPADFVALREADFPLPGHHASLLANCLAQSAALA
CCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FGQTAEEVRAAGIPEALIPYKVFPGNQPSNTLLLPSLDPYTLGQLLALFEHKVFCLGVLW
HCCCHHHHHHCCCCHHHCCEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEHHH
NLNAFDQWGVELGKQLAGQLTPLIEGNGDLSAFDSSTRGLITALKG
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MNPIDSPAWRALAAHAEAIRPLHLRDLFATDPQRFELFSLHHDGLLLDYSKQRVSVETMA
CCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEECCCEEEECCCHHHHHHHHH
LLRAYAETADVTGWRRRMLDGESINHTEGRAVRHMSLRAGDQAPAEVRAALARQQAFCES
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHEEEHHCCCCCCHHHHHHHHHHHHHHHHH
IHNGVWRGFSGERITDVVNIGIGGSDLGPRMAALALSARQQPDIAVHFIANVDSADIAPL
HHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
LASLNPRTTLFIVASKTFTTLETLTNARTARDWLLATAGQESAIARHFVAISTNLELTKQ
HHCCCCCEEEEEEECCHHHHHHHHHCCHHHHHHHEEECCCHHHHHHEEEEEECCCEEHHH
FGIADDNVFEFWDWVGGRFSIWSAIGLSLALAIGWKNFEQLQAGARAMDRHFIDTPADEN
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
LPLTLALLSLWNTNFLGASTEAMLPYSQSLHLFPAYLQQLEMESNGKQIDRDGKPLNIAT
CCHHHHHHHHHCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEC
SPVIWGESGTNGQHSFYQLFHQGGHLIPADFVALREADFPLPGHHASLLANCLAQSAALA
CCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FGQTAEEVRAAGIPEALIPYKVFPGNQPSNTLLLPSLDPYTLGQLLALFEHKVFCLGVLW
HCCCHHHHHHCCCCHHHCCEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEHHH
NLNAFDQWGVELGKQLAGQLTPLIEGNGDLSAFDSSTRGLITALKG
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA