Click here to switch to the map view.

The map label for this gene is cobC [H]

Identifier: 71905781

GI number: 71905781

Start: 152904

End: 153896

Strand: Reverse

Name: cobC [H]

Synonym: Daro_0139

Alternate gene names: 71905781

Gene position: 153896-152904 (Counterclockwise)

Preceding gene: 71905782

Following gene: 71905780

Centisome position: 3.42

GC content: 64.85

Gene sequence:

>993_bases
ATGCTTGAACACGGCGGCCGCCTGCGTGAAGCCGCGGCACACTACAACATCCCGCTGGAAAACTGGCTCGACTTGTCCAC
CGGCATCAATCCTGAGGCGTGGCCCGTCCCGGCGCTACCGCCGAGCGTCTGGCACCGCCTGCCGGAAAATCATGATGGAC
TGGAAGCTGCTGCCGCCGCCTATTACGGCAACGCCAACCTGCTGCCCGTCGCCGGCTCGCAAGCCGCCATCCAGTGGCTG
CCGACCCTGCTGCCCCGCGGCGTCGTCGCCTGCATTTCACCGATCTACGCCGAGCATCCGCAAGCCTGGCAGCACGCCGG
CCACAAGATTCGTTTCCTGCAAAATGCCCTGTTACCACGCGCACTTGCCGCAGCAACGCCCTACGTGCTGCTGTGCAATC
CAAACAATCCGACCGCCGACCGCCATCCGCACGACGTCGCTCTGGATGCGGCCCGGCAACTGAAGAAACGTGGCGGCTGG
CTGATTGTCGATGAGGCCTTCATCGACGCGACGCCGGAGGACAGCCTGACCCCGCTGGCCGGTAGCGAAGAAGCGCCGAA
CCTGATCGTCTTCCGTTCAATTGGCAAATTCTTCGGCCTGGCGGGCATCCGCGTCGGCTTCCTGTTCGCCGCCCCCGAAC
TGCTCGGTCGGATGAGCGAGGCCATGGGCCCGTGGACGATCAGTGGCCCGTCACGTGAAGCGGCCAAACTGGCCCTGCAG
GATATCGCCTGGCAAGACGCTTCCCGCCCCCGCCTGCTGTCCGCCGGCGAGCGTTTGCACCAGATGCTTTCCCCCCTCGG
CGAGGTCAAGTTCACTGCCTTGTTCGCGACGCTGACCTCGCACCACGCCAGTGAATTGCACGAAGCCCTCGCCCGCCAAG
GCATCCTGACCCGTCGCTTCGACCAGCAGCCACTACTGCGCTTTGGCCTGCCCTGCAGCGAAGACCAATGGCAACGTCTG
GGCAAGGCGCTTGCCGAATGGAAACCCGCATGA

Upstream 100 bases:

>100_bases
GGTCCGCCCCCAGCGGCCGCCGACCTTGGCCGGGCGATCTCCCTGATCAGGCACAGCCTGTGGTTATGGTTGGCCGTACT
TTTTGCGATTGGACTCCTGC

Downstream 100 bases:

>100_bases
AAATCCGCTTGCTTTCAGCCTTGGCGACCGCCTTCGTCGTTTCCACCAACGCCCACGCCGACCTCGTCATCAAGGATGAC
ATCGGCCAGGAAATCCGTCT

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MLEHGGRLREAAAHYNIPLENWLDLSTGINPEAWPVPALPPSVWHRLPENHDGLEAAAAAYYGNANLLPVAGSQAAIQWL
PTLLPRGVVACISPIYAEHPQAWQHAGHKIRFLQNALLPRALAAATPYVLLCNPNNPTADRHPHDVALDAARQLKKRGGW
LIVDEAFIDATPEDSLTPLAGSEEAPNLIVFRSIGKFFGLAGIRVGFLFAAPELLGRMSEAMGPWTISGPSREAAKLALQ
DIAWQDASRPRLLSAGERLHQMLSPLGEVKFTALFATLTSHHASELHEALARQGILTRRFDQQPLLRFGLPCSEDQWQRL
GKALAEWKPA

Sequences:

>Translated_330_residues
MLEHGGRLREAAAHYNIPLENWLDLSTGINPEAWPVPALPPSVWHRLPENHDGLEAAAAAYYGNANLLPVAGSQAAIQWL
PTLLPRGVVACISPIYAEHPQAWQHAGHKIRFLQNALLPRALAAATPYVLLCNPNNPTADRHPHDVALDAARQLKKRGGW
LIVDEAFIDATPEDSLTPLAGSEEAPNLIVFRSIGKFFGLAGIRVGFLFAAPELLGRMSEAMGPWTISGPSREAAKLALQ
DIAWQDASRPRLLSAGERLHQMLSPLGEVKFTALFATLTSHHASELHEALARQGILTRRFDQQPLLRFGLPCSEDQWQRL
GKALAEWKPA
>Mature_330_residues
MLEHGGRLREAAAHYNIPLENWLDLSTGINPEAWPVPALPPSVWHRLPENHDGLEAAAAAYYGNANLLPVAGSQAAIQWL
PTLLPRGVVACISPIYAEHPQAWQHAGHKIRFLQNALLPRALAAATPYVLLCNPNNPTADRHPHDVALDAARQLKKRGGW
LIVDEAFIDATPEDSLTPLAGSEEAPNLIVFRSIGKFFGLAGIRVGFLFAAPELLGRMSEAMGPWTISGPSREAAKLALQ
DIAWQDASRPRLLSAGERLHQMLSPLGEVKFTALFATLTSHHASELHEALARQGILTRRFDQQPLLRFGLPCSEDQWQRL
GKALAEWKPA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=216, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36150; Mature: 36150

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGRLREAAAHYNIPLENWLDLSTGINPEAWPVPALPPSVWHRLPENHDGLEAAAAA
CCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHH
YYGNANLLPVAGSQAAIQWLPTLLPRGVVACISPIYAEHPQAWQHAGHKIRFLQNALLPR
HCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHH
ALAAATPYVLLCNPNNPTADRHPHDVALDAARQLKKRGGWLIVDEAFIDATPEDSLTPLA
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCC
GSEEAPNLIVFRSIGKFFGLAGIRVGFLFAAPELLGRMSEAMGPWTISGPSREAAKLALQ
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHH
DIAWQDASRPRLLSAGERLHQMLSPLGEVKFTALFATLTSHHASELHEALARQGILTRRF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHC
DQQPLLRFGLPCSEDQWQRLGKALAEWKPA
CCCCHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLEHGGRLREAAAHYNIPLENWLDLSTGINPEAWPVPALPPSVWHRLPENHDGLEAAAAA
CCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHH
YYGNANLLPVAGSQAAIQWLPTLLPRGVVACISPIYAEHPQAWQHAGHKIRFLQNALLPR
HCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHH
ALAAATPYVLLCNPNNPTADRHPHDVALDAARQLKKRGGWLIVDEAFIDATPEDSLTPLA
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCC
GSEEAPNLIVFRSIGKFFGLAGIRVGFLFAAPELLGRMSEAMGPWTISGPSREAAKLALQ
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHH
DIAWQDASRPRLLSAGERLHQMLSPLGEVKFTALFATLTSHHASELHEALARQGILTRRF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHC
DQQPLLRFGLPCSEDQWQRLGKALAEWKPA
CCCCHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]