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The map label for this gene is holA [H]

Identifier: 71906182

GI number: 71906182

Start: 599624

End: 600631

Strand: Reverse

Name: holA [H]

Synonym: Daro_0542

Alternate gene names: 71906182

Gene position: 600631-599624 (Counterclockwise)

Preceding gene: 71906183

Following gene: 71906180

Centisome position: 13.34

GC content: 62.8

Gene sequence:

>1008_bases
ATGCTGCTCAAGGGCGAACAGCTCGCCGCGCACCTCGAACGCGAGTTGCGTCCGCTCTATGTGCTGTATGGCGATGATCC
GTTACTGGTCATTGAAGCGGCCGACGCGATCCGCGCCAAATCGCGGCAGCAGGGCTACAGCGAACGCGAGGTGCTGACCG
TGCTGCCGCAGTTCGACTGGGGAACCCTGCTCTCCGCTGGCGGCAACATGTCGCTGTTCGGCGATAAAAAACTGATCGAC
CTGCGCATTCCCACCGGCAAGCCGGGCAAGGAAGGCAGCGCAGCATTGCAGCAGTGGTGCCAGCACCTGTCGATGGACAA
CATGCTGCTGATTACGCTGCCTGAACTCGACTGGCGTGAGGAAAAGGCCGTCTGGTTCACTGCACTGGTCAATGCCGGCG
TGGCGATCAAGCTGATGGCCCCGCCGCTGGCCGAACTGCCGGGCTGGATTGCCGGTCGCCTGCGCCGTCAGCAACAGAGC
GCCGACCTGGAAAGCCTGAAGTTCATCGCCGAACGCGTCGAAGGCAATCTGCTCGCCGCCCATCAGGAAATCCAGAAGCT
CGGCCTGCTTTACCCGACCGGCCAACTGAGCATGGCGCAGATTCGCGAGGCCGTGCTCAATGTTGCCCGTTACGATATTG
ATGGTCTGCGCGAGGCGCTGCTGGCGGGCGACATCGGGCGCCTGACCCGGACGCTGGATGGCCTGATGCAGGAAGGTGAA
GCGCCACCGCTGGTCCTGTGGGCGATGAGCGAGGAAATTCGGGCACTGACCATCATCCGCGCCGGTATGGATGCCGGCAA
GCCGATGGATATGCTGCTCAAGGATGCCAAGGTTTGGGGGCCACGCGCTACCCCGGTCAAGAAGGCGCTGCAACGGCTGT
CGACTTCCGCACTGGAAGCAGCCCTGCAGCACGCTGGCAAGATCGACCGACTGGCCAAGGGGATCGGCCAGGGAAATATT
TGGGAAGAGTTCCTGCGGCTCGGCCTGCGCCTCACCGCCGCAAAATAA

Upstream 100 bases:

>100_bases
CTCGCAATAGCTTCGGCTATTGCTGCGGTTCGCGCCTAGCCGGCGGAACAAATCCTTCGCTTTCATTCTGTTCCGCAATC
TGCGGGACAGACCACCTGTA

Downstream 100 bases:

>100_bases
TCAGGCGGCTTCTGCCGAATCGTCGGCGGGCACGTCCGGTTCAAGGTCTTCCCAAATGCAGGAACACTCCTTGCGGACAT
CGTGAAGCCCGGGCTTGGCC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MLLKGEQLAAHLERELRPLYVLYGDDPLLVIEAADAIRAKSRQQGYSEREVLTVLPQFDWGTLLSAGGNMSLFGDKKLID
LRIPTGKPGKEGSAALQQWCQHLSMDNMLLITLPELDWREEKAVWFTALVNAGVAIKLMAPPLAELPGWIAGRLRRQQQS
ADLESLKFIAERVEGNLLAAHQEIQKLGLLYPTGQLSMAQIREAVLNVARYDIDGLREALLAGDIGRLTRTLDGLMQEGE
APPLVLWAMSEEIRALTIIRAGMDAGKPMDMLLKDAKVWGPRATPVKKALQRLSTSALEAALQHAGKIDRLAKGIGQGNI
WEEFLRLGLRLTAAK

Sequences:

>Translated_335_residues
MLLKGEQLAAHLERELRPLYVLYGDDPLLVIEAADAIRAKSRQQGYSEREVLTVLPQFDWGTLLSAGGNMSLFGDKKLID
LRIPTGKPGKEGSAALQQWCQHLSMDNMLLITLPELDWREEKAVWFTALVNAGVAIKLMAPPLAELPGWIAGRLRRQQQS
ADLESLKFIAERVEGNLLAAHQEIQKLGLLYPTGQLSMAQIREAVLNVARYDIDGLREALLAGDIGRLTRTLDGLMQEGE
APPLVLWAMSEEIRALTIIRAGMDAGKPMDMLLKDAKVWGPRATPVKKALQRLSTSALEAALQHAGKIDRLAKGIGQGNI
WEEFLRLGLRLTAAK
>Mature_335_residues
MLLKGEQLAAHLERELRPLYVLYGDDPLLVIEAADAIRAKSRQQGYSEREVLTVLPQFDWGTLLSAGGNMSLFGDKKLID
LRIPTGKPGKEGSAALQQWCQHLSMDNMLLITLPELDWREEKAVWFTALVNAGVAIKLMAPPLAELPGWIAGRLRRQQQS
ADLESLKFIAERVEGNLLAAHQEIQKLGLLYPTGQLSMAQIREAVLNVARYDIDGLREALLAGDIGRLTRTLDGLMQEGE
APPLVLWAMSEEIRALTIIRAGMDAGKPMDMLLKDAKVWGPRATPVKKALQRLSTSALEAALQHAGKIDRLAKGIGQGNI
WEEFLRLGLRLTAAK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=331, Percent_Identity=32.02416918429, Blast_Score=138, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36976; Mature: 36976

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKGEQLAAHLERELRPLYVLYGDDPLLVIEAADAIRAKSRQQGYSEREVLTVLPQFDW
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCEEECCCCCC
GTLLSAGGNMSLFGDKKLIDLRIPTGKPGKEGSAALQQWCQHLSMDNMLLITLPELDWRE
HHHHHCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCC
EKAVWFTALVNAGVAIKLMAPPLAELPGWIAGRLRRQQQSADLESLKFIAERVEGNLLAA
HHHHHHHHHHHCCEEEEEECCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHH
HQEIQKLGLLYPTGQLSMAQIREAVLNVARYDIDGLREALLAGDIGRLTRTLDGLMQEGE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCC
APPLVLWAMSEEIRALTIIRAGMDAGKPMDMLLKDAKVWGPRATPVKKALQRLSTSALEA
CCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ALQHAGKIDRLAKGIGQGNIWEEFLRLGLRLTAAK
HHHHCCHHHHHHHHCCCCHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MLLKGEQLAAHLERELRPLYVLYGDDPLLVIEAADAIRAKSRQQGYSEREVLTVLPQFDW
CCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCEEECCCCCC
GTLLSAGGNMSLFGDKKLIDLRIPTGKPGKEGSAALQQWCQHLSMDNMLLITLPELDWRE
HHHHHCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCC
EKAVWFTALVNAGVAIKLMAPPLAELPGWIAGRLRRQQQSADLESLKFIAERVEGNLLAA
HHHHHHHHHHHCCEEEEEECCCHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHH
HQEIQKLGLLYPTGQLSMAQIREAVLNVARYDIDGLREALLAGDIGRLTRTLDGLMQEGE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCC
APPLVLWAMSEEIRALTIIRAGMDAGKPMDMLLKDAKVWGPRATPVKKALQRLSTSALEA
CCCEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ALQHAGKIDRLAKGIGQGNIWEEFLRLGLRLTAAK
HHHHCCHHHHHHHHCCCCHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]